UniProtKB - Q2PWA3 (PA2HP_PROMU)
Protein
Basic phospholipase A2 homolog promutoxin
Gene
N/A
Organism
Protobothrops mucrosquamatus (Taiwan habu) (Trimeresurus mucrosquamatus)
Status
Functioni
Snake venom phospholipase A2 homolog that exhibits potent myotoxicity causing myonecrosis and myoedema in the gastrocnemius muscle of mice. Is also able to stimulate the release of IL12 (IL12A-IL12B), TNF-alpha (TNF), IL6 and IL1-beta (IL1B) from human monocytes, and induce IL2, TNFalpha and IL6 release from T-cells.1 Publication
Miscellaneous
Fails to induce platelet aggregation, and has little effect on the ADP-induced platelet aggregation. Does not show hemorrhagic activity (PubMed:16793192).1 Publication
Caution
Does not bind calcium as one of the calcium-binding sites is lost (Asp->Arg in position 64, which corresponds to 'Arg-49' in the current nomenclature).Curated
GO - Molecular functioni
- calcium ion binding Source: InterPro
- phospholipase A2 activity Source: InterPro
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- arachidonic acid secretion Source: InterPro
- lipid catabolic process Source: InterPro
- phospholipid metabolic process Source: InterPro
Keywordsi
Molecular function | Myotoxin, Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Basic phospholipase A2 homolog promutoxinShort name: svPLA2 homolog |
Organismi | Protobothrops mucrosquamatus (Taiwan habu) (Trimeresurus mucrosquamatus) |
Taxonomic identifieri | 103944 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Viperidae › Crotalinae › Protobothrops |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | 1 PublicationAdd BLAST | 16 | |
ChainiPRO_0000419213 | 17 – 138 | Basic phospholipase A2 homolog promutoxinAdd BLAST | 122 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 42 ↔ 132 | By similarity | ||
Disulfide bondi | 44 ↔ 60 | By similarity | ||
Disulfide bondi | 59 ↔ 112 | By similarity | ||
Disulfide bondi | 65 ↔ 138 | By similarity | ||
Disulfide bondi | 66 ↔ 105 | By similarity | ||
Disulfide bondi | 73 ↔ 98 | By similarity | ||
Disulfide bondi | 91 ↔ 103 | By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
PRIDEi | Q2PWA3 |
Expressioni
Tissue specificityi
Expressed by the venom gland.
Interactioni
Subunit structurei
Homodimer.
1 PublicationFamily & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalFamily and domain databases
CDDi | cd00125 PLA2c, 1 hit |
Gene3Di | 1.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR001211 PLipase_A2 IPR033112 PLipase_A2_Asp_AS IPR016090 PLipase_A2_dom IPR036444 PLipase_A2_dom_sf IPR033113 PLipase_A2_His_AS |
PANTHERi | PTHR11716 PTHR11716, 1 hit |
Pfami | View protein in Pfam PF00068 Phospholip_A2_1, 1 hit |
PRINTSi | PR00389 PHPHLIPASEA2 |
SMARTi | View protein in SMART SM00085 PA2c, 1 hit |
SUPFAMi | SSF48619 SSF48619, 1 hit |
PROSITEi | View protein in PROSITE PS00119 PA2_ASP, 1 hit PS00118 PA2_HIS, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q2PWA3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRTLWIMAVL LLGVEGSVIE LGKMVFQETG KNPVKNYGLY GCNCGVGKRG
60 70 80 90 100
KPVDATDSCC FVHRCCYKKV TGCDPKKDRY SYSWENKAIV CGEKNPPCLK
110 120 130
QVCECDKAVA ICLRENLGTY DKKHRVTMKF LCKAPESC
Mass spectrometryi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ299948 mRNA Translation: ABC02868.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ299948 mRNA Translation: ABC02868.1 |
3D structure databases
SMRi | Q2PWA3 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q2PWA3 |
Family and domain databases
CDDi | cd00125 PLA2c, 1 hit |
Gene3Di | 1.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR001211 PLipase_A2 IPR033112 PLipase_A2_Asp_AS IPR016090 PLipase_A2_dom IPR036444 PLipase_A2_dom_sf IPR033113 PLipase_A2_His_AS |
PANTHERi | PTHR11716 PTHR11716, 1 hit |
Pfami | View protein in Pfam PF00068 Phospholip_A2_1, 1 hit |
PRINTSi | PR00389 PHPHLIPASEA2 |
SMARTi | View protein in SMART SM00085 PA2c, 1 hit |
SUPFAMi | SSF48619 SSF48619, 1 hit |
PROSITEi | View protein in PROSITE PS00119 PA2_ASP, 1 hit PS00118 PA2_HIS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PA2HP_PROMU | |
Accessioni | Q2PWA3Primary (citable) accession number: Q2PWA3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2012 |
Last sequence update: | January 24, 2006 | |
Last modified: | May 8, 2019 | |
This is version 59 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families