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Protein

Cardiolipin synthase A

Gene

clsA

Organism
Sodalis glossinidius (strain morsitans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotation

Catalytic activityi

2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei224UniRule annotation1
Active sitei226UniRule annotation1
Active sitei231UniRule annotation1
Active sitei404UniRule annotation1
Active sitei406UniRule annotation1
Active sitei411UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthase AUniRule annotation (EC:2.7.8.-UniRule annotation)
Short name:
CL synthaseUniRule annotation
Gene namesi
Name:clsAUniRule annotation
Synonyms:cls
Ordered Locus Names:SG1378
OrganismiSodalis glossinidius (strain morsitans)
Taxonomic identifieri343509 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesPectobacteriaceaeSodalis
Proteomesi
  • UP000001932 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalUniRule annotationAdd BLAST21
Transmembranei38 – 58HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000775081 – 486Cardiolipin synthase AAdd BLAST486

Interactioni

Protein-protein interaction databases

STRINGi343509.SG1378

Structurei

3D structure databases

ProteinModelPortaliQ2NT72
SMRiQ2NT72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini219 – 246PLD phosphodiesterase 1UniRule annotationAdd BLAST28
Domaini399 – 426PLD phosphodiesterase 2UniRule annotationAdd BLAST28

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CQX Bacteria
COG1502 LUCA
KOiK06131
OMAiGGHNVGD
OrthoDBiPOG091H04OR

Family and domain databases

HAMAPiMF_00190 Cardiolipin_synth_ClsA, 1 hit
InterProiView protein in InterPro
IPR022924 Cardiolipin_synthase
IPR030840 CL_synthase_A
IPR027379 CLS_N
IPR025202 PLD-like_dom
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF13091 PLDc_2, 2 hits
PF13396 PLDc_N, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
TIGRFAMsiTIGR04265 bac_cardiolipin, 1 hit
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

Sequencei

Sequence statusi: Complete.

Q2NT72-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTLYTVINW LLLFGYWLLI AGVTLRVMMK RRAVPSAMAW LLVIYILPLV
60 70 80 90 100
GIITYLLFGE LNLGKRRAER SKALWPSTAK WIEDLKGCRR IFASENSEVA
110 120 130 140 150
RALFQLCEHR QGMGGLKGNQ MQLLTSSDDA LRALVRDIGL AQKNIEIVFY
160 170 180 190 200
IWQSGGLVDQ VAEALMAVAR RGVRCRLMLD SAGSVDFFRS PYPALMRAAG
210 220 230 240 250
VHVVEALHVS LLRVFLRRMD LRQHRKMVLI DNYVAYTGSM NMVDPRFFKQ
260 270 280 290 300
DAGVGQWIDI MARMEGPVAT AMGIIFSCDW EIETGERILP PLPDVNIMPF
310 320 330 340 350
EQATGHTIQV IASGPGFPEG VIHQALLTSI YAAREQLVMT TPYLVPSDDL
360 370 380 390 400
LQAICTAAQL GVEVHIIVPR HNDSMLVGWA SRAFFAELLE AGVLIHQFEG
410 420 430 440 450
GLLHTKSVLV DGQLSLVGTV NLDMRSLWLN FEITLVIDDD DFGSDLARVQ
460 470 480
EDYIARSRLI EPKVWSKRPY WQRIVERLFY FFSPLL
Length:486
Mass (Da):54,841
Last modified:February 7, 2006 - v1
Checksum:iDD46540842A3363E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008232 Genomic DNA Translation: BAE74653.1
RefSeqiWP_011411198.1, NC_007712.1

Genome annotation databases

EnsemblBacteriaiBAE74653; BAE74653; SG1378
KEGGisgl:SG1378

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008232 Genomic DNA Translation: BAE74653.1
RefSeqiWP_011411198.1, NC_007712.1

3D structure databases

ProteinModelPortaliQ2NT72
SMRiQ2NT72
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi343509.SG1378

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE74653; BAE74653; SG1378
KEGGisgl:SG1378

Phylogenomic databases

eggNOGiENOG4105CQX Bacteria
COG1502 LUCA
KOiK06131
OMAiGGHNVGD
OrthoDBiPOG091H04OR

Family and domain databases

HAMAPiMF_00190 Cardiolipin_synth_ClsA, 1 hit
InterProiView protein in InterPro
IPR022924 Cardiolipin_synthase
IPR030840 CL_synthase_A
IPR027379 CLS_N
IPR025202 PLD-like_dom
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF13091 PLDc_2, 2 hits
PF13396 PLDc_N, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
TIGRFAMsiTIGR04265 bac_cardiolipin, 1 hit
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCLSA_SODGM
AccessioniPrimary (citable) accession number: Q2NT72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 7, 2006
Last modified: July 18, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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