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Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Gene

murG

Organism
Moorella thermoacetica (strain ATCC 39073 / JCM 9320)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).UniRule annotation

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciMTHE264732:G1G5J-878-MONOMER
UniPathwayi
UPA00219

Protein family/group databases

CAZyiGT28 Glycosyltransferase Family 28

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUniRule annotation (EC:2.4.1.227UniRule annotation)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferaseUniRule annotation
Gene namesi
Name:murGUniRule annotation
Ordered Locus Names:Moth_0843
OrganismiMoorella thermoacetica (strain ATCC 39073 / JCM 9320)
Taxonomic identifieri264732 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeMoorella groupMoorella
Proteomesi
  • UP000007053 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003151181 – 371UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseAdd BLAST371

Proteomic databases

PRIDEiQ2RK79

Interactioni

Protein-protein interaction databases

STRINGi264732.Moth_0843

Structurei

3D structure databases

ProteinModelPortaliQ2RK79
SMRiQ2RK79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DVQ Bacteria
COG0707 LUCA
HOGENOMiHOG000218323
KOiK02563
OMAiHQTKNAM
OrthoDBiPOG091H02FX

Family and domain databases

CDDicd03785 GT1_MurG, 1 hit
HAMAPiMF_00033 MurG, 1 hit
InterProiView protein in InterPro
IPR006009 GlcNAc_MurG
IPR007235 Glyco_trans_28_C
IPR004276 GlycoTrans_28_N
PfamiView protein in Pfam
PF04101 Glyco_tran_28_C, 1 hit
PF03033 Glyco_transf_28, 1 hit
TIGRFAMsiTIGR01133 murG, 1 hit

Sequencei

Sequence statusi: Complete.

Q2RK79-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVIITGGGT GGHVYPALAI ARGLKEARPG VELLYIGTAR GLEADVVPRA
60 70 80 90 100
GLTLATITVQ GLVRRQVWKN IPALVKTGRG LGEAWQQVRR FRPDVVVGTG
110 120 130 140 150
GYVSGPVCLA AALQGVPVIL HEQNAFPGVT NRLLAILARC VCLTFPEAAS
160 170 180 190 200
RFPRRAKLVT TGLPVRPEII QADRDSCRQH FGLRPEQLFL VTVGGSQGAR
210 220 230 240 250
SINGAMLPIL KELAGCQDVS LLQVTGRRDY EAYLQQVRTQ GIDLAKYGNI
260 270 280 290 300
TIEPYVYNLE QALAAADLVI GRAGASFLAE VLARGLPSVL VPYPHAAANH
310 320 330 340 350
QEYNARAVAR QGAAVVVLDR ELKGGRLYQV VFELLRSREK LKAMAAAAAS
360 370
LGRPGALEAI IQVILKTVES G
Length:371
Mass (Da):39,696
Last modified:January 24, 2006 - v1
Checksum:iF089272587F12267
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000232 Genomic DNA Translation: ABC19160.1
RefSeqiWP_011392362.1, NC_007644.1
YP_429703.1, NC_007644.1

Genome annotation databases

EnsemblBacteriaiABC19160; ABC19160; Moth_0843
GeneIDi3831540
KEGGimta:Moth_0843
PATRICifig|264732.11.peg.905

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000232 Genomic DNA Translation: ABC19160.1
RefSeqiWP_011392362.1, NC_007644.1
YP_429703.1, NC_007644.1

3D structure databases

ProteinModelPortaliQ2RK79
SMRiQ2RK79
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi264732.Moth_0843

Protein family/group databases

CAZyiGT28 Glycosyltransferase Family 28

Proteomic databases

PRIDEiQ2RK79

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABC19160; ABC19160; Moth_0843
GeneIDi3831540
KEGGimta:Moth_0843
PATRICifig|264732.11.peg.905

Phylogenomic databases

eggNOGiENOG4105DVQ Bacteria
COG0707 LUCA
HOGENOMiHOG000218323
KOiK02563
OMAiHQTKNAM
OrthoDBiPOG091H02FX

Enzyme and pathway databases

UniPathwayi
UPA00219

BioCyciMTHE264732:G1G5J-878-MONOMER

Family and domain databases

CDDicd03785 GT1_MurG, 1 hit
HAMAPiMF_00033 MurG, 1 hit
InterProiView protein in InterPro
IPR006009 GlcNAc_MurG
IPR007235 Glyco_trans_28_C
IPR004276 GlycoTrans_28_N
PfamiView protein in Pfam
PF04101 Glyco_tran_28_C, 1 hit
PF03033 Glyco_transf_28, 1 hit
TIGRFAMsiTIGR01133 murG, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMURG_MOOTA
AccessioniPrimary (citable) accession number: Q2RK79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 24, 2006
Last modified: October 10, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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