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Protein

POC1 centriolar protein homolog A

Gene

POC1A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
POC1 centriolar protein homolog A
Alternative name(s):
WD repeat-containing protein 51A
Gene namesi
Name:POC1A
Synonyms:WDR51A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 22

Organism-specific databases

VGNCiVGNC:50094 POC1A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002315211 – 407POC1 centriolar protein homolog AAdd BLAST407

Proteomic databases

PaxDbiQ2TBP4
PRIDEiQ2TBP4

Expressioni

Gene expression databases

BgeeiENSBTAG00000001471 Expressed in 10 organ(s), highest expression level in testis

Interactioni

Subunit structurei

Interacts with POC1B.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001927

Structurei

3D structure databases

ProteinModelPortaliQ2TBP4
SMRiQ2TBP4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati17 – 56WD 1Add BLAST40
Repeati59 – 98WD 2Add BLAST40
Repeati101 – 140WD 3Add BLAST40
Repeati143 – 182WD 4Add BLAST40
Repeati185 – 224WD 5Add BLAST40
Repeati227 – 266WD 6Add BLAST40
Repeati269 – 308WD 7Add BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili369 – 397Sequence analysisAdd BLAST29

Sequence similaritiesi

Belongs to the WD repeat POC1 family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IF90 Eukaryota
ENOG410XR4H LUCA
GeneTreeiENSGT00810000125363
HOVERGENiHBG057502
InParanoidiQ2TBP4
KOiK16482
OMAiMDSCLMI
OrthoDBiEOG091G07ES
TreeFamiTF324210

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 7 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 7 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q2TBP4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAHCPEDPS LERHFKGHRD AVTSVDFSLN TKQLASGSMD SCLMVWHMKP
60 70 80 90 100
QTRAYRFAGH KDAVTCVNFS PSGHLLASGS RDKTVRIWVP NVKGESTVFR
110 120 130 140 150
AHTATVRSVH FCSDGQSFVT ASDDKTVKVW STHRQKFLFS LSQHINWVRC
160 170 180 190 200
AKFSPDGRLI VSASDDKTVK LWDKTSRECV HSYCEHGGFV TYVDFHPSGT
210 220 230 240 250
CIAAAGMDNT VKVWDVRTHR LLQHYQLHSA AVNALSFHPS GNYLVTASSD
260 270 280 290 300
STLKILDLME GRLLYTLHGH QGPATTVAFS RTGEYFASGG SDEQVMVWKS
310 320 330 340 350
NFDIVDYGEV LRVQRPPATR ASSSGTLPEV DPLVPPGRGR SQESMQSHSQ
360 370 380 390 400
EPVSVPQSLT STLEHIVGQL DVLTQTVSIL EQRLTLTEDK LKQCLENQQL

IMQRTTP
Length:407
Mass (Da):45,228
Last modified:January 24, 2006 - v1
Checksum:iA73AA7CAD0F87113
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109862 mRNA Translation: AAI09863.1
RefSeqiNP_001033649.1, NM_001038560.2
UniGeneiBt.4084

Genome annotation databases

EnsembliENSBTAT00000001927; ENSBTAP00000001927; ENSBTAG00000001471
GeneIDi534489
KEGGibta:534489

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109862 mRNA Translation: AAI09863.1
RefSeqiNP_001033649.1, NM_001038560.2
UniGeneiBt.4084

3D structure databases

ProteinModelPortaliQ2TBP4
SMRiQ2TBP4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001927

Proteomic databases

PaxDbiQ2TBP4
PRIDEiQ2TBP4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000001927; ENSBTAP00000001927; ENSBTAG00000001471
GeneIDi534489
KEGGibta:534489

Organism-specific databases

CTDi25886
VGNCiVGNC:50094 POC1A

Phylogenomic databases

eggNOGiENOG410IF90 Eukaryota
ENOG410XR4H LUCA
GeneTreeiENSGT00810000125363
HOVERGENiHBG057502
InParanoidiQ2TBP4
KOiK16482
OMAiMDSCLMI
OrthoDBiEOG091G07ES
TreeFamiTF324210

Gene expression databases

BgeeiENSBTAG00000001471 Expressed in 10 organ(s), highest expression level in testis

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 7 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 7 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPOC1A_BOVIN
AccessioniPrimary (citable) accession number: Q2TBP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: January 24, 2006
Last modified: November 7, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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