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Entry version 64 (29 Sep 2021)
Sequence version 1 (24 Jan 2006)
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Protein

11S globulin seed storage protein Jug r 4

Gene
N/A
Organism
Juglans regia (English walnut)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Seed storage protein.

UniRule annotation2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIgE-binding protein, Seed storage protein, Storage protein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
11S globulin seed storage protein Jug r 4Curated
Alternative name(s):
Allergen: Jug r 42 Publications
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiJuglans regia (English walnut)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri51240 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsfabidsFagalesJuglandaceaeJuglans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000235220 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section is used for proteins that cause an allergic reaction in mammals. We usually specify in which species the protein is allergenic.<p><a href='/help/allergenic_properties' target='_top'>More...</a></p>Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE.3 Publications

Keywords - Diseasei

Allergen

Protein family/group databases

Allergome; a platform for allergen knowledge

More...
Allergomei
1105, Jug r 4
3574, Jug r 4.0101

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23UniRule annotationAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000044601724 – 31511S globulin seed storage protein Jug r 4 acidic chain1 PublicationAdd BLAST292
ChainiPRO_0000446018316 – 50711S globulin seed storage protein Jug r 4 basic chain1 PublicationAdd BLAST192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi36 ↔ 69By similarity
Disulfide bondi112 ↔ 322Interchain (between acidic and basic chains)By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically processed from a single precursor to produce an acidic and a basic chain that are linked by a disulfide bond.1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q2TPW5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in seeds.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during seed development.2 Publications

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q2TPW5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 254Cupin type-1 1Sequence analysisAdd BLAST214
Domaini328 – 477Cupin type-1 2Sequence analysisAdd BLAST150

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 15IgE-binding1 PublicationAdd BLAST15
Regioni57 – 71IgE-binding1 PublicationAdd BLAST15
Regioni89 – 103IgE-binding1 PublicationAdd BLAST15
Regioni105 – 119IgE-binding1 PublicationAdd BLAST15
Regioni121 – 143IgE-binding1 PublicationAdd BLAST23
Regioni145 – 159IgE-binding1 PublicationAdd BLAST15
Regioni191 – 233DisorderedSequence analysisAdd BLAST43
Regioni201 – 223IgE-binding1 PublicationAdd BLAST23
Regioni233 – 247IgE-binding1 PublicationAdd BLAST15
Regioni257 – 295IgE-binding1 PublicationAdd BLAST39
Regioni281 – 316DisorderedSequence analysisAdd BLAST36
Regioni313 – 327IgE-binding1 PublicationAdd BLAST15
Regioni377 – 399IgE-binding1 PublicationAdd BLAST23
Regioni417 – 439IgE-binding1 PublicationAdd BLAST23
Regioni465 – 479IgE-binding1 PublicationAdd BLAST15
Regioni481 – 503IgE-binding1 PublicationAdd BLAST23
Regioni484 – 507DisorderedSequence analysisAdd BLAST24

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi315 – 320NGXEET; peptidase recognition motif1 Publication6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi200 – 217Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi218 – 232Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 11S seed storage protein (globulins) family.UniRule annotationCurated

Keywords - Domaini

Signal

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
603461at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022379, 11S_seedstore_CS
IPR006044, 11S_seedstore_pln
IPR006045, Cupin_1
IPR014710, RmlC-like_jellyroll
IPR011051, RmlC_Cupin_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00190, Cupin_1, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00439, 11SGLOBULIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00835, Cupin_1, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51182, SSF51182, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00305, 11S_SEED_STORAGE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q2TPW5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKPILLSIY LFLIVALFNG CLAQSGGRQQ QQFGQCQLNR LDALEPTNRI
60 70 80 90 100
EAEAGVIESW DPNNQQFQCA GVAVVRRTIE PNGLLLPQYS NAPQLVYIAR
110 120 130 140 150
GRGITGVLFP GCPETFEESQ RQSQQGQSRE FQQDRHQKIR HFREGDIIAF
160 170 180 190 200
PAGVAHWSYN DGSNPVVAIS LLDTNNNANQ LDQNPRNFYL AGNPDDEFRP
210 220 230 240 250
QGQQEYEQHR RQQQRQQRPG EHGQQQRGLG NNVFSGFDAD FLADAFNVDT
260 270 280 290 300
ETARRLQSEN DHRRSIVRVE GRQLQVIRPR WSREEQEREE RKERERERES
310 320 330 340 350
ESERRQSRRG GRDDNGLEET ICTLRLRENI GDPSRADIYT EEAGRISTVN
360 370 380 390 400
SHTLPVLRWL QLSAERGALY SDALYVPHWN LNAHSVVYAL RGRAEVQVVD
410 420 430 440 450
NFGQTVFDDE LREGQLLTIP QNFAVVKRAR NEGFEWVSFK TNENAMVSPL
460 470 480 490 500
AGRTSAIRAL PEEVLATAFQ IPREDARRLK FNRQESTLVR SRPSRSRSSR

SERRAEV
Length:507
Mass (Da):58,144
Last modified:January 24, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC587BAB906711472
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY692446 mRNA Translation: AAW29810.1

NCBI Reference Sequences

More...
RefSeqi
XP_018827329.1, XM_018971784.1

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
Jr01_32050_p1; cds.Jr01_32050_p1; Jr01_32050

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
108996042

Gramene; a comparative resource for plants

More...
Gramenei
Jr01_32050_p1; cds.Jr01_32050_p1; Jr01_32050

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
jre:108996042

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY692446 mRNA Translation: AAW29810.1
RefSeqiXP_018827329.1, XM_018971784.1

3D structure databases

SMRiQ2TPW5
ModBaseiSearch...

Protein family/group databases

Allergomei1105, Jug r 4
3574, Jug r 4.0101

Proteomic databases

PRIDEiQ2TPW5

Genome annotation databases

EnsemblPlantsiJr01_32050_p1; cds.Jr01_32050_p1; Jr01_32050
GeneIDi108996042
GrameneiJr01_32050_p1; cds.Jr01_32050_p1; Jr01_32050
KEGGijre:108996042

Phylogenomic databases

OrthoDBi603461at2759

Family and domain databases

Gene3Di2.60.120.10, 2 hits
InterProiView protein in InterPro
IPR022379, 11S_seedstore_CS
IPR006044, 11S_seedstore_pln
IPR006045, Cupin_1
IPR014710, RmlC-like_jellyroll
IPR011051, RmlC_Cupin_sf
PfamiView protein in Pfam
PF00190, Cupin_1, 2 hits
PRINTSiPR00439, 11SGLOBULIN
SMARTiView protein in SMART
SM00835, Cupin_1, 2 hits
SUPFAMiSSF51182, SSF51182, 1 hit
PROSITEiView protein in PROSITE
PS00305, 11S_SEED_STORAGE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJUGR4_JUGRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2TPW5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2019
Last sequence update: January 24, 2006
Last modified: September 29, 2021
This is version 64 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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