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UniProtKB - Q2V2M9 (FHOD3_HUMAN)

Entry version 124 (17 Jun 2020)
Sequence version 2 (13 Jul 2010)
Previous versions | rss
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Protein

FH1/FH2 domain-containing protein 3

Gene

FHOD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Actin-organizing protein that may cause stress fiber formation together with cell elongation (By similarity). Isoform 4 may play a role in actin filament polymerization in cardiomyocytes.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q2V2M9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FH1/FH2 domain-containing protein 3
Alternative name(s):
Formactin-2
Formin homolog overexpressed in spleen 2
Short name:
hFHOS2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FHOD3
Synonyms:FHOS2, KIAA1695
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000134775.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:26178 FHOD3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609691 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q2V2M9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		80206

Open Targets

More...OpenTargetsi		ENSG00000134775

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134929910

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q2V2M9 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FHOD3

Domain mapping of disease mutations (DMDM)

More...DMDMi		300669639

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002837911 – 1422FH1/FH2 domain-containing protein 3Add BLAST1422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei345PhosphoserineBy similarity1
Modified residuei375PhosphoserineBy similarity1
Modified residuei763PhosphoserineBy similarity1
Modified residuei775PhosphothreonineBy similarity1
Isoform 4 (identifier: Q2V2M9-4)
Modified residuei1474Phosphothreonine1 Publication1
Modified residuei1476Phosphothreonine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on Thr-1474 and Thr-1476 by CK2.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q2V2M9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q2V2M9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q2V2M9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q2V2M9

PeptideAtlas

More...PeptideAtlasi		Q2V2M9

PRoteomics IDEntifications database

More...PRIDEi		Q2V2M9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		61508 [Q2V2M9-1]
61509 [Q2V2M9-2]
61510 [Q2V2M9-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q2V2M9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q2V2M9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the heart, kidney and brain. May be down-regulated in various types of heart diseases, including idiopathic dilated, ventricular dilated, familial dilated and perinatal dilated cardiomyopathies, as well as ischemic heart disease (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000134775 Expressed in apex of heart and 181 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q2V2M9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q2V2M9 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000134775 Tissue enhanced (heart muscle, seminal vesicle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with nestin/NES-based interfilament (IF) (By similarity).

Interacts with SQSTM1; isoform 4 threonine phosphorylation disrupts SQSTM1-binding.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123175, 2 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q2V2M9

Protein interaction database and analysis system

More...IntActi		Q2V2M9, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000466937

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q2V2M9 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q2V2M9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 411GBD/FH3PROSITE-ProRule annotationAdd BLAST394
Domaini827 – 858FH1Add BLAST32
Domaini883 – 1279FH2PROSITE-ProRule annotationAdd BLAST397
Domaini1359 – 1391DADPROSITE-ProRule annotationAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili448 – 480Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi626 – 635Poly-Ser10
Compositional biasi827 – 872Pro-richAdd BLAST46
Compositional biasi889 – 892Poly-Lys4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the formin homology family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1925 Eukaryota
ENOG410XRBZ LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154807

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000814_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q2V2M9

KEGG Orthology (KO)

More...KOi		K23939

Identification of Orthologs from Complete Genome Data

More...OMAi		FNIYEVA

Database of Orthologous Groups

More...OrthoDBi		148001at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q2V2M9

TreeFam database of animal gene trees

More...TreeFami		TF316268

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.58.2220, 1 hit
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR014767 DAD_dom
IPR015425 FH2_Formin
IPR042201 FH2_Formin_sf
IPR041387 FHOD1_GBD_N
IPR027651 FHOD3
IPR014768 GBD/FH3_dom

The PANTHER Classification System

More...PANTHERi		PTHR45920:SF3 PTHR45920:SF3, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02181 FH2, 1 hit
PF18382 Formin_GBD_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00498 FH2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51231 DAD, 1 hit
PS51444 FH2, 1 hit
PS51232 GBD_FH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q2V2M9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATLACRVQF LDDTDPFNST NFPEPSRPPL FTFREDLALG TQLAGVHRLL 
        60         70         80         90        100
QAPHKLDDCT LQLSHNGAYL DLEATLAEQR DELEGFQDDA GRGKKHSIIL 
       110        120        130        140        150
RTQLSVRVHA CIEKLYNSSG RDLRRALFSL KQIFQDDKDL VHEFVVAEGL 
       160        170        180        190        200
TCLIKVGAEA DQNYQNYILR ALGQIMLYVD GMNGVINRNE TIQWLYTLIG 
       210        220        230        240        250
SKFRLVVKTA LKLLLVFVEY SESNAPLLIQ AVTAVDTKRG VKPWSNIMEI 
       260        270        280        290        300
LEEKDGVDTE LLVYAMTLVN KTLSGLPDQD TFYDVVDCLE ELGIAAVSQR 
       310        320        330        340        350
HLNKKGTDLD LVEQLNIYEV ALRHEDGDET TEPPPSGCRD RRRASVCSSG 
       360        370        380        390        400
GGEHRGLDRR RSRRHSVQSI KSTLSAPTSP CSQSAPSFKP NQVRDLREKY 
       410        420        430        440        450
SNFGNNSYHS SRPSSGSSVP TTPTSSVSPP QEARLERSSP SGLLTSSFRQ 
       460        470        480        490        500
HQESLAAERE RRRQEREERL QRIEREERNK FRYKYLEQLA AEEHEKELRS 
       510        520        530        540        550
RSVSRGRADL SLDLTSPAAP ACLAPLSHSP SSSDSQEALT VSASSPGTPH 
       560        570        580        590        600
HPQASAGDPE PESEAEPEAE AGAGQVADEA GQDIASAHEG AETEVEQALE 
       610        620        630        640        650
QEPEERASLS EKERQNEGVN ERDNCSASSV SSSSSTLERE EKEDKLSRDR 
       660        670        680        690        700
TTGLWPAGVQ DAGVNGQCGD ILTNKRFMLD MLYAHNRKSP DDEEKGDGEA 
       710        720        730        740        750
GRTQQEAEAV ASLATRISTL QANSQTQDES VRRVDVGCLD NRGSVKAFAE 
       760        770        780        790        800
KFNSGDLGRG SISPDAEPND KVPETAPVQP KTESDYIWDQ LMANPRELRI 
       810        820        830        840        850
QDMDFTDLGE EDDIDVLDVD LGHREAPGPP PPPPPTFLGL PPPPPPPLLD 
       860        870        880        890        900
SIPPPPVPGN LLVPPPPVFN APQGLGWSQV PRGQPTFTKK KKTIRLFWNE 
       910        920        930        940        950
VRPFDWPCKN NRRCREFLWS KLEPIKVDTS RLEHLFESKS KELSVSKKTA 
       960        970        980        990       1000
ADGKRQEIIV LDSKRSNAIN IGLTVLPPPR TIKIAILNFD EYALNKEGIE 
      1010       1020       1030       1040       1050
KILTMIPTDE EKQKIQEAQL ANPEIPLGSA EQFLLTLSSI SELSARLHLW 
      1060       1070       1080       1090       1100
AFKMDYETTE KEVAEPLLDL KEGIDQLENN KTLGFILSTL LAIGNFLNGT 
      1110       1120       1130       1140       1150
NAKAFELSYL EKVPEVKDTV HKQSLLHHVC TMVVENFPDS SDLYSEIGAI 
      1160       1170       1180       1190       1200
TRSAKVDFDQ LQDNLCQMER RCKASWDHLK AIAKHEMKPV LKQRMSEFLK 
      1210       1220       1230       1240       1250
DCAERIIILK IVHRRIINRF HSFLLFMGHP PYAIREVNIN KFCRIISEFA 
      1260       1270       1280       1290       1300
LEYRTTRERV LQQKQKRANH RERNKTRGKM ITDSGKFSGS SPAPPSQPQG 
      1310       1320       1330       1340       1350
LSYAEDAAEH ENMKAVLKTS SPSVEDATPA LGVRTRSRAS RGSTSSWTMG 
      1360       1370       1380       1390       1400
TDDSPNVTDD AADEIMDRIV KSATQVPSQR VVPRERKRSR ANRKSLRRTL 
      1410       1420 
KSGLTPEEAR ALGLVGTSEL QL
Length:1,422
Mass (Da):158,613
Last modified:July 13, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7CE7A8C0054856BE
GO
Isoform 2 (identifier: Q2V2M9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     400-437: Missing.
     481-481: F → FSRDYLDKREEQRQAREE

Show »
Length:1,401
Mass (Da):156,752
Checksum:iF2B9F0473D7D3BC6
GO
Isoform 3 (identifier: Q2V2M9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     481-481: F → FSRDYLDKREEQRQAREE

Show »
Length:1,439
Mass (Da):160,804
Checksum:i72C7122A8348E1A9
GO
Isoform 4 (identifier: Q2V2M9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     399-399: K → KEEEEEEEQP...YHFRSFSSNR
     481-481: F → FSRDYLDKREEQRQAREE
     1282-1283: TD → TDTDEEEEVE

Show »
Length:1,622
Mass (Da):180,080
Checksum:iEFCFEA5D7FF75299
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ER94K7ER94_HUMAN
FH1/FH2 domain-containing protein 3
FHOD3
1,200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MTS9A0A0A0MTS9_HUMAN
FH1/FH2 domain-containing protein 3
FHOD3
528Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EP24K7EP24_HUMAN
FH1/FH2 domain-containing protein 3
FHOD3
635Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKZ0K7EKZ0_HUMAN
FH1/FH2 domain-containing protein 3
FHOD3
375Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15292 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB15463 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti71D → G in BAC67014 (PubMed:15966898).Curated1
Sequence conflicti202K → E in ADL62709 (PubMed:21149568).Curated1
Sequence conflicti432E → G in ADL62709 (PubMed:21149568).Curated1
Sequence conflicti435L → W in BAC67014 (PubMed:15966898).Curated1
Sequence conflicti527S → G in ADL62709 (PubMed:21149568).Curated1
Sequence conflicti581G → A in ADL62709 (PubMed:21149568).Curated1
Sequence conflicti647S → P in ADL62709 (PubMed:21149568).Curated1
Sequence conflicti654L → K in BAC87252 (PubMed:14702039).Curated1
Sequence conflicti1134V → I in AAH81563 (PubMed:15489334).Curated1
Sequence conflicti1417T → A in BAB15463 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055804475R → W. Corresponds to variant dbSNP:rs9964535Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_044682399K → KEEEEEEEQPITEPSSEEER EDDASCQGKDSKVGAASGQS PTGRDAAPKSSALPAVSNAS SQGKPLLVGTAGGTTWHSGS SGSEATPSALLSPPASAARP SSATPGSLKVSPTIDKLPYV PHSPFHLFSYDFEDSSLSTK EKEAESQKENSSSDSFSLST YSASEPYHFRSFSSNR in isoform 4. 1 Publication1
Alternative sequenceiVSP_024397400 – 437Missing in isoform 2. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_024398481F → FSRDYLDKREEQRQAREE in isoform 2, isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_0446831282 – 1283TD → TDTDEEEEVE in isoform 4. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB084087 mRNA Translation: BAC67014.1
HM191478 mRNA Translation: ADL62709.1
AC023043 Genomic DNA No translation available.
AC055840 Genomic DNA No translation available.
AC090333 Genomic DNA No translation available.
AC131053 Genomic DNA No translation available.
AK025950 mRNA Translation: BAB15292.1 Different initiation.
AK026370 mRNA Translation: BAB15463.1 Different initiation.
AK128053 mRNA Translation: BAC87252.1
AB051482 mRNA Translation: BAB21786.1
BC050670 mRNA Translation: AAH50670.1
BC081563 mRNA Translation: AAH81563.1
AL834480 mRNA Translation: CAD39139.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32816.1 [Q2V2M9-3]
CCDS62418.1 [Q2V2M9-4]
CCDS62419.1 [Q2V2M9-1]

NCBI Reference Sequences

More...RefSeqi		NP_001268668.1, NM_001281739.2 [Q2V2M9-1]
NP_001268669.1, NM_001281740.2 [Q2V2M9-4]
NP_079411.2, NM_025135.4 [Q2V2M9-3]
XP_005258412.1, XM_005258355.1 [Q2V2M9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000257209; ENSP00000257209; ENSG00000134775 [Q2V2M9-3]
ENST00000359247; ENSP00000352186; ENSG00000134775 [Q2V2M9-1]
ENST00000590592; ENSP00000466937; ENSG00000134775 [Q2V2M9-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		80206

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:80206

UCSC genome browser

More...UCSCi		uc002kzs.3 human [Q2V2M9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB084087 mRNA Translation: BAC67014.1
HM191478 mRNA Translation: ADL62709.1
AC023043 Genomic DNA No translation available.
AC055840 Genomic DNA No translation available.
AC090333 Genomic DNA No translation available.
AC131053 Genomic DNA No translation available.
AK025950 mRNA Translation: BAB15292.1 Different initiation.
AK026370 mRNA Translation: BAB15463.1 Different initiation.
AK128053 mRNA Translation: BAC87252.1
AB051482 mRNA Translation: BAB21786.1
BC050670 mRNA Translation: AAH50670.1
BC081563 mRNA Translation: AAH81563.1
AL834480 mRNA Translation: CAD39139.1
CCDSiCCDS32816.1 [Q2V2M9-3]
CCDS62418.1 [Q2V2M9-4]
CCDS62419.1 [Q2V2M9-1]
RefSeqiNP_001268668.1, NM_001281739.2 [Q2V2M9-1]
NP_001268669.1, NM_001281740.2 [Q2V2M9-4]
NP_079411.2, NM_025135.4 [Q2V2M9-3]
XP_005258412.1, XM_005258355.1 [Q2V2M9-2]

3D structure databases

SMRiQ2V2M9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123175, 2 interactors
ELMiQ2V2M9
IntActiQ2V2M9, 4 interactors
STRINGi9606.ENSP00000466937

PTM databases

iPTMnetiQ2V2M9
PhosphoSitePlusiQ2V2M9

Polymorphism and mutation databases

BioMutaiFHOD3
DMDMi300669639

Proteomic databases

jPOSTiQ2V2M9
MassIVEiQ2V2M9
MaxQBiQ2V2M9
PaxDbiQ2V2M9
PeptideAtlasiQ2V2M9
PRIDEiQ2V2M9
ProteomicsDBi61508 [Q2V2M9-1]
61509 [Q2V2M9-2]
61510 [Q2V2M9-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		8734 57 antibodies

Genome annotation databases

EnsembliENST00000257209; ENSP00000257209; ENSG00000134775 [Q2V2M9-3]
ENST00000359247; ENSP00000352186; ENSG00000134775 [Q2V2M9-1]
ENST00000590592; ENSP00000466937; ENSG00000134775 [Q2V2M9-4]
GeneIDi80206
KEGGihsa:80206
UCSCiuc002kzs.3 human [Q2V2M9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		80206
DisGeNETi80206
EuPathDBiHostDB:ENSG00000134775.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		FHOD3
HGNCiHGNC:26178 FHOD3
HPAiENSG00000134775 Tissue enhanced (heart muscle, seminal vesicle)
MIMi609691 gene
neXtProtiNX_Q2V2M9
OpenTargetsiENSG00000134775
PharmGKBiPA134929910

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1925 Eukaryota
ENOG410XRBZ LUCA
GeneTreeiENSGT00940000154807
HOGENOMiCLU_000814_0_1_1
InParanoidiQ2V2M9
KOiK23939
OMAiFNIYEVA
OrthoDBi148001at2759
PhylomeDBiQ2V2M9
TreeFamiTF316268

Enzyme and pathway databases

SIGNORiQ2V2M9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		80206 3 hits in 790 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FHOD3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		80206
PharosiQ2V2M9 Tdark

Protein Ontology

More...PROi		PR:Q2V2M9
RNActiQ2V2M9 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000134775 Expressed in apex of heart and 181 other tissues
ExpressionAtlasiQ2V2M9 baseline and differential
GenevisibleiQ2V2M9 HS

Family and domain databases

Gene3Di1.20.58.2220, 1 hit
1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR014767 DAD_dom
IPR015425 FH2_Formin
IPR042201 FH2_Formin_sf
IPR041387 FHOD1_GBD_N
IPR027651 FHOD3
IPR014768 GBD/FH3_dom
PANTHERiPTHR45920:SF3 PTHR45920:SF3, 1 hit
PfamiView protein in Pfam
PF02181 FH2, 1 hit
PF18382 Formin_GBD_N, 1 hit
SMARTiView protein in SMART
SM00498 FH2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51231 DAD, 1 hit
PS51444 FH2, 1 hit
PS51232 GBD_FH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFHOD3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2V2M9
Secondary accession number(s): A8MQT4
, E5F5Q0, Q642I2, Q6ZRQ7, Q86TF9, Q8N3A5, Q9C0G8, Q9H604, Q9H6G7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: July 13, 2010
Last modified: June 17, 2020
This is version 124 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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