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Protein

Potassium channel regulatory protein

Gene

Kcnrg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel regulatory protein
Short name:
Potassium channel regulator
Alternative name(s):
Protein CLLD4
Gene namesi
Name:Kcnrg
Synonyms:Clld4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2685591 Kcnrg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002389461 – 264Potassium channel regulatory proteinAdd BLAST264

Proteomic databases

MaxQBiQ2TUM3
PaxDbiQ2TUM3
PRIDEiQ2TUM3

PTM databases

iPTMnetiQ2TUM3
PhosphoSitePlusiQ2TUM3

Expressioni

Gene expression databases

BgeeiENSMUSG00000046168 Expressed in 18 organ(s), highest expression level in lung
CleanExiMM_KCNRG

Interactioni

Subunit structurei

Can form homooligomers. Interacts with KCNA1 (via cytoplasmic N-terminal domain) and KCNA4.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055327

Structurei

3D structure databases

ProteinModelPortaliQ2TUM3
SMRiQ2TUM3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 74BTBAdd BLAST70

Phylogenomic databases

eggNOGiKOG2723 Eukaryota
ENOG410Z155 LUCA
GeneTreeiENSGT00760000119013
HOGENOMiHOG000230898
HOVERGENiHBG079982
InParanoidiQ2TUM3
OMAiRYVSIKP
OrthoDBiEOG091G0EJ2
PhylomeDBiQ2TUM3
TreeFamiTF315332

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q2TUM3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGQDLVTLN VGGRIFTTRP STLKQFPASR LAGMLDGRDQ EFKTVDGQIF
60 70 80 90 100
VDRDGALFSF ILDFLRNHEL LLPSDFADHH RLQREALFYE LDSLVDLLSQ
110 120 130 140 150
FLLQSRSAVM EVHFLNQNTQ AFFRVFGSCS KTIEMLSGRI TMFVERPTAL
160 170 180 190 200
TGNRNSPLAL PPQRPSHHDL LFHCGSDGAA ENQAGVRYIS IKPDNRKLAN
210 220 230 240 250
GTNVLGLLVD TLLKEGFHLV STRTPASGEK SECYVFERIT TPQVLGMSKT
260
PKSETTTMPA PSQK
Length:264
Mass (Da):29,417
Last modified:January 24, 2006 - v1
Checksum:i6DDC26A43A999668
GO
Isoform 2 (identifier: Q2TUM3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     189-191: ISI → FEC
     192-264: Missing.

Show »
Length:191
Mass (Da):21,553
Checksum:i02C6F6D27894DA92
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019023189 – 191ISI → FEC in isoform 2. 3 Publications3
Alternative sequenceiVSP_019024192 – 264Missing in isoform 2. 3 PublicationsAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY491736 mRNA Translation: AAS72551.1
AY491737 mRNA Translation: AAS72552.1
AK053138 mRNA Translation: BAC35277.1
BC147091 mRNA Translation: AAI47092.1
BC147092 mRNA Translation: AAI47093.1
BC171997 mRNA Translation: AAI71997.1
CCDSiCCDS27187.1 [Q2TUM3-1]
RefSeqiNP_001034194.1, NM_001039105.3 [Q2TUM3-1]
NP_996857.1, NM_206974.1 [Q2TUM3-3]
UniGeneiMm.224464

Genome annotation databases

EnsembliENSMUST00000051184; ENSMUSP00000055327; ENSMUSG00000046168 [Q2TUM3-1]
ENSMUST00000225582; ENSMUSP00000153429; ENSMUSG00000046168 [Q2TUM3-3]
GeneIDi328424
KEGGimmu:328424
UCSCiuc007ugd.1 mouse [Q2TUM3-3]
uc007uge.2 mouse [Q2TUM3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY491736 mRNA Translation: AAS72551.1
AY491737 mRNA Translation: AAS72552.1
AK053138 mRNA Translation: BAC35277.1
BC147091 mRNA Translation: AAI47092.1
BC147092 mRNA Translation: AAI47093.1
BC171997 mRNA Translation: AAI71997.1
CCDSiCCDS27187.1 [Q2TUM3-1]
RefSeqiNP_001034194.1, NM_001039105.3 [Q2TUM3-1]
NP_996857.1, NM_206974.1 [Q2TUM3-3]
UniGeneiMm.224464

3D structure databases

ProteinModelPortaliQ2TUM3
SMRiQ2TUM3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055327

PTM databases

iPTMnetiQ2TUM3
PhosphoSitePlusiQ2TUM3

Proteomic databases

MaxQBiQ2TUM3
PaxDbiQ2TUM3
PRIDEiQ2TUM3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051184; ENSMUSP00000055327; ENSMUSG00000046168 [Q2TUM3-1]
ENSMUST00000225582; ENSMUSP00000153429; ENSMUSG00000046168 [Q2TUM3-3]
GeneIDi328424
KEGGimmu:328424
UCSCiuc007ugd.1 mouse [Q2TUM3-3]
uc007uge.2 mouse [Q2TUM3-1]

Organism-specific databases

CTDi283518
MGIiMGI:2685591 Kcnrg

Phylogenomic databases

eggNOGiKOG2723 Eukaryota
ENOG410Z155 LUCA
GeneTreeiENSGT00760000119013
HOGENOMiHOG000230898
HOVERGENiHBG079982
InParanoidiQ2TUM3
OMAiRYVSIKP
OrthoDBiEOG091G0EJ2
PhylomeDBiQ2TUM3
TreeFamiTF315332

Miscellaneous databases

PROiPR:Q2TUM3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046168 Expressed in 18 organ(s), highest expression level in lung
CleanExiMM_KCNRG

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKCNRG_MOUSE
AccessioniPrimary (citable) accession number: Q2TUM3
Secondary accession number(s): B2RV87
, B7ZWD9, Q6P8J6, Q8C6V1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 24, 2006
Last modified: September 12, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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