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Protein
Submitted name:

Spt20, isoform C

Gene

Spt20

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • histone acetylation Source: FlyBase
  • regulation of transcription by RNA polymerase II Source: GO_Central

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Spt20, isoform CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Spt20Imported
Synonyms:Dmel\CG17689Imported, lincRNA.S5070Imported
ORF Names:CG17689Imported, Dmel_CG17689Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0036374 Spt20

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q2PDX8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0036374 Expressed in 21 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q2PDX8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q2PDX8 DM

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili821 – 845Sequence analysisAdd BLAST25

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJ9A Eukaryota
ENOG410YRYS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013549

KEGG Orthology (KO)

More...
KOi
K21245

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0VSR

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021950 Spt20

The PANTHER Classification System

More...
PANTHERi
PTHR13526 PTHR13526, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12090 Spt20, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q2PDX8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQSLDSSCQE ADFIINDTLK KLKGSSNADH VQGLAVHAHG SGVHQTQFVQ
60 70 80 90 100
YGTSGSSPQL QPQQSYHQLH PTLQQQQFAS SSSKSYLETS LLQAIPQIPA
110 120 130 140 150
QPPICIFDDD ESPTEGTGGS LGSLLTEPTS ATPSGLPTAI APSPSSCSSS
160 170 180 190 200
TTTMSNFNSI TSPSPVVPDL LLSTPPGVNS SLSNSSTGAA SVSSKKSEKR
210 220 230 240 250
PPSANSTASG GGHHLHHHHL HQTHNHHVLA SPTSSPSKRQ KSNSSSKESS
260 270 280 290 300
SSSRSSAIPA ASVSTATSSS QSARAGAGAA SSNSNSKPPS SVCQSGNSKF
310 320 330 340 350
FNLHEKIRDL YLQLLSNDLN YFAETGLKQR TRSFTLERLV DREKLNTIVV
360 370 380 390 400
NLYPGNKGYS LALHYDEHMV LNPQTNEWSP TDKDETSSDA AGLGTGTGSH
410 420 430 440 450
RSRPKPLAQD ESQSKTEAGH AKHDFGLVEV LRWPYENDLL LQCIDREMLP
460 470 480 490 500
EFLMDLLVAE TVSLSDGEGT RVYAKPSVFY AGCVIAQIRD FRQTFATSTN
510 520 530 540 550
ICDMKHILLR PTNATLFAEV QQMGSQLPAE DKLALESQLV LATAEPLCLE
560 570 580 590 600
PDPSIGRQAI NSQHQRQLYN SHELRRQMKK FTQTAINRKR KLDQFTHHHG
610 620 630 640 650
LELCDYLARL RQRPRTGSSS GGANATPATA PTNNPLVGAM LSSFTSKVPR
660 670 680 690 700
RPHEVIRPIR PPTLEYPANL KVPEHVISVE KYAKAYEPLN EFSEACKDGC
710 720 730 740 750
QPNCRHNFQP QLVEEYILET EREASEGRRA LYHIKLSIFQ RPSDAEYLGE
760 770 780 790 800
LYVDRDYREG ERNGESCRFA LGTRVHANRY IQQFREIFTE EGRKAVKITH
810 820 830 840 850
LIPGHMPIVT HTGLTNEQRI LLQQQQQQQQ RQAQMQQQQQ QQQQQVVVVA
860 870 880 890 900
NQQQQSQQQQ QTQQAGQQLS ATVHHVALPR QQITQKTLNL AGSNVINVQQ
910 920 930 940 950
NFRQQSAQQQ QPQTYTIEAP QQQAAAQIVP QQQQQQQQQQ QQHIHLQQLA
960 970 980 990 1000
TGSSNTSTTT HQVSLSNGSL VLVQQQQPQQ QSQQLAQALQ HSGITIQPAT
1010 1020 1030 1040 1050
IQQQQQQVKG TSVVGANSAL RAQLNSNVPI LQTQLKVQQQ QIMQKQQQQQ
1060 1070 1080 1090 1100
TTATSNNNNN NNNNNNMNNN TAIHPNPAIN AIVNSIMNSA NQYQQQQQQQ
1110 1120 1130 1140 1150
HQQQHQQQTG NTSSNNNAAG SGGSTNNNGS STSATTLKNS SNASILNLLN
1160 1170 1180 1190 1200
SAPAAMTSTP VASGTFTTST GQQQPQTLTL VQHQQQSTPN TADAATATYV
1210 1220 1230 1240 1250
QTTRGTPTLV STQRKQQSSE VLQNLLNANR KIGGGGTTTT TFRTNSAGNL
1260 1270 1280 1290 1300
IAVNLNQAGQ SHHQQTGDGS QTVRVSMSAL ASQLASPPAV MTNPTTSYTV
1310 1320 1330 1340 1350
ISSGNSAAAA AAWIQSPTGP VQQRILSSLR RDSTTAPPNA IVVGMAAPSP
1360 1370 1380 1390 1400
GSDSNASNAS GFAVPNNLAS TSSGGGGGGG ALSALLTNAA TPSPSGSDHS
1410 1420 1430 1440 1450
QSSQTHQNQA LLERLSNVTS NVSAVSMPHM SPQQPQPTQQ FITKTIVHSP
1460 1470 1480 1490 1500
ATSSIHSPMS SPHPQPSASP QQQQQQQQQQ TTATLNLQGI NLSQLQGAMA
1510 1520 1530 1540 1550
NFAGLQNVQV QIPGFTQPIS LQFSGNSLQQ QQSGNTATGA GTAQGQQRSV
1560 1570 1580 1590 1600
LVSVPVSSQQ QQLPHTITLQ TQSAPHHQQQ HQQTQQQHAP PTGTIVSLPS
1610 1620 1630 1640
SGPGTQTVVI TNNSGGGVTA GSSTSGSAGG GGGSGATTAM LTLPIV
Length:1,646
Mass (Da):176,725
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i101DC49D27D48D46
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9VU86Q9VU86_DROME
LD34837p
Spt20 Dmel\CG17689, lincRNA.S5070, CG17689, Dmel_CG17689
1,873Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014296 Genomic DNA Translation: ABC66150.2

NCBI Reference Sequences

More...
RefSeqi
NP_001034005.2, NM_001038916.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Dm.18611

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0304904; FBpp0293443; FBgn0036374

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
39522

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG17689

UCSC genome browser

More...
UCSCi
CG17689-RB d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: ABC66150.2
RefSeqiNP_001034005.2, NM_001038916.3
UniGeneiDm.18611

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Proteomic databases

PRIDEiQ2PDX8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0304904; FBpp0293443; FBgn0036374
GeneIDi39522
KEGGidme:Dmel_CG17689
UCSCiCG17689-RB d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
39522
FlyBaseiFBgn0036374 Spt20

Phylogenomic databases

eggNOGiENOG410IJ9A Eukaryota
ENOG410YRYS LUCA
GeneTreeiENSGT00390000013549
KOiK21245
OrthoDBiEOG091G0VSR

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
39522

Gene expression databases

BgeeiFBgn0036374 Expressed in 21 organ(s), highest expression level in embryo
ExpressionAtlasiQ2PDX8 baseline and differential
GenevisibleiQ2PDX8 DM

Family and domain databases

InterProiView protein in InterPro
IPR021950 Spt20
PANTHERiPTHR13526 PTHR13526, 2 hits
PfamiView protein in Pfam
PF12090 Spt20, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ2PDX8_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2PDX8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 7, 2006
Last sequence update: June 26, 2013
Last modified: December 5, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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