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Protein

Collagen alpha-1(XXVIII) chain

Gene

Col28a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a cell-binding protein.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor
Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-8948216 Collagen chain trimerization

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XXVIII) chain
Gene namesi
Name:Col28a1
Synonyms:Col28
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2685312 Col28a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500007466521 – 1141Collagen alpha-1(XXVIII) chainAdd BLAST1121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi1088 ↔ 1138PROSITE-ProRule annotation
Disulfide bondi1097 ↔ 1121PROSITE-ProRule annotation
Disulfide bondi1113 ↔ 1134PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ2UY11
PaxDbiQ2UY11
PRIDEiQ2UY11

PTM databases

PhosphoSitePlusiQ2UY11

Expressioni

Tissue specificityi

Expressed in skin, intestine, sternum, brain and kidney. Lower expression is also observed in heart, lung, sciatic nerve, dorsal root ganglia, peripheral nerves and calvaria of newborn mice and in intestine and brain of adult mice. Found in basement membrane surrounding a particular subset of Schwann cells in adult sciatic nerve.1 Publication

Developmental stagei

Major expression in dorsal root ganglia and peripheral nerves, with small amounts in connective tissues like calvaria and skin.1 Publication

Gene expression databases

BgeeiENSMUSG00000068794 Expressed in 15 organ(s), highest expression level in brown adipose tissue
CleanExiMM_COL28A1
ExpressionAtlasiQ2UY11 baseline and differential

Interactioni

Subunit structurei

Trimer or homomer. Secreted into as a 135 kDa monomer under reducing conditions and as a homotrimer under non-reducing conditions.1 Publication

Protein-protein interaction databases

ComplexPortaliCPX-3029 Collagen type XXVIII trimer
STRINGi10090.ENSMUSP00000111199

Structurei

3D structure databases

ProteinModelPortaliQ2UY11
SMRiQ2UY11
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 227VWFA 1PROSITE-ProRule annotationAdd BLAST180
Domaini243 – 300Collagen-like 1Add BLAST58
Domaini301 – 358Collagen-like 2Add BLAST58
Domaini501 – 544Collagen-like 3Add BLAST44
Domaini545 – 588Collagen-like 4Add BLAST44
Domaini733 – 769Collagen-like 5Add BLAST37
Domaini798 – 976VWFA 2PROSITE-ProRule annotationAdd BLAST179
Domaini1088 – 1138BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd BLAST51

Sequence similaritiesi

Belongs to the VWA-containing collagen family.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
KOG3544 Eukaryota
ENOG410ZJ4P LUCA
GeneTreeiENSGT00820000126981
HOGENOMiHOG000085654
HOVERGENiHBG104822
InParanoidiQ2UY11
OMAiIQGISGP
OrthoDBiEOG091G0T4R
PhylomeDBiQ2UY11
TreeFamiTF331207

Family and domain databases

CDDicd00109 KU, 1 hit
Gene3Di3.40.50.410, 2 hits
4.10.410.10, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR020901 Prtase_inh_Kunz-CS
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01391 Collagen, 1 hit
PF00014 Kunitz_BPTI, 1 hit
PF00092 VWA, 2 hits
SMARTiView protein in SMART
SM00131 KU, 1 hit
SM00327 VWA, 2 hits
SUPFAMiSSF53300 SSF53300, 2 hits
SSF57362 SSF57362, 1 hit
PROSITEiView protein in PROSITE
PS00280 BPTI_KUNITZ_1, 1 hit
PS50279 BPTI_KUNITZ_2, 1 hit
PS50234 VWFA, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q2UY11-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRRRDVAFCL LLLPAFMTQA VYGQRKKGPK PNTLARKNDF QDAICFIDVV
60 70 80 90 100
FILDSSESSK IVLFDNQKDF VDSLSEKIFQ LTPGRSLKYD IKLAALQFSS
110 120 130 140 150
SVQIDPPLSS WKDLRTFKQR VKSLNLIGQG TFSYYAISNA TRLLKREGRK
160 170 180 190 200
DGVKVALLMT DGIDHPKSPD VQSISEDARI LGISFITVGL STVVNEAKLR
210 220 230 240 250
LISGDPSNEP VLLLSDPTLV DRIQERLGVL FERKCEHKIC ECEKGEPGDP
260 270 280 290 300
GPPGTHGNPG IKGERGPKGN PGDAQKGETG ERGPVGIPGY KGDKGERGEC
310 320 330 340 350
GKPGMKGDKG PEGPYGPKGP RGIQGIGGPP GDPGPKGFQG NKGEPGPPGP
360 370 380 390 400
YGPPGAPGIG QQGVKGERGQ EGRMGAPGPI GIGEPGQPGP RGPEGAPGER
410 420 430 440 450
GLPGEGFPGP KGEKGSEGPI GPQGLQGLSI KGDKGDLGPV GPQGPAGIPG
460 470 480 490 500
IGSQGEQGIQ GPSGPPGPQG PPGQGSPGPK GEVGQMGPTG PRGPMGIGVQ
510 520 530 540 550
GPKGEPGTVG LPGQPGVPGE DGASGKKGEA GLPGTRGPEG MPGKGQPGPK
560 570 580 590 600
GDEGKKGSKG NQGQRGFPGP EGPKGEPGVM GPFGMPGASI PGPSGPKGDR
610 620 630 640 650
GGPGMPGLKG EPGLPVRGPK GAQGPRGPVG APGLKGDGYP GVAGPRGLPG
660 670 680 690 700
PPGPMGLRGV GDTGAKGEPG VRGPPGPSGP RGIGTQGPKG DTGQKGLPGP
710 720 730 740 750
PGPPGYGSQG IKGEQGPQGF PGSKGTVGLG LPGQKGEHGD RGDVGRKGEK
760 770 780 790 800
GETGEPGSPG KQGLQGPKGD LGLTKEEIIK LIIEICGCGP KCKETPLELV
810 820 830 840 850
FVIDSSESVG PENFQIIQSF VKTLADRVAL DLGTARIGII NYSHKVEKVA
860 870 880 890 900
SLKQFSSKDD FKLVVDNMQY LGEGTYTATA LQAANDMFKE ARPGVKKVAL
910 920 930 940 950
VITDGQTDSR DKKKLADVVK DANDSNVEIF VIGVVKKDDP NFEIFHKEMN
960 970 980 990 1000
LIATDAEHVY QFDDFFTLQD TLKQKLSKKI CEDFDSYLIQ VFGSPSFQPE
1010 1020 1030 1040 1050
FGVSEREVSV STPKPAKEMS KSFNVSRGQN EETESYVLTE AGILAIPTPP
1060 1070 1080 1090 1100
EATNTLEPLL SSREGVETRT PNPNLLQSEK SLYKDPRCEE ALKPGECGDY
1110 1120 1130 1140
VVRWYYDKQV NSCARFWFSG CNGSGNRFHS EKECRETCIK Q
Length:1,141
Mass (Da):118,749
Last modified:January 24, 2006 - v1
Checksum:iA2C43C4BB7913272
GO
Isoform 2 (identifier: Q2UY11-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     667-699: GEPGVRGPPGPSGPRGIGTQGPKGDTGQKGLPG → VRFLKEAKILVFKKVLIDDFGKCVLFLSGTQEE
     700-1141: Missing.

Show »
Length:699
Mass (Da):71,075
Checksum:i35385C4AE8FC3DC6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SSY2A0A1L1SSY2_MOUSE
Collagen alpha-1(XXVIII) chain
Col28a1
234Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031095667 – 699GEPGV…KGLPG → VRFLKEAKILVFKKVLIDDF GKCVLFLSGTQEE in isoform 2. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_031096700 – 1141Missing in isoform 2. 1 PublicationAdd BLAST442

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ890449 mRNA Translation: CAI67593.1
AJ890450 mRNA Translation: CAI67594.1
CCDSiCCDS39424.1 [Q2UY11-1]
RefSeqiNP_001032954.1, NM_001037865.1 [Q2UY11-1]
XP_006505094.1, XM_006505031.2 [Q2UY11-1]
XP_006505095.1, XM_006505032.3 [Q2UY11-1]
XP_017176991.1, XM_017321502.1 [Q2UY11-1]
UniGeneiMm.297404

Genome annotation databases

EnsembliENSMUST00000115537; ENSMUSP00000111199; ENSMUSG00000068794 [Q2UY11-1]
GeneIDi213945
KEGGimmu:213945
UCSCiuc009axi.1 mouse [Q2UY11-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ890449 mRNA Translation: CAI67593.1
AJ890450 mRNA Translation: CAI67594.1
CCDSiCCDS39424.1 [Q2UY11-1]
RefSeqiNP_001032954.1, NM_001037865.1 [Q2UY11-1]
XP_006505094.1, XM_006505031.2 [Q2UY11-1]
XP_006505095.1, XM_006505032.3 [Q2UY11-1]
XP_017176991.1, XM_017321502.1 [Q2UY11-1]
UniGeneiMm.297404

3D structure databases

ProteinModelPortaliQ2UY11
SMRiQ2UY11
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-3029 Collagen type XXVIII trimer
STRINGi10090.ENSMUSP00000111199

PTM databases

PhosphoSitePlusiQ2UY11

Proteomic databases

MaxQBiQ2UY11
PaxDbiQ2UY11
PRIDEiQ2UY11

Protocols and materials databases

DNASUi213945
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115537; ENSMUSP00000111199; ENSMUSG00000068794 [Q2UY11-1]
GeneIDi213945
KEGGimmu:213945
UCSCiuc009axi.1 mouse [Q2UY11-1]

Organism-specific databases

CTDi340267
MGIiMGI:2685312 Col28a1

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
KOG3544 Eukaryota
ENOG410ZJ4P LUCA
GeneTreeiENSGT00820000126981
HOGENOMiHOG000085654
HOVERGENiHBG104822
InParanoidiQ2UY11
OMAiIQGISGP
OrthoDBiEOG091G0T4R
PhylomeDBiQ2UY11
TreeFamiTF331207

Enzyme and pathway databases

ReactomeiR-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-8948216 Collagen chain trimerization

Miscellaneous databases

PROiPR:Q2UY11
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068794 Expressed in 15 organ(s), highest expression level in brown adipose tissue
CleanExiMM_COL28A1
ExpressionAtlasiQ2UY11 baseline and differential

Family and domain databases

CDDicd00109 KU, 1 hit
Gene3Di3.40.50.410, 2 hits
4.10.410.10, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR020901 Prtase_inh_Kunz-CS
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01391 Collagen, 1 hit
PF00014 Kunitz_BPTI, 1 hit
PF00092 VWA, 2 hits
SMARTiView protein in SMART
SM00131 KU, 1 hit
SM00327 VWA, 2 hits
SUPFAMiSSF53300 SSF53300, 2 hits
SSF57362 SSF57362, 1 hit
PROSITEiView protein in PROSITE
PS00280 BPTI_KUNITZ_1, 1 hit
PS50279 BPTI_KUNITZ_2, 1 hit
PS50234 VWFA, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCOSA1_MOUSE
AccessioniPrimary (citable) accession number: Q2UY11
Secondary accession number(s): Q2UY10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 24, 2006
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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