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Protein

Hydroxyproline dehydrogenase

Gene

Prodh2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis.By similarity

Catalytic activityi

Trans-4-hydroxy-L-proline + a quinone = (3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + a quinol.By similarity
L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol.By similarity

Cofactori

FADBy similarity

GO - Molecular functioni

  • FAD binding Source: GO_Central
  • oxidoreductase activity, acting on the CH-NH group of donors Source: UniProtKB
  • proline dehydrogenase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processProline metabolism
LigandFAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyproline dehydrogenaseBy similarity (EC:1.5.5.3By similarity)
Short name:
HYPDHBy similarity
Alternative name(s):
Probable proline dehydrogenase 2By similarity (EC:1.5.5.2By similarity)
Probable proline oxidase 2
Proline oxidase-like protein
Gene namesi
Name:Prodh2Imported
Synonyms:HypdhBy similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1306761 Prodh2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003086251 – 456Hydroxyproline dehydrogenaseAdd BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei310N6-acetyllysineBy similarity1
Modified residuei320N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ2V057
PRIDEiQ2V057

PTM databases

iPTMnetiQ2V057
PhosphoSitePlusiQ2V057

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028392

Structurei

3D structure databases

ProteinModelPortaliQ2V057
SMRiQ2V057
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the proline oxidase family.Curated

Phylogenomic databases

eggNOGiKOG0186 Eukaryota
COG0506 LUCA
HOGENOMiHOG000233406
HOVERGENiHBG108294
InParanoidiQ2V057
PhylomeDBiQ2V057

Family and domain databases

InterProiView protein in InterPro
IPR029041 FAD-linked_oxidoreductase-like
IPR002872 Proline_DH_dom
IPR015659 Proline_oxidase
PANTHERiPTHR13914 PTHR13914, 1 hit
PfamiView protein in Pfam
PF01619 Pro_dh, 1 hit
SUPFAMiSSF51730 SSF51730, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q2V057-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIWTRLPLYG HSKPSTGGWQ PLRFDGGAFH LKRTAELARA LLVLRLCAWP
60 70 80 90 100
PLVTHGLAFQ AWSQRLLGSR LSGALLRASI YGQFVAGETA EEVRGCVQQL
110 120 130 140 150
QAIGLQPLLA VPTEEEPDSA AKTSEAWYEG NLSAMLHCVD LSRAVADAHG
160 170 180 190 200
PARNSLMQLK VTALTSPRLC KELSAWIQRP RGSSELRPER LAEAMESGRN
210 220 230 240 250
LQLSCLSTEQ NQHLQASLSR LHRVAQHARA QDVRLLVDAE YTFINPALSL
260 270 280 290 300
LVAALAMRLD SSEEEGPWVW NTYQAYLKDT HERLERDAKA AHEAGLAFGV
310 320 330 340 350
KLVRGAYLDK ERSVTQLHGK EDCTQPDYEA TSRSYSRCLE LMLRRVSNHG
360 370 380 390 400
PRCHLMVASH NEESIRQATR RMWELGIPLD GPVCFGQLLG MCDHVSLALG
410 420 430 440 450
QAGYMVYKSI PYGCLEEVIP YLIRRAQENR SVLQGARREQ ALLSQELWRR

LLGRTA
Length:456
Mass (Da):51,002
Last modified:January 24, 2006 - v1
Checksum:i03DA662B133B5857
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K5H0A0A0G2K5H0_RAT
Proline dehydrogenase
Prodh2
453Annotation score:
A0A0G2KA22A0A0G2KA22_RAT
Proline dehydrogenase
Prodh2
375Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222852 mRNA Translation: AAQ13908.1
UniGeneiRn.4247

Genome annotation databases

UCSCiRGD:1306761 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222852 mRNA Translation: AAQ13908.1
UniGeneiRn.4247

3D structure databases

ProteinModelPortaliQ2V057
SMRiQ2V057
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028392

PTM databases

iPTMnetiQ2V057
PhosphoSitePlusiQ2V057

Proteomic databases

PaxDbiQ2V057
PRIDEiQ2V057

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:1306761 rat

Organism-specific databases

RGDi1306761 Prodh2

Phylogenomic databases

eggNOGiKOG0186 Eukaryota
COG0506 LUCA
HOGENOMiHOG000233406
HOVERGENiHBG108294
InParanoidiQ2V057
PhylomeDBiQ2V057

Miscellaneous databases

PROiPR:Q2V057

Family and domain databases

InterProiView protein in InterPro
IPR029041 FAD-linked_oxidoreductase-like
IPR002872 Proline_DH_dom
IPR015659 Proline_oxidase
PANTHERiPTHR13914 PTHR13914, 1 hit
PfamiView protein in Pfam
PF01619 Pro_dh, 1 hit
SUPFAMiSSF51730 SSF51730, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHYPDH_RAT
AccessioniPrimary (citable) accession number: Q2V057
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: January 24, 2006
Last modified: November 7, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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