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Entry version 81 (08 May 2019)
Sequence version 1 (24 Jan 2006)
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Protein

Mediator of RNA polymerase II transcription subunit 12

Gene

med12

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for development of the body axis, brain, ear, kidney, forelimb and neural crest and for pigmentation. Acts as a coactivator for sox9a and/or sox9b promoting the expression of several neuronal determination genes.By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, Repressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 12
Alternative name(s):
Mediator complex subunit 12
Protein kohtalo
Protein motionless
Thyroid hormone receptor-associated protein complex 230 kDa component
Short name:
Trap230
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:med12
Synonyms:kto, mot, trap230
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-060125-1 med12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003129601 – 2173Mediator of RNA polymerase II transcription subunit 12Add BLAST2173

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q2QCI8

PRoteomics IDEntifications database

More...
PRIDEi
Q2QCI8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Maternally expressed. Widely expressed in the early embryo and concentrated in the head by 48 hpf.2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Mediator complex.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000124576

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1872 – 2167Gln-richAdd BLAST296

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mediator complex subunit 12 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3598 Eukaryota
ENOG410XP2V LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q2QCI8

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q2QCI8

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019035 Mediator_Med12
IPR021989 Mediator_Med12_catenin-bd
IPR021990 Mediator_Med12_LCEWAV

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09497 Med12, 1 hit
PF12145 Med12-LCEWAV, 1 hit
PF12144 Med12-PQL, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01281 Med12, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q2QCI8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAFGVLSYE HRPLKRPRLG PPDVYPQDPK QKEDELTALN VKQGFNNQPA
60 70 80 90 100
VSGDEHGSAK NVNFNSSKIS SNFSSIIAEK LRCNTFPDTG KRKPQVNQKD
110 120 130 140 150
NFWLVTARSQ SSINNWFTDL AGTKPLTQLA KKVPIFSKKE EVFGYLAKYS
160 170 180 190 200
VPVMRSAWMI KMTCAYHAAI TENKMKKRHV IDPCIEWTPI ITKYLWEQLQ
210 220 230 240 250
KVAEFYRQSP SQGCGSPLPA PPAEVETAMK QWEYNEKLAM FMFQDGMLDR
260 270 280 290 300
HEFLTWVLEC FEKIRPGEDE LLRLLLPLLL QYSGEFVQSA YLSRRLAYFC
310 320 330 340 350
TRRLNLLLSD GSIGPGPGGH QAHGISAQQG NALPPTPTSQ PAGGNQPQTP
360 370 380 390 400
FTDFYICPQH RPVVFGLSCM LQSIVLCCPS ALVWHYSLTD SRNKTGSPLD
410 420 430 440 450
LLPIAPSNLP MPGGNSTFNQ QVRAKVREIE EQIKERGQAV EFRWSFDKCQ
460 470 480 490 500
ETTAGFTISR VLHTLEVLDN HSFEKSDFSN SLDSLYNRIF GSGQSKDGHE
510 520 530 540 550
MSPDDDAVVT LLCEWAVSCK RSGPHRAMVV AKLLEKRQTE IEAERCGESE
560 570 580 590 600
VVDEKGSVSS GSLSAATLPV FQDVLLQFLD TQAPVLTEPG NESERVEFSN
610 620 630 640 650
LVLLFYELIR HDVFSHNIYM CTLISRGDLA SNSHLPRPRS PSDEPSDESE
660 670 680 690 700
RKDQDAGSSV KMEDTGMSES MEIDHNSSAN FDEMFSPPMH CESKGSPSPE
710 720 730 740 750
KQAQEQESKS TAKDKGMDPA FPLVYEQPRH IQYATHFPIP QEESASHECN
760 770 780 790 800
QRLVVLYGVG KQRDEARHAI KKITKDILKV LNRKSTAETG GEEGQKRKRS
810 820 830 840 850
KPEAFPTAED IFSKFQHLSH FDQHQVTSQV SRNVLEQITS FALGMSYHLP
860 870 880 890 900
LVQHIQFIFD LMEYSLNISG LIDFAIQLLN ELSLVEAELL LKSSNLAGSY
910 920 930 940 950
TTGLCLCIVA VLRRYHSCLI LNPDQTAQVF DGLRIVVKSG VNPADCSSAE
960 970 980 990 1000
RCILAYLYDL YTSCSHLKSK FGEIFSEFCS KVKNSIYYNI DPSDSNMLWD
1010 1020 1030 1040 1050
QMFMIDAITN PTAHNLNHSM LGKITNELND SPANRYSFVC NVLMDVCVDH
1060 1070 1080 1090 1100
RDPERVNDIG ILCAELTAYC RSLSAEWLGV LKALCCSSNN GNCGFNDLLC
1110 1120 1130 1140 1150
NVDVSDLSFH DSLATFVAIL IARQCLLLED LVRCVAIPSL LNAACSEQDS
1160 1170 1180 1190 1200
EPGARLTCRI LLHLFRTPQR NPCPQDGTKS DKSIVGIRSS CDRHLLAASQ
1210 1220 1230 1240 1250
NSIVVGAVFA VLKAVFMLGD AELKGSGFSH PAGLDDIGED DMGSKKSGGR
1260 1270 1280 1290 1300
NVSIETASLV VYAKYVLKSI CHQEWVGERC LKSLSEDSSA LQDPVLVNIQ
1310 1320 1330 1340 1350
AQRLLQLICY PHRQLDSEEG DNPQRQRIKR ILQNMDQWTM RQSSLELQLM
1360 1370 1380 1390 1400
IKQSSNNELY SLLENIAKAT IEVFQKSAEM NSSNPSWNGS AVSGSSVSNS
1410 1420 1430 1440 1450
NSASKLKPVL SSSERSGVWL VAPLIGKLPT SVQGHVLKAA GEELEKGQHL
1460 1470 1480 1490 1500
GPSSRKERDR QKQKSMSLLS QQPFLSLVLT CLKGQDEQRE GLLTSLYSQV
1510 1520 1530 1540 1550
QQIVTNWRED QYQDDCKAKQ MMHEALKLRL NLVGGMFDTV QRSTQQTTEW
1560 1570 1580 1590 1600
AVLLLDIISS GTVDMQSNNE LFTTVLDMLS VLINGTLAAD MSSISQGSME
1610 1620 1630 1640 1650
ENKRAYMNLV KKLRKELGDR QSESLEKVRQ LLPLPKQTRD VITCEPQGSL
1660 1670 1680 1690 1700
IDTKGNKIAG FEKEGLQVST KQKISPWDVF EGLKHSAPLS WGWFGTIRVD
1710 1720 1730 1740 1750
RKVTKFEEQQ RLLLYHTHIK PKQRSYYLAP LNLPQEEEEP LTPVPPEPDK
1760 1770 1780 1790 1800
KLDTAKVEKS VSNVPTKKKK KKPASTVKQE DYKPHNTVMQ YAPGMTPDLP
1810 1820 1830 1840 1850
LSMGQTNMSY RMGYQAPMNM YAQNQPLPPG GPGLEPPFRP RVPMNKMPPR
1860 1870 1880 1890 1900
PNYTMPNMQT AGMGNLMGME KQYQMNYKPM PNMAQGQMLR HQLQGHNHLI
1910 1920 1930 1940 1950
GQQIRQVTPN PQYSSMQPAQ NIPQGYTSYG SHMGMQPHPS QTPGMVPNSY
1960 1970 1980 1990 2000
GNQGFQTGHP ATNPTMVDSI RQMQQRPGYV HQQAPAAYGH TIQSTQRFPH
2010 2020 2030 2040 2050
QSMQQTPMMH GLAQSHLGVQ GIHPNMRPNQ MMEQQQQQQQ QQQQQQQQQQ
2060 2070 2080 2090 2100
QVHQQQQHIR QGPVFRPQQQ QQVQQQVQQQ VQQQQVQQQQ VQQQVQPQQV
2110 2120 2130 2140 2150
QQQQVQQQQQ QQVSAAQPPA QALGMQALPP QQPMFQRQGM QQTQQQQQTA
2160 2170
ALVRQLQQQL SSTQPAQNNS SYY
Length:2,173
Mass (Da):243,992
Last modified:January 24, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9BE52FEAAEB97F88
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4IBL3A0A0R4IBL3_DANRE
Mediator of RNA polymerase II trans...
med12
2,175Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QEP6A0A2R8QEP6_DANRE
Mediator of RNA polymerase II trans...
med12
2,188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4IEY1A0A0R4IEY1_DANRE
Mediator of RNA polymerase II trans...
med12
267Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ133567 mRNA Translation: AAZ73481.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ133567 mRNA Translation: AAZ73481.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000124576

Proteomic databases

PaxDbiQ2QCI8
PRIDEiQ2QCI8

Organism-specific databases

ZFINiZDB-GENE-060125-1 med12

Phylogenomic databases

eggNOGiKOG3598 Eukaryota
ENOG410XP2V LUCA
InParanoidiQ2QCI8
PhylomeDBiQ2QCI8

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q2QCI8

Family and domain databases

InterProiView protein in InterPro
IPR019035 Mediator_Med12
IPR021989 Mediator_Med12_catenin-bd
IPR021990 Mediator_Med12_LCEWAV
PfamiView protein in Pfam
PF09497 Med12, 1 hit
PF12145 Med12-LCEWAV, 1 hit
PF12144 Med12-PQL, 1 hit
SMARTiView protein in SMART
SM01281 Med12, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMED12_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2QCI8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 24, 2006
Last modified: May 8, 2019
This is version 81 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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