UniProtKB - Q2U256 (PPIL4_ASPOR)
Protein
Peptidyl-prolyl cis-trans isomerase-like 4
Gene
cyp6
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Functioni
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity
Catalytic activityi
- EC:5.2.1.8
GO - Molecular functioni
- peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW
- RNA binding Source: UniProtKB-KW
Keywordsi
Molecular function | Isomerase, RNA-binding, Rotamase |
Names & Taxonomyi
Protein namesi | Recommended name: Peptidyl-prolyl cis-trans isomerase-like 4 (EC:5.2.1.8)Short name: PPIase Alternative name(s): Rotamase |
Gene namesi | Name:cyp6 ORF Names:AO090038000594 |
Organismi | Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) |
Taxonomic identifieri | 510516 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Circumdati › |
Proteomesi |
|
Subcellular locationi
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000232975 | 1 – 461 | Peptidyl-prolyl cis-trans isomerase-like 4Add BLAST | 461 |
Proteomic databases
PRIDEi | Q2U256 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 171 | PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST | 171 | |
Domaini | 248 – 326 | RRMPROSITE-ProRule annotationAdd BLAST | 79 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 205 – 234 | Sequence analysisAdd BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 386 – 461 | Arg-richAdd BLAST | 76 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
HOGENOMi | CLU_018791_2_1_1 |
OMAi | HSVQKNF |
Family and domain databases
CDDi | cd01921, cyclophilin_RRM, 1 hit |
Gene3Di | 2.40.100.10, 1 hit 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR035542, CRIP IPR029000, Cyclophilin-like_dom_sf IPR002130, Cyclophilin-type_PPIase_dom IPR035538, Cyclophilin_PPIL4 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
PANTHERi | PTHR45843, PTHR45843, 1 hit |
Pfami | View protein in Pfam PF00160, Pro_isomerase, 1 hit PF00076, RRM_1, 1 hit |
PRINTSi | PR00153, CSAPPISMRASE |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF50891, SSF50891, 1 hit SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50072, CSA_PPIASE_2, 1 hit PS50102, RRM, 1 hit |
i Sequence
Sequence statusi: Complete.
Q2U256-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVLLETSLG DIVIDLLVDE CPKACENFLK LCKVKYYNFS PVHSVQKNFT
60 70 80 90 100
FQTGDPLGPD SSESDGGSSI WGLLEGPPKR TFSLEPPPKL KHDERGTVSM
110 120 130 140 150
ATVPSPHDPD QRIAASQFIV TLGENLDYLD GKAVIFGKVV EGFDVLEKVN
160 170 180 190 200
EAFIDDRGRP LKDIRIRHTV ILDDPFDDPP GLVAPAESPL PSKAQLATVR
210 220 230 240 250
IADDEELDDN MDEESMEKLR REREARAQAL TLEMVGDLPF AEVKPPENVL
260 270 280 290 300
FVCKLNPVTQ DEDLHLIFSR FGTILSCEVI RDKRTGDSLQ YAFIEFENQK
310 320 330 340 350
DCEQAYFKMQ GVLIDDHRIH VDFSQSVSKL SESWRNATIS KRSGQRGGFG
360 370 380 390 400
GVASLEKKRQ YRASDNAREK ENDYTLVFDK GDKAPRRRSY SRSPQRSSNR
410 420 430 440 450
DRRASRSPRR DSYRDPYRRR PGDRSHSRSP ARGEYRDKDR GRYNHRERRR
460
DDERYRERRR R
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP007169 Genomic DNA Translation: BAE64359.1 |
RefSeqi | XP_001825492.1, XM_001825440.2 |
Genome annotation databases
EnsemblFungii | BAE64359; BAE64359; AO090038000594 |
GeneIDi | 5997587 |
KEGGi | aor:AO090038000594 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP007169 Genomic DNA Translation: BAE64359.1 |
RefSeqi | XP_001825492.1, XM_001825440.2 |
3D structure databases
SMRi | Q2U256 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q2U256 |
Genome annotation databases
EnsemblFungii | BAE64359; BAE64359; AO090038000594 |
GeneIDi | 5997587 |
KEGGi | aor:AO090038000594 |
Phylogenomic databases
HOGENOMi | CLU_018791_2_1_1 |
OMAi | HSVQKNF |
Family and domain databases
CDDi | cd01921, cyclophilin_RRM, 1 hit |
Gene3Di | 2.40.100.10, 1 hit 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR035542, CRIP IPR029000, Cyclophilin-like_dom_sf IPR002130, Cyclophilin-type_PPIase_dom IPR035538, Cyclophilin_PPIL4 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
PANTHERi | PTHR45843, PTHR45843, 1 hit |
Pfami | View protein in Pfam PF00160, Pro_isomerase, 1 hit PF00076, RRM_1, 1 hit |
PRINTSi | PR00153, CSAPPISMRASE |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF50891, SSF50891, 1 hit SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50072, CSA_PPIASE_2, 1 hit PS50102, RRM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PPIL4_ASPOR | |
Accessioni | Q2U256Primary (citable) accession number: Q2U256 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 18, 2006 |
Last sequence update: | January 24, 2006 | |
Last modified: | December 2, 2020 | |
This is version 88 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families