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UniProtKB - Q2QY12 (ACA9_ORYSJ)
Protein
Probable calcium-transporting ATPase 9, plasma membrane-type
Gene
ACA9
Organism
Oryza sativa subsp. japonica (Rice)
Status
Functioni
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol out of the cell, into the endoplasmic reticulum, or into organelles.
By similarityCatalytic activityi
- EC:7.2.2.10
Activity regulationi
Activated by calmodulin.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 456 | 4-aspartylphosphate intermediateBy similarity | 1 | |
Metal bindingi | 758 | MagnesiumBy similarity | 1 | |
Metal bindingi | 762 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- ATPase-coupled cation transmembrane transporter activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- P-type calcium transporter activity Source: GO_Central
Keywordsi
Molecular function | Calmodulin-binding, Translocase |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | ATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Probable calcium-transporting ATPase 9, plasma membrane-typeCurated (EC:7.2.2.10)Short name: OsACA91 Publication Alternative name(s): Ca(2+)-ATPase isoform 9Curated |
Gene namesi | Name:ACA91 Publication Ordered Locus Names:Os12g0136900Imported, LOC_Os12g04220Imported ORF Names:OsJ_35157Imported |
Organismi | Oryza sativa subsp. japonica (Rice) |
Taxonomic identifieri | 39947 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Liliopsida › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa |
Proteomesi |
|
Subcellular locationi
Other locations
- Membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- intracellular membrane-bounded organelle Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 175 | CytoplasmicSequence analysisAdd BLAST | 175 | |
Transmembranei | 176 – 196 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 199 – 219 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 220 – 250 | CytoplasmicSequence analysisAdd BLAST | 31 | |
Transmembranei | 251 – 271 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 353 – 373 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 374 – 406 | CytoplasmicSequence analysisAdd BLAST | 33 | |
Transmembranei | 407 – 427 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 825 – 845 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 846 – 847 | CytoplasmicSequence analysis | 2 | |
Transmembranei | 848 – 868 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 892 – 912 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 913 – 960 | CytoplasmicSequence analysisAdd BLAST | 48 | |
Transmembranei | 961 – 981 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 995 – 1015 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1016 – 1039 | CytoplasmicSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000247303 | 1 – 1039 | Probable calcium-transporting ATPase 9, plasma membrane-typeAdd BLAST | 1039 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q2QY12 |
Interactioni
GO - Molecular functioni
- calmodulin binding Source: UniProtKB-KW
Protein-protein interaction databases
STRINGi | 4530.OS12T0136900-00 |
Family & Domainsi
Domaini
The N-terminus contains an autoinhibitory calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion.By similarity
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0204, Eukaryota |
HOGENOMi | CLU_002360_9_2_1 |
InParanoidi | Q2QY12 |
OMAi | IIPRLHV |
OrthoDBi | 115892at2759 |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR024750, Ca_ATPase_N_dom IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006408, P-type_ATPase_IIB IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF12515, CaATP_NAI, 1 hit PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
PRINTSi | PR00120, HATPASE |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01517, ATPase-IIB_Ca, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q2QY12-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKLDRYLQE NFDVPAKNPS EEAQRRWRQA VGTIVKNRRR RFRWVPDLER
60 70 80 90 100
RSLDKAKVRS TQEKIRVALY VQQAALIFSD GAKKKEYKLT GDIIKAGYAI
110 120 130 140 150
NPDELALITS KHDSKALKMH GGVDGISIKV RSSFDHGIYA SELDTRQNIY
160 170 180 190 200
GVNRYAEKPS RSFWMFVWDA LQDMTLIILM VCALLSVAVG LATEGWPKGM
210 220 230 240 250
YDGLGIILSI FLVVMVTAVS DYKQSLQFKE LDNEKKKIFI HVTRDGRRQK
260 270 280 290 300
ISIYDLVVGD IVHLSIGDQV PADGLYIHGY SLLIDESSLS GESDPVYVSQ
310 320 330 340 350
DKPFILAGTK VQDGSAKMIV TAVGMRTEWG KLMSTLSEGG EDETPLQVKL
360 370 380 390 400
NGVATIIGKI GLVFAILTFL VLLVRFLIDK GMTVGLLKWY STDALTIVNY
410 420 430 440 450
FATAVTIIVV AVPEGLPLAV TLSLAFAMKK LMNDKALVRH LSACETMGSA
460 470 480 490 500
GTICTDKTGT LTTNHMVVDK IWISEVSKSV TSNTISGELN SVVSSSTLSL
510 520 530 540 550
LLQGIFENTS AEVVKEKDGK QTVLGTPTER AILEFGLGLK GDHDAEYRAC
560 570 580 590 600
TKVKVEPFNS VKKKMAVLIS LPNGTSRWFC KGASEIILQM CDMMVDGDGN
610 620 630 640 650
AIPLSEAQRK NILDTINSFA SDALRTLCLA YKEVDDDIDD NADSPTSGFT
660 670 680 690 700
LIAIFGIKDP VRPGVKDAVK TCMSAGITVR MVTGDNINTA KAIAKECGIL
710 720 730 740 750
TEDGVAIEGP EFHSKSTEEM RDLILNIQVM ARSLPLDKHT LVTNLRGMFD
760 770 780 790 800
EVVSVTGDGT NDAPALHEAD IGLAMGIAGT EVAKESADVI VLDDNFTTII
810 820 830 840 850
NVARWGRAVY INIQKFVQFQ LTVNIVALVI NFVSACIIGS APLTAVQLLW
860 870 880 890 900
VNMIMDTLGA LALATEPPND EMMKRPPVRK GESFITKFMW RNIMGQSLYQ
910 920 930 940 950
LFVLGALMFG GERLLNIKGA DSKSIINTLI FNSFVFCQVF NEINSREMQK
960 970 980 990 1000
INVFRGIISN WIFIAVIAAT VAFQVVIIEF LGTFASTVPL NWQHWLLSVG
1010 1020 1030
LGSISLIVGV ILKCIPVGSG ETSATPNGYR PLANGPDDI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX000502 Genomic DNA No translation available. DP000011 Genomic DNA Translation: ABA95758.1 AP008218 Genomic DNA Translation: BAF29124.1 AP014968 Genomic DNA Translation: BAT15803.1 CM000149 Genomic DNA Translation: EAZ19580.1 |
RefSeqi | XP_015620481.1, XM_015764995.1 |
Genome annotation databases
EnsemblPlantsi | Os12t0136900-00; Os12t0136900-00; Os12g0136900 |
GeneIDi | 4351449 |
Gramenei | Os12t0136900-00; Os12t0136900-00; Os12g0136900 |
KEGGi | osa:4351449 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX000502 Genomic DNA No translation available. DP000011 Genomic DNA Translation: ABA95758.1 AP008218 Genomic DNA Translation: BAF29124.1 AP014968 Genomic DNA Translation: BAT15803.1 CM000149 Genomic DNA Translation: EAZ19580.1 |
RefSeqi | XP_015620481.1, XM_015764995.1 |
3D structure databases
SMRi | Q2QY12 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 4530.OS12T0136900-00 |
Proteomic databases
PaxDbi | Q2QY12 |
Genome annotation databases
EnsemblPlantsi | Os12t0136900-00; Os12t0136900-00; Os12g0136900 |
GeneIDi | 4351449 |
Gramenei | Os12t0136900-00; Os12t0136900-00; Os12g0136900 |
KEGGi | osa:4351449 |
Phylogenomic databases
eggNOGi | KOG0204, Eukaryota |
HOGENOMi | CLU_002360_9_2_1 |
InParanoidi | Q2QY12 |
OMAi | IIPRLHV |
OrthoDBi | 115892at2759 |
Gene expression databases
Genevisiblei | Q2QY12, OS |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR024750, Ca_ATPase_N_dom IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006408, P-type_ATPase_IIB IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF12515, CaATP_NAI, 1 hit PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
PRINTSi | PR00120, HATPASE |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01517, ATPase-IIB_Ca, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ACA9_ORYSJ | |
Accessioni | Q2QY12Primary (citable) accession number: Q2QY12 Secondary accession number(s): A0A0P0Y711, Q0IQ91 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 25, 2006 |
Last sequence update: | January 24, 2006 | |
Last modified: | February 23, 2022 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Oryza sativa (rice)
Index of Oryza sativa entries and their corresponding gene designations - SIMILARITY comments
Index of protein domains and families