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Protein

COMM domain-containing protein 9

Gene

COMMD9

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na+ transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits.By similarity

GO - Biological processi

Keywordsi

Biological processIon transport, Sodium transport, Transcription, Transcription regulation, Transport, Ubl conjugation pathway
LigandSodium

Names & Taxonomyi

Protein namesi
Recommended name:
COMM domain-containing protein 9
Gene namesi
Name:COMMD9
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002601852 – 198COMM domain-containing protein 9Add BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ2TBN5
PRIDEiQ2TBN5

Interactioni

Subunit structurei

Interacts with RELB and NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025346

Structurei

3D structure databases

SMRiQ2TBN5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini122 – 196COMMPROSITE-ProRule annotationAdd BLAST75

Phylogenomic databases

eggNOGiENOG410II5T Eukaryota
ENOG4111H94 LUCA
HOGENOMiHOG000232004
HOVERGENiHBG080522
InParanoidiQ2TBN5
KOiK22565

Family and domain databases

InterProiView protein in InterPro
IPR017920 COMM
IPR037360 COMMD9
PANTHERiPTHR15663 PTHR15663, 1 hit
PfamiView protein in Pfam
PF07258 COMM_domain, 1 hit
PROSITEiView protein in PROSITE
PS51269 COMM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2TBN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALTAENFA ALQSLLKASS KDVVRQLCQE SFSSSALGSK NLLDVTCSSL
60 70 80 90 100
SVTQEEAEQL LQALHRLTRL AVFRDLSSAE AILALFPENF HQNLKNLLTK
110 120 130 140 150
IILEHVSAWR AEAQVNQISL PRLVDLDWRV DIKTSSDSIS RMAVPTCLLQ
160 170 180 190
MKIQEDPSLC GDRPSVSDVT VELSKETLDT MLDGLGRIRD QLSAVASK
Length:198
Mass (Da):21,781
Last modified:January 24, 2006 - v1
Checksum:i5CC7CCB77EEEFA17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109885 mRNA Translation: AAI09886.1
RefSeqiNP_001033609.1, NM_001038520.2
UniGeneiBt.16244

Genome annotation databases

GeneIDi510280
KEGGibta:510280

Similar proteinsi

Entry informationi

Entry nameiCOMD9_BOVIN
AccessioniPrimary (citable) accession number: Q2TBN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: January 24, 2006
Last modified: May 23, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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