UniProtKB - Q2V3L3 (YY1_ARATH)
Protein
Zinc finger transcription factor YY1
Gene
YY1
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Dual-function transcription factor with both repression and activation activities. Binds to 5'-CCATATT-3' motif in target gene promoters (e.g. ABR1) (PubMed:26961720). Binds also to G-rich DNA motif 5'-GGGGGCAGTGG-3' (PubMed:22508367). Regulates the expression of genes involved in diverse cellular pathways, including glucose metabolism, photosynthesis, phototropism and stress response (e.g. salt, drought and osmotic stress) (PubMed:22508367, PubMed:26961720). Regulates plant immunity, especially during necrotrophic fungal infection (e.g. B.cinerea) (PubMed:24451981). Binds to ABR1 promoter and promotes its expression, thus negatively regulating the abscisic acid (ABA) signaling pathway. Represses ABA- and salt-responsive genes expression (PubMed:26961720).3 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 79 – 103 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 108 – 132 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 138 – 162 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 168 – 193 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 230 – 255 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 26 |
GO - Molecular functioni
- DNA binding Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: TAIR
GO - Biological processi
- abscisic acid-activated signaling pathway Source: UniProtKB-KW
- defense response Source: UniProtKB-KW
- negative regulation of abscisic acid-activated signaling pathway Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: TAIR
- positive regulation of transcription, DNA-templated Source: TAIR
- regulation of defense response to fungus Source: UniProtKB
- regulation of response to salt stress Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
- response to abscisic acid Source: UniProtKB
- response to absence of light Source: UniProtKB
- response to light stimulus Source: UniProtKB
- response to osmotic stress Source: UniProtKB
- response to salt stress Source: UniProtKB
- response to water deprivation Source: UniProtKB
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Abscisic acid signaling pathway, Plant defense, Stress response, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger transcription factor YY11 PublicationAlternative name(s): Protein YIN YANG 11 Publication Short name: AtYY11 Publication |
Gene namesi | Name:YY11 Publication Ordered Locus Names:At4g06634Imported ORF Names:F8H12Curated |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT4G06634 |
TAIRi | locus:1005716361, AT4G06634 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Nucleus
- nuclear chromatin Source: GO_Central
- nucleus Source: UniProtKB
- PcG protein complex Source: GO_Central
Other locations
- transcription regulator complex Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
Deregulated expression of glutaredoxins GRX480, GRXS13 and thioredoxin TRX-h5 leading to enhanced susceptibility to fungal infection (e.g. B.cinerea) (PubMed:24451981). Increased sensitivity to abscisic acid (ABA), drought, and salt (NaCl) stress. Reduced induction of ABR1, but reduced repression of RD29A, RD29B, and COR15A in response to abiotic stresses (PubMed:26961720).2 Publications
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000305942 | 1 – 387 | Zinc finger transcription factor YY1Add BLAST | 387 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 284 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q2V3L3 |
PRIDEi | Q2V3L3 |
ProteomicsDBi | 242960 [Q2V3L3-1] |
PTM databases
iPTMneti | Q2V3L3 |
Expressioni
Tissue specificityi
Mostly expressed in flowers, to a lower extent in seedlings, stems and leaves, and, at low levels, in roots and senescent leaves.1 Publication
Developmental stagei
Rapidly induced following seed germination, especially in tender cotyledons.1 Publication
Inductioni
Induced by abscisic acid (ABA) in an ABI1- and ABI4-dependent manner. Stimulated by stress conditions including high salt, osmotic stress (e.g. mannitol) and dehydration. May be induced by ABI4 but repressed by ABR1. Repressed by darkness but induced by light.1 Publication
Gene expression databases
ExpressionAtlasi | Q2V3L3, baseline and differential |
Interactioni
Subunit structurei
Interacts with MED18 to suppress disease susceptibility via the repression of genes glutaredoxins GRX480, GRXS13 and thioredoxin TRX-h5.
1 PublicationProtein-protein interaction databases
BioGRIDi | 11401, 5 interactors |
IntActi | Q2V3L3, 3 interactors |
STRINGi | 3702.AT4G06634.1 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 201 – 290 | MED18-binding1 PublicationAdd BLAST | 90 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 339 – 367 | Sequence analysisAdd BLAST | 29 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 319 – 326 | Nuclear localization signalPROSITE-ProRule annotation | 8 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 341 – 386 | Glu-richPROSITE-ProRule annotationAdd BLAST | 46 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 79 – 103 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 108 – 132 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 138 – 162 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 168 – 193 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 230 – 255 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 26 |
Keywords - Domaini
Coiled coil, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
HOGENOMi | CLU_040248_0_0_1 |
InParanoidi | Q2V3L3 |
OMAi | HNEKQYI |
PhylomeDBi | Q2V3L3 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q2V3L3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDHQNYQYQN PFERRPILKS KAPAVKWIKE WVPQDIVATG GKCHLHKWVT
60 70 80 90 100
EDTFSRLKEK EKEPDVPEPE PEPTTEILFL CSYDGCGKTF FDVSALRKHS
110 120 130 140 150
HIHGERQYVC DQEGCGKKFL DSSKLKRHYL IHTGERNYIC TYEGCGKAFS
160 170 180 190 200
LDFNLRSHMK THSQENYHIC PYSGCVKRYA HEYKLKNHVA AYHEKNGGGE
210 220 230 240 250
TPKYTPPAEK VLRTVKTPAT VCGPSSDRPY ACPYEGCEKA YIHEYKLKLH
260 270 280 290 300
LKREHPGHLQ EENADTPTLN KHNGNDRNEI DDGSDQDVYR KHASNGKGQT
310 320 330 340 350
HKQQSRAKPN MRTPPAKVGK KGSTSSPAKA RIAKKPWQAK ETFEEVEREE
360 370 380
EEDSEETEED RDNVEDGWRF GENNEDDDDD EETEYED
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF4JGT7 | F4JGT7_ARATH | Zinc finger (C2H2 type) family prot... | YY1 AtYY1, Yin Yang 1, At4g06634 | 380 | Annotation score: |
Sequence cautioni
The sequence BAB83613 differs from that shown. Reason: Erroneous gene model prediction.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028387 | 1 – 38 | Missing in isoform 2. CuratedAdd BLAST | 38 | |
Alternative sequenceiVSP_028388 | 39 – 50 | TGGKC…HKWVT → MLNCIIVLLLLP in isoform 2. CuratedAdd BLAST | 12 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB073162 Genomic DNA Translation: BAB83613.1 Sequence problems. CP002687 Genomic DNA Translation: AEE82553.1 CP002687 Genomic DNA Translation: AEE82554.1 |
RefSeqi | NP_001031589.1, NM_001036512.2 [Q2V3L3-2] NP_849323.1, NM_178992.4 [Q2V3L3-1] |
Genome annotation databases
EnsemblPlantsi | AT4G06634.1; AT4G06634.1; AT4G06634 [Q2V3L3-1] AT4G06634.2; AT4G06634.2; AT4G06634 [Q2V3L3-2] |
GeneIDi | 826093 |
Gramenei | AT4G06634.1; AT4G06634.1; AT4G06634 [Q2V3L3-1] AT4G06634.2; AT4G06634.2; AT4G06634 [Q2V3L3-2] |
KEGGi | ath:AT4G06634 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB073162 Genomic DNA Translation: BAB83613.1 Sequence problems. CP002687 Genomic DNA Translation: AEE82553.1 CP002687 Genomic DNA Translation: AEE82554.1 |
RefSeqi | NP_001031589.1, NM_001036512.2 [Q2V3L3-2] NP_849323.1, NM_178992.4 [Q2V3L3-1] |
3D structure databases
SMRi | Q2V3L3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 11401, 5 interactors |
IntActi | Q2V3L3, 3 interactors |
STRINGi | 3702.AT4G06634.1 |
PTM databases
iPTMneti | Q2V3L3 |
Proteomic databases
PaxDbi | Q2V3L3 |
PRIDEi | Q2V3L3 |
ProteomicsDBi | 242960 [Q2V3L3-1] |
Genome annotation databases
EnsemblPlantsi | AT4G06634.1; AT4G06634.1; AT4G06634 [Q2V3L3-1] AT4G06634.2; AT4G06634.2; AT4G06634 [Q2V3L3-2] |
GeneIDi | 826093 |
Gramenei | AT4G06634.1; AT4G06634.1; AT4G06634 [Q2V3L3-1] AT4G06634.2; AT4G06634.2; AT4G06634 [Q2V3L3-2] |
KEGGi | ath:AT4G06634 |
Organism-specific databases
Araporti | AT4G06634 |
TAIRi | locus:1005716361, AT4G06634 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
HOGENOMi | CLU_040248_0_0_1 |
InParanoidi | Q2V3L3 |
OMAi | HNEKQYI |
PhylomeDBi | Q2V3L3 |
Miscellaneous databases
PROi | PR:Q2V3L3 |
Gene expression databases
ExpressionAtlasi | Q2V3L3, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | YY1_ARATH | |
Accessioni | Q2V3L3Primary (citable) accession number: Q2V3L3 Secondary accession number(s): Q27GJ7, Q8W3M5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | January 10, 2006 | |
Last modified: | August 12, 2020 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names