CCT4

Functionⁱ

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.By similarity

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
protein binding involved in protein folding Source: GO_Central
unfolded protein binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

'de novo' protein folding Source: GO_Central
chaperone-mediated protein folding Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone
Ligand	ATP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: T-complex protein 1 subunit delta Short name: TCP-1-delta Alternative name(s): CCT-delta
Gene namesⁱ	Name:CCT4
Organismⁱ	Bos taurus (Bovine)
Taxonomic identifierⁱ	9913 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
Proteomesⁱ	UP000009136 Componentⁱ: Unplaced

Keywords - Cellular componentⁱ

Cell projection, Cilium, Cytoplasm, Cytoskeleton

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000236261	1 – 542	T-complex protein 1 subunit deltaAdd BLAST		542

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	22	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	24	N6-acetyllysineBy similarity	1
Modified residueⁱ	39	PhosphoserineBy similarity	1
Modified residueⁱ	187	PhosphoserineBy similarity	1
Modified residueⁱ	205	PhosphoserineBy similarity	1
Modified residueⁱ	291	N6-acetyllysineBy similarity	1
Modified residueⁱ	305	N6-acetyllysineBy similarity	1
Modified residueⁱ	322	N6-acetyllysineBy similarity	1
Modified residueⁱ	329	N6-acetyllysineBy similarity	1
Modified residueⁱ	447	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q2T9X2
PeptideAtlas More...PeptideAtlasⁱ	Q2T9X2
PRIDEⁱ	Q2T9X2

Interactionⁱ

Subunit structureⁱ

Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG (By similarity). Interacts with DNAAF4 (By similarity).By similarity

GO - Molecular functionⁱ

protein binding involved in protein folding Source: GO_Central
unfolded protein binding Source: GO_Central

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

CORUMⁱ	Q2T9X2
Database of interacting proteins More...DIPⁱ	DIP-58619N
IntActⁱ	Q2T9X2, 1 interactor
STRINGⁱ	9913.ENSBTAP00000042274

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q2T9X2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0358 Eukaryota COG0459 LUCA
HOGENOMⁱ	HOG000226735
HOVERGENⁱ	HBG106507
InParanoidⁱ	Q2T9X2
KEGG Orthology (KO) More...KOⁱ	K09496

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03338 TCP1_delta, 1 hit
Gene3Dⁱ	1.10.560.10, 2 hits 3.50.7.10, 1 hit
InterProⁱ	View protein in InterPro IPR012717 Chap_CCT_delta IPR017998 Chaperone_TCP-1 IPR002194 Chaperonin_TCP-1_CS IPR002423 Cpn60/TCP-1 IPR027409 GroEL-like_apical_dom_sf IPR027413 GROEL-like_equatorial_sf IPR027410 TCP-1-like_intermed_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00118 Cpn60_TCP1, 1 hit
PRINTSⁱ	PR00304 TCOMPLEXTCP1
SUPFAMⁱ	SSF48592 SSF48592, 2 hits SSF52029 SSF52029, 1 hit SSF54849 SSF54849, 2 hits
TIGRFAMsⁱ	TIGR02342 chap_CCT_delta, 1 hit
PROSITEⁱ	View protein in PROSITE PS00750 TCP1_1, 1 hit PS00751 TCP1_2, 1 hit PS00995 TCP1_3, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.ⁱShow all

Q2T9X2-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MPENVAPRTG PPAGAAGAAG GRGKSAYQDR DKPAQIRFSN ISAAKAVADA 
        60         70         80         90        100
IRTSLGPKGM DKMIQDGKGD VTITNDGATI LKQMQVLHPA ARMLVELSKA 
       110        120        130        140        150
QDIEAGDGTT SVVIIAGSLL DSCTKLLQKG IHPTIISESF QKALEKGIEI 
       160        170        180        190        200
LTDMSRPEEL SDRETLLNSA ATSLNSKVVS QYSSLLSPMS VDAVMKVIDP 
       210        220        230        240        250
ATATSVDLRD IKIVKKLGGT IDDCELVEGL VLTQKVANSG ITRVEKAKIG 
       260        270        280        290        300
LIQFCLSAPK TDMDNQIVVS DYVQMDRVLR EERAYILNLV KQIKKTGCNV 
       310        320        330        340        350
LLIQKSILRD ALSDLALHFL NKMKIMVVKD IEREDIEFIC KTIGTKPVAH 
       360        370        380        390        400
VDQFTADMLG SAELAEEVSL NGSGKLIKIT GCASPGKTVT IVVRGSNKLV 
       410        420        430        440        450
IEEAERSIHD ALCVIRCLVK KRALIAGGGA PEIELALRLT EYSRTLSGME 
       460        470        480        490        500
SYCIRAFADA MEVIPSTLAE NAGLNPISTV TELRNRHAQG EKTTGINVRK 
       510        520        530        540 
GGISNILEEQ VVQPLLVSVS ALTLATETVR SILKIDDVVN TR

Length:542

Mass (Da):58,206

Last modified:January 23, 2007 - v3

Checksum:ⁱ00610BF36473BB97

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	F1N0E5	F1N0E5_BOVIN		T-complex protein 1 subunit delta T-complex protein 1 subunit delta	CCT4	542	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC111225 mRNA Translation: AAI11226.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001033283.1, NM_001038194.1
UniGeneⁱ	Bt.6427

Genome annotation databases

GeneIDⁱ	613336
KEGGⁱ	bta:613336

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q2T9X2	T-complex protein 1 subunit delta		HUMAN		539	UniRef90_P50991
T-complex protein 1 subunit delta		MOUSE		539
T-complex protein 1 subunit delta		PONAB		539
T-complex protein 1 subunit delta		RAT		539
T-complex protein 1 subunit delta		PANTR		539
+158

Protein	Similar proteins		Species	Score	Length	Source
Q2T9X2	T-complex protein 1 subunit delta		HUMAN		539	UniRef50_P50991
T-complex protein 1 subunit delta		MOUSE		539
T-complex protein 1 subunit delta		PONAB		539
T-complex protein 1 subunit delta		RAT		539
T-complex protein 1 subunit delta		CAEEL		540
+677

Entry informationⁱ

Entry nameⁱ	TCPD_BOVIN
Accessionⁱ	Q2T9X2Primary (citable) accession number: Q2T9X2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 88 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

UniProtKB

UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - Q2T9X2 (TCPD_BOVIN)

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T-complex protein 1 subunit delta

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

Cytoskeleton

Cytosol

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Sequence databases

Genome annotation databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Computationally mapped potential isoform sequencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ