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Entry version 82 (29 Sep 2021)
Sequence version 1 (10 Jan 2006)
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Protein

Catalase

Gene
N/A
Organism
Penicillium citrinum
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.

UniRule annotationARBA annotation

Serves to protect cells from the toxic effects of hydrogen peroxide.

UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

hemeUniRule annotationARBA annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei109UniRule annotation1
Active sitei182UniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi396Iron (heme axial ligand)UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxideUniRule annotationARBA annotation
LigandHemeUniRule annotationARBA annotation, Iron, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CatalaseUniRule annotationARBA annotation (EC:1.11.1.6UniRule annotationARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPenicillium citrinumImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5077 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicillium

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Protein family/group databases

Allergome; a platform for allergen knowledge

More...
Allergomei
3595, Pen c 30
3596, Pen c 30.0101

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500421768017 – 733CatalaseSequence analysisAdd BLAST717

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q2V6Q5

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q2V6Q5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini63 – 450CatalaseInterPro annotationAdd BLAST388

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni449 – 474DisorderedSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the catalase family.UniRule annotationARBA annotation

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Conserved Domains Database

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CDDi
cd03132, GATase1_catalase, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.1370.20, 1 hit
3.40.50.880, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018028, Catalase
IPR024708, Catalase_AS
IPR024712, Catalase_clade2
IPR043156, Catalase_clade2_helical
IPR011614, Catalase_core
IPR002226, Catalase_haem_BS
IPR010582, Catalase_immune_responsive
IPR041399, Catalase_large_C
IPR020835, Catalase_sf
IPR029062, Class_I_gatase-like

The PANTHER Classification System

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PANTHERi
PTHR42821, PTHR42821, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00199, Catalase, 1 hit
PF06628, Catalase-rel, 1 hit
PF18011, Catalase_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF038927, Catalase_clade2, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00067, CATALASE

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01060, Catalase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52317, SSF52317, 1 hit
SSF56634, SSF56634, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00437, CATALASE_1, 1 hit
PS00438, CATALASE_2, 1 hit
PS51402, CATALASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q2V6Q5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHLLAFATDL VGIANAACPY MTGEVPGDYS PHELHRRADE GAADNTEEFL
60 70 80 90 100
SQFYLNDKDA YLTSDVGGPI EDQNSLSAGE RGPTLLEDFI FRQKIQHFDH
110 120 130 140 150
ERVPERAVHA RGAGAHGVFT SYADWSNITA ASFLSKKDKE TPMFVRFSTV
160 170 180 190 200
AGSRGSADTA RDVHGFATRF YTDEGNFDIV GNNIPVFFIQ DAIQFPDLIH
210 220 230 240 250
AVKPSGDNEI PQAATAHDSA WDFFSQQPSS LHTLLWAMAG HGIPRSFRNV
260 270 280 290 300
DGFGVHTFRF VTDSGKSKLV KFHWKGLQGK ASLVWEEAQQ ISGKNPDFLR
310 320 330 340 350
QDLWDAIEAG RFPEWELGVQ IMDEEDQLRF GFDLLDPTKI VPEEIIPVTK
360 370 380 390 400
LGKMTLNRNP RNYFAETEQV MFQPGHIVRG VDFTDDPLLQ GRLFSYLDTQ
410 420 430 440 450
LNRHGGPNFE QLPINRPRTP IHNNNRDGAG QMFIPLNKDA YSPNTLNNAS
460 470 480 490 500
PKQANQTTGK GFFTTPSRKG NGKLQRTVSS TFEDVWSQPR LFWNSLVEAE
510 520 530 540 550
KQFVVDATRF ENSNVVSDIV RNNVIIQLNR ISNDLAKRVA EAIGIEAPKP
560 570 580 590 600
DPSFYHDNTT AHIGAFGQKL LKLEGLKVGV LASVQNASSV SSAASLQSQL
610 620 630 640 650
KDAGVDVVVV AERLGDGVNQ TYSGSDAIQF DAVVVADGAE GLFSSRSFTE
660 670 680 690 700
KPVKNKASSL FPAGRPLDIL VDAFRFGKPV GAIGKGAAAL RAAQISSDRE
710 720 730
GVYAAKSIGN EFVKGLKEGL RIFKFLDRFA LDA
Length:733
Mass (Da):80,730
Last modified:January 10, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD7A1AD4600C40847
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ288844 mRNA Translation: ABB89950.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ288844 mRNA Translation: ABB89950.1

3D structure databases

SMRiQ2V6Q5
ModBaseiSearch...

Protein family/group databases

Allergomei3595, Pen c 30
3596, Pen c 30.0101

Miscellaneous databases

EvolutionaryTraceiQ2V6Q5

Family and domain databases

CDDicd03132, GATase1_catalase, 1 hit
Gene3Di1.20.1370.20, 1 hit
3.40.50.880, 1 hit
InterProiView protein in InterPro
IPR018028, Catalase
IPR024708, Catalase_AS
IPR024712, Catalase_clade2
IPR043156, Catalase_clade2_helical
IPR011614, Catalase_core
IPR002226, Catalase_haem_BS
IPR010582, Catalase_immune_responsive
IPR041399, Catalase_large_C
IPR020835, Catalase_sf
IPR029062, Class_I_gatase-like
PANTHERiPTHR42821, PTHR42821, 1 hit
PfamiView protein in Pfam
PF00199, Catalase, 1 hit
PF06628, Catalase-rel, 1 hit
PF18011, Catalase_C, 1 hit
PIRSFiPIRSF038927, Catalase_clade2, 1 hit
PRINTSiPR00067, CATALASE
SMARTiView protein in SMART
SM01060, Catalase, 1 hit
SUPFAMiSSF52317, SSF52317, 1 hit
SSF56634, SSF56634, 1 hit
PROSITEiView protein in PROSITE
PS00437, CATALASE_1, 1 hit
PS00438, CATALASE_2, 1 hit
PS51402, CATALASE_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ2V6Q5_PENCI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2V6Q5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 10, 2006
Last sequence update: January 10, 2006
Last modified: September 29, 2021
This is version 82 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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