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Protein

L-lactate dehydrogenase

Gene

ldh

Organism
Salinibacter ruber (strain DSM 13855 / M31)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of lactate to pyruvate.UniRule annotation

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Activity regulationi

Allosterically activated by fructose 1,6-bisphosphate (FBP).UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (ldh)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei15NAD; via amide nitrogenUniRule annotation1
Binding sitei36NADUniRule annotation1
Binding sitei41NADUniRule annotation1
Binding sitei66NADUniRule annotation1
Binding sitei83SubstrateUniRule annotation1
Binding sitei90SubstrateUniRule annotation1
Binding sitei145NADUniRule annotation1
Binding sitei155Allosteric activatorUniRule annotation1
Binding sitei170Allosteric activatorUniRule annotation1
Active sitei177Proton acceptorUniRule annotation1
Binding sitei231SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi80 – 81NADUniRule annotation2
Nucleotide bindingi120 – 122NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Oxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciSRUB309807:G1G5H-680-MONOMER
UniPathwayi
UPA00554;UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Short name:
L-LDHUniRule annotation
Gene namesi
Name:ldhUniRule annotation
Ordered Locus Names:SRU_0681
OrganismiSalinibacter ruber (strain DSM 13855 / M31)
Taxonomic identifieri309807 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidetes Order II. Incertae sedisRhodothermaceaeSalinibacter
Proteomesi
  • UP000008674 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002375561 – 316L-lactate dehydrogenaseAdd BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei222PhosphotyrosineUniRule annotation1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi309807.SRU_0681

Structurei

3D structure databases

ProteinModelPortaliQ2S4R2
SMRiQ2S4R2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni122 – 125Substrate bindingUniRule annotation4
Regioni150 – 153Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213793
KOiK00016
OMAiRQPGQTR
OrthoDBiPOG091H02EQ

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

Q2S4R2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIQRRTVGIV GTGNVGTAAA YAMFNQSLAS EILLLDQDTR RAEGEAMDLM
60 70 80 90 100
HGQQLVGGIT CRAVEYAALS NAQIIVLSAG ASQQSPDETR LGLLQRNAEI
110 120 130 140 150
FREIIIQLDK HAPNAILVVA TNPVDVLTYI CQELSSRPNR RILGTGTLLD
160 170 180 190 200
TARFRALLGR HYGVDPRSVH AYILGEHGDS EVPIWSNATI GGQKIRGETV
210 220 230 240 250
LGKEWEEEAM QSIFEQARDA AYEIIDRKGH TDTAIGLVIA RIVRAVLEDQ
260 270 280 290 300
QNVLPVSTRP DGAYGIDDVC LSVPCVVGLE GMEKRVDPGL SDEEREALRD
310
SARALRDSRA DLTVGT
Length:316
Mass (Da):34,382
Last modified:January 24, 2006 - v1
Checksum:i743B1DA72AABB0EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000159 Genomic DNA Translation: ABC46260.1
RefSeqiWP_011403452.1, NC_007677.1
YP_444819.1, NC_007677.1

Genome annotation databases

EnsemblBacteriaiABC46260; ABC46260; SRU_0681
GeneIDi3852560
KEGGisru:SRU_0681
PATRICifig|309807.25.peg.700

Similar proteinsi

Entry informationi

Entry nameiLDH_SALRD
AccessioniPrimary (citable) accession number: Q2S4R2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 24, 2006
Last modified: September 12, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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