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Entry version 102 (22 Apr 2020)
Sequence version 2 (08 Apr 2008)
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Protein

Transient receptor potential cation channel subfamily M member 1

Gene

Trpm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. Calcium channel which may play a role in metastasis suppression. May act as a spontaneously active, calcium-permeable plasma membrane channel.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Sensory transduction, Transport, Vision

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3295583 TRP channels

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily M member 1
Alternative name(s):
Long transient receptor potential channel 1
Short name:
LTrpC1
Melastatin-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Trpm1Imported
Synonyms:Ltrpc1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1330305 Trpm1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 790ExtracellularSequence analysisAdd BLAST790
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei791 – 811HelicalSequence analysisAdd BLAST21
Topological domaini812 – 875CytoplasmicSequence analysisAdd BLAST64
Transmembranei876 – 896HelicalSequence analysisAdd BLAST21
Topological domaini897ExtracellularSequence analysis1
Transmembranei898 – 918HelicalSequence analysisAdd BLAST21
Topological domaini919 – 942CytoplasmicSequence analysisAdd BLAST24
Transmembranei943 – 963HelicalSequence analysisAdd BLAST21
Topological domaini964 – 973ExtracellularSequence analysis10
Transmembranei974 – 994HelicalSequence analysisAdd BLAST21
Topological domaini995 – 1006CytoplasmicSequence analysisAdd BLAST12
Transmembranei1007 – 1027HelicalSequence analysisAdd BLAST21
Topological domaini1028 – 1099ExtracellularSequence analysisAdd BLAST72
Transmembranei1100 – 1120HelicalSequence analysisAdd BLAST21
Topological domaini1121 – 1150CytoplasmicSequence analysisAdd BLAST30
Transmembranei1151 – 1171HelicalSequence analysisAdd BLAST21
Topological domaini1172 – 1622ExtracellularSequence analysisAdd BLAST451

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003289311 – 1622Transient receptor potential cation channel subfamily M member 1Add BLAST1622

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q2TV84

PRoteomics IDEntifications database

More...
PRIDEi
Q2TV84

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q2TV84

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q2TV84

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the retina where it localizes on dendritic tips of ON bipolar cells. Not detected in brain, lung, liver, heart, kidney, spleen or small intestine. Also expressed at high levels in poorly metastatic variants of B16 melanoma and at much reduced levels in highly metastatic variants of B16 melanoma.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000030523 Expressed in iris and 81 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q2TV84 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q2TV84 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000082318

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q2TV84 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1224 – 1252Sequence analysisAdd BLAST29

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3614 Eukaryota
ENOG410XR5B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155024

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_022373_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q2TV84

KEGG Orthology (KO)

More...
KOi
K04976

Identification of Orthologs from Complete Genome Data

More...
OMAi
TEWKYEV

Database of Orthologous Groups

More...
OrthoDBi
738147at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q2TV84

TreeFam database of animal gene trees

More...
TreeFami
TF314204

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.5.1010, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005821 Ion_trans_dom
IPR029588 TRPM1
IPR041491 TRPM_SLOG
IPR032415 TRPM_tetra
IPR037162 TRPM_tetra_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13800:SF13 PTHR13800:SF13, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520 Ion_trans, 1 hit
PF18139 LSDAT_euk, 1 hit
PF16519 TRPM_tetra, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q2TV84-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSMRKMSSS FKRGSIKSST SGSQKGQKAW IEKTFCKREC IFVIPSTKDP
60 70 80 90 100
NRCCCGQLTN QHIPPLPSGA PSTTGEDTKQ ADTQSGKWSV SKHTQSYPTD
110 120 130 140 150
SYGILEFQGG GYSNKAMYIR VSYDTKPDSL LHLMVKDWQL ELPKLLISVH
160 170 180 190 200
GGLQSFEMQP KLKQVFGKGL IKAAMTTGAW IFTGGVSTGV VSHVGDALKD
210 220 230 240 250
HSSKSRGRLC AIGIAPWGMV ENKEDLIGKD VTRVYQTMSN PLSKLSVLNN
260 270 280 290 300
SHTHFILADN GTLGKYGAEV KLRRQLEKHI SLQKINTRLG QGVPVVGLVV
310 320 330 340 350
EGGPNVVSIV LEYLKEDPPV PVVVCDGSGR ASDILSFAHK YCDEGGVINE
360 370 380 390 400
SLRDQLLVTI QKTFNYSKSQ SYQLFAIIME CMKKKELVTV FRMGSEGQQD
410 420 430 440 450
VEMAILTALL KGTNASAPDQ LSLALAWNRV DIARSQIFVF GPHWPPLGSL
460 470 480 490 500
APPVDTKATE KEKKPPTATT KGRGKGKGKK KGKVKEEVEE ETDPRKLELL
510 520 530 540 550
NWVNALEQAM LDALVLDRVD FVKLLIENGV NMQHFLTIPR LEELYNTRLG
560 570 580 590 600
PPNTLHLLVR DVKKSNLPPD YHISLIDIGL VLEYLMGGAY RCNYTRKSFR
610 620 630 640 650
TLYNNLFGPK RPKALKLLGM EDDEPPAKGK KKKKKKKEEE IDIDVDDPAV
660 670 680 690 700
SRFQYPFHEL MVWAVLMKRQ KMAVFLWQRG EECMAKALVA CKLYKAMAHE
710 720 730 740 750
SSESELVDDI SQDLDNNSKD FGQLAVELLD QSYKHDEQVA MKLLTYELKN
760 770 780 790 800
WSNSTCLKLA VAAKHRDFIA HTCSQMLLTD MWMGRLRMRK NPGLKVIMGI
810 820 830 840 850
LIPPTILFLE FRTYDDFSYQ TSKENEDGKE KEEENVDANA DAGSRKGDEE
860 870 880 890 900
NEHKKQRSIP IGTKICEFYN APIVKFWFYT ISYLGYLLLF NYVILVRMDG
910 920 930 940 950
WPSPQEWIVI SYIVSLALEK IREILMSEPG KLSQKIKVWL QEYWNITDLV
960 970 980 990 1000
AISMFMVGAI LRLQSQPYMG YGRVIYCVDI ILWYIRVLDI FGVNKYLGPY
1010 1020 1030 1040 1050
VMMIGKMMID MLYFVVIMLV VLMSFGVARQ AILHPEEKPS WKLARNIFYM
1060 1070 1080 1090 1100
PYWMIYGEVF ADQIDLYAME INPPCGENLY DEEGKRLPPC IPGAWLTPAL
1110 1120 1130 1140 1150
MACYLLVANI LLVNLLIAVF NNTFFEVKSI SNQVWKFQRY QLIMTFHDRP
1160 1170 1180 1190 1200
VLPPPMIILS HIYIIIMRLS GRCRKKREGD QEERDRGLKL FLSDEELKKL
1210 1220 1230 1240 1250
HEFEEQCVQE HFREKEDEQQ SSSDERIRVT SERVENMSMR LEEINERENF
1260 1270 1280 1290 1300
MKTSLQTVDL RLSQLEELSG RMVSALENLA GIDRSDLIQA RSRASSECEA
1310 1320 1330 1340 1350
TYLLRQSSIN SADGYSLYRY HFNGEELLFE EPALSTSPGT AFRKKTYSFR
1360 1370 1380 1390 1400
VKDEDAKSHL DQPSNLHHTP GPSPPATPGR SRLALEGPLS TELRPGSDPG
1410 1420 1430 1440 1450
ISAGEFDPRA DFKSTEAAPS LNAAGVTGTQ LTVESTDSHP LRESKLVRYY
1460 1470 1480 1490 1500
PGDPNTYKTM KSRSFVYTEG RKLVRGLSNW SAEYSSIMDQ AWNATEWRCQ
1510 1520 1530 1540 1550
VQRITRSRST DIPYIVSEAA SQDELEDEHR GSLLDPQISR SALTVSDRPE
1560 1570 1580 1590 1600
KENLLSVKPH QTLGFPCLRS RSLHGRPRSA EPAPSKLDRA GHASSTSNLA
1610 1620
VMSVVPEGQN TQQEKRSAET EC
Length:1,622
Mass (Da):183,527
Last modified:April 8, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFB4786BD92D4ED5E
GO
Isoform 21 Publication (identifier: Q2TV84-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     189-189: G → A
     190-1073: Missing.

Show »
Length:738
Mass (Da):82,761
Checksum:iC6E3B0F989EC9553
GO
Isoform 32 Publications (identifier: Q2TV84-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
     612-658: PKALKLLGME...AVSRFQYPFH → VELSRHTVSC...SQTDITPPLP
     659-1622: Missing.

Show »
Length:542
Mass (Da):60,175
Checksum:iC03217ED13695993
GO
Isoform 42 Publications (identifier: Q2TV84-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
     504-559: NALEQAMLDA...GPPNTLHLLV → CAHVLVSLPV...LHGNSVFTSM
     560-1622: Missing.

Show »
Length:443
Mass (Da):48,351
Checksum:iA688891BA62D1D9D
GO
Isoform 51 Publication (identifier: Q2TV84-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.
     504-559: NALEQAMLDA...GPPNTLHLLV → CAHVLVSLPV...LHGNSVFTSM
     560-1622: Missing.

Show »
Length:426
Mass (Da):46,318
Checksum:iD27C1FD1E6D37CCF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RPV6A0A0U1RPV6_MOUSE
Transient receptor potential cation...
Trpm1
1,506Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQ32A0A0U1RQ32_MOUSE
Transient receptor potential cation...
Trpm1
1,628Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RPQ0A0A0U1RPQ0_MOUSE
Transient receptor potential cation...
Trpm1
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RNU7A0A0U1RNU7_MOUSE
Transient receptor potential cation...
Trpm1
461Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQ58A0A0U1RQ58_MOUSE
Transient receptor potential cation...
Trpm1
28Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQB3A0A0U1RQB3_MOUSE
Transient receptor potential cation...
Trpm1
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RPI6A0A0U1RPI6_MOUSE
Transient receptor potential cation...
Trpm1
20Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RP37A0A0U1RP37_MOUSE
Transient receptor potential cation...
Trpm1
19Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RPX6A0A0U1RPX6_MOUSE
Transient receptor potential cation...
Trpm1
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti160P → S in AAC13683 (PubMed:9537257).Curated1
Sequence conflicti246S → Y in BAE28794 (PubMed:16141072).Curated1
Sequence conflicti459T → A in AAC13683 (PubMed:9537257).Curated1
Sequence conflicti459T → A in BAE28340 (PubMed:16141072).Curated1
Sequence conflicti459T → A in BAE28448 (PubMed:16141072).Curated1
Sequence conflicti459T → A in BAE28453 (PubMed:16141072).Curated1
Sequence conflicti1481S → G in CAI30140 (PubMed:9537257).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0527511 – 133Missing in isoform 5. 1 PublicationAdd BLAST133
Alternative sequenceiVSP_0527521 – 116Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST116
Alternative sequenceiVSP_052753189G → A in isoform 2. 1 Publication1
Alternative sequenceiVSP_052754190 – 1073Missing in isoform 2. 1 PublicationAdd BLAST884
Alternative sequenceiVSP_052755504 – 559NALEQ…LHLLV → CAHVLVSLPVCLQSSGLAFP KFSGRDSLVTFASSLPGWGT DGLMSILHGNSVFTSM in isoform 4 and isoform 5. 2 PublicationsAdd BLAST56
Alternative sequenceiVSP_052756560 – 1622Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST1063
Alternative sequenceiVSP_052757612 – 658PKALK…QYPFH → VELSRHTVSCASQSNMWFLD VLPQKPTCAECNSSPHLSQT DITPPLP in isoform 3. 2 PublicationsAdd BLAST47
Alternative sequenceiVSP_052758659 – 1622Missing in isoform 3. 2 PublicationsAdd BLAST964

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF047714 mRNA Translation: AAC13683.1
AJ867481 mRNA Translation: CAI30140.1
AY180104 mRNA Translation: AAO43093.2
AK148094 mRNA Translation: BAE28340.1
AK148268 mRNA Translation: BAE28448.1
AK148275 mRNA Translation: BAE28453.1
AK149290 mRNA Translation: BAE28794.1
AK164395 mRNA Translation: BAE37771.1
AC127565 Genomic DNA No translation available.
AC139849 Genomic DNA No translation available.
BC082560 mRNA Translation: AAH82560.1
BC085168 mRNA Translation: AAH85168.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS21332.2 [Q2TV84-1]
CCDS39975.2 [Q2TV84-3]

NCBI Reference Sequences

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RefSeqi
NP_001034193.2, NM_001039104.2 [Q2TV84-1]
NP_061222.3, NM_018752.3 [Q2TV84-3]
XP_017177502.1, XM_017322013.1 [Q2TV84-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000085222; ENSMUSP00000082318; ENSMUSG00000030523 [Q2TV84-1]
ENSMUST00000177102; ENSMUSP00000134947; ENSMUSG00000030523 [Q2TV84-3]
ENSMUST00000205731; ENSMUSP00000145776; ENSMUSG00000030523 [Q2TV84-4]
ENSMUST00000206314; ENSMUSP00000145593; ENSMUSG00000030523 [Q2TV84-2]
ENSMUST00000206706; ENSMUSP00000146265; ENSMUSG00000030523 [Q2TV84-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
17364

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:17364

UCSC genome browser

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UCSCi
uc009hfp.2 mouse [Q2TV84-2]
uc009hfr.2 mouse [Q2TV84-4]
uc009hft.2 mouse [Q2TV84-5]
uc009hfu.2 mouse [Q2TV84-3]
uc009hfw.2 mouse [Q2TV84-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047714 mRNA Translation: AAC13683.1
AJ867481 mRNA Translation: CAI30140.1
AY180104 mRNA Translation: AAO43093.2
AK148094 mRNA Translation: BAE28340.1
AK148268 mRNA Translation: BAE28448.1
AK148275 mRNA Translation: BAE28453.1
AK149290 mRNA Translation: BAE28794.1
AK164395 mRNA Translation: BAE37771.1
AC127565 Genomic DNA No translation available.
AC139849 Genomic DNA No translation available.
BC082560 mRNA Translation: AAH82560.1
BC085168 mRNA Translation: AAH85168.1
CCDSiCCDS21332.2 [Q2TV84-1]
CCDS39975.2 [Q2TV84-3]
RefSeqiNP_001034193.2, NM_001039104.2 [Q2TV84-1]
NP_061222.3, NM_018752.3 [Q2TV84-3]
XP_017177502.1, XM_017322013.1 [Q2TV84-3]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082318

PTM databases

iPTMnetiQ2TV84
PhosphoSitePlusiQ2TV84

Proteomic databases

PaxDbiQ2TV84
PRIDEiQ2TV84

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
9410 67 antibodies

The DNASU plasmid repository

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DNASUi
17364

Genome annotation databases

EnsembliENSMUST00000085222; ENSMUSP00000082318; ENSMUSG00000030523 [Q2TV84-1]
ENSMUST00000177102; ENSMUSP00000134947; ENSMUSG00000030523 [Q2TV84-3]
ENSMUST00000205731; ENSMUSP00000145776; ENSMUSG00000030523 [Q2TV84-4]
ENSMUST00000206314; ENSMUSP00000145593; ENSMUSG00000030523 [Q2TV84-2]
ENSMUST00000206706; ENSMUSP00000146265; ENSMUSG00000030523 [Q2TV84-5]
GeneIDi17364
KEGGimmu:17364
UCSCiuc009hfp.2 mouse [Q2TV84-2]
uc009hfr.2 mouse [Q2TV84-4]
uc009hft.2 mouse [Q2TV84-5]
uc009hfu.2 mouse [Q2TV84-3]
uc009hfw.2 mouse [Q2TV84-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4308
MGIiMGI:1330305 Trpm1

Phylogenomic databases

eggNOGiKOG3614 Eukaryota
ENOG410XR5B LUCA
GeneTreeiENSGT00940000155024
HOGENOMiCLU_022373_0_0_1
InParanoidiQ2TV84
KOiK04976
OMAiTEWKYEV
OrthoDBi738147at2759
PhylomeDBiQ2TV84
TreeFamiTF314204

Enzyme and pathway databases

ReactomeiR-MMU-3295583 TRP channels

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Trpm1 mouse

Protein Ontology

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PROi
PR:Q2TV84
RNActiQ2TV84 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000030523 Expressed in iris and 81 other tissues
ExpressionAtlasiQ2TV84 baseline and differential
GenevisibleiQ2TV84 MM

Family and domain databases

Gene3Di1.20.5.1010, 1 hit
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR029588 TRPM1
IPR041491 TRPM_SLOG
IPR032415 TRPM_tetra
IPR037162 TRPM_tetra_sf
PANTHERiPTHR13800:SF13 PTHR13800:SF13, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF18139 LSDAT_euk, 1 hit
PF16519 TRPM_tetra, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRPM1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2TV84
Secondary accession number(s): O70334
, Q2WEA6, Q3TPG5, Q3UEW7, Q3UFV6, Q3UFW1, Q3UG69, Q5U4B3, Q640P5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: April 22, 2020
This is version 102 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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