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Protein

Guanylate kinase 1

Gene

GK1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Essential for recycling GMP and indirectly, cGMP.1 Publication

Miscellaneous

Plants silencing GK1 have no visible phenotype.1 Publication

Catalytic activityi

ATP + GMP = ADP + GDP.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei168By similarity1
Active sitei261By similarity1
Active sitei272By similarity1
Binding sitei295ATPBy similarity1
Binding sitei296ATP; via carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi135 – 142ATPBy similarity8

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase 1 (EC:2.7.4.8)
Short name:
OsGK1
Alternative name(s):
GMP kinase 1
Gene namesi
Name:GK1
Ordered Locus Names:Os12g0515600, LOC_Os12g33100
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004301281 – 382Guanylate kinase 1Add BLAST382

Proteomic databases

PaxDbiQ2QPW1.

Expressioni

Gene expression databases

ExpressionAtlasiQ2QPW1. baseline and differential.
GenevisibleiQ2QPW1. OS.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi39947.LOC_Os12g33100.1.

Structurei

3D structure databases

SMRiQ2QPW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 310Guanylate kinase-likeBy similarityAdd BLAST183

Sequence similaritiesi

Belongs to the guanylate kinase family.Curated

Phylogenomic databases

eggNOGiKOG0707. Eukaryota.
COG0194. LUCA.
InParanoidiQ2QPW1.
KOiK00942.
OMAiLESCYEN.
OrthoDBiEOG09360BLY.

Family and domain databases

HAMAPiMF_00328. Guanylate_kinase. 1 hit.
InterProiView protein in InterPro
IPR011043. Gal_Oxase/kelch_b-propeller.
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00625. Guanylate_kin. 1 hit.
SMARTiView protein in SMART
SM00072. GuKc. 1 hit.
SUPFAMiSSF50965. SSF50965. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiView protein in PROSITE
PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2QPW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEEAPEFRV ESVALESKDC LQNAIDIGDK TYVISRSDDP KSSITIKILD
60 70 80 90 100
KLTQTWVVPT VLGAPPNPTS SHSAVLVNNE KILIIEKGVP LNDSIWFLEV
110 120 130 140 150
DTPFVKQQSK IKGTVVVAWS KGVIGEGQKP IVISGPSGVG KGTLIAKLMK
160 170 180 190 200
EYPSKFGFSV SHTTRAPREK EIDGVHYHFT ERSKIEEEIS EGKFLEFAHV
210 220 230 240 250
HGNVYGTSVE AVESVTDEGK RCILDIDVQG ARSVRASSLE AIFIFVCPPS
260 270 280 290 300
FEELEKRLRA RGTETEEQIQ KRLRNARAEL DQSNSPGLFD HLLVNDDLEA
310 320 330 340 350
CYENLKKLLS LDDDHEDSND SFIKDGKETA CYSILSKTNS EILLQSETNE
360 370 380
AEKGTTNLLS LDLSLSGGAP GRTRGLKISP VN
Length:382
Mass (Da):42,014
Last modified:July 11, 2006 - v2
Checksum:iD08262E054B87CD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB267729 mRNA. Translation: BAF46275.1.
DP000011 Genomic DNA. Translation: ABA98706.2.
AP008218 Genomic DNA. Translation: BAF29906.1.
AP014968 Genomic DNA. Translation: BAT17372.1.
RefSeqiXP_015620685.1. XM_015765199.1.
UniGeneiOs.27776.

Genome annotation databases

EnsemblPlantsiOs12t0515600-01; Os12t0515600-01; Os12g0515600.
GeneIDi4352344.
GrameneiOs12t0515600-01; Os12t0515600-01; Os12g0515600.
KEGGiosa:4352344.

Similar proteinsi

Entry informationi

Entry nameiGMK1_ORYSJ
AccessioniPrimary (citable) accession number: Q2QPW1
Secondary accession number(s): A0A0P0YAW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 3, 2014
Last sequence update: July 11, 2006
Last modified: March 28, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome