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Protein

RNA polymerase II transcription factor B subunit 2

Gene

AO090206000056

Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor B subunit 2UniRule annotation
Gene namesi
ORF Names:AO090206000056Imported
OrganismiAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)Imported
Taxonomic identifieri510516 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006564 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi5062.CADAORAP00011976

Structurei

3D structure databases

ProteinModelPortaliQ2PIU7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000170529
KOiK03144
OMAiYLEQYAH
OrthoDBiEOG092C3703

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
TIGRFAMsiTIGR00625 tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

Q2PIU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMAVAPSRP FDYLESLPGT TFYKLYQQPS TALAIFRRML PDLAKCFVMA
60 70 80 90 100
LLYLKDPLPA TDLEAWVKAE SLKERDNALS ILGRLHILSN TVITDNVRAY
110 120 130 140 150
KVTDPFASSL RQALTGAEKT QSFGVLWHIS DGAAVSIAEL DEYARRQWEG
160 170 180 190 200
VLGYMVGTSG LGIQRDANLS KGVKQLLQAG HLVEIRDRRV EITQDGFAFV
210 220 230 240 250
LQDVSTQVWH ILMLYVESAD AIGMSSVEVL SFVFLLSSLE LGKAYDKKHL
260 270 280 290 300
TSNQLRTLTD LADFGIVYQD SPDASHFYPT RLATTLTSDS SALSNPISGS
310 320 330 340 350
LSGPSGTGSN KAGSGFIIVE TNYRLYAYTS SPLQISLIAL FTTLKYRFPN
360 370 380 390 400
LITGKITRQS VRRAIEMGIT ADQIISYLAT HAHPQMRKHN VSRSTSNQAG
410 420 430 440 450
IPPSVLPPTV TDQIRLWQLE RDRVKATPGF LFKDFVSLAE YEAPCRYAEE
460 470 480
IGVLVWKSDR KRMFFVTRHE QVAAFLRSRK
Length:480
Mass (Da):53,463
Last modified:January 24, 2006 - v1
Checksum:i7F6C66A01DD9BA0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007172 Genomic DNA Translation: BAE65427.1
RefSeqiXP_001826560.1, XM_001826508.1

Genome annotation databases

EnsemblFungiiBAE65427; BAE65427; AO090206000056
GeneIDi5998676
KEGGiaor:AO090206000056

Similar proteinsi

Entry informationi

Entry nameiQ2PIU7_ASPOR
AccessioniPrimary (citable) accession number: Q2PIU7
Entry historyiIntegrated into UniProtKB/TrEMBL: January 24, 2006
Last sequence update: January 24, 2006
Last modified: May 23, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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