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Protein

Chemotaxis response regulator protein-glutamate methylesterase

Gene

cheB

Organism
Moorella thermoacetica (strain ATCC 39073 / JCM 9320)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei241UniRule annotation1
Active sitei268UniRule annotation1
Active sitei365UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Enzyme and pathway databases

BioCyciMTHE264732:G1G5J-779-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesteraseUniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheBUniRule annotation
Ordered Locus Names:Moth_0743
OrganismiMoorella thermoacetica (strain ATCC 39073 / JCM 9320)
Taxonomic identifieri264732 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella
Proteomesi
  • UP000007053 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002642911 – 424Chemotaxis response regulator protein-glutamate methylesteraseAdd BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei574-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi264732.Moth_0743

Structurei

3D structure databases

ProteinModelPortaliQ2RKH8
SMRiQ2RKH8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 123Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini229 – 423CheB-type methylesteraseUniRule annotationAdd BLAST195

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP Bacteria
COG2201 LUCA
HOGENOMiHOG000151424
KOiK03412
OMAiMLEMHRA
OrthoDBiPOG091H045J

Family and domain databases

CDDicd16432 CheB_Rec, 1 hit
cd00156 REC, 1 hit
Gene3Di3.40.50.180, 1 hit
HAMAPiMF_00099 CheB_methylest, 1 hit
InterProiView protein in InterPro
IPR035909 CheB_C
IPR011006 CheY-like_superfamily
IPR008248 Sig_transdc_resp-reg_CheB
IPR000673 Sig_transdc_resp-reg_Me-estase
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF01339 CheB_methylest, 1 hit
PF00072 Response_reg, 1 hit
SMARTiView protein in SMART
SM00448 REC, 1 hit
SUPFAMiSSF52172 SSF52172, 1 hit
SSF52738 SSF52738, 1 hit
PROSITEiView protein in PROSITE
PS50122 CHEB, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

Sequencei

Sequence statusi: Complete.

Q2RKH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWPVRVLVV DDSAFSRRLV TDILQADPDI QVVGYARNGR EALEKVASLQ
60 70 80 90 100
PRVVTLDQEM PVMDGLTTLT ALMAGNPVAV IMLSSHTAAG AAVTIKALEL
110 120 130 140 150
GAVDFIPKPA PGDSLDDFTR QLTEKVKAAA RVPVTRLCRG KNCRENTPAP
160 170 180 190 200
FISPRPGREE AVAAVTGSAA ATAAIGSRLS PGRSPGGKEG VAGAVSAGST
210 220 230 240 250
RGEAIRPGKG TPAAIKGAVA AGAGRLPGRR PGIEVVAIGT STGGPAALRQ
260 270 280 290 300
VLTALPGNLP AGIVIVQHMP AGFTGPLARR LDELAALEVR EAAAGDILRP
310 320 330 340 350
GLALLAPAGR QMLLERHGDA VQVHLAAEAG ITTLFKPSVD ALFLTVAREY
360 370 380 390 400
GPRSLGVILT GMGNDGLRGL RAIKEQGGTV IAQDEATSVV YGMPRAAVEA
410 420
GLADLVLPLE DIAPAIVALV TGAG
Length:424
Mass (Da):43,300
Last modified:January 24, 2006 - v1
Checksum:i8EBEF555A2644F73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000232 Genomic DNA Translation: ABC19061.1
RefSeqiWP_011392264.1, NC_007644.1
YP_429604.1, NC_007644.1

Genome annotation databases

EnsemblBacteriaiABC19061; ABC19061; Moth_0743
GeneIDi3831135
KEGGimta:Moth_0743
PATRICifig|264732.11.peg.798

Similar proteinsi

Entry informationi

Entry nameiCHEB_MOOTA
AccessioniPrimary (citable) accession number: Q2RKH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 24, 2006
Last modified: February 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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