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Protein

Macoilin

Gene

MACO1

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in the regulation of neuronal activity.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Macoilin
Alternative name(s):
Transmembrane protein 57
Gene namesi
Name:MACO1
Synonyms:TMEM57
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 48HelicalSequence analysisAdd BLAST21
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000702691 – 664MacoilinAdd BLAST664

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei305PhosphoserineBy similarity1
Glycosylationi324N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei332PhosphoserineBy similarity1
Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi452N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei631PhosphoserineBy similarity1
Modified residuei634PhosphoserineBy similarity1
Glycosylationi655N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ2TLZ5

Expressioni

Gene expression databases

BgeeiENSPTRG00000029594

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000049985

Structurei

3D structure databases

SMRiQ2TLZ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the macoilin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1821 Eukaryota
ENOG410XRFG LUCA
HOGENOMiHOG000049147
HOVERGENiHBG059955
InParanoidiQ2TLZ5

Family and domain databases

InterProiView protein in InterPro
IPR019130 Macoilin
PfamiView protein in Pfam
PF09726 Macoilin, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2TLZ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRRNADCSK LRRPLKRNRI TEGIYGSTFL YLKFLVVWAL VLLADFVVEF
60 70 80 90 100
RFEYLWPFWL FIRSVYDSFR YQGLAFSVFF VCVAFTSNII CLLFIPIQWL
110 120 130 140 150
FFAASTYVWV QYVWHTERGV CLPTVSLWIL FVYIEAAIRF KDLKNFHVDL
160 170 180 190 200
CRPFAAHCIG YPVVTLGFGF KSYVSYKMRL RKQKEVQKEN EFYMQLLQQA
210 220 230 240 250
LPPEQQMLQK QEKEAEEAAK GLPDMDSSIL IHHNGGIPAN KKLSTTLPEI
260 270 280 290 300
EYREKGKEKD KDAKKHNLGI NNNNILQPVD SKIQEIEYME NHINSKRLNN
310 320 330 340 350
DLVGSTENLL KEDSCTASSK NYKNASGVVN SSPRSHSATN GSIPSSSSKN
360 370 380 390 400
EKKQKCTSKS PSTHKDLMEN CIPNNQLSKP DALVRLEQDI KKLKADLQAS
410 420 430 440 450
RQVEQELRSQ ISSLSSTERG IRSEMGQLRQ ENELLQNKLH NAVQMKQKDK
460 470 480 490 500
QNISQLEKKL KAEQEARSFV EKQLMEEKKR KKLEEATAAR AVAFAAASRG
510 520 530 540 550
ECTETLRNRI RELEAEGKKL TMDMKVKEDQ IRELELKVQE LRKYKENEKD
560 570 580 590 600
TEVLMSALSA MQDKTQHLEN SLSAETRIKL DLFSALGDAK RQLEIAQGQI
610 620 630 640 650
LQKDQEIKDL KQKIAEVMAV MPSITYSAAT SPLSPVSPHY SSKFVETSPS
660
GLDPNASVYQ PLKK
Length:664
Mass (Da):76,164
Last modified:February 7, 2006 - v1
Checksum:i932DC0FEC9984D5D
GO
Isoform 2 (identifier: Q2TLZ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     27-384: Missing.

Show »
Length:306
Mass (Da):35,026
Checksum:i7E4942B918C8C88A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01720727 – 384Missing in isoform 2. 1 PublicationAdd BLAST358

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY845016 mRNA Translation: AAX11914.1
AY845037 mRNA Translation: AAX11935.1
RefSeqiNP_001033738.1, NM_001038649.1 [Q2TLZ5-1]
UniGeneiPtr.4924

Genome annotation databases

GeneIDi456502
KEGGiptr:456502

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMACOI_PANTR
AccessioniPrimary (citable) accession number: Q2TLZ5
Secondary accession number(s): Q2TLX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: February 28, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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