UniProtKB - Q2QLA9 (MET_HORSE)
Hepatocyte growth factor receptor
MET
Functioni
Catalytic activityi
- EC:2.7.10.1PROSITE-ProRule annotation
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 1110 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 1204 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 1084 – 1092 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- hepatocyte growth factor-activated receptor activity Source: GO_Central
- semaphorin receptor activity Source: InterPro
- transmembrane receptor protein tyrosine kinase activity Source: GO_Central
GO - Biological processi
- cell migration Source: GO_Central
- liver development Source: GO_Central
- multicellular organism development Source: GO_Central
- nervous system development Source: GO_Central
- neuron differentiation Source: GO_Central
- pancreas development Source: GO_Central
- phagocytosis Source: GO_Central
- positive chemotaxis Source: UniProtKB
- positive regulation of endothelial cell chemotaxis Source: UniProtKB
- positive regulation of kinase activity Source: GO_Central
- positive regulation of protein kinase B signaling Source: GO_Central
- semaphorin-plexin signaling pathway Source: UniProtKB
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Keywordsi
Molecular function | Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Hepatocyte growth factor receptor (EC:2.7.10.1)Short name: HGF receptor Alternative name(s): HGF/SF receptor Proto-oncogene c-Met Scatter factor receptor Short name: SF receptor Tyrosine-protein kinase Met |
Gene namesi | Name:MET |
Organismi | Equus caballus (Horse) |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:20111, MET |
Subcellular locationi
Other locations
- Membrane By similarity; Single-pass type I membrane protein By similarity
Plasma Membrane
- basal plasma membrane Source: GO_Central
- integral component of plasma membrane Source: GO_Central
Other locations
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 934 | ExtracellularSequence analysisAdd BLAST | 910 | |
Transmembranei | 935 – 955 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 956 – 1381 | CytoplasmicSequence analysisAdd BLAST | 426 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_0000226362 | 25 – 1381 | Hepatocyte growth factor receptorAdd BLAST | 1357 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 45 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 95 ↔ 101 | PROSITE-ProRule annotation | ||
Disulfide bondi | 98 ↔ 160 | PROSITE-ProRule annotation | ||
Glycosylationi | 106 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 133 ↔ 141 | PROSITE-ProRule annotation | ||
Disulfide bondi | 172 ↔ 175 | PROSITE-ProRule annotation | ||
Glycosylationi | 202 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 298 ↔ 363 | PROSITE-ProRule annotation | ||
Glycosylationi | 358 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 385 ↔ 397 | PROSITE-ProRule annotation | ||
Glycosylationi | 399 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 405 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 449 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 520 ↔ 538 | PROSITE-ProRule annotation | ||
Disulfide bondi | 526 ↔ 561 | PROSITE-ProRule annotation | ||
Disulfide bondi | 529 ↔ 545 | PROSITE-ProRule annotation | ||
Disulfide bondi | 541 ↔ 551 | PROSITE-ProRule annotation | ||
Glycosylationi | 553 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 607 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 635 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 785 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 879 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 930 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 966 | PhosphoserineBy similarity | 1 | |
Modified residuei | 977 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 990 | PhosphoserineBy similarity | 1 | |
Modified residuei | 997 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1000 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1003 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 1230 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 1234 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 1235 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 1289 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1349 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 1356 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 1365 | PhosphotyrosineBy similarity | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 307 – 308 | CleavageSequence analysis | 2 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q2QLA9 |
PRIDEi | Q2QLA9 |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000010385, Expressed in liver and 19 other tissues |
ExpressionAtlasi | Q2QLA9, baseline |
Interactioni
Subunit structurei
Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1.
Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and GAB1.
Interacts with SPSB1, SPSB2 and SPSB4.
Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2.
Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction.
Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation.
Interacts with GRB10.
Interacts with PTPN1 and PTPN2.
Interacts with HSP90AA1 and HSP90AB1; the interaction suppresses MET kinase activity.
By similarityFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 515 | SemaPROSITE-ProRule annotationAdd BLAST | 489 | |
Domaini | 563 – 655 | IPT/TIG 1Add BLAST | 93 | |
Domaini | 657 – 739 | IPT/TIG 2Add BLAST | 83 | |
Domaini | 742 – 836 | IPT/TIG 3Add BLAST | 95 | |
Domaini | 1078 – 1345 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 268 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1212 – 1381 | Interaction with RANBP9By similarityAdd BLAST | 170 | |
Regioni | 1320 – 1359 | Interaction with MUC20By similarityAdd BLAST | 40 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
GeneTreei | ENSGT00940000158022 |
HOGENOMi | CLU_005158_0_0_1 |
InParanoidi | Q2QLA9 |
OMAi | DEEPGQC |
OrthoDBi | 408584at2759 |
TreeFami | TF317402 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR011009, Kinase-like_dom_sf IPR031148, Plexin IPR002165, Plexin_repeat IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR016201, PSI IPR001627, Semap_dom IPR036352, Semap_dom_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016244, Tyr_kinase_HGF/MSP_rcpt IPR015943, WD40/YVTN_repeat-like_dom_sf |
PANTHERi | PTHR22625, PTHR22625, 1 hit |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF01437, PSI, 1 hit PF01403, Sema, 1 hit PF01833, TIG, 3 hits |
PIRSFi | PIRSF000617, TyrPK_HGF-R, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00429, IPT, 4 hits SM00423, PSI, 1 hit SM00630, Sema, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF101912, SSF101912, 1 hit SSF56112, SSF56112, 1 hit SSF81296, SSF81296, 3 hits |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS51004, SEMA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MKAPAVLAPG ILVLLFTLVQ KSDGECKEAL VKSEMNVNMK YQLPNFTAET
60 70 80 90 100
PIQNVVLHKH HIYLGATNYI YVLNDKDLQK VAEYKTGPVL EHPDCFPCQD
110 120 130 140 150
CSRKANLSGG AWKDNINMAL LVDTYYDDQL ISCGSVHRGT CQRHVLPLNN
160 170 180 190 200
VADIQSEVYC MYSPQAEEPH QCPDCVVSAL GTKVLLSEKD RFVTFFVGNT
210 220 230 240 250
INSSYLPDHS LHSISVRRLK ETQDGFKFLT DQSYIDVLPE FRDSYPIKYI
260 270 280 290 300
HAFESNHFIY FLTVQRETLD AQTFHTRIIR FCSVDSGLHS YMEMPLECIL
310 320 330 340 350
TEKRRKRSTS EEVFNILQAA YVSKPGAHLA KQIGANLNDD ILYGVFAQSK
360 370 380 390 400
PDSAEPMNRS AVCAFPVKYV NEFFNKIVNK NNVRCLQHFY GPHHEHCFNR
410 420 430 440 450
TLLRNSSGCE VRNDEYRTEF TTALQRVDLF MGQFNQVLLT SISTFIKGNL
460 470 480 490 500
TIANLGTSEG RFMQVVVSRS GSSTPHVNFH LDSHPVSPEV IVEHPLNQNG
510 520 530 540 550
YTLVVTGKKI TKIPLNGLGC EHFQSCSQCL SAPPFVQCGW CHDKCVRLEE
560 570 580 590 600
CHNGTWTQEI CLPTIYKVFP TSAPLEGGTT LTVCGWDFGF RKNNKLDSKK
610 620 630 640 650
TKVLLGNESC TLTLSESTSN TLKCTVGPAM NERFNISITV SNSRGTARYS
660 670 680 690 700
TFSYVDPIIT SISPSYGPKT GGTLLTLTGK YLNSGNSRHI SIGGKTCTLK
710 720 730 740 750
SVSDSILECY TPAQTTPTEF PVKLKIDLAN REMNSFSYRE DPIVYEIHPT
760 770 780 790 800
KSFISGGSTI TGVGKNLNSV SVLRMVINVR EAGRNFTVAC QHRSNSEIIC
810 820 830 840 850
CTTPSLQQLN LQLPLKTKAF FMLDGIHSKY FDLIYVHNPV FKPFEKPVMI
860 870 880 890 900
SIGNENVLEI KGNDIDPEAV KGEVLKVGNK SCENIHSHSE AVLCTVPSDL
910 920 930 940 950
LKLNSELNIE WKQAVSSTIL GKVIVQPDQN FTGLIVGVVS ISIILLLLLG
960 970 980 990 1000
LFLWLKRRKQ IKDLGSELVR YDARVHTPHL DRLVSARSVS PTTEMVSNES
1010 1020 1030 1040 1050
VDYRATFPED QFPNSSQNGS CRQVQYPLTD LSPILTSGDS DISSPLLQNT
1060 1070 1080 1090 1100
VHIDLSALNP ELVQAVQHVV IGPSSLIVHF NEVIGRGHFG CVYHGTLLDN
1110 1120 1130 1140 1150
DDKKIHCAVK SLNRITDIGE VSQFLTEGII MKDFSHPNVL SLLGICLRSE
1160 1170 1180 1190 1200
GSPLVVLPYM KHGDLRNFIR NETHNPTVKD LIGFGLQVAK GMKYLASKKF
1210 1220 1230 1240 1250
VHRDLAARNC MLDEKFTVKV ADFGLARDMY DKEYYSVHNK TGAKLPVKWM
1260 1270 1280 1290 1300
ALESLQTQKF TTKSDVWSFG VLLWELMTRG APPYPDVNTF DITVYLLQGR
1310 1320 1330 1340 1350
RLLQPEYCPD PLYEVMLKCW HPKAELRPSF SELVSRISAI FSTFIGEHYV
1360 1370 1380
HVNATYVNVK CVAPYPSLLS SQDNVDGEVD T
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A452GEQ5 | A0A452GEQ5_HORSE | HGF/SF receptor | MET | 1,412 | Annotation score: | ||
A0A3Q2I975 | A0A3Q2I975_HORSE | HGF/SF receptor | MET | 1,397 | Annotation score: | ||
A0A3Q2HWY0 | A0A3Q2HWY0_HORSE | HGF/SF receptor | MET | 1,334 | Annotation score: | ||
A0A3Q2HUW1 | A0A3Q2HUW1_HORSE | HGF/SF receptor | MET | 1,364 | Annotation score: | ||
A0A5F5PLQ3 | A0A5F5PLQ3_HORSE | HGF/SF receptor | MET | 1,332 | Annotation score: | ||
A0A5F5PNT8 | A0A5F5PNT8_HORSE | Hepatocyte growth factor receptor | MET | 764 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DP000020 Genomic DNA Translation: ABB89800.1 |
RefSeqi | NP_001107619.1, NM_001114147.1 |
Genome annotation databases
Ensembli | ENSECAT00000038754; ENSECAP00000023529; ENSECAG00000010385 |
GeneIDi | 100056013 |
KEGGi | ecb:100056013 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DP000020 Genomic DNA Translation: ABB89800.1 |
RefSeqi | NP_001107619.1, NM_001114147.1 |
3D structure databases
SMRi | Q2QLA9 |
ModBasei | Search... |
Proteomic databases
PaxDbi | Q2QLA9 |
PRIDEi | Q2QLA9 |
Genome annotation databases
Ensembli | ENSECAT00000038754; ENSECAP00000023529; ENSECAG00000010385 |
GeneIDi | 100056013 |
KEGGi | ecb:100056013 |
Organism-specific databases
CTDi | 4233 |
VGNCi | VGNC:20111, MET |
Phylogenomic databases
GeneTreei | ENSGT00940000158022 |
HOGENOMi | CLU_005158_0_0_1 |
InParanoidi | Q2QLA9 |
OMAi | DEEPGQC |
OrthoDBi | 408584at2759 |
TreeFami | TF317402 |
Gene expression databases
Bgeei | ENSECAG00000010385, Expressed in liver and 19 other tissues |
ExpressionAtlasi | Q2QLA9, baseline |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR011009, Kinase-like_dom_sf IPR031148, Plexin IPR002165, Plexin_repeat IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR016201, PSI IPR001627, Semap_dom IPR036352, Semap_dom_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016244, Tyr_kinase_HGF/MSP_rcpt IPR015943, WD40/YVTN_repeat-like_dom_sf |
PANTHERi | PTHR22625, PTHR22625, 1 hit |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF01437, PSI, 1 hit PF01403, Sema, 1 hit PF01833, TIG, 3 hits |
PIRSFi | PIRSF000617, TyrPK_HGF-R, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00429, IPT, 4 hits SM00423, PSI, 1 hit SM00630, Sema, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF101912, SSF101912, 1 hit SSF56112, SSF56112, 1 hit SSF81296, SSF81296, 3 hits |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS51004, SEMA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MET_HORSE | |
Accessioni | Q2QLA9Primary (citable) accession number: Q2QLA9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 7, 2006 |
Last sequence update: | January 24, 2006 | |
Last modified: | December 2, 2020 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families