TID1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP binding Source: InterPro
• GTPase regulator activity Source: RGD
• Hsp70 protein binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Identification of rTid-1, the rat homologue of the drosophila tumor suppressor l(2)tid gene."
    Fujita M., Nagai Y., Sawada T., Heese K.
    Mol Cell Biochem 258:183-189(2004) [PubMed] [Europe PMC] [Abstract]
• metal ion binding Source: UniProtKB-KW
• protein kinase binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• receptor tyrosine kinase binding Source: RGD
• unfolded protein binding Source: RGD

GO - Biological processⁱ

• activation-induced cell death of T cells Source: RGD
• apoptotic process Source: RGD
• cell aging Source: RGD
• mitochondrial DNA replication Source: RGD
• mitochondrion organization Source: RGD
• negative regulation of apoptotic process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell population proliferation Source: RGD
• negative regulation of NF-kappaB transcription factor activity Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Functional genetic screen for genes involved in senescence: role of Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in senescence and cell survival."
    Tarunina M., Alger L., Chu G., Munger K., Gudkov A., Jat P.S.
    Mol Cell Biol 24:10792-10801(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of programmed cell death Source: RGD
• negative regulation of transcription by RNA polymerase II Source: RGD
• neuromuscular junction development Source: RGD
• positive regulation of T cell proliferation Source: RGD
• protein folding Source: InterPro
• response to heat Source: InterPro
• skeletal muscle acetylcholine-gated channel clustering Source: RGD
• small GTPase mediated signal transduction Source: RGD
• T cell differentiation in thymus Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Keywords - PTMⁱ

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• Hsp70 protein binding Source: RGDInferred from physical interactionⁱ
  • "Identification of rTid-1, the rat homologue of the drosophila tumor suppressor l(2)tid gene."
    Fujita M., Nagai Y., Sawada T., Heese K.
    Mol Cell Biochem 258:183-189(2004) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• receptor tyrosine kinase binding Source: RGD
• unfolded protein binding Source: RGD

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Zinc finger

Keywords - Domainⁱ

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MAAWCSPRWL RVAVGTPRLP AAAGRGVQQP QGGVVAASLC RKLCVSAFGL 
        60         70         80         90        100
SMGAHGPRAL LTLRPGVRLT GTKSFPFVCT ASFHTSASLA KDDYYQILGV 
       110        120        130        140        150
PRNASQKDIK KAYYQLAKKY HPDTNKDDPK AKEKFSQLAE AYEVLSDEVK 
       160        170        180        190        200
RKQYDAYGSA GFDPGASSSG QGYWRGGPSV DPEELFRKIF GEFSSSPFGD 
       210        220        230        240        250
FQNVFDQPQE YIMELTFNQA AKGVNKEFTV NIMDTCERCD GKGNEPGTKV 
       260        270        280        290        300
QHCHYCSGSG METINTGPFV MRSTCRRCGG RGSIITNPCV VCRGAGQAKQ 
       310        320        330        340        350
KKRVTVPVPA GVEDGQTVRM PVGKREIFVT FRVQKSPVFR RDGADIHSDL 
       360        370        380        390        400
FISIAQAILG GTAKAQGLYE TINVTIPAGI QTDQKIRLTG KGIPRINSYG 
       410        420        430        440        450
YGDHYIHIKI RVPKRLSSRQ QNLILSYAED ETDVEGTVNG VTHTSTGKRS 

TGN                                                    

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genome annotation databases

Organism-specific databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ