UniProtKB - Q2SZ20 (KATG_BURTA)
Protein
Catalase-peroxidase
Gene
katG
Organism
Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)
Status
Functioni
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation
Catalytic activityi
Cofactori
heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 88 | Transition state stabilizerUniRule annotation | 1 | |
Active sitei | 92 | Proton acceptorUniRule annotation | 1 | |
Metal bindingi | 259 | Iron (heme axial ligand)UniRule annotation | 1 |
GO - Molecular functioni
- catalase activity Source: UniProtKB-UniRule
- heme binding Source: InterPro
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- hydrogen peroxide catabolic process Source: UniProtKB-KW
- response to oxidative stress Source: InterPro
Keywordsi
Molecular function | Oxidoreductase, Peroxidase |
Biological process | Hydrogen peroxide |
Ligand | Heme, Iron, Metal-binding |
Protein family/group databases
PeroxiBasei | 3663, BthCP01_E264 |
Names & Taxonomyi
Protein namesi | Recommended name: Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)Short name: CPUniRule annotation Alternative name(s): Peroxidase/catalaseUniRule annotation |
Gene namesi | Name:katGUniRule annotation Ordered Locus Names:BTH_I1282 |
Organismi | Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264) |
Taxonomic identifieri | 271848 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000354751 | 1 – 728 | Catalase-peroxidaseAdd BLAST | 728 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 91 ↔ 218 | Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-244)UniRule annotation | ||
Cross-linki | 218 ↔ 244 | Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-91)UniRule annotation |
Post-translational modificationi
Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation
Proteomic databases
PRIDEi | Q2SZ20 |
Interactioni
Subunit structurei
Homodimer or homotetramer.
UniRule annotationFamily & Domainsi
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_025424_2_0_4 |
OMAi | GPETTWL |
OrthoDBi | 49441at2 |
Family and domain databases
HAMAPi | MF_01961, Catal_peroxid, 1 hit |
InterProi | View protein in InterPro IPR000763, Catalase_peroxidase IPR002016, Haem_peroxidase IPR010255, Haem_peroxidase_sf IPR019794, Peroxidases_AS IPR019793, Peroxidases_heam-ligand_BS |
PANTHERi | PTHR30555, PTHR30555, 1 hit |
Pfami | View protein in Pfam PF00141, peroxidase, 2 hits |
PRINTSi | PR00460, BPEROXIDASE PR00458, PEROXIDASE |
SUPFAMi | SSF48113, SSF48113, 2 hits |
TIGRFAMsi | TIGR00198, cat_per_HPI, 1 hit |
PROSITEi | View protein in PROSITE PS00435, PEROXIDASE_1, 1 hit PS00436, PEROXIDASE_2, 1 hit PS50873, PEROXIDASE_4, 1 hit |
i Sequence
Sequence statusi: Complete.
Q2SZ20-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSNEAKCPFH HAAGNGTSNR DWWPDQLDLS ALHRHSSLSD PMDRDFNYAQ
60 70 80 90 100
AFEKLDLAAV KRDLHALMTT SQDWWPADFG HYGGLFIRMA WHSAGTYRTA
110 120 130 140 150
DGRGGAGEGQ QRFAPLNSWP DNANLDKARR LLWPIKQKYG RSISWADLLI
160 170 180 190 200
LTGNVALESM GFKTFGFAGG RADTWEPEDV YWGSEKIWLE LSGGPNSRYS
210 220 230 240 250
GDRQLENPLA AVQMGLIYVN PEGPDGNPDP VAAARDIRDT FARMAMNDEE
260 270 280 290 300
TVALIAGGHT FGKTHGAGPA SNVGPEPEAA GLEEQGLGWK SAYGTGKGAD
310 320 330 340 350
AITSGLEVTW TKTPTQWSNN FFENLFGYEW ELTKSPAGAH QWVAKDADAV
360 370 380 390 400
IPDAFDPSKK HRPTMLTTDL SLRFDPAYEK ISRRFHEHPD EFADAFARAW
410 420 430 440 450
FKLTHRDMGP RARYLGPEVP AEELLWQDPI PAVDHPLIDA ADVAALKAQV
460 470 480 490 500
LASGLSVSQL VSTAWAAAST FRGSDKRGGA NGARIRLAPQ KDWEANQPEQ
510 520 530 540 550
LATVLATLEA IRRTFNGAQS GGKRVSLADL IVLAGCAGVE QAAKNAGHAV
560 570 580 590 600
TVPFAPGRMD ASQEQTDVES MAVLEPLADG FRNYLKGKYR VPAEVLLVDK
610 620 630 640 650
AQLLTLSAPE MTVLLGGLRV LGANAGQSRH GVFTARAQAL TNDFFVNLLD
660 670 680 690 700
MSTEWKPASA DADVFEGRDR ATGALKWTGT RVDLVFGSHS QLRALAEVYA
710 720
SADAQEKFVR DFVAVWNKVM NLDRFDLA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000086 Genomic DNA Translation: ABC36439.1 |
RefSeqi | WP_009889205.1, NZ_CP008785.1 |
Genome annotation databases
EnsemblBacteriai | ABC36439; ABC36439; BTH_I1282 |
GeneIDi | 45121028 |
KEGGi | bte:BTH_I1282 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000086 Genomic DNA Translation: ABC36439.1 |
RefSeqi | WP_009889205.1, NZ_CP008785.1 |
3D structure databases
SMRi | Q2SZ20 |
ModBasei | Search... |
Protein family/group databases
PeroxiBasei | 3663, BthCP01_E264 |
Proteomic databases
PRIDEi | Q2SZ20 |
Genome annotation databases
EnsemblBacteriai | ABC36439; ABC36439; BTH_I1282 |
GeneIDi | 45121028 |
KEGGi | bte:BTH_I1282 |
Phylogenomic databases
HOGENOMi | CLU_025424_2_0_4 |
OMAi | GPETTWL |
OrthoDBi | 49441at2 |
Family and domain databases
HAMAPi | MF_01961, Catal_peroxid, 1 hit |
InterProi | View protein in InterPro IPR000763, Catalase_peroxidase IPR002016, Haem_peroxidase IPR010255, Haem_peroxidase_sf IPR019794, Peroxidases_AS IPR019793, Peroxidases_heam-ligand_BS |
PANTHERi | PTHR30555, PTHR30555, 1 hit |
Pfami | View protein in Pfam PF00141, peroxidase, 2 hits |
PRINTSi | PR00460, BPEROXIDASE PR00458, PEROXIDASE |
SUPFAMi | SSF48113, SSF48113, 2 hits |
TIGRFAMsi | TIGR00198, cat_per_HPI, 1 hit |
PROSITEi | View protein in PROSITE PS00435, PEROXIDASE_1, 1 hit PS00436, PEROXIDASE_2, 1 hit PS50873, PEROXIDASE_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KATG_BURTA | |
Accessioni | Q2SZ20Primary (citable) accession number: Q2SZ20 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 25, 2008 |
Last sequence update: | January 24, 2006 | |
Last modified: | December 2, 2020 | |
This is version 88 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |