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Entry version 80 (13 Feb 2019)
Sequence version 3 (22 Sep 2009)
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Protein

Tumor suppressor candidate gene 1 protein

Gene

TUSC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor suppressor candidate gene 1 protein
Alternative name(s):
TSG-9
Short name:
TSG9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TUSC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000198680.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:31010 TUSC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610529 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q2TAM9

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
286319

Open Targets

More...
OpenTargetsi
ENSG00000198680

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134889281

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TUSC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
259016374

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003122841 – 212Tumor suppressor candidate gene 1 proteinAdd BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei153PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q2TAM9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q2TAM9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q2TAM9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q2TAM9

PeptideAtlas

More...
PeptideAtlasi
Q2TAM9

PRoteomics IDEntifications database

More...
PRIDEi
Q2TAM9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61470

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q2TAM9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q2TAM9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed at low level. Expressed at higher level in testis, weakly expressed in muscle, colon, lung and spleen. Not detected in 3 non small cell lung carcinoma (NSCLC) cell lines with homozygous deletion of the 9p region, while it is down-regulated in 3 other tumor cell lines.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198680 Expressed in 210 organ(s), highest expression level in epithelium of mammary gland

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q2TAM9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051426

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
130351, 3 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q2TAM9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q2TAM9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili73 – 117Sequence analysisAdd BLAST45
Coiled coili155 – 180Sequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 56Gly-richAdd BLAST48

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IYF1 Eukaryota
ENOG41117ET LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013920

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154715

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG094925

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q2TAM9

Identification of Orthologs from Complete Genome Data

More...
OMAi
GPMWRMR

Database of Orthologous Groups

More...
OrthoDBi
1386758at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q2TAM9

TreeFam database of animal gene trees

More...
TreeFami
TF336220

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q2TAM9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPMWRMRGG ATRRGSCCGG DGAADGRGPG RSGRARGGGS PSGGGGGVGW
60 70 80 90 100
RGRADGARQQ LEERFADLAA SHLEAIRARD EWDRQNARLR QENARLRLEN
110 120 130 140 150
RRLKRENRSL FRQALRLPGE GGNGTPAEAR RVPEEASTNR RARDSGREDE
160 170 180 190 200
PGSPRALRAR LEKLEAMYRR ALLQLHLEQR GPRPSGDKEE QPLQEPDSGL
210
RSRDSEPSGP WL
Length:212
Mass (Da):23,390
Last modified:September 22, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8D7B0038B40AA9B4
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAO38227 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037471123N → DCombined sources1 PublicationCorresponds to variant dbSNP:rs34498078Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY168647 mRNA Translation: AAO38227.2 Different initiation.
AL590322 Genomic DNA No translation available.
BC017510 mRNA Translation: AAH17510.1
BC028316 mRNA Translation: AAH28316.1
BC046919 mRNA Translation: AAH46919.1
BC110824 mRNA Translation: AAI10825.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34999.1

NCBI Reference Sequences

More...
RefSeqi
NP_001004125.1, NM_001004125.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.26268
Hs.606014

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000358022; ENSP00000350716; ENSG00000198680

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
286319

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:286319

UCSC genome browser

More...
UCSCi
uc003zpx.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY168647 mRNA Translation: AAO38227.2 Different initiation.
AL590322 Genomic DNA No translation available.
BC017510 mRNA Translation: AAH17510.1
BC028316 mRNA Translation: AAH28316.1
BC046919 mRNA Translation: AAH46919.1
BC110824 mRNA Translation: AAI10825.1
CCDSiCCDS34999.1
RefSeqiNP_001004125.1, NM_001004125.2
UniGeneiHs.26268
Hs.606014

3D structure databases

ProteinModelPortaliQ2TAM9
SMRiQ2TAM9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130351, 3 interactors

PTM databases

iPTMnetiQ2TAM9
PhosphoSitePlusiQ2TAM9

Polymorphism and mutation databases

BioMutaiTUSC1
DMDMi259016374

Proteomic databases

EPDiQ2TAM9
jPOSTiQ2TAM9
MaxQBiQ2TAM9
PaxDbiQ2TAM9
PeptideAtlasiQ2TAM9
PRIDEiQ2TAM9
ProteomicsDBi61470

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358022; ENSP00000350716; ENSG00000198680
GeneIDi286319
KEGGihsa:286319
UCSCiuc003zpx.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
286319
DisGeNETi286319
EuPathDBiHostDB:ENSG00000198680.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TUSC1
HGNCiHGNC:31010 TUSC1
HPAiHPA051426
MIMi610529 gene
neXtProtiNX_Q2TAM9
OpenTargetsiENSG00000198680
PharmGKBiPA134889281

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IYF1 Eukaryota
ENOG41117ET LUCA
GeneTreeiENSGT00390000013920
HOGENOMiHOG000154715
HOVERGENiHBG094925
InParanoidiQ2TAM9
OMAiGPMWRMR
OrthoDBi1386758at2759
PhylomeDBiQ2TAM9
TreeFamiTF336220

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
286319

Protein Ontology

More...
PROi
PR:Q2TAM9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198680 Expressed in 210 organ(s), highest expression level in epithelium of mammary gland
GenevisibleiQ2TAM9 HS

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTUSC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2TAM9
Secondary accession number(s): A0PJ78
, Q67GI3, Q86SS1, Q8TAH8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: September 22, 2009
Last modified: February 13, 2019
This is version 80 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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