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Protein

Transmembrane protein 216

Gene

TMEM216

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition.By similarity

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-BTA-5620912 Anchoring of the basal body to the plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 216
Gene namesi
Name:TMEM216
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 29

Organism-specific databases

VGNCiVGNC:36038 TMEM216

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003189541 – 141Transmembrane protein 216Add BLAST141

Proteomic databases

PaxDbiQ2TA01

Expressioni

Gene expression databases

BgeeiENSBTAG00000021517

Interactioni

Subunit structurei

Part of the tectonic-like complex (also named B9 complex). Interacts with TMEM107.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028677

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4502 Eukaryota
ENOG4111ZCW LUCA
GeneTreeiENSGT00390000002170
HOGENOMiHOG000076881
HOVERGENiHBG059533
InParanoidiQ2TA01
KOiK19385
OMAiYFLLLQT
OrthoDBiEOG091G0UR4
TreeFamiTF323824

Family and domain databases

InterProiView protein in InterPro
IPR019184 Uncharacterised_TM-17
PANTHERiPTHR13531 PTHR13531, 1 hit
PfamiView protein in Pfam
PF09799 Transmemb_17, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2TA01-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPRGKRLSS TPLEILFFLN GWYYATYFLL ELFIFLYKGL LLPYPTANLV
60 70 80 90 100
LDVVMLFLYL GVEVIRLFFG TKGNLCQRKM PLGISVALTF PSTMMASYYL
110 120 130 140
LLQTYVLRLE AIMNSILLFF CGSELLLEVL TLTAFSSMDR M
Length:141
Mass (Da):16,186
Last modified:March 21, 2012 - v2
Checksum:i970FD4525EB8848D
GO
Isoform 2 (identifier: Q2TA01-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.

Note: No experimental confirmation available.
Show »
Length:87
Mass (Da):9,901
Checksum:i7290265C931FEAB5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0425891 – 54Missing in isoform 2. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02063463 Genomic DNA No translation available.
BC111187 mRNA Translation: AAI11188.1
RefSeqiNP_001160035.1, NM_001166563.2 [Q2TA01-2]
XP_005226951.1, XM_005226894.3 [Q2TA01-1]
XP_010819304.1, XM_010821002.2 [Q2TA01-1]
XP_015316719.1, XM_015461233.1 [Q2TA01-2]
UniGeneiBt.91666

Genome annotation databases

EnsembliENSBTAT00000028677; ENSBTAP00000028677; ENSBTAG00000021517 [Q2TA01-1]
GeneIDi508031
KEGGibta:508031

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTM216_BOVIN
AccessioniPrimary (citable) accession number: Q2TA01
Secondary accession number(s): G5E5R2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 21, 2012
Last modified: March 28, 2018
This is version 76 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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