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Entry version 111 (31 Jul 2019)
Sequence version 3 (18 May 2010)
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Protein

Autophagy-related protein 2 homolog A

Gene

ATG2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in autophagosome assembly, regulating the size of nascent autophagosomes (PubMed:28561066). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.15.2.1 the autophagy-related phagophore-formation transporter (apt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Autophagy-related protein 2 homolog A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATG2A
Synonyms:KIAA0404
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29028 ATG2A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
616225 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q2TAZ0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Lipid droplet, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000110046

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162377101

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ATG2A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439433

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003152341 – 1938Autophagy-related protein 2 homolog AAdd BLAST1938

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei765PhosphoserineCombined sources1
Modified residuei878PhosphoserineBy similarity1
Modified residuei892PhosphoserineBy similarity1
Modified residuei894PhosphoserineBy similarity1
Modified residuei1266PhosphoserineBy similarity1
Modified residuei1301PhosphoserineCombined sources1
Modified residuei1309PhosphoserineCombined sources1
Modified residuei1402PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q2TAZ0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q2TAZ0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q2TAZ0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q2TAZ0

PeptideAtlas

More...
PeptideAtlasi
Q2TAZ0

PRoteomics IDEntifications database

More...
PRIDEi
Q2TAZ0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61475 [Q2TAZ0-1]
61476 [Q2TAZ0-3]
61477 [Q2TAZ0-4]
61478 [Q2TAZ0-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q2TAZ0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q2TAZ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110046 Expressed in 215 organ(s), highest expression level in bone marrow

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q2TAZ0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q2TAZ0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038715

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with WDR45.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116748, 20 interactors

Protein interaction database and analysis system

More...
IntActi
Q2TAZ0, 22 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000366475

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATG2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2993 Eukaryota
ENOG410XRAR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00620000087966

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q2TAZ0

KEGG Orthology (KO)

More...
KOi
K17906

Identification of Orthologs from Complete Genome Data

More...
OMAi
SGYMELT

Database of Orthologous Groups

More...
OrthoDBi
196897at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q2TAZ0

TreeFam database of animal gene trees

More...
TreeFami
TF313482

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026849 ATG2
IPR015412 Autophagy-rel_C
IPR026854 VPS13_N

The PANTHER Classification System

More...
PANTHERi
PTHR13190 PTHR13190, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09333 ATG_C, 1 hit
PF12624 Chorein_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q2TAZ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRWLWPWSN CVKERVCRYL LHHYLGHFFQ EHLSLDQLSL DLYKGSVALR
60 70 80 90 100
DIHLEIWSVN EVLESMESPL ELVEGFVGSI EVAVPWAALL TDHCTVRVSG
110 120 130 140 150
LQLTLQPRRG PAPGAADSQS WASCMTTSLQ LAQECLRDGL PEPSEPPQPL
160 170 180 190 200
EGLEMFAQTI ETVLRRIKVT FLDTVVRVEH SPGDGERGVA VEVRVQRLEY
210 220 230 240 250
CDEAVRDPSQ APPVDVHQPP AFLHKLLQLA GVRLHYEELP AQEEPPEPPL
260 270 280 290 300
QIGSCSGYME LMVKLKQNEA FPGPKLEVAG QLGSLHLLLT PRQLQQLQEL
310 320 330 340 350
LSAVSLTDHE GLADKLNKSR PLGAEDLWLI EQDLNQQLQA GAVAEPLSPD
360 370 380 390 400
PLTNPLLNLD NTDLFFSMAG LTSSVASALS ELSLSDVDLA SSVRSDMASR
410 420 430 440 450
RLSAQAHPAG KMAPNPLLDT MRPDSLLKMT LGGVTLTLLQ TSAPSSGPPD
460 470 480 490 500
LATHFFTEFD ATKDGPFGSR DFHHLRPRFQ RACPCSHVRL TGTAVQLSWE
510 520 530 540 550
LRTGSRGRRT TSMEVHFGQL EVLECLWPRG TSEPEYTEIL TFPGTLGSQA
560 570 580 590 600
SARPCAHLRH TQILRRVPKS RPRRSVACHC HSELALDLAN FQADVELGAL
610 620 630 640 650
DRLAALLRLA TVPAEPPAGL LTEPLPAMEQ QTVFRLSAPR ATLRLRFPIA
660 670 680 690 700
DLRPEPDPWA GQAVRAEQLR LELSEPQFRS ELSSGPGPPV PTHLELTCSD
710 720 730 740 750
LHGIYEDGGK PPVPCLRVSK ALDPKSTGRK YFLPQVVVTV NPQSSSTQWE
760 770 780 790 800
VAPEKGEELE LSVESPCELR EPEPSPFSSK RTMYETEEMV IPGDPEEMRT
810 820 830 840 850
FQSRTLALSR CSLEVILPSV HIFLPSKEVY ESIYNRINND LLMWEPADLL
860 870 880 890 900
PTPDPAAQPS GFPGPSGFWH DSFKMCKSAF KLANCFDLTP DSDSDDEDAH
910 920 930 940 950
FFSVGASGGP QAAAPEAPSL HLQSTFSTLV TVLKGRITAL CETKDEGGKR
960 970 980 990 1000
LEAVHGELVL DMEHGTLFSV SQYCGQPGLG YFCLEAEKAT LYHRAAVDDY
1010 1020 1030 1040 1050
PLPSHLDLPS FAPPAQLAPT IYPSEEGVTE RGASGRKGQG RGPHMLSTAV
1060 1070 1080 1090 1100
RIHLDPHKNV KEFLVTLRLH KATLRHYMAL PEQSWHSQLL EFLDVLDDPV
1110 1120 1130 1140 1150
LGYLPPTVIT ILHTHLFSCS VDYRPLYLPV RVLITAETFT LSSNIIMDTS
1160 1170 1180 1190 1200
TFLLRFILDD SALYLSDKCE VETLDLRRDY VCVLDVDLLE LVIKTWKGST
1210 1220 1230 1240 1250
EGKLSQPLFE LRCSNNVVHV HSCADSCALL VNLLQYVMST GDLHPPPRPP
1260 1270 1280 1290 1300
SPTEIAGQKL SESPASLPSC PPVETALINQ RDLADALLDT ERSLRELAQP
1310 1320 1330 1340 1350
SGGHLPQASP ISVYLFPGER SGAPPPSPPV GGPAGSLGSC SEEKEDEREE
1360 1370 1380 1390 1400
EGDGDTLDSD EFCILDAPGL GIPPRDGEPV VTQLHPGPIV VRDGYFSRPI
1410 1420 1430 1440 1450
GSTDLLRAPA HFPVPSTRVV LREVSLVWHL YGGRDFGPHP GHRARTGLSG
1460 1470 1480 1490 1500
PRSSPSRCSG PNRPQNSWRT QGGSGRQHHV LMEIQLSKVS FQHEVYPAEP
1510 1520 1530 1540 1550
ATGPAAPSQE LEERPLSRQV FIVQELEVRD RLASSQINKF LYLHTSERMP
1560 1570 1580 1590 1600
RRAHSNMLTI KALHVAPTTN LGGPECCLRV SLMPLRLNVD QDALFFLKDF
1610 1620 1630 1640 1650
FTSLVAGINP VVPGETSAEA RPETRAQPSS PLEGQAEGVE TTGSQEAPGG
1660 1670 1680 1690 1700
GHSPSPPDQQ PIYFREFRFT SEVPIWLDYH GKHVTMDQVG TFAGLLIGLA
1710 1720 1730 1740 1750
QLNCSELKLK RLCCRHGLLG VDKVLGYALN EWLQDIRKNQ LPGLLGGVGP
1760 1770 1780 1790 1800
MHSVVQLFQG FRDLLWLPIE QYRKDGRLMR GLQRGAASFG SSTASAALEL
1810 1820 1830 1840 1850
SNRLVQAIQA TAETVYDILS PAAPVSRSLQ DKRSARRLRR GQQPADLREG
1860 1870 1880 1890 1900
VAKAYDTVRE GILDTAQTIC DVASRGHEQK GLTGAVGGVI RQLPPTVVKP
1910 1920 1930
LILATEATSS LLGGMRNQIV PDAHKDHALK WRSDSAQD
Length:1,938
Mass (Da):212,860
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB0072E075E305A33
GO
Isoform 2 (identifier: Q2TAZ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1259-1259: K → KVQ

Note: No experimental confirmation available.
Show »
Length:1,940
Mass (Da):213,087
Checksum:i7236DF3A60D98208
GO
Isoform 3 (identifier: Q2TAZ0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1607: Missing.
     1608-1724: INPVVPGETS...RHGLLGVDKV → MAVAMVKLCE...SSARGCRLTE

Note: No experimental confirmation available.
Show »
Length:331
Mass (Da):35,255
Checksum:iA6DFB099A5053B97
GO
Isoform 4 (identifier: Q2TAZ0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-121: SVNEVLESME...APGAADSQSW → VRSQARVQEV...AHLAAPPGSR
     122-1938: Missing.

Note: No experimental confirmation available.
Show »
Length:121
Mass (Da):13,576
Checksum:i40E9AF595AA38556
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C3T2H7C3T2_HUMAN
Autophagy-related protein 2 homolog...
ATG2A
1,742Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA23700 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1286A → S in AAI10651 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038158175V → I. Corresponds to variant dbSNP:rs12293826Ensembl.1
Natural variantiVAR_061027394R → C. Corresponds to variant dbSNP:rs35115827Ensembl.1
Natural variantiVAR_061028404A → V. Corresponds to variant dbSNP:rs60711419Ensembl.1
Natural variantiVAR_038159627A → V. Corresponds to variant dbSNP:rs2285347Ensembl.1
Natural variantiVAR_061029656P → R2 PublicationsCorresponds to variant dbSNP:rs656195Ensembl.1
Natural variantiVAR_038160948G → R. Corresponds to variant dbSNP:rs11827140Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0305101 – 1607Missing in isoform 3. 1 PublicationAdd BLAST1607
Alternative sequenceiVSP_03051158 – 121SVNEV…DSQSW → VRSQARVQEVCERGAGVNGV TAGAGGRLRGLHRGGRALGC SAHRPLHSARVRPPAHLAAP PGSR in isoform 4. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_030512122 – 1938Missing in isoform 4. 1 PublicationAdd BLAST1817
Alternative sequenceiVSP_0305151259K → KVQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_0305161608 – 1724INPVV…GVDKV → MAVAMVKLCERAGLPLLAAP LLRSLLPRAPQPGPAQPRSV QGQRCPARHPPGNLVCERGA GVNGVTAGAGGRLRGLHRGG RALGCSAHRPLHSARVRPPA HLAAPPGSSARGCRLTE in isoform 3. 1 PublicationAdd BLAST117

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB007864 mRNA Translation: BAA23700.1 Different initiation.
AK126181 mRNA Translation: BAC86477.1
AP001187 Genomic DNA No translation available.
BC008593 mRNA Translation: AAH08593.1
BC027481 mRNA Translation: AAH27481.1
BC053596 mRNA Translation: AAH53596.1
BC110650 mRNA Translation: AAI10651.1
BC113091 mRNA Translation: AAI13092.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31602.1 [Q2TAZ0-1]

Protein sequence database of the Protein Information Resource

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PIRi
T00051

NCBI Reference Sequences

More...
RefSeqi
NP_055919.2, NM_015104.2 [Q2TAZ0-1]
XP_011543165.1, XM_011544863.2 [Q2TAZ0-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000377264; ENSP00000366475; ENSG00000110046 [Q2TAZ0-1]
ENST00000421419; ENSP00000410522; ENSG00000110046 [Q2TAZ0-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23130

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23130

UCSC genome browser

More...
UCSCi
uc001obx.4 human [Q2TAZ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007864 mRNA Translation: BAA23700.1 Different initiation.
AK126181 mRNA Translation: BAC86477.1
AP001187 Genomic DNA No translation available.
BC008593 mRNA Translation: AAH08593.1
BC027481 mRNA Translation: AAH27481.1
BC053596 mRNA Translation: AAH53596.1
BC110650 mRNA Translation: AAI10651.1
BC113091 mRNA Translation: AAI13092.1
CCDSiCCDS31602.1 [Q2TAZ0-1]
PIRiT00051
RefSeqiNP_055919.2, NM_015104.2 [Q2TAZ0-1]
XP_011543165.1, XM_011544863.2 [Q2TAZ0-3]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi116748, 20 interactors
IntActiQ2TAZ0, 22 interactors
STRINGi9606.ENSP00000366475

Protein family/group databases

TCDBi9.A.15.2.1 the autophagy-related phagophore-formation transporter (apt) family

PTM databases

iPTMnetiQ2TAZ0
PhosphoSitePlusiQ2TAZ0

Polymorphism and mutation databases

BioMutaiATG2A
DMDMi296439433

Proteomic databases

EPDiQ2TAZ0
jPOSTiQ2TAZ0
MaxQBiQ2TAZ0
PaxDbiQ2TAZ0
PeptideAtlasiQ2TAZ0
PRIDEiQ2TAZ0
ProteomicsDBi61475 [Q2TAZ0-1]
61476 [Q2TAZ0-3]
61477 [Q2TAZ0-4]
61478 [Q2TAZ0-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377264; ENSP00000366475; ENSG00000110046 [Q2TAZ0-1]
ENST00000421419; ENSP00000410522; ENSG00000110046 [Q2TAZ0-4]
GeneIDi23130
KEGGihsa:23130
UCSCiuc001obx.4 human [Q2TAZ0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23130

GeneCards: human genes, protein and diseases

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GeneCardsi
ATG2A
HGNCiHGNC:29028 ATG2A
HPAiHPA038715
MIMi616225 gene
neXtProtiNX_Q2TAZ0
OpenTargetsiENSG00000110046
PharmGKBiPA162377101

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2993 Eukaryota
ENOG410XRAR LUCA
GeneTreeiENSGT00620000087966
InParanoidiQ2TAZ0
KOiK17906
OMAiSGYMELT
OrthoDBi196897at2759
PhylomeDBiQ2TAZ0
TreeFamiTF313482

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ATG2A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23130

Protein Ontology

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PROi
PR:Q2TAZ0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000110046 Expressed in 215 organ(s), highest expression level in bone marrow
ExpressionAtlasiQ2TAZ0 baseline and differential
GenevisibleiQ2TAZ0 HS

Family and domain databases

InterProiView protein in InterPro
IPR026849 ATG2
IPR015412 Autophagy-rel_C
IPR026854 VPS13_N
PANTHERiPTHR13190 PTHR13190, 1 hit
PfamiView protein in Pfam
PF09333 ATG_C, 1 hit
PF12624 Chorein_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATG2A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2TAZ0
Secondary accession number(s): O43154
, Q14DM2, Q6ZTV2, Q7Z6K8, Q8IVY5, Q8TAI8, Q96HH7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 18, 2010
Last modified: July 31, 2019
This is version 111 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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