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Protein

Chemotaxis response regulator protein-glutamate methylesterase 3

Gene

cheB3

Organism
Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei181UniRule annotation1
Active sitei207UniRule annotation1
Active sitei303UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesterase 3UniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheB3UniRule annotation
Ordered Locus Names:BTH_II0162
OrganismiBurkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)
Taxonomic identifieri271848 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000001930 Componenti: Chromosome II

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002642691 – 360Chemotaxis response regulator protein-glutamate methylesterase 3Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei654-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ2T8Y5

Structurei

3D structure databases

ProteinModelPortaliQ2T8Y5
SMRiQ2T8Y5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 131Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini169 – 360CheB-type methylesteraseUniRule annotationAdd BLAST192

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000151423
KOiK03412
OMAiRPCAILI
OrthoDBiPOG091H01L0

Family and domain databases

CDDicd16432 CheB_Rec, 1 hit
cd00156 REC, 1 hit
Gene3Di3.40.50.180, 1 hit
HAMAPiMF_00099 CheB_methylest, 1 hit
InterProiView protein in InterPro
IPR035909 CheB_C
IPR011006 CheY-like_superfamily
IPR008248 Sig_transdc_resp-reg_CheB
IPR000673 Sig_transdc_resp-reg_Me-estase
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF01339 CheB_methylest, 1 hit
PF00072 Response_reg, 1 hit
PIRSFiPIRSF000876 RR_chemtxs_CheB, 1 hit
SMARTiView protein in SMART
SM00448 REC, 1 hit
SUPFAMiSSF52172 SSF52172, 1 hit
SSF52738 SSF52738, 1 hit
PROSITEiView protein in PROSITE
PS50122 CHEB, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

Sequencei

Sequence statusi: Complete.

Q2T8Y5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEFSSKERY TMIRVLVIDD SATMRILLKK LIDKNEHMEC VGVAPNPVAA
60 70 80 90 100
QELLRETRPD VITLDIEMPK MNGLDFLDRI MRLMPVAVIM ISTLTEAGSE
110 120 130 140 150
SALRALELGA IDFIAKPKLD FAEGVQAYAE EIYRKIETAG RAKVKKLTRD
160 170 180 190 200
VPPVRMDAEP PAKPLLAEAG KDGRVVAVGA STGGTEAVKE LLLSLPADCP
210 220 230 240 250
PLLIAQHMPE PFMRSLAKRL DLLCAMRVKM AEDGETLRRG CVYIAPGHSN
260 270 280 290 300
LTIDATAAGY VCRIVRNAGE AQSDSSVDEL FRSVAAAAGA RGVGIVLTGS
310 320 330 340 350
GSDGAAGARA MMAAGAFNIA QDAETSVVYS MPDAAIAACG INEVLPLEKI
360
AGKLMELDGA
Length:360
Mass (Da):38,354
Last modified:January 24, 2006 - v1
Checksum:i11A536BBAA7FA599
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000085 Genomic DNA Translation: ABC34755.1

Genome annotation databases

EnsemblBacteriaiABC34755; ABC34755; BTH_II0162
KEGGibte:BTH_II0162

Similar proteinsi

Entry informationi

Entry nameiCHEB3_BURTA
AccessioniPrimary (citable) accession number: Q2T8Y5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 24, 2006
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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