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Entry version 104 (11 Dec 2019)
Sequence version 1 (07 Feb 2006)
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Protein
Submitted name:

Long form of collagen XVIII alpha 1 chain

Gene

col18a1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Long form of collagen XVIII alpha 1 chainImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:col18a1aImported
Synonyms:col18a1Imported, col18a1lImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030516-3 col18a1a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500421331725 – 1396Sequence analysisAdd BLAST1372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi217 ↔ 263PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini202 – 319FZInterPro annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni77 – 103DisorderedSequence analysisAdd BLAST27
Regioni517 – 760DisorderedSequence analysisAdd BLAST244
Regioni781 – 1056DisorderedSequence analysisAdd BLAST276
Regioni1123 – 1225DisorderedSequence analysisAdd BLAST103

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi586 – 604PolyampholyteSequence analysisAdd BLAST19
Compositional biasi648 – 662Pro-richSequence analysisAdd BLAST15
Compositional biasi684 – 701Pro-richSequence analysisAdd BLAST18
Compositional biasi714 – 728PolarSequence analysisAdd BLAST15
Compositional biasi740 – 754Pro-richSequence analysisAdd BLAST15
Compositional biasi877 – 895Pro-richSequence analysisAdd BLAST19
Compositional biasi941 – 955PolyampholyteSequence analysisAdd BLAST15
Compositional biasi977 – 1000Pro-richSequence analysisAdd BLAST24
Compositional biasi1009 – 1050Pro-richSequence analysisAdd BLAST42
Compositional biasi1124 – 1138PolarSequence analysisAdd BLAST15

Keywords - Domaini

CollagenImported, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3546 Eukaryota
ENOG410XQ04 LUCA

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07455 CRD_Collagen_XVIII, 1 hit
cd00247 Endostatin-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.2000.10, 1 hit
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR035523 Collagen_XVIII_Fz
IPR010515 Collagenase_NC10/endostatin
IPR013320 ConA-like_dom_sf
IPR016187 CTDL_fold
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06482 Endostatin, 1 hit
PF01392 Fz, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00063 FRI, 1 hit
SM00210 TSPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit
SSF56436 SSF56436, 1 hit
SSF63501 SSF63501, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50038 FZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q2PBM7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMAELRFWLC LFILACVRIR HTHGWFWFDD SKEIEKGVQT PAYLTTVGPT
60 70 80 90 100
SLPRTEPSRT TGTSASVTEE VAKEVSFEGE PEVRSRSGLG IESGSGSGSS
110 120 130 140 150
SFERQHEYLT SSDKIWGIID DNSSLHNQVT KVDQTDGLDP ANSRFNEGVN
160 170 180 190 200
VSFTNITAKN NVNESNFAEH ANTTLYSSEY AVSDNALTIE SQFLIASMPA
210 220 230 240 250
SFEPLRCLPV DSGLPFCTRR GVESFSVPNF LNQSSVEEVR MVLTEWAWLL
260 270 280 290 300
RSGCHHSLEW FFCLLLTPRC GHSGSLLPCR SSCEVLQDSC WTLLDEGRLP
310 320 330 340 350
VECKSLPEEK HDGYRCLSVS NLKEESGVSL LQLIGDPPPN GVSKVFDQAN
360 370 380 390 400
SPGYVFGPSS NVGQSAAAHL PNPFYRDFSL IFNIKPTSSK PGVIFSITDP
410 420 430 440 450
TQNIMYVGVK LSAVERGKQS IIFYYTEPDS QSSYEAARFS VSSMLNIWTR
460 470 480 490 500
FSISVLNEQV SLYFNCDSDP QVVNFERSPD DMDMDAGAGV FVGHASGADP
510 520 530 540 550
DKFLGVIGDL RVSRDPGAAE RHCEEEEDDY AAEASGDYGA SGDGEQPSPV
560 570 580 590 600
QPTPPSSRPI QRPPVISRDP IQRPPVISRE PIQQTVARGE KGDRGEKGAK
610 620 630 640 650
GDRGLAGPKG DVGSGSVSGG GSKGDKGVPG EKGMKGTSGF GYPGSKGDRG
660 670 680 690 700
PPGPPGPPGP QGPSAXVEVR GDGSVVQKVT GPRGPPGPQG PPGPPGPEGE
710 720 730 740 750
PGDPGENGKA GQVGPSWFSW NSWESWTQGD KGDRSESQPG PRGPPGPPGP
760 770 780 790 800
PETSPGFDRL LLGNGRLWIX XXXXXXLAVQ LRPPGGRGNS IGLPGYDIKG
810 820 830 840 850
EKGEPGLILG PDGNPLYLGG LTGQKGERGI SGPVGPPGPA GPPGAKGEFG
860 870 880 890 900
TPGRPGRPGV NGYKGEKGEP SSGSGYGYPG PPGPPGPPGP PGPAVPLDRF
910 920 930 940 950
GRYEDYARLY PATKGEKGDQ GAPGIPGSPG FSTNFDIYSL KNEMKGERGE
960 970 980 990 1000
SGLKGEKGEP GGGFYDPRFG AVQGPPGNPG PAGPKGDSIR GPPGPQGPPG
1010 1020 1030 1040 1050
TPGVGYDGRP GNPGPPGPPG PPGSPSLPGP YRPPLSIPGP PGPPGPPGIP
1060 1070 1080 1090 1100
GTGSGVTVLR SHDIMIATAR RQTEGTLIYI LDRNDLYLRV RDGVRQVMLG
1110 1120 1130 1140 1150
DYKPLYGELD NEVAAVQPPP VVHYSQDHTA NNGAEQISPP HQPIDFPTRE
1160 1170 1180 1190 1200
QENRNPNPQP DPRYPDPRYP PYTDNRYTDP VEPNIRYPVQ PERNPITPAR
1210 1220 1230 1240 1250
RPIPPVNQPG GHAHTHTSGP GLHLIALNSP QVGNMRGIRG ADFMCFQQAR
1260 1270 1280 1290 1300
AVGMKGTFRA FLSSKLQDLY SIVRRSDRET LPIVNLKDQV LFSSWESLFS
1310 1320 1330 1340 1350
DSESRMKDNA PIYSFDGRDV LRDSAWPEKM IWHGSDGRGH RQTDNYCETW
1360 1370 1380 1390
RAGDRAVTGL ASSLQAGQLL QQTSSSCSSS YIALCIENSY MTQSKK
Length:1,396
Mass (Da):149,008
Last modified:February 7, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i82A130A3DA0B327C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ967006 mRNA Translation: CAI91300.1

NCBI Reference Sequences

More...
RefSeqi
NP_001034719.1, NM_001039630.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ967006 mRNA Translation: CAI91300.1
RefSeqiNP_001034719.1, NM_001039630.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Organism-specific databases

ZFINiZDB-GENE-030516-3 col18a1a

Phylogenomic databases

eggNOGiKOG3546 Eukaryota
ENOG410XQ04 LUCA

Family and domain databases

CDDicd07455 CRD_Collagen_XVIII, 1 hit
cd00247 Endostatin-like, 1 hit
Gene3Di1.10.2000.10, 1 hit
3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR035523 Collagen_XVIII_Fz
IPR010515 Collagenase_NC10/endostatin
IPR013320 ConA-like_dom_sf
IPR016187 CTDL_fold
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR001791 Laminin_G
PfamiView protein in Pfam
PF06482 Endostatin, 1 hit
PF01392 Fz, 1 hit
SMARTiView protein in SMART
SM00063 FRI, 1 hit
SM00210 TSPN, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF56436 SSF56436, 1 hit
SSF63501 SSF63501, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ2PBM7_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2PBM7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 7, 2006
Last sequence update: February 7, 2006
Last modified: December 11, 2019
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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