UniProtKB - Q2T9X2 (TCPD_BOVIN)
Protein
T-complex protein 1 subunit delta
Gene
CCT4
Organism
Bos taurus (Bovine)
Status
Functioni
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.By similarity
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- unfolded protein binding Source: InterPro
GO - Biological processi
- protein folding Source: InterPro
Keywordsi
Molecular function | Chaperone |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: T-complex protein 1 subunit deltaShort name: TCP-1-delta Alternative name(s): CCT-delta |
Gene namesi | Name:CCT4 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Cytoskeleton
- centrosome By similarity
- cilium basal body By similarity
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- Melanosome By similarity
Cytoskeleton
- microtubule organizing center Source: UniProtKB-SubCell
Cytosol
- chaperonin-containing T-complex Source: UniProtKB
Other locations
- cilium Source: UniProtKB-KW
- melanosome Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell projection, Cilium, Cytoplasm, CytoskeletonPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000236261 | 1 – 542 | T-complex protein 1 subunit deltaAdd BLAST | 542 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 22 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 24 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 39 | PhosphoserineBy similarity | 1 | |
Modified residuei | 187 | PhosphoserineBy similarity | 1 | |
Modified residuei | 205 | PhosphoserineBy similarity | 1 | |
Modified residuei | 291 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 305 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 322 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 329 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 447 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
PaxDbi | Q2T9X2 |
PeptideAtlasi | Q2T9X2 |
PRIDEi | Q2T9X2 |
Interactioni
Subunit structurei
Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
Interacts with PACRG (By similarity).
Interacts with DNAAF4 (By similarity).
By similarityGO - Molecular functioni
- unfolded protein binding Source: InterPro
Protein-protein interaction databases
CORUMi | Q2T9X2 |
DIPi | DIP-58619N |
IntActi | Q2T9X2, 1 interactor |
STRINGi | 9913.ENSBTAP00000042274 |
Family & Domainsi
Sequence similaritiesi
Belongs to the TCP-1 chaperonin family.Curated
Phylogenomic databases
eggNOGi | KOG0358, Eukaryota |
InParanoidi | Q2T9X2 |
OrthoDBi | 511484at2759 |
Family and domain databases
CDDi | cd03338, TCP1_delta, 1 hit |
Gene3Di | 1.10.560.10, 2 hits 3.50.7.10, 1 hit |
InterProi | View protein in InterPro IPR012717, Chap_CCT_delta IPR017998, Chaperone_TCP-1 IPR002194, Chaperonin_TCP-1_CS IPR002423, Cpn60/TCP-1 IPR027409, GroEL-like_apical_dom_sf IPR027413, GROEL-like_equatorial_sf IPR027410, TCP-1-like_intermed_sf |
Pfami | View protein in Pfam PF00118, Cpn60_TCP1, 1 hit |
PRINTSi | PR00304, TCOMPLEXTCP1 |
SUPFAMi | SSF48592, SSF48592, 1 hit SSF52029, SSF52029, 1 hit SSF54849, SSF54849, 1 hit |
TIGRFAMsi | TIGR02342, chap_CCT_delta, 1 hit |
PROSITEi | View protein in PROSITE PS00750, TCP1_1, 1 hit PS00751, TCP1_2, 1 hit PS00995, TCP1_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q2T9X2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPENVAPRTG PPAGAAGAAG GRGKSAYQDR DKPAQIRFSN ISAAKAVADA
60 70 80 90 100
IRTSLGPKGM DKMIQDGKGD VTITNDGATI LKQMQVLHPA ARMLVELSKA
110 120 130 140 150
QDIEAGDGTT SVVIIAGSLL DSCTKLLQKG IHPTIISESF QKALEKGIEI
160 170 180 190 200
LTDMSRPEEL SDRETLLNSA ATSLNSKVVS QYSSLLSPMS VDAVMKVIDP
210 220 230 240 250
ATATSVDLRD IKIVKKLGGT IDDCELVEGL VLTQKVANSG ITRVEKAKIG
260 270 280 290 300
LIQFCLSAPK TDMDNQIVVS DYVQMDRVLR EERAYILNLV KQIKKTGCNV
310 320 330 340 350
LLIQKSILRD ALSDLALHFL NKMKIMVVKD IEREDIEFIC KTIGTKPVAH
360 370 380 390 400
VDQFTADMLG SAELAEEVSL NGSGKLIKIT GCASPGKTVT IVVRGSNKLV
410 420 430 440 450
IEEAERSIHD ALCVIRCLVK KRALIAGGGA PEIELALRLT EYSRTLSGME
460 470 480 490 500
SYCIRAFADA MEVIPSTLAE NAGLNPISTV TELRNRHAQG EKTTGINVRK
510 520 530 540
GGISNILEEQ VVQPLLVSVS ALTLATETVR SILKIDDVVN TR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC111225 mRNA Translation: AAI11226.1 |
RefSeqi | NP_001033283.1, NM_001038194.1 |
Genome annotation databases
GeneIDi | 613336 |
KEGGi | bta:613336 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC111225 mRNA Translation: AAI11226.1 |
RefSeqi | NP_001033283.1, NM_001038194.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3IYG | electron microscopy | - | D | 25-542 | [»] | |
4B2T | X-ray | 5.50 | D/d | 1-542 | [»] | |
SMRi | Q2T9X2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
CORUMi | Q2T9X2 |
DIPi | DIP-58619N |
IntActi | Q2T9X2, 1 interactor |
STRINGi | 9913.ENSBTAP00000042274 |
Proteomic databases
PaxDbi | Q2T9X2 |
PeptideAtlasi | Q2T9X2 |
PRIDEi | Q2T9X2 |
Genome annotation databases
GeneIDi | 613336 |
KEGGi | bta:613336 |
Organism-specific databases
CTDi | 10575 |
Phylogenomic databases
eggNOGi | KOG0358, Eukaryota |
InParanoidi | Q2T9X2 |
OrthoDBi | 511484at2759 |
Family and domain databases
CDDi | cd03338, TCP1_delta, 1 hit |
Gene3Di | 1.10.560.10, 2 hits 3.50.7.10, 1 hit |
InterProi | View protein in InterPro IPR012717, Chap_CCT_delta IPR017998, Chaperone_TCP-1 IPR002194, Chaperonin_TCP-1_CS IPR002423, Cpn60/TCP-1 IPR027409, GroEL-like_apical_dom_sf IPR027413, GROEL-like_equatorial_sf IPR027410, TCP-1-like_intermed_sf |
Pfami | View protein in Pfam PF00118, Cpn60_TCP1, 1 hit |
PRINTSi | PR00304, TCOMPLEXTCP1 |
SUPFAMi | SSF48592, SSF48592, 1 hit SSF52029, SSF52029, 1 hit SSF54849, SSF54849, 1 hit |
TIGRFAMsi | TIGR02342, chap_CCT_delta, 1 hit |
PROSITEi | View protein in PROSITE PS00750, TCP1_1, 1 hit PS00751, TCP1_2, 1 hit PS00995, TCP1_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TCPD_BOVIN | |
Accessioni | Q2T9X2Primary (citable) accession number: Q2T9X2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2006 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 97 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families