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Protein

Collagen alpha-1(XXVIII) chain

Gene

COL28A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a cell-binding protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor
Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-8948216 Collagen chain trimerization

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I02.974

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen alpha-1(XXVIII) chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL28A1
Synonyms:COL28
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000215018.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:22442 COL28A1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609996 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q2UY09

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
340267

Open Targets

More...
OpenTargetsi
ENSG00000215018

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485437

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2364188

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
COL28A1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
167009138

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500007466724 – 1125Collagen alpha-1(XXVIII) chainAdd BLAST1102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1072 ↔ 1122PROSITE-ProRule annotation
Disulfide bondi1081 ↔ 1105PROSITE-ProRule annotation
Disulfide bondi1097 ↔ 1118PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q2UY09

PeptideAtlas

More...
PeptideAtlasi
Q2UY09

PRoteomics IDEntifications database

More...
PRIDEi
Q2UY09

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61505
61506 [Q2UY09-2]
61507 [Q2UY09-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q2UY09-2 [Q2UY09-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q2UY09

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q2UY09

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000215018 Expressed in 137 organ(s), highest expression level in pituitary gland

CleanEx database of gene expression profiles

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CleanExi
HS_COL28A1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q2UY09 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q2UY09 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043844
HPA060468

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Trimer or homomer. Secreted as a 135 kDa monomer under reducing conditions and as a homotrimer under non-reducing conditions (By similarity).By similarity

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1769 Collagen type XXVIII trimer

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000382356

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q2UY09

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q2UY09

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini48 – 227VWFA 1PROSITE-ProRule annotationAdd BLAST180
Domaini243 – 274Collagen-like 1Add BLAST32
Domaini301 – 360Collagen-like 2Add BLAST60
Domaini383 – 405Collagen-like 3Add BLAST23
Domaini501 – 544Collagen-like 4Add BLAST44
Domaini545 – 583Collagen-like 5Add BLAST39
Domaini730 – 769Collagen-like 6Add BLAST40
Domaini798 – 980VWFA 2PROSITE-ProRule annotationAdd BLAST183
Domaini1072 – 1122BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd BLAST51

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VWA-containing collagen family.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IR6I Eukaryota
ENOG410YF6I LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161647

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG104822

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q2UY09

Identification of Orthologs from Complete Genome Data

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OMAi
IQGISGP

Database of Orthologous Groups

More...
OrthoDBi
293907at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q2UY09

TreeFam database of animal gene trees

More...
TreeFami
TF331207

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00109 KU, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.410, 2 hits
4.10.410.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR008160 Collagen
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR020901 Prtase_inh_Kunz-CS
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391 Collagen, 4 hits
PF00014 Kunitz_BPTI, 1 hit
PF00092 VWA, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00131 KU, 1 hit
SM00327 VWA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300 SSF53300, 2 hits
SSF57362 SSF57362, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00280 BPTI_KUNITZ_1, 1 hit
PS50279 BPTI_KUNITZ_2, 1 hit
PS50234 VWFA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q2UY09-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWNRYFVFYL LLLSAFTSQT VSGQRKKGPK SNLLARKSDV QGSICFIDIV
60 70 80 90 100
FIVDSSESSK IALFDKQKDF VDSLSDKIFQ LTPGRSLEYD IKLAALQFSS
110 120 130 140 150
SVQIDPPFSS WKDLQTFKQK VKSMNLIGQG TFSYYAISNA TRLLKREGRK
160 170 180 190 200
DGVKVVLLMT DGIDHPKNPD VQSISEDARI SGISFITIAL STVVNEAKLR
210 220 230 240 250
LISGDSSSEP TLLLSDPTLV DKIQDRLDIL FEKKCERKIC ECEKGDPGDP
260 270 280 290 300
GPPGTHGNPG IKGERGPKGN PGNAQKGEAG ERGPGGIPGY KGDKGERGEC
310 320 330 340 350
GKPGIKGDKG SPGPYGPKGP RGIQGITGPP GDPGPKGFQG NKGEPGPPGP
360 370 380 390 400
YGSPGAPGIG QQGIKGERGQ EGRPGAPGPI GVGEPGQPGP RGPEGVPGER
410 420 430 440 450
GLPGEGFPGP KGEKGSEGPT GPQGLQGLSI KGEKGDIGPV GPQGPMGIPG
460 470 480 490 500
IGSQGEQGIQ GPIGPPGPQG PAGQGLPGSK GEVGQMGPTG PRGPVGIGVQ
510 520 530 540 550
GPKGEPGSIG LPGQPGVPGE DGAAGKKGEA GLPGARGPEG PPGKGQPGPK
560 570 580 590 600
GDEGKKGSKG NQGQRGLPGP EGPKGEPGIM GPFGMPGTSI PGPPGPKGDR
610 620 630 640 650
GGPGIPGFKG EPGLSIRGPK GVQGPRGPVG APGLKGDGYP GVPGPRGLPG
660 670 680 690 700
PPGPMGLRGV GDTGAKGEPG VRGPPGPSGP RGVGTQGPKG DTGQKGLPGP
710 720 730 740 750
PGPPGYGSQG IKGEQGPQGF PGPKGTMGHG LPGQKGEHGE RGDVGKKGDK
760 770 780 790 800
GEIGEPGSPG KQGLQGPKGD LGLTKEEIIK LITEICGCGP KCKETPLELV
810 820 830 840 850
FVIDSSESVG PENFQIIKNF VKTMADRVAL DLATARIGII NYSHKVEKVA
860 870 880 890 900
NLKQFSSKDD FKLAVDNMQY LGEGTYTATA LQAANDMFED ARPGVKKVAL
910 920 930 940 950
VITDGQTDSR DKEKLTEVVK NASDTNVEIF VIGVVKKNDP NFEIFHKEMN
960 970 980 990 1000
LIATDPEHVY QFDDFFTLQD TLKQKLFQKI CEDFDSYLVQ IFGSSSPQPG
1010 1020 1030 1040 1050
FGMSGEELSE STPEPQKEIS ESLSVTRDQD EDDKAPEPTW ADDLPATTSS
1060 1070 1080 1090 1100
EATTTPRPLL STPVDGAEDP RCLEALKPGN CGEYVVRWYY DKQVNSCARF
1110 1120
WFSGCNGSGN RFNSEKECQE TCIQG
Length:1,125
Mass (Da):116,657
Last modified:February 5, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0969733A0D1095F2
GO
Isoform 2 (identifier: Q2UY09-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     667-713: GEPGVRGPPG...PGYGSQGIKG → TLNTSHGLED...IPASGTRQDG
     714-1125: Missing.

Show »
Length:713
Mass (Da):72,210
Checksum:iA1EF4CE194D7C78A
GO
Isoform 3 (identifier: Q2UY09-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     295-334: GERGECGKPG...GITGPPGDPG → QYSREDREVE...SLTHHGTCSH
     335-1125: Missing.

Show »
Length:334
Mass (Da):36,755
Checksum:i4CA00ED002DB706A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BZU0H7BZU0_HUMAN
Collagen alpha-1(XXVIII) chain
COL28A1
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3P2H7C3P2_HUMAN
Collagen alpha-1(XXVIII) chain
COL28A1
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DG72A0A0C4DG72_HUMAN
Collagen alpha-1(XXVIII) chain
COL28A1
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DG66A0A0C4DG66_HUMAN
Collagen alpha-1(XXVIII) chain
COL28A1
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence EAL24305 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAL24306 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAL24307 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038566189A → G2 PublicationsCorresponds to variant dbSNP:rs7804532Ensembl.1
Natural variantiVAR_038567239I → V. Corresponds to variant dbSNP:rs10486180Ensembl.1
Natural variantiVAR_038568327T → S. Corresponds to variant dbSNP:rs10486176Ensembl.1
Natural variantiVAR_038569433E → D. Corresponds to variant dbSNP:rs6952195Ensembl.1
Natural variantiVAR_061117437I → M. Corresponds to variant dbSNP:rs55745506Ensembl.1
Natural variantiVAR_038570472A → P. Corresponds to variant dbSNP:rs17167927Ensembl.1
Natural variantiVAR_038571741R → Q. Corresponds to variant dbSNP:rs17167102Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_031091295 – 334GERGE…PGDPG → QYSREDREVEHNNEKYVACL LPSPALLQQSSLTHHGTCSH in isoform 3. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_031092335 – 1125Missing in isoform 3. 1 PublicationAdd BLAST791
Alternative sequenceiVSP_031093667 – 713GEPGV…QGIKG → TLNTSHGLEDPSCPDCSFCH FSLAADIQPKWPALLQLIPA SGTRQDG in isoform 2. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_031094714 – 1125Missing in isoform 2. 1 PublicationAdd BLAST412

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ890451 mRNA Translation: CAI67595.1
AJ890452 mRNA Translation: CAI67596.1
AJ890453 mRNA Translation: CAI67597.1
AC004982 Genomic DNA No translation available.
CH236948 Genomic DNA Translation: EAL24305.1 Sequence problems.
CH236948 Genomic DNA Translation: EAL24306.1 Sequence problems.
CH236948 Genomic DNA Translation: EAL24307.1 Sequence problems.
BC136892 mRNA Translation: AAI36893.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43553.1 [Q2UY09-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001032852.2, NM_001037763.2 [Q2UY09-1]
XP_011513660.1, XM_011515358.2 [Q2UY09-1]
XP_011513661.1, XM_011515359.2 [Q2UY09-1]
XP_011513662.1, XM_011515360.2 [Q2UY09-1]
XP_011513665.1, XM_011515363.2 [Q2UY09-2]
XP_016867620.1, XM_017012131.1 [Q2UY09-1]
XP_016867621.1, XM_017012132.1 [Q2UY09-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.491104

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000399429; ENSP00000382356; ENSG00000215018 [Q2UY09-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
340267

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:340267

UCSC genome browser

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UCSCi
uc003src.2 human [Q2UY09-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ890451 mRNA Translation: CAI67595.1
AJ890452 mRNA Translation: CAI67596.1
AJ890453 mRNA Translation: CAI67597.1
AC004982 Genomic DNA No translation available.
CH236948 Genomic DNA Translation: EAL24305.1 Sequence problems.
CH236948 Genomic DNA Translation: EAL24306.1 Sequence problems.
CH236948 Genomic DNA Translation: EAL24307.1 Sequence problems.
BC136892 mRNA Translation: AAI36893.1
CCDSiCCDS43553.1 [Q2UY09-1]
RefSeqiNP_001032852.2, NM_001037763.2 [Q2UY09-1]
XP_011513660.1, XM_011515358.2 [Q2UY09-1]
XP_011513661.1, XM_011515359.2 [Q2UY09-1]
XP_011513662.1, XM_011515360.2 [Q2UY09-1]
XP_011513665.1, XM_011515363.2 [Q2UY09-2]
XP_016867620.1, XM_017012131.1 [Q2UY09-1]
XP_016867621.1, XM_017012132.1 [Q2UY09-1]
UniGeneiHs.491104

3D structure databases

ProteinModelPortaliQ2UY09
SMRiQ2UY09
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-1769 Collagen type XXVIII trimer
STRINGi9606.ENSP00000382356

Chemistry databases

ChEMBLiCHEMBL2364188

Protein family/group databases

MEROPSiI02.974

PTM databases

iPTMnetiQ2UY09
PhosphoSitePlusiQ2UY09

Polymorphism and mutation databases

BioMutaiCOL28A1
DMDMi167009138

Proteomic databases

PaxDbiQ2UY09
PeptideAtlasiQ2UY09
PRIDEiQ2UY09
ProteomicsDBi61505
61506 [Q2UY09-2]
61507 [Q2UY09-3]
TopDownProteomicsiQ2UY09-2 [Q2UY09-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399429; ENSP00000382356; ENSG00000215018 [Q2UY09-1]
GeneIDi340267
KEGGihsa:340267
UCSCiuc003src.2 human [Q2UY09-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
340267
DisGeNETi340267
EuPathDBiHostDB:ENSG00000215018.9

GeneCards: human genes, protein and diseases

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GeneCardsi
COL28A1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0034009
HGNCiHGNC:22442 COL28A1
HPAiHPA043844
HPA060468
MIMi609996 gene
neXtProtiNX_Q2UY09
OpenTargetsiENSG00000215018
PharmGKBiPA143485437

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IR6I Eukaryota
ENOG410YF6I LUCA
GeneTreeiENSGT00940000161647
HOVERGENiHBG104822
InParanoidiQ2UY09
OMAiIQGISGP
OrthoDBi293907at2759
PhylomeDBiQ2UY09
TreeFamiTF331207

Enzyme and pathway databases

ReactomeiR-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-8948216 Collagen chain trimerization

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
COL28A1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
340267

Protein Ontology

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PROi
PR:Q2UY09

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000215018 Expressed in 137 organ(s), highest expression level in pituitary gland
CleanExiHS_COL28A1
ExpressionAtlasiQ2UY09 baseline and differential
GenevisibleiQ2UY09 HS

Family and domain databases

CDDicd00109 KU, 1 hit
Gene3Di3.40.50.410, 2 hits
4.10.410.10, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR020901 Prtase_inh_Kunz-CS
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01391 Collagen, 4 hits
PF00014 Kunitz_BPTI, 1 hit
PF00092 VWA, 2 hits
SMARTiView protein in SMART
SM00131 KU, 1 hit
SM00327 VWA, 2 hits
SUPFAMiSSF53300 SSF53300, 2 hits
SSF57362 SSF57362, 1 hit
PROSITEiView protein in PROSITE
PS00280 BPTI_KUNITZ_1, 1 hit
PS50279 BPTI_KUNITZ_2, 1 hit
PS50234 VWFA, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOSA1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2UY09
Secondary accession number(s): A4D101
, A4D106, A4D107, A8MVR2, B9EGX9, Q2UY07, Q2UY08
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: January 16, 2019
This is version 119 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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