UniProtKB - Q2Q551 (Q2Q551_DANRE)
Protein
Calcium channel voltage-dependent subunit beta 1
Gene
cacnb1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- high voltage-gated calcium channel activity Source: GO_Central
- voltage-gated calcium channel activity Source: ZFIN
GO - Biological processi
- chemical synaptic transmission Source: GO_Central
- muscle contraction Source: ZFIN
- neuromuscular junction development Source: GO_Central
- regulation of voltage-gated calcium channel activity Source: GO_Central
- voltage-gated calcium channel complex assembly Source: ZFIN
Keywordsi
Molecular function | Calcium channelARBA annotation, Ion channel, ReceptorImported, Voltage-gated channelARBA annotation |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium |
Enzyme and pathway databases
Reactomei | R-DRE-112308, Presynaptic depolarization and calcium channel opening R-DRE-5576892, Phase 0 - rapid depolarisation R-DRE-5576893, Phase 2 - plateau phase |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium channel voltage-dependent subunit beta 1ARBA annotationAlternative name(s): Voltage-dependent L-type calcium channel subunit beta-1ARBA annotation |
Gene namesi | Name:cacnb1Imported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-040718-399, cacnb1 |
Subcellular locationi
Plasma membrane
- sarcolemma ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
- Cell membrane ARBA annotation; Peripheral membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Peripheral membrane protein ARBA annotation
Plasma Membrane
- sarcolemma Source: UniProtKB-SubCell
- voltage-gated calcium channel complex Source: ZFIN
Other locations
Expressioni
Gene expression databases
Bgeei | ENSDARG00000002167, Expressed in muscle organ and 42 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 103 – 172 | SH3InterPro annotationAdd BLAST | 70 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 84 | DisorderedSequence analysisAdd BLAST | 84 | |
Regioni | 172 – 221 | DisorderedSequence analysisAdd BLAST | 50 | |
Regioni | 457 – 603 | DisorderedSequence analysisAdd BLAST | 147 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 21 | PolarSequence analysisAdd BLAST | 21 | |
Compositional biasi | 46 – 72 | PolarSequence analysisAdd BLAST | 27 | |
Compositional biasi | 172 – 199 | PolarSequence analysisAdd BLAST | 28 | |
Compositional biasi | 470 – 506 | PolarSequence analysisAdd BLAST | 37 |
Sequence similaritiesi
Belongs to the calcium channel beta subunit family.ARBA annotation
Keywords - Domaini
SH3 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG3812, Eukaryota |
GeneTreei | ENSGT00950000182837 |
HOGENOMi | CLU_021995_3_0_1 |
TreeFami | TF316195 |
Family and domain databases
InterProi | View protein in InterPro IPR008145, GK/Ca_channel_bsu IPR027417, P-loop_NTPase IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR005443, VDCC_L_b1su IPR000584, VDCC_L_bsu |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF12052, VGCC_beta4Aa_N, 1 hit |
PRINTSi | PR01626, LCACHANNELB PR01627, LCACHANNELB1 |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q2Q551-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVQEGNMSRT PSTSTQEIQM DMFDHHGSHA QGKYAKRKSR FKRSDGSTSS
60 70 80 90 100
DTTSNSFVRQ GSADSYTSRP SDSDVSLEED PEALRKEADR QALATLEKAK
110 120 130 140 150
TKPVAFAVRT NVGYNPGPND DVPVQGMAIS FEPKDFLHIK EKYNNDWWIG
160 170 180 190 200
RLVKEGCEVG FIPSPVKLES TRQLQEQRMR QNRLSSSKSG GSSSLDVATG
210 220 230 240 250
ARRPTPPGTG GPAKQKQKSM EHVPPYDVVP SMRPIILVGP SLKGYEVTDM
260 270 280 290 300
MQKALFDFLK HKFEGRISIT RVTADISLAK RSVLNNPSKH TIIERSSTRS
310 320 330 340 350
SLAEVQSEIE RIFELARTLQ LVALDADTIN HPSQLAKTSL APIIVYIKIA
360 370 380 390 400
SPKVLQRLIK SRGKSQAKHL NVQMVAADKL AQCPPELFDI ILDENQLEDA
410 420 430 440 450
CEHLAEYLEA YWKATHPPSS NPPNPLLNRT MATAALAASP EPVSNLQGPF
460 470 480 490 500
LVHGEQKREM PERGGLQDYQ SDLSGKQPLR SSRSQLQTGS RGLSRQDTFD
510 520 530 540 550
SETQGSRDSA YTDDMETDPY EEPDPCRSYR LNPAHHAPRQ ASWEDEGAEP
560 570 580 590 600
DQENLNMVPP PANQHQRGRG KLRERYCQDA EAGGATTGRN HNQEEWSRDV
YIR
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ6DG31 | Q6DG31_DANRE | Calcium channel voltage-dependent s... | cacnb1 | 478 | Annotation score: | ||
F1R605 | F1R605_DANRE | Calcium channel voltage-dependent s... | cacnb1 | 520 | Annotation score: | ||
Q2Q552 | Q2Q552_DANRE | Calcium channel voltage-dependent s... | cacnb1 | 517 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR387933 Genomic DNA No translation available. CR388097 Genomic DNA No translation available. DQ198172 mRNA Translation: ABB05051.1 |
RefSeqi | XP_009297553.1, XM_009299278.2 |
Genome annotation databases
Ensembli | ENSDART00000057159; ENSDARP00000057158; ENSDARG00000002167 |
GeneIDi | 436925 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR387933 Genomic DNA No translation available. CR388097 Genomic DNA No translation available. DQ198172 mRNA Translation: ABB05051.1 |
RefSeqi | XP_009297553.1, XM_009299278.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000107021 |
Genome annotation databases
Ensembli | ENSDART00000057159; ENSDARP00000057158; ENSDARG00000002167 |
GeneIDi | 436925 |
Organism-specific databases
CTDi | 782 |
ZFINi | ZDB-GENE-040718-399, cacnb1 |
Phylogenomic databases
eggNOGi | KOG3812, Eukaryota |
GeneTreei | ENSGT00950000182837 |
HOGENOMi | CLU_021995_3_0_1 |
TreeFami | TF316195 |
Enzyme and pathway databases
Reactomei | R-DRE-112308, Presynaptic depolarization and calcium channel opening R-DRE-5576892, Phase 0 - rapid depolarisation R-DRE-5576893, Phase 2 - plateau phase |
Gene expression databases
Bgeei | ENSDARG00000002167, Expressed in muscle organ and 42 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR008145, GK/Ca_channel_bsu IPR027417, P-loop_NTPase IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR005443, VDCC_L_b1su IPR000584, VDCC_L_bsu |
Pfami | View protein in Pfam PF00625, Guanylate_kin, 1 hit PF12052, VGCC_beta4Aa_N, 1 hit |
PRINTSi | PR01626, LCACHANNELB PR01627, LCACHANNELB1 |
SMARTi | View protein in SMART SM00072, GuKc, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q2Q551_DANRE | |
Accessioni | Q2Q551Primary (citable) accession number: Q2Q551 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 24, 2006 |
Last sequence update: | January 24, 2006 | |
Last modified: | October 7, 2020 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |