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Protein

UvrABC system protein C

Gene

uvrC

Organism
Moorella thermoacetica (strain ATCC 39073 / JCM 9320)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nuclease
Biological processDNA damage, DNA excision, DNA repair, SOS response

Enzyme and pathway databases

BioCyciMTHE264732:G1G5J-273-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:Moth_0256
OrganismiMoorella thermoacetica (strain ATCC 39073 / JCM 9320)
Taxonomic identifieri264732 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella
Proteomesi
  • UP000007053 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002649121 – 613UvrABC system protein CAdd BLAST613

Proteomic databases

PRIDEiQ2RLU8

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.UniRule annotation

Protein-protein interaction databases

STRINGi264732.Moth_0256

Structurei

3D structure databases

ProteinModelPortaliQ2RLU8
SMRiQ2RLU8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 89GIY-YIGUniRule annotationAdd BLAST78
Domaini199 – 234UVRUniRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CII Bacteria
COG0322 LUCA
HOGENOMiHOG000279960
KOiK03703
OMAiLFPIRQC
OrthoDBiPOG091H01BS

Family and domain databases

Gene3Di3.30.420.340, 1 hit
3.40.1440.10, 1 hit
HAMAPiMF_00203 UvrC, 1 hit
InterProiView protein in InterPro
IPR000305 GIY-YIG_endonuc
IPR035901 GIY-YIG_endonuc_sf
IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif
IPR010994 RuvA_2-like
IPR001943 UVR_dom
IPR036876 UVR_dom_sf
IPR004791 UvrC
IPR001162 UvrC_homol_region
IPR038476 UvrC_homol_region_sf
PfamiView protein in Pfam
PF01541 GIY-YIG, 1 hit
PF02151 UVR, 1 hit
PF08459 UvrC_HhH_N, 1 hit
SMARTiView protein in SMART
SM00465 GIYc, 1 hit
SM00278 HhH1, 2 hits
SUPFAMiSSF46600 SSF46600, 1 hit
SSF47781 SSF47781, 1 hit
SSF82771 SSF82771, 1 hit
TIGRFAMsiTIGR00194 uvrC, 1 hit
PROSITEiView protein in PROSITE
PS50164 GIY_YIG, 1 hit
PS50151 UVR, 1 hit
PS50165 UVRC, 1 hit

Sequencei

Sequence statusi: Complete.

Q2RLU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLEEKLARL PDHPGVYIMH DANGAIIYVG KAASLRNRVR SYFRGQHQPR
60 70 80 90 100
TQAMVSHVAD FEYILTDNEV EALILECNLI KQHRPRYNVS LKDDKSYPYI
110 120 130 140 150
KITTQEDFPR IQITRSVTRD GSRYFGPYTS AGSLKETLKL LRGLFPIRTC
160 170 180 190 200
RDTPLQPRSR PCLNAHIGRC LAPCAGQVDR ETYREAVDNV IMFLEGRHTA
210 220 230 240 250
LVKELKEQME AAAARLEFEK AARLRDQLRA VQEVCEKQKL AAASGEDADA
260 270 280 290 300
IAFAREGEAA LGLIFFSRGG KVIGRDHFFL TGSEGLSRGE VMAALLKEYY
310 320 330 340 350
SRGVEIPPEI LLHDEPEDAA TIASWLSRLR GGRVNLRVPK RGTKLKLLRL
360 370 380 390 400
VHENAVSLLQ EHLLTRRRQE EGSRAALLEL QEILELPRLP RRMEAYDISN
410 420 430 440 450
FQGSSQVGAM AVFVDGRPLP SAYRRFQIKT VRGPNDFASL QEVLSRRFRR
460 470 480 490 500
AAEQDPHFAD LPDFVLIDGG LGQLHAARET MEAMGVGYIP TFGLAKEEEL
510 520 530 540 550
LFRVGTSEPI RLPRESKALQ ILQHLRDEVH RFAITYHRQK REKTAYRSVL
560 570 580 590 600
DDIPGVGPKR KKALLRHFGS VAAISKATLE DLLAVEGMNR TVAARILAGL
610
GRRSDGEDST GSP
Length:613
Mass (Da):68,956
Last modified:January 24, 2006 - v1
Checksum:i52BB1C8CDCDBA864
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000232 Genomic DNA Translation: ABC18591.1
RefSeqiWP_011391800.1, NC_007644.1
YP_429134.1, NC_007644.1

Genome annotation databases

EnsemblBacteriaiABC18591; ABC18591; Moth_0256
GeneIDi3833219
KEGGimta:Moth_0256
PATRICifig|264732.11.peg.272

Similar proteinsi

Entry informationi

Entry nameiUVRC_MOOTA
AccessioniPrimary (citable) accession number: Q2RLU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 24, 2006
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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