UniProtKB - Q2TBI4 (TRAP1_BOVIN)
Heat shock protein 75 kDa, mitochondrial
TRAP1
Functioni
Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 118 | ATPBy similarity | 1 | |
Binding sitei | 157 | ATPBy similarity | 1 | |
Binding sitei | 170 | ATPBy similarity | 1 | |
Binding sitei | 204 | ATP; via amide nitrogenBy similarity | 1 | |
Binding sitei | 401 | ATPBy similarity | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: InterPro
- protein kinase binding Source: GO_Central
- unfolded protein binding Source: GO_Central
GO - Biological processi
- negative regulation of cellular respiration Source: UniProtKB
- protein folding Source: GO_Central
Keywordsi
Molecular function | Chaperone |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Heat shock protein 75 kDa, mitochondrialShort name: HSP 75 Alternative name(s): TNFR-associated protein 1 Tumor necrosis factor type 1 receptor-associated protein Short name: TRAP-1 |
Gene namesi | Name:TRAP1 Synonyms:HSP75 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000020109 |
VGNCi | VGNC:36283, TRAP1 |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
- Mitochondrion inner membrane By similarity
- Mitochondrion matrix By similarity
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB
- mitochondrial matrix Source: UniProtKB
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 56 | MitochondrionBy similarityAdd BLAST | 56 | |
ChainiPRO_0000245028 | 57 – 703 | Heat shock protein 75 kDa, mitochondrialAdd BLAST | 647 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 169 | PhosphoserineBy similarity | 1 | |
Modified residuei | 173 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 423 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 430 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 465 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 493 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PaxDbi | Q2TBI4 |
PeptideAtlasi | Q2TBI4 |
PRIDEi | Q2TBI4 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000020109, Expressed in heart and 97 other tissues |
ExpressionAtlasi | Q2TBI4, baseline and differential |
Interactioni
Subunit structurei
Binds to the intracellular domain of tumor necrosis factor type 1 receptor. Binds to RB1 (By similarity).
Interacts with SRC (By similarity).
Interacts with SDHA (By similarity).
By similarityGO - Molecular functioni
- protein kinase binding Source: GO_Central
- unfolded protein binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 171097, 1 interactor |
STRINGi | 9913.ENSBTAP00000026786 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG0019, Eukaryota |
GeneTreei | ENSGT01020000230401 |
HOGENOMi | CLU_006684_3_1_1 |
InParanoidi | Q2TBI4 |
OMAi | YTRKVLI |
OrthoDBi | 924636at2759 |
TreeFami | TF315234 |
Family and domain databases
Gene3Di | 1.20.120.790, 1 hit 3.30.565.10, 1 hit |
HAMAPi | MF_00505, HSP90, 1 hit |
InterProi | View protein in InterPro IPR003594, HATPase_C IPR036890, HATPase_C_sf IPR037196, HSP90_C IPR001404, Hsp90_fam IPR020575, Hsp90_N IPR020568, Ribosomal_S5_D2-typ_fold |
PANTHERi | PTHR11528, PTHR11528, 1 hit |
Pfami | View protein in Pfam PF00183, HSP90, 1 hit |
PIRSFi | PIRSF002583, Hsp90, 1 hit |
PRINTSi | PR00775, HEATSHOCK90 |
SMARTi | View protein in SMART SM00387, HATPase_c, 1 hit |
SUPFAMi | SSF110942, SSF110942, 1 hit SSF54211, SSF54211, 1 hit SSF55874, SSF55874, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MARELRMLLL WGRRLRAPAL AAACGGKPVL CPWRPPAQSW GPPRSLASSF
60 70 80 90 100
HVGRPFSSQA AEDQAEAGPL HSVISSLEAV QGSATKHEFQ AETKKLLDIV
110 120 130 140 150
ARSLYSEKEV FIRELISNAS DALEKLRHKL VSEGQALPDM EIHLQTDADR
160 170 180 190 200
GTITIQDTGV GMSREELVSN LGTIARSGSK AFLDALQNQA EAGSKIIGQF
210 220 230 240 250
GVGFYSAFMV ADRVEVYSRS VDAGSLGYRW LSDGSGVFEV AEASGVRTGT
260 270 280 290 300
KIIIHLKADS REFASEARVR DVVTKYSNFV SFPLYLNGRR MNTLQAIWMM
310 320 330 340 350
DPKDVGEGQH EEFYRYVAQA HDRPRYTLHY RTDAPLSIRS IFYVPDAKPS
360 370 380 390 400
MFDVSRELGS SVSLYSRKVL IQTKATNILP TWLRFVRGVV DSEDIPLNLS
410 420 430 440 450
RELLQESALI RKLQGVLQQR LIKFFTDQSK KDAEKYARFF EDYGLFVREG
460 470 480 490 500
IVTTAEQEVK EDIAKLLRYE SSALPAGQLT SLSDYASRMQ AGTRNIYYLC
510 520 530 540 550
APNRHLAEHS PYYEAMKRKN TEVLFCYEQF DELTLLHLRE FDKKKLISVE
560 570 580 590 600
TDIVVDHYKE EKFEDGAPAG DCLSEKETED LMAWMRNALG SRITDVKVTL
610 620 630 640 650
RLDTHPAMIT VLEMGAARHF LRMRQLAKTQ EERAQLLQPT LEINPRHVLI
660 670 680 690 700
KKLSQLRDSE PDLAQLLVDQ IYENAMITAG LIDDPRPMVG RLNQLLVKAL
ERH
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1MT00 | A0A3Q1MT00_BOVIN | Heat shock protein 75 kDa, mitochon... | TRAP1 | 706 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC110148 mRNA Translation: AAI10149.1 |
RefSeqi | NP_001033764.1, NM_001038675.2 |
Genome annotation databases
Ensembli | ENSBTAT00000026786; ENSBTAP00000026786; ENSBTAG00000020109 |
GeneIDi | 514472 |
KEGGi | bta:514472 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC110148 mRNA Translation: AAI10149.1 |
RefSeqi | NP_001033764.1, NM_001038675.2 |
3D structure databases
AlphaFoldDBi | Q2TBI4 |
SMRi | Q2TBI4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 171097, 1 interactor |
STRINGi | 9913.ENSBTAP00000026786 |
Proteomic databases
PaxDbi | Q2TBI4 |
PeptideAtlasi | Q2TBI4 |
PRIDEi | Q2TBI4 |
Genome annotation databases
Ensembli | ENSBTAT00000026786; ENSBTAP00000026786; ENSBTAG00000020109 |
GeneIDi | 514472 |
KEGGi | bta:514472 |
Organism-specific databases
CTDi | 10131 |
VEuPathDBi | HostDB:ENSBTAG00000020109 |
VGNCi | VGNC:36283, TRAP1 |
Phylogenomic databases
eggNOGi | KOG0019, Eukaryota |
GeneTreei | ENSGT01020000230401 |
HOGENOMi | CLU_006684_3_1_1 |
InParanoidi | Q2TBI4 |
OMAi | YTRKVLI |
OrthoDBi | 924636at2759 |
TreeFami | TF315234 |
Miscellaneous databases
PROi | PR:Q2TBI4 |
Gene expression databases
Bgeei | ENSBTAG00000020109, Expressed in heart and 97 other tissues |
ExpressionAtlasi | Q2TBI4, baseline and differential |
Family and domain databases
Gene3Di | 1.20.120.790, 1 hit 3.30.565.10, 1 hit |
HAMAPi | MF_00505, HSP90, 1 hit |
InterProi | View protein in InterPro IPR003594, HATPase_C IPR036890, HATPase_C_sf IPR037196, HSP90_C IPR001404, Hsp90_fam IPR020575, Hsp90_N IPR020568, Ribosomal_S5_D2-typ_fold |
PANTHERi | PTHR11528, PTHR11528, 1 hit |
Pfami | View protein in Pfam PF00183, HSP90, 1 hit |
PIRSFi | PIRSF002583, Hsp90, 1 hit |
PRINTSi | PR00775, HEATSHOCK90 |
SMARTi | View protein in SMART SM00387, HATPase_c, 1 hit |
SUPFAMi | SSF110942, SSF110942, 1 hit SSF54211, SSF54211, 1 hit SSF55874, SSF55874, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TRAP1_BOVIN | |
Accessioni | Q2TBI4Primary (citable) accession number: Q2TBI4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2006 |
Last sequence update: | January 24, 2006 | |
Last modified: | May 25, 2022 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families