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UniProtKB - Q2QMX9 (ACA10_ORYSJ)
Protein
Calcium-transporting ATPase 10, plasma membrane-type
Gene
ACA10
Organism
Oryza sativa subsp. japonica (Rice)
Status
Functioni
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol out of the cell, into the endoplasmic reticulum, or into organelles.
By similarityCatalytic activityi
- EC:7.2.2.10
Activity regulationi
Activated by calmodulin.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 456 | 4-aspartylphosphate intermediateBy similarity | 1 | |
Metal bindingi | 758 | MagnesiumBy similarity | 1 | |
Metal bindingi | 762 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- ATPase-coupled cation transmembrane transporter activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: InterPro
- calmodulin binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- P-type calcium transporter activity Source: GO_Central
Keywordsi
Molecular function | Calmodulin-binding, Translocase |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | ATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium-transporting ATPase 10, plasma membrane-typeCurated (EC:7.2.2.10)Short name: OsACA101 Publication Alternative name(s): Ca(2+)-ATPase isoform 10Curated Plastid envelope ATPase 1Curated |
Gene namesi | Name:ACA101 Publication Ordered Locus Names:Os12g0586600, LOC_Os12g39660 ORF Names:OsJ_36685 |
Organismi | Oryza sativa subsp. japonica (Rice) |
Taxonomic identifieri | 39947 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Liliopsida › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa |
Proteomesi |
|
Subcellular locationi
Other locations
- Membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- intracellular membrane-bounded organelle Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 175 | CytoplasmicSequence analysisAdd BLAST | 175 | |
Transmembranei | 176 – 196 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 199 – 219 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 220 – 263 | CytoplasmicSequence analysisAdd BLAST | 44 | |
Transmembranei | 264 – 284 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 352 – 372 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 373 – 400 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 401 – 421 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 843 – 863 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 864 – 887 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 888 – 907 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 924 – 944 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 945 – 961 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 962 – 982 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 995 – 1015 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1016 – 1020 | CytoplasmicSequence analysis | 5 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000247300 | 1 – 1020 | Calcium-transporting ATPase 10, plasma membrane-typeAdd BLAST | 1020 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q2QMX9 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q2QMX9, baseline and differential |
Genevisiblei | Q2QMX9, OS |
Interactioni
GO - Molecular functioni
- calmodulin binding Source: UniProtKB-KW
Protein-protein interaction databases
STRINGi | 4530.OS12T0586600-01 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 21 – 32 | Interaction with calmodulinBy similarityAdd BLAST | 12 |
Domaini
The N-terminus contains an autoinhibitory calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion.By similarity
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0204, Eukaryota |
InParanoidi | Q2QMX9 |
OMAi | SKKYHEG |
OrthoDBi | 115892at2759 |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR024750, Ca_ATPase_N_dom IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006408, P-type_ATPase_IIB IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF12515, CaATP_NAI, 1 hit PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
PRINTSi | PR00120, HATPASE |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01517, ATPase-IIB_Ca, 1 hit TIGR01494, ATPase_P-type, 3 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q2QMX9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MESYLEENFG GVKAKNSSEE ALRRWRKLCG VVKNPKRRFR FTANLDKRGE
60 70 80 90 100
AQAIKHANHE KLRVAVLVSK AALQFIQGLS LRSEYVVPEE VKAAGFQICA
110 120 130 140 150
DELGSIVEGH DSKKLITHGG VTGIADKLAT SPADGLSTAE ESIKRRQDVY
160 170 180 190 200
GLNKFTESEV RSFWVFVWEA LQDTTLIILA VCAFVSLVVG IAMEGWPKGA
210 220 230 240 250
HDGLGIVASI LLVVFVTATS DYRQSLQFKD LDKEKKKIQV QVTRNGFRQR
260 270 280 290 300
LSIYDLLPGD VVHLAIGDQV PADGLFISGF SLLINESSLT GESEPVVVNE
310 320 330 340 350
DNPFLLSGTK VQDGSCKMLI TTVGMRTQWG KLMATLSEGG DDETPLQVKL
360 370 380 390 400
NGVATIIGKI GLFFAVITFI VLSQGLISKK YHEGLLLSWS GDDALEMLEH
410 420 430 440 450
FAIAVTIVVV AVPEGLPLAV TLSLAFAMKK MMNDKALVRH LAACETMGSA
460 470 480 490 500
TTICSDKTGT LTTNHMTVVK ACICGNIKEV NNPKNASDLC SELPETVVKT
510 520 530 540 550
LLESIFNNTG GEVVIDQDGK YQILGTPTET ALLEFALSLG GNFKAKRDET
560 570 580 590 600
KIVKMEPFNS TKKRMCVVLK LPGGGCRAHC KGASEIVLAA CDKFMDETGA
610 620 630 640 650
VVPLDKTTAD KLNGIIESFA NEALRTLCLG YREMEEGFSV EEQIPLQGYT
660 670 680 690 700
CIGIVGIKDP VRPGVRESVA TCRSAGIMVR MVTGDNINTA KAIARECGIL
710 720 730 740 750
TEDGLAIEGP EFREKSLDEL LKLIPKIQVM ARSSPLDKHT LVKHLRTTFN
760 770 780 790 800
EVVAVTGDGT NDAPALHEAD IGLAMGIAGT EVAKESADVI ILDDNFSTIV
810 820 830 840 850
TVAKWGRSVY VNIQKFVQFQ LTVNVVALLV NFSSACFTGN APLTAVQLLW
860 870 880 890 900
VNMIMDTLGA LALATEPPND DLMKREPVGR TGKFITNVMW RNILGQSFYQ
910 920 930 940 950
FIVMWYLQTQ GKSMFGLDGP DAEVVLNTII FNSFVFCQVF NEISSREMEK
960 970 980 990 1000
INVLRGILKN YVFLGVLTST VVFQFIMVQF LGEFANTIPL TRLQWIASVL
1010 1020
LGLIGMPISA IIKLLPVGSS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0P0YBQ1 | A0A0P0YBQ1_ORYSJ | P-type Ca(2+) transporter | Os12g0586600, OSNPB_120586600 | 901 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DP000011 Genomic DNA Translation: ABA99736.1 AP008218 Genomic DNA Translation: BAF30178.1 AP014968 Genomic DNA Translation: BAT17855.1 CM000149 Genomic DNA Translation: EAZ21038.1 AK066259 mRNA Translation: BAG89887.1 |
RefSeqi | XP_015620081.1, XM_015764595.1 |
Genome annotation databases
EnsemblPlantsi | Os12t0586600-01; Os12t0586600-01; Os12g0586600 |
GeneIDi | 4352664 |
Gramenei | Os12t0586600-01; Os12t0586600-01; Os12g0586600 |
KEGGi | osa:4352664 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DP000011 Genomic DNA Translation: ABA99736.1 AP008218 Genomic DNA Translation: BAF30178.1 AP014968 Genomic DNA Translation: BAT17855.1 CM000149 Genomic DNA Translation: EAZ21038.1 AK066259 mRNA Translation: BAG89887.1 |
RefSeqi | XP_015620081.1, XM_015764595.1 |
3D structure databases
AlphaFoldDBi | Q2QMX9 |
SMRi | Q2QMX9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 4530.OS12T0586600-01 |
Proteomic databases
PaxDbi | Q2QMX9 |
Genome annotation databases
EnsemblPlantsi | Os12t0586600-01; Os12t0586600-01; Os12g0586600 |
GeneIDi | 4352664 |
Gramenei | Os12t0586600-01; Os12t0586600-01; Os12g0586600 |
KEGGi | osa:4352664 |
Phylogenomic databases
eggNOGi | KOG0204, Eukaryota |
InParanoidi | Q2QMX9 |
OMAi | SKKYHEG |
OrthoDBi | 115892at2759 |
Gene expression databases
ExpressionAtlasi | Q2QMX9, baseline and differential |
Genevisiblei | Q2QMX9, OS |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR024750, Ca_ATPase_N_dom IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006408, P-type_ATPase_IIB IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF12515, CaATP_NAI, 1 hit PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
PRINTSi | PR00120, HATPASE |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01517, ATPase-IIB_Ca, 1 hit TIGR01494, ATPase_P-type, 3 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ACA10_ORYSJ | |
Accessioni | Q2QMX9Primary (citable) accession number: Q2QMX9 Secondary accession number(s): A0A0P0YBR1, Q0IM87 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 25, 2006 |
Last sequence update: | January 24, 2006 | |
Last modified: | May 25, 2022 | |
This is version 111 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Oryza sativa (rice)
Index of Oryza sativa entries and their corresponding gene designations - SIMILARITY comments
Index of protein domains and families