UniProtKB - Q2V2M9 (FHOD3_HUMAN)
FH1/FH2 domain-containing protein 3
FHOD3
Functioni
Actin-organizing protein that may cause stress fiber formation together with cell elongation (By similarity).
Isoform 4 may play a role in actin filament polymerization in cardiomyocytes.
By similarity1 PublicationGO - Molecular functioni
- actin filament binding Source: GO_Central
GO - Biological processi
- actin filament network formation Source: GO_Central
- cardiac myofibril assembly Source: GO_Central
- cortical actin cytoskeleton organization Source: GO_Central
- negative regulation of actin filament polymerization Source: Ensembl
- sarcomere organization Source: GO_Central
Keywordsi
Molecular function | Actin-binding |
Enzyme and pathway databases
PathwayCommonsi | Q2V2M9 |
SignaLinki | Q2V2M9 |
SIGNORi | Q2V2M9 |
Names & Taxonomyi
Protein namesi | Recommended name: FH1/FH2 domain-containing protein 3Alternative name(s): Formactin-2 Formin homolog overexpressed in spleen 2 Short name: hFHOS2 |
Gene namesi | Name:FHOD3 Synonyms:FHOS2, KIAA1695 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26178, FHOD3 |
MIMi | 609691, gene |
neXtProti | NX_Q2V2M9 |
VEuPathDBi | HostDB:ENSG00000134775 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 1 Publication
Note: Main part of the protein localizes to actin fibers and the remaining part displays filamentous staining.By similarity
Other locations
Note: Threonine phosphorylation in isoform 4-specific sequence TDTDEEEEVE is required for targeting to myofibrils in cardiomyocytes.
Cytoskeleton
- cytoskeleton Source: GO_Central
Other locations
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Involvement in diseasei
Cardiomyopathy, familial hypertrophic 28 (CMH28)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Natural variantiVAR_085890 | 321 | A → V in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085891 | 351 | G → R in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085892 | 363 | R → C in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085893 | 371 | K → R in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085894 | 383 | Q → H in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085895 | 419 | V → E in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085896 | 440 | P → L in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085897 | 459 | R → G in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085898 | 462 | R → G in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085899 | 462 | R → P in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085900 | 462 | R → W in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085901 | 466 | R → S in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085902 | 469 | R → S in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085903 | 479 | N → K in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085904 | 640 | E → K in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085905 | 653 | G → C in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085906 | 657 | A → T in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085907 | 770 | D → N in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085908 | 865 | P → L in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085909 | 871 | A → T in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085910 | 1194 | R → Q in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085911 | 1356 | N → H in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085912 | 1376 | V → G in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085913 | 1397 – 1422 | Missing in CMH28; unknown pathological significance. 1 PublicationAdd BLAST | 26 | ||
Isoform 4 (identifier: Q2V2M9-4) | |||||
Natural variantiVAR_085914 | 527 | Missing in CMH28. 2 Publications | 1 | ||
Natural variantiVAR_085915 | 528 | Y → C in CMH28. 1 Publication | 1 | ||
Natural variantiVAR_085916 | 542 | A → E in CMH28; unknown pathological significance. 1 Publication | 1 |
Keywords - Diseasei
Cardiomyopathy, Disease variantOrganism-specific databases
DisGeNETi | 80206 |
MIMi | 619402, phenotype |
OpenTargetsi | ENSG00000134775 |
PharmGKBi | PA134929910 |
Miscellaneous databases
Pharosi | Q2V2M9, Tbio |
Genetic variation databases
BioMutai | FHOD3 |
DMDMi | 300669639 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000283791 | 1 – 1422 | FH1/FH2 domain-containing protein 3Add BLAST | 1422 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 345 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 375 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 763 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 775 | PhosphothreonineBy similarity | 1 | ||
Isoform 4 (identifier: Q2V2M9-4) | |||||
Modified residuei | 1474 | Phosphothreonine1 Publication | 1 | ||
Modified residuei | 1476 | Phosphothreonine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q2V2M9 |
jPOSTi | Q2V2M9 |
MassIVEi | Q2V2M9 |
MaxQBi | Q2V2M9 |
PaxDbi | Q2V2M9 |
PeptideAtlasi | Q2V2M9 |
PRIDEi | Q2V2M9 |
ProteomicsDBi | 61508 [Q2V2M9-1] 61509 [Q2V2M9-2] 61510 [Q2V2M9-3] |
PTM databases
iPTMneti | Q2V2M9 |
PhosphoSitePlusi | Q2V2M9 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000134775, Expressed in apex of heart and 197 other tissues |
ExpressionAtlasi | Q2V2M9, baseline and differential |
Genevisiblei | Q2V2M9, HS |
Organism-specific databases
HPAi | ENSG00000134775, Tissue enhanced (heart) |
Interactioni
Subunit structurei
Interacts with nestin/NES-based interfilament (IF) (By similarity).
Interacts with SQSTM1; isoform 4 threonine phosphorylation disrupts SQSTM1-binding.
By similarity1 PublicationBinary interactionsi
Q2V2M9
With | #Exp. | IntAct |
---|---|---|
SQSTM1 [Q13501] | 6 | EBI-6395541,EBI-307104 |
Isoform 4 [Q2V2M9-4]
With | #Exp. | IntAct |
---|---|---|
SQSTM1 [Q13501] | 4 | EBI-6395505,EBI-307104 |
GO - Molecular functioni
- actin filament binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 123175, 4 interactors |
ELMi | Q2V2M9 |
IntActi | Q2V2M9, 5 interactors |
Miscellaneous databases
RNActi | Q2V2M9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 411 | GBD/FH3PROSITE-ProRule annotationAdd BLAST | 394 | |
Domaini | 827 – 858 | FH1Add BLAST | 32 | |
Domaini | 883 – 1279 | FH2PROSITE-ProRule annotationAdd BLAST | 397 | |
Domaini | 1359 – 1391 | DADPROSITE-ProRule annotationAdd BLAST | 33 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 323 – 464 | DisorderedSequence analysisAdd BLAST | 142 | |
Regioni | 521 – 666 | DisorderedSequence analysisAdd BLAST | 146 | |
Regioni | 687 – 708 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 754 – 781 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 821 – 850 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 1262 – 1305 | DisorderedSequence analysisAdd BLAST | 44 | |
Regioni | 1320 – 1357 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 1374 – 1410 | DisorderedSequence analysisAdd BLAST | 37 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 448 – 480 | Sequence analysisAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 323 – 339 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 368 – 390 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 398 – 452 | Polar residuesSequence analysisAdd BLAST | 55 | |
Compositional biasi | 526 – 551 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 589 – 620 | Basic and acidic residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 621 – 635 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 636 – 650 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 687 – 702 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 825 – 850 | Pro residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 1281 – 1298 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1337 – 1355 | Polar residuesSequence analysisAdd BLAST | 19 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG1925, Eukaryota |
GeneTreei | ENSGT00940000154807 |
HOGENOMi | CLU_000814_0_1_1 |
InParanoidi | Q2V2M9 |
OMAi | EDDAQCQ |
OrthoDBi | 148001at2759 |
PhylomeDBi | Q2V2M9 |
TreeFami | TF316268 |
Family and domain databases
Gene3Di | 1.20.58.2220, 1 hit 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR014767, DAD_dom IPR015425, FH2_Formin IPR042201, FH2_Formin_sf IPR041387, FHOD1_GBD_N IPR014768, GBD/FH3_dom |
Pfami | View protein in Pfam PF02181, FH2, 1 hit PF18382, Formin_GBD_N, 1 hit |
SMARTi | View protein in SMART SM00498, FH2, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51231, DAD, 1 hit PS51444, FH2, 1 hit PS51232, GBD_FH3, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATLACRVQF LDDTDPFNST NFPEPSRPPL FTFREDLALG TQLAGVHRLL
60 70 80 90 100
QAPHKLDDCT LQLSHNGAYL DLEATLAEQR DELEGFQDDA GRGKKHSIIL
110 120 130 140 150
RTQLSVRVHA CIEKLYNSSG RDLRRALFSL KQIFQDDKDL VHEFVVAEGL
160 170 180 190 200
TCLIKVGAEA DQNYQNYILR ALGQIMLYVD GMNGVINRNE TIQWLYTLIG
210 220 230 240 250
SKFRLVVKTA LKLLLVFVEY SESNAPLLIQ AVTAVDTKRG VKPWSNIMEI
260 270 280 290 300
LEEKDGVDTE LLVYAMTLVN KTLSGLPDQD TFYDVVDCLE ELGIAAVSQR
310 320 330 340 350
HLNKKGTDLD LVEQLNIYEV ALRHEDGDET TEPPPSGCRD RRRASVCSSG
360 370 380 390 400
GGEHRGLDRR RSRRHSVQSI KSTLSAPTSP CSQSAPSFKP NQVRDLREKY
410 420 430 440 450
SNFGNNSYHS SRPSSGSSVP TTPTSSVSPP QEARLERSSP SGLLTSSFRQ
460 470 480 490 500
HQESLAAERE RRRQEREERL QRIEREERNK FRYKYLEQLA AEEHEKELRS
510 520 530 540 550
RSVSRGRADL SLDLTSPAAP ACLAPLSHSP SSSDSQEALT VSASSPGTPH
560 570 580 590 600
HPQASAGDPE PESEAEPEAE AGAGQVADEA GQDIASAHEG AETEVEQALE
610 620 630 640 650
QEPEERASLS EKERQNEGVN ERDNCSASSV SSSSSTLERE EKEDKLSRDR
660 670 680 690 700
TTGLWPAGVQ DAGVNGQCGD ILTNKRFMLD MLYAHNRKSP DDEEKGDGEA
710 720 730 740 750
GRTQQEAEAV ASLATRISTL QANSQTQDES VRRVDVGCLD NRGSVKAFAE
760 770 780 790 800
KFNSGDLGRG SISPDAEPND KVPETAPVQP KTESDYIWDQ LMANPRELRI
810 820 830 840 850
QDMDFTDLGE EDDIDVLDVD LGHREAPGPP PPPPPTFLGL PPPPPPPLLD
860 870 880 890 900
SIPPPPVPGN LLVPPPPVFN APQGLGWSQV PRGQPTFTKK KKTIRLFWNE
910 920 930 940 950
VRPFDWPCKN NRRCREFLWS KLEPIKVDTS RLEHLFESKS KELSVSKKTA
960 970 980 990 1000
ADGKRQEIIV LDSKRSNAIN IGLTVLPPPR TIKIAILNFD EYALNKEGIE
1010 1020 1030 1040 1050
KILTMIPTDE EKQKIQEAQL ANPEIPLGSA EQFLLTLSSI SELSARLHLW
1060 1070 1080 1090 1100
AFKMDYETTE KEVAEPLLDL KEGIDQLENN KTLGFILSTL LAIGNFLNGT
1110 1120 1130 1140 1150
NAKAFELSYL EKVPEVKDTV HKQSLLHHVC TMVVENFPDS SDLYSEIGAI
1160 1170 1180 1190 1200
TRSAKVDFDQ LQDNLCQMER RCKASWDHLK AIAKHEMKPV LKQRMSEFLK
1210 1220 1230 1240 1250
DCAERIIILK IVHRRIINRF HSFLLFMGHP PYAIREVNIN KFCRIISEFA
1260 1270 1280 1290 1300
LEYRTTRERV LQQKQKRANH RERNKTRGKM ITDSGKFSGS SPAPPSQPQG
1310 1320 1330 1340 1350
LSYAEDAAEH ENMKAVLKTS SPSVEDATPA LGVRTRSRAS RGSTSSWTMG
1360 1370 1380 1390 1400
TDDSPNVTDD AADEIMDRIV KSATQVPSQR VVPRERKRSR ANRKSLRRTL
1410 1420
KSGLTPEEAR ALGLVGTSEL QL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7ER94 | K7ER94_HUMAN | FH1/FH2 domain-containing protein 3 | FHOD3 | 1,200 | Annotation score: | ||
K7EP24 | K7EP24_HUMAN | FH1/FH2 domain-containing protein 3 | FHOD3 | 635 | Annotation score: | ||
A0A0A0MTS9 | A0A0A0MTS9_HUMAN | FH1/FH2 domain-containing protein 3 | FHOD3 | 528 | Annotation score: | ||
K7EKZ0 | K7EKZ0_HUMAN | FH1/FH2 domain-containing protein 3 | FHOD3 | 375 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 71 | D → G in BAC67014 (PubMed:15966898).Curated | 1 | |
Sequence conflicti | 202 | K → E in ADL62709 (PubMed:21149568).Curated | 1 | |
Sequence conflicti | 432 | E → G in ADL62709 (PubMed:21149568).Curated | 1 | |
Sequence conflicti | 435 | L → W in BAC67014 (PubMed:15966898).Curated | 1 | |
Sequence conflicti | 527 | S → G in ADL62709 (PubMed:21149568).Curated | 1 | |
Sequence conflicti | 581 | G → A in ADL62709 (PubMed:21149568).Curated | 1 | |
Sequence conflicti | 647 | S → P in ADL62709 (PubMed:21149568).Curated | 1 | |
Sequence conflicti | 654 | L → K in BAC87252 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1134 | V → I in AAH81563 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1417 | T → A in BAB15463 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Natural variantiVAR_085890 | 321 | A → V in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085891 | 351 | G → R in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085892 | 363 | R → C in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085893 | 371 | K → R in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085894 | 383 | Q → H in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085895 | 419 | V → E in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085896 | 440 | P → L in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085897 | 459 | R → G in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085898 | 462 | R → G in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085899 | 462 | R → P in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085900 | 462 | R → W in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085901 | 466 | R → S in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085902 | 469 | R → S in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_055804 | 475 | R → W. Corresponds to variant dbSNP:rs9964535Ensembl. | 1 | ||
Natural variantiVAR_085903 | 479 | N → K in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085904 | 640 | E → K in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085905 | 653 | G → C in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085906 | 657 | A → T in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085907 | 770 | D → N in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085908 | 865 | P → L in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085909 | 871 | A → T in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085910 | 1194 | R → Q in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085911 | 1356 | N → H in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085912 | 1376 | V → G in CMH28; unknown pathological significance. 1 Publication | 1 | ||
Natural variantiVAR_085913 | 1397 – 1422 | Missing in CMH28; unknown pathological significance. 1 PublicationAdd BLAST | 26 | ||
Isoform 4 (identifier: Q2V2M9-4) | |||||
Natural variantiVAR_085914 | 527 | Missing in CMH28. 2 Publications | 1 | ||
Natural variantiVAR_085915 | 528 | Y → C in CMH28. 1 Publication | 1 | ||
Natural variantiVAR_085916 | 542 | A → E in CMH28; unknown pathological significance. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044682 | 399 | K → KEEEEEEEQPITEPSSEEER EDDASCQGKDSKVGAASGQS PTGRDAAPKSSALPAVSNAS SQGKPLLVGTAGGTTWHSGS SGSEATPSALLSPPASAARP SSATPGSLKVSPTIDKLPYV PHSPFHLFSYDFEDSSLSTK EKEAESQKENSSSDSFSLST YSASEPYHFRSFSSNR in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_024397 | 400 – 437 | Missing in isoform 2. 1 PublicationAdd BLAST | 38 | |
Alternative sequenceiVSP_024398 | 481 | F → FSRDYLDKREEQRQAREE in isoform 2, isoform 3 and isoform 4. 2 Publications | 1 | |
Alternative sequenceiVSP_044683 | 1282 – 1283 | TD → TDTDEEEEVE in isoform 4. 1 Publication | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB084087 mRNA Translation: BAC67014.1 HM191478 mRNA Translation: ADL62709.1 AC023043 Genomic DNA No translation available. AC055840 Genomic DNA No translation available. AC090333 Genomic DNA No translation available. AC131053 Genomic DNA No translation available. AK025950 mRNA Translation: BAB15292.1 Different initiation. AK026370 mRNA Translation: BAB15463.1 Different initiation. AK128053 mRNA Translation: BAC87252.1 AB051482 mRNA Translation: BAB21786.1 BC050670 mRNA Translation: AAH50670.1 BC081563 mRNA Translation: AAH81563.1 AL834480 mRNA Translation: CAD39139.1 |
CCDSi | CCDS32816.1 [Q2V2M9-3] CCDS62418.1 [Q2V2M9-4] CCDS62419.1 [Q2V2M9-1] |
RefSeqi | NP_001268668.1, NM_001281739.2 [Q2V2M9-1] NP_001268669.1, NM_001281740.2 [Q2V2M9-4] NP_079411.2, NM_025135.4 [Q2V2M9-3] XP_005258412.1, XM_005258355.1 [Q2V2M9-2] |
Genome annotation databases
Ensembli | ENST00000257209.8; ENSP00000257209.3; ENSG00000134775.16 [Q2V2M9-3] ENST00000359247.8; ENSP00000352186.3; ENSG00000134775.16 ENST00000590592.6; ENSP00000466937.1; ENSG00000134775.16 [Q2V2M9-4] |
GeneIDi | 80206 |
KEGGi | hsa:80206 |
MANE-Selecti | ENST00000590592.6; ENSP00000466937.1; NM_001281740.3; NP_001268669.1 [Q2V2M9-4] |
UCSCi | uc002kzs.3, human [Q2V2M9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB084087 mRNA Translation: BAC67014.1 HM191478 mRNA Translation: ADL62709.1 AC023043 Genomic DNA No translation available. AC055840 Genomic DNA No translation available. AC090333 Genomic DNA No translation available. AC131053 Genomic DNA No translation available. AK025950 mRNA Translation: BAB15292.1 Different initiation. AK026370 mRNA Translation: BAB15463.1 Different initiation. AK128053 mRNA Translation: BAC87252.1 AB051482 mRNA Translation: BAB21786.1 BC050670 mRNA Translation: AAH50670.1 BC081563 mRNA Translation: AAH81563.1 AL834480 mRNA Translation: CAD39139.1 |
CCDSi | CCDS32816.1 [Q2V2M9-3] CCDS62418.1 [Q2V2M9-4] CCDS62419.1 [Q2V2M9-1] |
RefSeqi | NP_001268668.1, NM_001281739.2 [Q2V2M9-1] NP_001268669.1, NM_001281740.2 [Q2V2M9-4] NP_079411.2, NM_025135.4 [Q2V2M9-3] XP_005258412.1, XM_005258355.1 [Q2V2M9-2] |
3D structure databases
AlphaFoldDBi | Q2V2M9 |
SMRi | Q2V2M9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123175, 4 interactors |
ELMi | Q2V2M9 |
IntActi | Q2V2M9, 5 interactors |
PTM databases
iPTMneti | Q2V2M9 |
PhosphoSitePlusi | Q2V2M9 |
Genetic variation databases
BioMutai | FHOD3 |
DMDMi | 300669639 |
Proteomic databases
EPDi | Q2V2M9 |
jPOSTi | Q2V2M9 |
MassIVEi | Q2V2M9 |
MaxQBi | Q2V2M9 |
PaxDbi | Q2V2M9 |
PeptideAtlasi | Q2V2M9 |
PRIDEi | Q2V2M9 |
ProteomicsDBi | 61508 [Q2V2M9-1] 61509 [Q2V2M9-2] 61510 [Q2V2M9-3] |
Protocols and materials databases
Antibodypediai | 8734, 56 antibodies from 13 providers |
DNASUi | 80206 |
Genome annotation databases
Ensembli | ENST00000257209.8; ENSP00000257209.3; ENSG00000134775.16 [Q2V2M9-3] ENST00000359247.8; ENSP00000352186.3; ENSG00000134775.16 ENST00000590592.6; ENSP00000466937.1; ENSG00000134775.16 [Q2V2M9-4] |
GeneIDi | 80206 |
KEGGi | hsa:80206 |
MANE-Selecti | ENST00000590592.6; ENSP00000466937.1; NM_001281740.3; NP_001268669.1 [Q2V2M9-4] |
UCSCi | uc002kzs.3, human [Q2V2M9-1] |
Organism-specific databases
CTDi | 80206 |
DisGeNETi | 80206 |
GeneCardsi | FHOD3 |
HGNCi | HGNC:26178, FHOD3 |
HPAi | ENSG00000134775, Tissue enhanced (heart) |
MIMi | 609691, gene 619402, phenotype |
neXtProti | NX_Q2V2M9 |
OpenTargetsi | ENSG00000134775 |
PharmGKBi | PA134929910 |
VEuPathDBi | HostDB:ENSG00000134775 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1925, Eukaryota |
GeneTreei | ENSGT00940000154807 |
HOGENOMi | CLU_000814_0_1_1 |
InParanoidi | Q2V2M9 |
OMAi | EDDAQCQ |
OrthoDBi | 148001at2759 |
PhylomeDBi | Q2V2M9 |
TreeFami | TF316268 |
Enzyme and pathway databases
PathwayCommonsi | Q2V2M9 |
SignaLinki | Q2V2M9 |
SIGNORi | Q2V2M9 |
Miscellaneous databases
BioGRID-ORCSi | 80206, 14 hits in 1077 CRISPR screens |
ChiTaRSi | FHOD3, human |
GenomeRNAii | 80206 |
Pharosi | Q2V2M9, Tbio |
PROi | PR:Q2V2M9 |
RNActi | Q2V2M9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000134775, Expressed in apex of heart and 197 other tissues |
ExpressionAtlasi | Q2V2M9, baseline and differential |
Genevisiblei | Q2V2M9, HS |
Family and domain databases
Gene3Di | 1.20.58.2220, 1 hit 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR014767, DAD_dom IPR015425, FH2_Formin IPR042201, FH2_Formin_sf IPR041387, FHOD1_GBD_N IPR014768, GBD/FH3_dom |
Pfami | View protein in Pfam PF02181, FH2, 1 hit PF18382, Formin_GBD_N, 1 hit |
SMARTi | View protein in SMART SM00498, FH2, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51231, DAD, 1 hit PS51444, FH2, 1 hit PS51232, GBD_FH3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FHOD3_HUMAN | |
Accessioni | Q2V2M9Primary (citable) accession number: Q2V2M9 Secondary accession number(s): A8MQT4 Q9H6G7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 17, 2007 |
Last sequence update: | July 13, 2010 | |
Last modified: | May 25, 2022 | |
This is version 132 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families