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Entry version 133 (02 Jun 2021)
Sequence version 2 (27 Jul 2011)
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Protein

Protocadherin Fat 4

Gene

Fat4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cadherins are cell-cell interaction molecules. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protocadherin Fat 4
Alternative name(s):
FAT tumor suppressor homolog 4
Fat-like cadherin protein FAT-J
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fat4
Synonyms:Fatj
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3045256, Fat4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini43 – 4505ExtracellularSequence analysisAdd BLAST4463
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4506 – 4526HelicalSequence analysisAdd BLAST21
Topological domaini4527 – 4981CytoplasmicSequence analysisAdd BLAST455

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Deficient mice exhibit postnatal lethality, growth retardation, small lungs, abnormal cochlea morphology, abnormal kidney morphology, cardiovascular abnormalities and skeletal abnormalities. DCHS1 and FAT4 single mutants and DCHS1/FAT4 double mutants have similar phenotypes.3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 42Sequence analysisAdd BLAST42
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032463843 – 4981Protocadherin Fat 4Add BLAST4939

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi237N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi393N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi416N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi435N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi483N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi551N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi615N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi676N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi721N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi825N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi880N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi948N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1085N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1225N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1296N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1389N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1514N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1828N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1899N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1967N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2119N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2387N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2432N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2923N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2939N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3038N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3142N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3219N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3394N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3479N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3708N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3760N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi3808 ↔ 3819By similarity
Disulfide bondi3813 ↔ 3850By similarity
Disulfide bondi3852 ↔ 3861By similarity
Disulfide bondi3868 ↔ 3879By similarity
Disulfide bondi3873 ↔ 3888By similarity
Disulfide bondi3890 ↔ 3899By similarity
Disulfide bondi3906 ↔ 3917By similarity
Disulfide bondi3911 ↔ 3926By similarity
Disulfide bondi3928 ↔ 3937By similarity
Disulfide bondi3944 ↔ 3955By similarity
Disulfide bondi3949 ↔ 3964By similarity
Disulfide bondi3966 ↔ 3975By similarity
Glycosylationi4019N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4135 ↔ 4161By similarity
Disulfide bondi4168 ↔ 4179By similarity
Disulfide bondi4173 ↔ 4188By similarity
Disulfide bondi4190 ↔ 4199By similarity
Glycosylationi4269N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi4314N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi4366 ↔ 4399By similarity
Disulfide bondi4431 ↔ 4442By similarity
Disulfide bondi4436 ↔ 4452By similarity
Disulfide bondi4454 ↔ 4463By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei4878PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q2PZL6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q2PZL6

PeptideAtlas

More...
PeptideAtlasi
Q2PZL6

PRoteomics IDEntifications database

More...
PRIDEi
Q2PZL6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
275590 [Q2PZL6-1]
275591 [Q2PZL6-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2656, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q2PZL6, 38 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q2PZL6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q2PZL6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in all layers of the developing brain, with expression being most prominent at the ventricular margin.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000046743, Expressed in pineal body and 237 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q2PZL6, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterophilic interaction with DCHS1; this interaction affects their respective protein levels.

Interacts (via cytoplasmic domain) with MPDZ.

Forms a complex with PALS1 and MPDZ.

1 Publication

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q2PZL6, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000061836

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q2PZL6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q2PZL6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 135Cadherin 1PROSITE-ProRule annotationAdd BLAST92
Domaini136 – 250Cadherin 2PROSITE-ProRule annotationAdd BLAST115
Domaini251 – 353Cadherin 3PROSITE-ProRule annotationAdd BLAST103
Domaini359 – 475Cadherin 4PROSITE-ProRule annotationAdd BLAST117
Domaini476 – 582Cadherin 5PROSITE-ProRule annotationAdd BLAST107
Domaini584 – 689Cadherin 6PROSITE-ProRule annotationAdd BLAST106
Domaini690 – 793Cadherin 7PROSITE-ProRule annotationAdd BLAST104
Domaini794 – 893Cadherin 8PROSITE-ProRule annotationAdd BLAST100
Domaini894 – 996Cadherin 9PROSITE-ProRule annotationAdd BLAST103
Domaini997 – 1100Cadherin 10PROSITE-ProRule annotationAdd BLAST104
Domaini1101 – 1210Cadherin 11PROSITE-ProRule annotationAdd BLAST110
Domaini1211 – 1315Cadherin 12PROSITE-ProRule annotationAdd BLAST105
Domaini1316 – 1420Cadherin 13PROSITE-ProRule annotationAdd BLAST105
Domaini1421 – 1529Cadherin 14PROSITE-ProRule annotationAdd BLAST109
Domaini1529 – 1629Cadherin 15PROSITE-ProRule annotationAdd BLAST101
Domaini1630 – 1740Cadherin 16PROSITE-ProRule annotationAdd BLAST111
Domaini1741 – 1841Cadherin 17PROSITE-ProRule annotationAdd BLAST101
Domaini1842 – 1944Cadherin 18PROSITE-ProRule annotationAdd BLAST103
Domaini1945 – 2051Cadherin 19PROSITE-ProRule annotationAdd BLAST107
Domaini2051 – 2154Cadherin 20PROSITE-ProRule annotationAdd BLAST104
Domaini2155 – 2259Cadherin 21PROSITE-ProRule annotationAdd BLAST105
Domaini2260 – 2364Cadherin 22PROSITE-ProRule annotationAdd BLAST105
Domaini2365 – 2468Cadherin 23PROSITE-ProRule annotationAdd BLAST104
Domaini2469 – 2569Cadherin 24PROSITE-ProRule annotationAdd BLAST101
Domaini2570 – 2671Cadherin 25PROSITE-ProRule annotationAdd BLAST102
Domaini2672 – 2775Cadherin 26PROSITE-ProRule annotationAdd BLAST104
Domaini2775 – 2874Cadherin 27PROSITE-ProRule annotationAdd BLAST100
Domaini2875 – 2985Cadherin 28PROSITE-ProRule annotationAdd BLAST111
Domaini2986 – 3091Cadherin 29PROSITE-ProRule annotationAdd BLAST106
Domaini3092 – 3196Cadherin 30PROSITE-ProRule annotationAdd BLAST105
Domaini3197 – 3300Cadherin 31PROSITE-ProRule annotationAdd BLAST104
Domaini3301 – 3406Cadherin 32PROSITE-ProRule annotationAdd BLAST106
Domaini3407 – 3512Cadherin 33PROSITE-ProRule annotationAdd BLAST106
Domaini3511 – 3622Cadherin 34PROSITE-ProRule annotationAdd BLAST112
Domaini3804 – 3862EGF-like 1PROSITE-ProRule annotationAdd BLAST59
Domaini3864 – 3900EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini3902 – 3938EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini3940 – 3976EGF-like 4PROSITE-ProRule annotationAdd BLAST37
Domaini3977 – 4161Laminin G-like 1PROSITE-ProRule annotationAdd BLAST185
Domaini4164 – 4200EGF-like 5PROSITE-ProRule annotationAdd BLAST37
Domaini4219 – 4399Laminin G-like 2PROSITE-ProRule annotationAdd BLAST181
Domaini4427 – 4464EGF-like 6PROSITE-ProRule annotationAdd BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni4535 – 4585DisorderedSequence analysisAdd BLAST51
Regioni4677 – 4713DisorderedSequence analysisAdd BLAST37
Regioni4708 – 4797Necessary and sufficient for interaction with MPDZ1 PublicationAdd BLAST90
Regioni4753 – 4773DisorderedSequence analysisAdd BLAST21
Regioni4796 – 4911DisorderedSequence analysisAdd BLAST116
Regioni4957 – 4981DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4535 – 4556Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi4677 – 4705Polar residuesSequence analysisAdd BLAST29
Compositional biasi4813 – 4827Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi4849 – 4865Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi4875 – 4891Basic and acidic residuesSequence analysisAdd BLAST17

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217, Eukaryota
KOG3594, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155719

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000042_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q2PZL6

Identification of Orthologs from Complete Genome Data

More...
OMAi
LFTIGRQ

Database of Orthologous Groups

More...
OrthoDBi
34489at2759

TreeFam database of animal gene trees

More...
TreeFami
TF331335

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR001791, Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028, Cadherin, 33 hits
PF00008, EGF, 2 hits
PF07645, EGF_CA, 1 hit
PF12661, hEGF, 1 hit
PF02210, Laminin_G_2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205, CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112, CA, 34 hits
SM00181, EGF, 6 hits
SM00179, EGF_CA, 5 hits
SM00282, LamG, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313, SSF49313, 34 hits
SSF49899, SSF49899, 2 hits
SSF57184, SSF57184, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 2 hits
PS00232, CADHERIN_1, 22 hits
PS50268, CADHERIN_2, 34 hits
PS00022, EGF_1, 7 hits
PS01186, EGF_2, 3 hits
PS50026, EGF_3, 6 hits
PS01187, EGF_CA, 2 hits
PS50025, LAM_G_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q2PZL6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNLAANRAPG RRRLPLPSPS LCQLLRVWGL LSLLPGSARV QAAEQRQVFQ
60 70 80 90 100
VMEEQPPGTL VGTIPTRPGF TYRLSESHAL FAINSSTGAL YTTATIDRES
110 120 130 140 150
LPSDVVNLVV LSSSPTYPTE VRVLVRDLND NAPVFPDPSI VVTFKEDSGS
160 170 180 190 200
GRQVILDTAT DSDIGSNGVD HHSYRIVSGN EAGRFRLDIT LNPSGEGAFL
210 220 230 240 250
HLVSKGGLDR EVTPQYQLLV EVEDKGEPKR RGYLQVNVTV QDINDNPPVF
260 270 280 290 300
GSSHYQAGVP EDAVVGSSVL QVAAADADEG TNADIRYRLQ DEGTPFQMDP
310 320 330 340 350
ETGLITVREP LDFEARRQYS LTVQATDRGV PSLTGRAEAF IQLLDVNDND
360 370 380 390 400
PVVKFRYFPA TSRYASVDEN AQVGTVVALL TVTDADSPAA NGNISVQILG
410 420 430 440 450
GNEQRHFEVQ RSKVPNLSLI KVASALDRER IPSYNLTVSV SDNSGAPPTA
460 470 480 490 500
EVQARSSVAS LVIFVNDIND HPPVFEQQVY RVNLSEEVPP GSYVSGVSAT
510 520 530 540 550
DGDSGLNANL RYSIVSGNGL GWFHISEHSG LVTTSAAGGL DRELASQIVL
560 570 580 590 600
NISARDQGVH PKVSYAQLVV TVLDVNDEKP VFSQPEGYEV SVVENAPTGT
610 620 630 640 650
ELLVLGATDR DLGDNGTVRF SLQEAENDQR LFRLDPVSGR LSTASSLDRE
660 670 680 690 700
EQAFYCLSIL ATDLGSPPQS STAQVNVSLL DINDNSPVFY PVQYFAHIQE
710 720 730 740 750
NEPGGSYVTT VSATDPDMGP NGTVKYSISA GDRSRFQIHA KSGVISTKMA
760 770 780 790 800
LDREEKTAYQ LQVVATDGGN LQSPNQAIVT VTVLDTQDNP PVFSQAAYSF
810 820 830 840 850
VVFENVALGY HVGSVSATTM DLNANISYLI TTGDQRGMFA MNPVTGQLTT
860 870 880 890 900
ASVIDREEQS FYQLKIVASG GAVTGDTVVN ITVKDLNDNA PHFLQAVESI
910 920 930 940 950
NAVENWQAGH SIFQAKAVDP DEGVNGRVLY SLKQNPKNLF TINEQNGNIS
960 970 980 990 1000
LLGALDVHAG SYQVEIVASD MGVPQLSSSI LLTVYVHDVN DNPPVFDQIS
1010 1020 1030 1040 1050
YEVTLSESEP VNSRFFKVQA SDKDSGANGE IAYTITDGNN GDAFGIFPDG
1060 1070 1080 1090 1100
QLYIKSELDR ELQDRYVLLV VASDRAVEPL SATVNVTVLL EDVNDNRPLF
1110 1120 1130 1140 1150
NSTNYTFYFE EEQRAGSFVG KVSAVDKDFG PNGEVRYAFE VTQPNFELHA
1160 1170 1180 1190 1200
VTGEITSTHK FDRESLMRRR GTAVFSFTVT AMDRGLPQPL KDQATVHVYM
1210 1220 1230 1240 1250
KDINDNAPKF LKDFYQATVS ETATNLTQVL RVSASDVDEG SNGLIHYSIL
1260 1270 1280 1290 1300
KGNEERQFAI DSFSGQVTLV GKLDYEATSA YSLLIQAVDS GAIPLNSTCT
1310 1320 1330 1340 1350
LSIDILDEND NTPSFPKSTL FVDVLENMRI GELVSSVTAT DSDSGVNADL
1360 1370 1380 1390 1400
HYTITGSNNH GTFSISPNTG SIFLAKKLDF ETQSLYKLNI TAKDQGRPPR
1410 1420 1430 1440 1450
SSTMSVVIQV RDFNDNPPSF PPGDIFKSIV ENIPLGTSVI SVTAHDPDAD
1460 1470 1480 1490 1500
INGQLSYAII QQMPRGNHFS IDEVKGTIYT SAEIDREFAN LFELTVKAND
1510 1520 1530 1540 1550
QAVPIETRRY ALKNVTILVT DLNDNVPMFI SQNALAADPS AMIGSVLTTI
1560 1570 1580 1590 1600
MAADPDEGAN GEVEYEILNG DTDTFTVDRY SGDLRVASAL VPSQLIYNLI
1610 1620 1630 1640 1650
VSATDLGPER RKSTTELTVI LQGLDGPVFT QTKYITILKE GEPIGTNVIS
1660 1670 1680 1690 1700
IEAASPRGSE APVEYYIVSV RCEEKTVGRL FTIGRQTGVI QTAAILDREQ
1710 1720 1730 1740 1750
GACLYLVDVY AIEKSSAFPR TQRAEVEITL QDINDNPPVF PTDTLDLTVE
1760 1770 1780 1790 1800
ENIGDGSKIM QLTAMDADEG ANALVTYALI SGADDSFRID PESGDLIATK
1810 1820 1830 1840 1850
RLDREHRSKY SLLVRADDGL QSSDMRINIT ISDVNDHTPR FSRPVYSFDI
1860 1870 1880 1890 1900
PEDTTPGSLV AAILATDDDS GVNGEISYVV EEDDGDGVFF LNLVTGVFNL
1910 1920 1930 1940 1950
TRALDYETQQ YYILTVRAED GGGQSTTIRA YFNILDVNDN PPVFSMSSYS
1960 1970 1980 1990 2000
TSLMENLPLG STVLVFNVTD ADDGVNSQLS YSIASGDSLG QFAVDKHGVL
2010 2020 2030 2040 2050
KTLKALDRES QSFYNLVIQV HDLPQPPTSR FTSTAQVSII LLDVNDNPPM
2060 2070 2080 2090 2100
FLSPKLTYIP ENTPIDTVVF KAQATDPDSG PNSYIEYTLL NPSGNKFSIG
2110 2120 2130 2140 2150
TIDGEVHLTG ELDREEVSNY SLTVVATDKG QPPLSSSTEV VVMVLDINDN
2160 2170 2180 2190 2200
NPVFAQAMYR VQIKENILTG TDIIQVSAAD NDEGTNGQVR YGIVGGNTHQ
2210 2220 2230 2240 2250
EFRIDSVTGA ITVAKSLDRE TTPAYTLTVQ ATDRGSSPRT DSCTVAITLL
2260 2270 2280 2290 2300
DMNDFVPVFE LSPYSVNVPE NLGTLPRAIL QVVARDDDQG PNSQLSYVLL
2310 2320 2330 2340 2350
GGNEDNAFVL TASGELRVTQ SLDREARDHF VLVVTAADAG SPALTGTGTI
2360 2370 2380 2390 2400
NIIVDDINDN VPTFANNMYL TSIAEDARTG TDVLLVNASD ADAAANAVIS
2410 2420 2430 2440 2450
YSIIGGNSQF TINPSTGQII TSALLDRETK DNYTLVVVAS DAGSPESLSS
2460 2470 2480 2490 2500
STSVLVTITD VNDNPPRFQH HPYVTHIPSP TPPGSFVFAV TVTDADIGSN
2510 2520 2530 2540 2550
SELHYSLSGR NSEKFHIDPL RGAIMAAGPL SGASEVTFSV HVKDGGSFPK
2560 2570 2580 2590 2600
TDSTTVTVRF ANKADFPKVR AKEQTFMFPE NQPVGTLVTT ITGSSLRGET
2610 2620 2630 2640 2650
LSYYIASGNL GDTFQIDPLT GQVSISQPLD FEKIQKYVVW IEARDGGFPP
2660 2670 2680 2690 2700
FSSYEKLDIT VLDINDNAPT FEEDPFVSEI LENLSPRKIL TVSATDKDSG
2710 2720 2730 2740 2750
PNGQLDYEIV NGNQESSFTI NHATGEIRSI RPLDREKISH YELTVKSSDK
2760 2770 2780 2790 2800
GSPSQSTSVK VIISILDEND NAPRFSQIFS AYVSENSPLG YTVTRVTTSD
2810 2820 2830 2840 2850
EDIGINAISR YSIVDTSLPF TINPNTGDIV ISRPLNREDT DRYRIRVSAH
2860 2870 2880 2890 2900
DSGWTVSTDV TIFVTDINDN TPRFSRPSYY LDCPELPELG SRVTQVSATD
2910 2920 2930 2940 2950
PDEGSNGQVF YFIKSQSEYF RINATTGEIF NKQVLKYQNV SGFSNVNINR
2960 2970 2980 2990 3000
HSFIVTASDR GNPSLLSETT VTINTVDSND NPPQFLQNKY FTPVTKNVKV
3010 3020 3030 3040 3050
GTKLIKVTAV DDKDFGLNSE VEYFVSDGNH LGKFKLDNDT GWISIASSLV
3060 3070 3080 3090 3100
SDLNQNFLIR VTAKDKGNPP LSSQAVVHIT VTEENYHTPE FSQNHISATI
3110 3120 3130 3140 3150
PESHSIGSVV RTVSARDRDT AMNGLISYNI ISGNEEGIFA INSSTGVVTL
3160 3170 3180 3190 3200
AKALDYEMSS KHEMTISATD GGWVARTGYC SLTVSVIDVN DNSPVFVPDE
3210 3220 3230 3240 3250
FFPTVMENAP SGTTVIHLNA TDADSGANAV IAYTVQSSDS DLFVIDPNMG
3260 3270 3280 3290 3300
VITTQGFLDF ETKQSYHLTV KAFNVPDEEK CSFATVDIQL KGTNEYVPRF
3310 3320 3330 3340 3350
VSKLYYFEVS EAASRGTAVG EVFASDRDMG ADGEVHYLIF GNSRKKGFQI
3360 3370 3380 3390 3400
NKMTGQIYVS GLLDREKEER VSLKVLAKNF GNIRGADIDE VTVNITVLDA
3410 3420 3430 3440 3450
NDPPVFSLST YRVQISEGVP IGTHVTFVSA FDSDSIPSWS RFSYFIGSGN
3460 3470 3480 3490 3500
ENGAFSINPQ TGQITVTSGL DRESLPVYNL TVLAVDSGTP SATGSASLVV
3510 3520 3530 3540 3550
TLEDINDNGP VLTVSEGEVL ENKRPGTLVM TLQSTDPDLP PNQGPFNYYL
3560 3570 3580 3590 3600
LSTGPATNYF SLSTAGVLST TREIDREQIA DFYLSVVTRD SGAPQMSSTG
3610 3620 3630 3640 3650
TVHITVLDQN DNPSQSRTVE IFVNYYGNLF PGGTLGSVKP QDPDVLDSFH
3660 3670 3680 3690 3700
CSLTSGVTSL FSIPAGSCDL SSQPRSTDGT FDLTVVSSDG VHSTVTNNIR
3710 3720 3730 3740 3750
VFFAGFSNAT IDNSILLRVG VPTVKDFLTN HYLHFLRIAS SQLTGLGTAV
3760 3770 3780 3790 3800
QLYAAYEENN RTFLLAAVKR NNNQYVNPSG VATFFESIKE ILLRQSGVKV
3810 3820 3830 3840 3850
ESVDHDPCIH GPCQNGGSCL RRLAVGSALK IQESLPVIIV ANEPLQPSQC
3860 3870 3880 3890 3900
KCVPGYAGSW CEVDIDECLP APCHNGGTCH NLVGGFSCSC PEGFTGRACE
3910 3920 3930 3940 3950
RDINECLPSP CKHGAVCQNF PGGFNCVCKT GYTGKMCESS VNYCECNPCF
3960 3970 3980 3990 4000
NGGSCQSGVE SYYCHCPFGV FGKHCELNSY GFEELSYMEF PSLDPNNNYI
4010 4020 4030 4040 4050
YVKFATIKSH ALLLYNYDNQ TGERAEFLAL EIAEERLRFS YNLGSGTYKL
4060 4070 4080 4090 4100
TTMKKVSDGQ FHTVIARRAG MAASLTVDSC SENQEPGYCT VSNVAVSDDW
4110 4120 4130 4140 4150
TLDVQPNRVT VGGIRSLEPI LQRRGHVESH DFVGCVMEFA VNGRPLEPSQ
4160 4170 4180 4190 4200
ALAAQGILDQ CPRLEGTCAR NPCQHGGTCV DFWSWQQCQC MEGLTGKYCE
4210 4220 4230 4240 4250
KSVTPDTALS LEGKGRLDYH MSQSEKREYL LTQSIRDTTL EPFGVNSLEV
4260 4270 4280 4290 4300
KFRTRSENGI LIHIQESSNY TTVKIKNGKV HFTSDAGVAG KVERIIPEAY
4310 4320 4330 4340 4350
IADGHWHTFR ISKNGSITVL SVDRIHNRDI VHPTQDFGGI EVLSMSLGGI
4360 4370 4380 4390 4400
PPNQAHRDTQ TGFNGCIASV LYGGESLPFS GKHSLASISK TDPSVKIGCR
4410 4420 4430 4440 4450
GPNICASNPC WGDLLCINQW YAYKCVPPGD CASHPCQNGG SCEPGLLSGY
4460 4470 4480 4490 4500
TCSCPESHTG RTCETVVACL GVLCPQGKVC KAGSPGGHVC VQSQGPDEIS
4510 4520 4530 4540 4550
LPLWAVPAIV GSCATALALL VLSLILCNQC RGKMPKNPKE EKKPKEKKKK
4560 4570 4580 4590 4600
GSENVAFDDP DNIPPYGDDL AVRKQPEGNP KPDIIERENP YLIFDETDIP
4610 4620 4630 4640 4650
HNSETIPSAP LASPEQEIEH YDIDNASSIA PSDADIIQHY KQFRSHTPKF
4660 4670 4680 4690 4700
SIQRHSPLGF ARQSPMPLGA SSLTYQPSSY GQGLRTSSLS HSACPTPNPL
4710 4720 4730 4740 4750
SRHSPAPFSK PSAFYRNSPA RELHLPLRDG GTLEMHGDPC QPGMFNYATR
4760 4770 4780 4790 4800
LGRRSKSPQA MASHGSRPGS RLKQPIAQIP LESSPPVGLS IEEVERLNTP
4810 4820 4830 4840 4850
RPRNPSICSA DHGRSSSEED CRRPLSRTRN PADGIPAPES SSDSDSHDSF
4860 4870 4880 4890 4900
TCSEMEYDRE KPVVYTSRMP KLSQVNESDA DDEDNYGARL KPRRYHGRRA
4910 4920 4930 4940 4950
EGGPVGTPAA ASGAADSTLK LGQQAGNFNW DNLLNWGPGF GHYVDVFKDL
4960 4970 4980
ASLPEKAAGN EEGKSGAAKP AAKDGEAEQY V
Length:4,981
Mass (Da):540,316
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD0436BAC3162CFD2
GO
Isoform 2 (identifier: Q2PZL6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1975-1978: VNSQ → MSFL
     1979-4981: Missing.

Show »
Length:1,978
Mass (Da):214,692
Checksum:i438491FB872838C1
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC27359 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC28751 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1481S → N in ABB88946 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0323391975 – 1978VNSQ → MSFL in isoform 2. 1 Publication4
Alternative sequenceiVSP_0323401979 – 4981Missing in isoform 2. 1 PublicationAdd BLAST3003

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ286572 mRNA Translation: ABB88946.1
AC122841 Genomic DNA No translation available.
AC161228 Genomic DNA No translation available.
AK031348 mRNA Translation: BAC27359.1 Different initiation.
AK034552 mRNA Translation: BAC28751.1 Different initiation.
BC079887 mRNA Translation: AAH79887.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS17325.1 [Q2PZL6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_899044.3, NM_183221.3 [Q2PZL6-1]
XP_006535547.1, XM_006535484.3 [Q2PZL6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000061260; ENSMUSP00000061836; ENSMUSG00000046743 [Q2PZL6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
329628

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:329628

UCSC genome browser

More...
UCSCi
uc008pbe.1, mouse [Q2PZL6-2]
uc008pbf.1, mouse [Q2PZL6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ286572 mRNA Translation: ABB88946.1
AC122841 Genomic DNA No translation available.
AC161228 Genomic DNA No translation available.
AK031348 mRNA Translation: BAC27359.1 Different initiation.
AK034552 mRNA Translation: BAC28751.1 Different initiation.
BC079887 mRNA Translation: AAH79887.1
CCDSiCCDS17325.1 [Q2PZL6-1]
RefSeqiNP_899044.3, NM_183221.3 [Q2PZL6-1]
XP_006535547.1, XM_006535484.3 [Q2PZL6-1]

3D structure databases

SMRiQ2PZL6
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ2PZL6, 1 interactor
STRINGi10090.ENSMUSP00000061836

PTM databases

GlyConnecti2656, 1 N-Linked glycan (1 site)
GlyGeniQ2PZL6, 38 sites
iPTMnetiQ2PZL6
PhosphoSitePlusiQ2PZL6

Proteomic databases

MaxQBiQ2PZL6
PaxDbiQ2PZL6
PeptideAtlasiQ2PZL6
PRIDEiQ2PZL6
ProteomicsDBi275590 [Q2PZL6-1]
275591 [Q2PZL6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
62649, 109 antibodies

Genome annotation databases

EnsembliENSMUST00000061260; ENSMUSP00000061836; ENSMUSG00000046743 [Q2PZL6-1]
GeneIDi329628
KEGGimmu:329628
UCSCiuc008pbe.1, mouse [Q2PZL6-2]
uc008pbf.1, mouse [Q2PZL6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79633
MGIiMGI:3045256, Fat4

Phylogenomic databases

eggNOGiKOG1217, Eukaryota
KOG3594, Eukaryota
GeneTreeiENSGT00940000155719
HOGENOMiCLU_000042_1_0_1
InParanoidiQ2PZL6
OMAiLFTIGRQ
OrthoDBi34489at2759
TreeFamiTF331335

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
329628, 0 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Fat4, mouse

Protein Ontology

More...
PROi
PR:Q2PZL6
RNActiQ2PZL6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000046743, Expressed in pineal body and 237 other tissues
GenevisibleiQ2PZL6, MM

Family and domain databases

InterProiView protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR001791, Laminin_G
PfamiView protein in Pfam
PF00028, Cadherin, 33 hits
PF00008, EGF, 2 hits
PF07645, EGF_CA, 1 hit
PF12661, hEGF, 1 hit
PF02210, Laminin_G_2, 2 hits
PRINTSiPR00205, CADHERIN
SMARTiView protein in SMART
SM00112, CA, 34 hits
SM00181, EGF, 6 hits
SM00179, EGF_CA, 5 hits
SM00282, LamG, 2 hits
SUPFAMiSSF49313, SSF49313, 34 hits
SSF49899, SSF49899, 2 hits
SSF57184, SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 2 hits
PS00232, CADHERIN_1, 22 hits
PS50268, CADHERIN_2, 34 hits
PS00022, EGF_1, 7 hits
PS01186, EGF_2, 3 hits
PS50026, EGF_3, 6 hits
PS01187, EGF_CA, 2 hits
PS50025, LAM_G_DOMAIN, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFAT4_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2PZL6
Secondary accession number(s): E9QMR9
, Q68FE0, Q8BM82, Q8CD68
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 27, 2011
Last modified: June 2, 2021
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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