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Protein

Caveolin-2

Gene

CAV2

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Caveolin-2
Gene namesi
Name:CAV2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 86CytoplasmicSequence analysisAdd BLAST86
Intramembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 162CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002260591 – 162Caveolin-2Add BLAST162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Phosphotyrosine; by SRCBy similarity1
Modified residuei20PhosphoserineBy similarity1
Modified residuei23PhosphoserineBy similarity1
Modified residuei27Phosphotyrosine; by SRCBy similarity1

Post-translational modificationi

Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ2QLE2
PeptideAtlasiQ2QLE2
PRIDEiQ2QLE2

Expressioni

Gene expression databases

BgeeiENSSSCG00000016635 Expressed in 5 organ(s), highest expression level in heart
GenevisibleiQ2QLE2 SS

Interactioni

Subunit structurei

Monomer or homodimer (By similarity). Interacts with CAV1; the interaction forms a stable heterooligomeric complex that is required for targeting to lipid rafts and for caveolae formation. Tyrosine phosphorylated forms do not form heterooligomers with the Tyr-19-phosphorylated form existing as a monomer or dimer, and the Tyr-27-form as a monomer only. Interacts (tyrosine phosphorylated form) with the SH2 domain-containing proteins, RASA1, NCK1 and SRC. Interacts (tyrosine phosphorylated form) with INSR, the interaction (Tyr-27-phosphorylated form) is increased on insulin stimulation. Interacts (Tyr-19 phosphorylated form) with MAPK1 (phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with STAT3; the interaction is increased on insulin-induced tyrosine phosphorylation leading to STAT activation (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000017623

Structurei

3D structure databases

SMRiQ2QLE2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the caveolin family.Curated

Phylogenomic databases

eggNOGiENOG410IFFB Eukaryota
ENOG4111STF LUCA
GeneTreeiENSGT00390000014924
HOGENOMiHOG000036550
HOVERGENiHBG003422
InParanoidiQ2QLE2
KOiK12958
OMAiHLKVGFE
OrthoDBiEOG091G0M1R
TreeFamiTF315736

Family and domain databases

InterProiView protein in InterPro
IPR033306 CAV-2
IPR001612 Caveolin
IPR018361 Caveolin_CS
PANTHERiPTHR10844 PTHR10844, 1 hit
PTHR10844:SF3 PTHR10844:SF3, 1 hit
PfamiView protein in Pfam
PF01146 Caveolin, 1 hit
PROSITEiView protein in PROSITE
PS01210 CAVEOLIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q2QLE2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLETEKADV QLFMDDDSYS RHSGVDYADP KKFVDPGTDR DPHRLNSNLK
60 70 80 90 100
VGFEDVIAEP VSTHSFDKVW ICSHALFEIS KYVIYKFLTV FLAIPLAFAA
110 120 130 140 150
GILFATLSCL HIWIIIPFVK TCLMVLPSVQ TIWKSVTDVV IAPLCTSAGR
160
SFSSVSLQLS HD
Length:162
Mass (Da):18,056
Last modified:January 24, 2006 - v1
Checksum:i931E54403BB21E9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000017 Genomic DNA Translation: AAR16299.1
RefSeqiNP_001116563.1, NM_001123091.1
UniGeneiSsc.1291

Genome annotation databases

EnsembliENSSSCT00000018113; ENSSSCP00000017623; ENSSSCG00000016635
GeneIDi100125375
KEGGissc:100125375

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000017 Genomic DNA Translation: AAR16299.1
RefSeqiNP_001116563.1, NM_001123091.1
UniGeneiSsc.1291

3D structure databases

SMRiQ2QLE2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000017623

Proteomic databases

PaxDbiQ2QLE2
PeptideAtlasiQ2QLE2
PRIDEiQ2QLE2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000018113; ENSSSCP00000017623; ENSSSCG00000016635
GeneIDi100125375
KEGGissc:100125375

Organism-specific databases

CTDi858

Phylogenomic databases

eggNOGiENOG410IFFB Eukaryota
ENOG4111STF LUCA
GeneTreeiENSGT00390000014924
HOGENOMiHOG000036550
HOVERGENiHBG003422
InParanoidiQ2QLE2
KOiK12958
OMAiHLKVGFE
OrthoDBiEOG091G0M1R
TreeFamiTF315736

Gene expression databases

BgeeiENSSSCG00000016635 Expressed in 5 organ(s), highest expression level in heart
GenevisibleiQ2QLE2 SS

Family and domain databases

InterProiView protein in InterPro
IPR033306 CAV-2
IPR001612 Caveolin
IPR018361 Caveolin_CS
PANTHERiPTHR10844 PTHR10844, 1 hit
PTHR10844:SF3 PTHR10844:SF3, 1 hit
PfamiView protein in Pfam
PF01146 Caveolin, 1 hit
PROSITEiView protein in PROSITE
PS01210 CAVEOLIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAV2_PIG
AccessioniPrimary (citable) accession number: Q2QLE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: January 24, 2006
Last modified: September 12, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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