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Entry version 89 (26 Feb 2020)
Sequence version 2 (29 Apr 2008)
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Protein

Filaggrin-2

Gene

Flg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi62 – 73PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6798695 Neutrophil degranulation
R-MMU-6809371 Formation of the cornified envelope

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Filaggrin-2
Short name:
FLG-2
Alternative name(s):
Intermediate filament-associated protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Flg2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3645678 Flg2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003314551 – 2362Filaggrin-2Add BLAST2362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1198PhosphoserineCombined sources1
Modified residuei1204PhosphoserineCombined sources1
Modified residuei1205PhosphoserineCombined sources1
Modified residuei1278PhosphoserineCombined sources1
Modified residuei1284PhosphoserineCombined sources1
Modified residuei1285PhosphoserineCombined sources1
Modified residuei1356PhosphoserineCombined sources1
Modified residuei1362PhosphoserineCombined sources1
Modified residuei1363PhosphoserineCombined sources1
Modified residuei1438PhosphoserineCombined sources1
Modified residuei1439PhosphoserineCombined sources1
Modified residuei1510PhosphoserineCombined sources1
Modified residuei1516PhosphoserineCombined sources1
Modified residuei1517PhosphoserineCombined sources1
Modified residuei1590PhosphoserineCombined sources1
Modified residuei1596PhosphoserineCombined sources1
Modified residuei1597PhosphoserineCombined sources1
Modified residuei1744PhosphoserineCombined sources1
Modified residuei1750PhosphoserineCombined sources1
Modified residuei1751PhosphoserineCombined sources1
Modified residuei1824PhosphoserineCombined sources1
Modified residuei1830PhosphoserineCombined sources1
Modified residuei1831PhosphoserineCombined sources1
Modified residuei1902PhosphoserineCombined sources1
Modified residuei1908PhosphoserineCombined sources1
Modified residuei1909PhosphoserineCombined sources1
Modified residuei1980PhosphoserineCombined sources1
Modified residuei1986PhosphoserineCombined sources1
Modified residuei1987PhosphoserineCombined sources1
Modified residuei2104PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Deiminated by PADI1, PADI2 or PADI3 in vitro. The deiminated form is degraded by calpain-1/CAPN1 more quickly and into shorter peptides than the intact protein.By similarity
May be processed by calpain-1/CAPN1.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q2VIS4

PRoteomics IDEntifications database

More...
PRIDEi
Q2VIS4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q2VIS4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q2VIS4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000096482

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q2VIS4 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q2VIS4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 43EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini49 – 84EF-hand 2PROSITE-ProRule annotationAdd BLAST36
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati261 – 308Filaggrin 1Add BLAST48
Repeati373 – 414Filaggrin 2Add BLAST42
Repeati555 – 607Filaggrin 3Add BLAST53
Repeati672 – 723Filaggrin 4Add BLAST52
Repeati880 – 927Filaggrin 5Add BLAST48
Repeati984 – 1035Filaggrin 6Add BLAST52
Repeati1165 – 1210Filaggrin 7Add BLAST46
Repeati1280 – 1334Filaggrin 8Add BLAST55
Repeati1474 – 1522Filaggrin 9Add BLAST49
Repeati1723 – 1756Filaggrin 10Add BLAST34
Repeati2016 – 2070Filaggrin 11Add BLAST55
Repeati2218 – 2259Filaggrin 12Add BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 81S-100-likeBy similarityAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi110 – 120Poly-GluAdd BLAST11
Compositional biasi265 – 911Ser-richAdd BLAST647
Compositional biasi994 – 1970Gln-richAdd BLAST977

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the S100-fused protein family.Curated
In the N-terminal section; belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IX7U Eukaryota
ENOG410ZH9F LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q2VIS4

KEGG Orthology (KO)

More...
KOi
K10384

Database of Orthologous Groups

More...
OrthoDBi
1315634at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q2VIS4

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00213 S-100, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR034325 S-100_dom
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01023 S_100, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01394 S_100, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 2 hits
PS00303 S100_CABP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q2VIS4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYLLRSVVT IIDVFYKYTK QDEECGTLSK DELKELLEKE FRPILKNPDD
60 70 80 90 100
PDTVDVIMHM LDRDHDRRLD FTEFILMIFK LALACNKVLG KEYCKASGSK
110 120 130 140 150
KHRRGHQHQE EESETEEEEE TPRQKSGFRF SSWSEGEEHG HSSGGSRGPA
160 170 180 190 200
KHRRGSNSKR LERQDELSSS EESRKKHHGS IFGHSWSSNK EKDGSRSEEL
210 220 230 240 250
GEKGDKSYDS PSRESEEEYE SGYRLNHQGR EGHSGLSCGL EKNKYELNYI
260 270 280 290 300
QLRKGGEQKL GYNTSSSGNS KIQSHVYGFS NSSGCCRPKN ASSSCQASRS
310 320 330 340 350
QGQGNQSCRT QSNCQSGTSG GQGYGCVSEG QSSRCCQPKP RSCSQSSSQR
360 370 380 390 400
GYGSKQCGQP QNCGRQQRMG SSHSSCCGPY GSGATQSSGC GQQRMSSCGH
410 420 430 440 450
SSSSHQKGCS SNGFSKGDQR ASGSGHSSCC EQHGTNSSQS SGFKQHGHES
460 470 480 490 500
GQSCCGQHGT ASSQSSGYSQ HRVGSGQSCH YGQHGSSSGQ SSSSGRHGSG
510 520 530 540 550
SGQSSSSRHN RSGSSQSSGL EEHGSSSHQS HSSGHHGSGS RQSSGSEQHG
560 570 580 590 600
AVSGQSSGSG KHETGPSQSS SSGHHGSGSQ QHGGGSGQST GFGEHESSSG
610 620 630 640 650
HSSSSGQHRS GSRHSSGSGK HESGRSQSSG SGHHGSGSQQ HGGGSGNSTG
660 670 680 690 700
FGEHGSSSHP LPSSGQNESS SGQSSRSERH GTGSGQSSGF GQHGSGSHQS
710 720 730 740 750
SSSGHNEYGS GQTSSSWPHG KGSGQESGYG EQESGHGQSS SSWQHGTGPG
760 770 780 790 800
QSSSSEEEES RPGQSSSSWQ HGKGSGQESG YGEQEAGHGQ SSSSWQHGTG
810 820 830 840 850
AGNQSSGYGE HKSGPSHSSR SWHHGTGSGQ SLGFGQHGKG SHQSESSGHY
860 870 880 890 900
ESVSEPSSSS WQHGNGSGES YGYGEHESGH GQSSSAWNHG NESGQSNGYG
910 920 930 940 950
EHESGHGQSS SAWNHGNESG QSNGFGENES GRDQEGYQQR ESFHGQHRHP
960 970 980 990 1000
LSQHEQHSQF GYGRSPRSPV HPESSEGEEH SVVPRRYSGY GHGQGQAGHQ
1010 1020 1030 1040 1050
QRESGYGQRG RPQGPSQDSS RQPQAGHGQP SQSGYGRSPR RSQVHPEYSE
1060 1070 1080 1090 1100
GEAHSEVSQR HSGSSHCHCH CHGQARHQQR ESVHGQRGRP QGPSQDSSRH
1110 1120 1130 1140 1150
PQAGPGQPSQ SGSRRSPRSQ PVHPESSEGE EHSVVPQRHS GSGHGHGQGQ
1160 1170 1180 1190 1200
GQAGHQQRES VHGQQGRPQG PSQDSSRQPQ AGQGQPSQSG SGRSPRRSPV
1210 1220 1230 1240 1250
HPESSEGEEH SVVPQRHSGS GHGHGQGQGQ GQAGHQQRES VHGQRSRPQG
1260 1270 1280 1290 1300
PFQDSSRQPQ AGQGQPSQSG SGRSPRRSPV HPESSEGEEH SVVPQRHSGS
1310 1320 1330 1340 1350
GHGHGQGQGQ AGHQQRESVH GQPVRPEVPT QDSSRQPQAG QGQPSQSGSG
1360 1370 1380 1390 1400
RSPRRSPVHP ESSEGEEHSV VPQRNSESCH CHCHDQAGHQ QRESVHGQRG
1410 1420 1430 1440 1450
RPQGPSQDSS RHPQAGPGQP SQSGSRRSPR SSPVHPESSE GEEHSVVPQR
1460 1470 1480 1490 1500
HSGSGHGHGQ GQGQAGHQQR ESVHGQRGRP QGPTQDSSRQ PQAGQGQPSQ
1510 1520 1530 1540 1550
SGSGRSPRRS PVHPESSEGE EHSVVPQRHS GSGHGHGHGQ GQGQAGHQQR
1560 1570 1580 1590 1600
ESVHGQRGRP QGPSQDSSRQ PQAGQGQPSQ SGSGRSPRRS PVHPESSEGE
1610 1620 1630 1640 1650
EHSVVPQRYS GSGHGHGQGQ AGHQQRESVH GQRGRPQGPS QDSSRQPQAG
1660 1670 1680 1690 1700
QGQPSQSGSG RSPRRSPVHP ESSEGEEHSV IPQRHSGSGH SHGQGQVHAE
1710 1720 1730 1740 1750
HQQRESVHGQ RGRPQGPSQD SSRQPQAGQG QPSLSGSGRS PRRSPVHPES
1760 1770 1780 1790 1800
SEGEEHSVVP QRHSHSESGH GHGQGQGQAG HQQRESVHGQ RGRPQGPSQD
1810 1820 1830 1840 1850
SSRQPQAGQG QPSQSGSGRS PGRSPVHPES SEGEEHSVVP QRHSESGHGH
1860 1870 1880 1890 1900
GQGQGQAGHQ QRESVHGQRG RPQGPSQDSS RQPQAGQGQP SQSGSGRSPR
1910 1920 1930 1940 1950
RSPVHPESSE GEEHSVVPQR HSGSGHGHGQ GQGQAGHQQR ESVHGQPVRP
1960 1970 1980 1990 2000
QGPSQDSSSQ PQASQGQPSQ SGSGRSPRRS PVHPESSEGE EHSVVPQRHS
2010 2020 2030 2040 2050
GSGHGHGQGQ GQAGHQQRES LHGQRGRSQS PFHPSHSIHW QSKCTISKKS
2060 2070 2080 2090 2100
SRLSGHYGRN HFQSTISGNQ YDSSQSSRHG SYGPQDYDYG QSGYGPSGRL
2110 2120 2130 2140 2150
RSNSQSSIPF SSAHRATNME VLPCGQSFSP SDHVGTKANE QIGELVFKYR
2160 2170 2180 2190 2200
ESETGPDQSV DYYNLTESNS TTRGHECSHG HSVVVPEHSD DSDFNYGHSY
2210 2220 2230 2240 2250
NGKQQICQSQ PTVQSCFDDS QYILFQKHLE SPSFGNQSGF SPNERQLYTC
2260 2270 2280 2290 2300
NESIDSYHLS SDSNNRNQIY SSNNSFPNLY CIGTEQCIYL PSATILGEGT
2310 2320 2330 2340 2350
EGQEPGYTQP GTICKYNQFL DGRKSRTRGN HETGKMKSGS AYLDSNTPLY
2360
TYVQEQKSYY FE
Length:2,362
Mass (Da):251,372
Last modified:April 29, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3FB473737052808
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QPZ3E9QPZ3_MOUSE
Filaggrin-2
Flg2
2,336Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC29615 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2118N → H in AAZ99028 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ118292 Genomic DNA Translation: AAZ99028.1
AK036878 mRNA Translation: BAC29615.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_001013826.1, NM_001013804.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
229574

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:229574

UCSC genome browser

More...
UCSCi
uc029unl.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ118292 Genomic DNA Translation: AAZ99028.1
AK036878 mRNA Translation: BAC29615.1 Different initiation.
RefSeqiNP_001013826.1, NM_001013804.1

3D structure databases

SMRiQ2VIS4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096482

PTM databases

iPTMnetiQ2VIS4
PhosphoSitePlusiQ2VIS4

Proteomic databases

PaxDbiQ2VIS4
PRIDEiQ2VIS4

Genome annotation databases

GeneIDi229574
KEGGimmu:229574
UCSCiuc029unl.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
388698
MGIiMGI:3645678 Flg2

Phylogenomic databases

eggNOGiENOG410IX7U Eukaryota
ENOG410ZH9F LUCA
InParanoidiQ2VIS4
KOiK10384
OrthoDBi1315634at2759
PhylomeDBiQ2VIS4

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-6809371 Formation of the cornified envelope

Miscellaneous databases

Protein Ontology

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PROi
PR:Q2VIS4
RNActiQ2VIS4 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Family and domain databases

CDDicd00213 S-100, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR034325 S-100_dom
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 2 hits
PS00303 S100_CABP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFILA2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2VIS4
Secondary accession number(s): Q8CB36
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: February 26, 2020
This is version 89 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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