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Protein

Brorin

Gene

VWC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity).By similarity

GO - Biological processi

  • negative regulation of BMP signaling pathway Source: HGNC
  • positive regulation of cell-substrate adhesion Source: Ensembl
  • positive regulation of neuron differentiation Source: HGNC

Names & Taxonomyi

Protein namesi
Recommended name:
Brorin
Alternative name(s):
Brain-specific chordin-like protein
von Willebrand factor C domain-containing protein 2
Gene namesi
Name:VWC2
ORF Names:UNQ739/PRO1434
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000188730.4
HGNCiHGNC:30200 VWC2
MIMi611108 gene
neXtProtiNX_Q2TAL6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Cell junction, Extracellular matrix, Secreted, Synapse

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188730
PharmGKBiPA147357154

Polymorphism and mutation databases

BioMutaiVWC2
DMDMi121941771

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000030715928 – 325BrorinAdd BLAST298

Proteomic databases

PaxDbiQ2TAL6
PeptideAtlasiQ2TAL6
PRIDEiQ2TAL6
ProteomicsDBi61467

Expressioni

Gene expression databases

BgeeiENSG00000188730
CleanExiHS_VWC2
GenevisibleiQ2TAL6 HS

Organism-specific databases

HPAiHPA055243

Interactioni

Subunit structurei

Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including VWC2. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi131984, 4 interactors
IntActiQ2TAL6, 57 interactors
STRINGi9606.ENSP00000341819

Structurei

3D structure databases

ProteinModelPortaliQ2TAL6
SMRiQ2TAL6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 212VWFC 1PROSITE-ProRule annotationAdd BLAST60
Domaini216 – 274VWFC 2PROSITE-ProRule annotationAdd BLAST59

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi114 – 116Mediates cell adhesionBy similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi120 – 127Poly-Ala8

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IK6F Eukaryota
ENOG410YDUI LUCA
GeneTreeiENSGT00720000108792
HOGENOMiHOG000036086
HOVERGENiHBG094842
InParanoidiQ2TAL6
OMAiCTRHECK
OrthoDBiEOG091G0Q3M
PhylomeDBiQ2TAL6
TreeFamiTF329913

Family and domain databases

InterProiView protein in InterPro
IPR001007 VWF_dom
PfamiView protein in Pfam
PF00093 VWC, 1 hit
SMARTiView protein in SMART
SM00214 VWC, 2 hits
PROSITEiView protein in PROSITE
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2TAL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSSTAMAVG ALSSSLLVTC CLMVALCSPS IPLEKLAQAP EQPGQEKREH
60 70 80 90 100
ASRDGPGRVN ELGRPARDEG GSGRDWKSKS GRGLAGREPW SKLKQAWVSQ
110 120 130 140 150
GGGAKAGDLQ VRPRGDTPQA EALAAAAQDA IGPELAPTPE PPEEYVYPDY
160 170 180 190 200
RGKGCVDESG FVYAIGEKFA PGPSACPCLC TEEGPLCAQP ECPRLHPRCI
210 220 230 240 250
HVDTSQCCPQ CKERKNYCEF RGKTYQTLEE FVVSPCERCR CEANGEVLCT
260 270 280 290 300
VSACPQTECV DPVYEPDQCC PICKNGPNCF AETAVIPAGR EVKTDECTIC
310 320
HCTYEEGTWR IERQAMCTRH ECRQM
Length:325
Mass (Da):35,282
Last modified:January 24, 2006 - v1
Checksum:iA38B673AB376B64D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52S → T in BAF51551 (PubMed:17400546).Curated1
Sequence conflicti52S → T in AAQ88759 (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035371120A → G. Corresponds to variant dbSNP:rs769604Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB292671 mRNA Translation: BAF51551.1
AY358393 mRNA Translation: AAQ88759.1
CH471128 Genomic DNA Translation: EAW60985.1
CH236955 Genomic DNA Translation: EAL23904.1
BC110857 mRNA Translation: AAI10858.1
CCDSiCCDS5508.1
RefSeqiNP_940972.2, NM_198570.4
UniGeneiHs.629302
Hs.629814
Hs.657556

Genome annotation databases

EnsembliENST00000340652; ENSP00000341819; ENSG00000188730
GeneIDi375567
KEGGihsa:375567
UCSCiuc003tot.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiVWC2_HUMAN
AccessioniPrimary (citable) accession number: Q2TAL6
Secondary accession number(s): Q6UXE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: January 24, 2006
Last modified: July 18, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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