UniProtKB - Q2NSH9 (PDXB_SODGM)
Protein
Erythronate-4-phosphate dehydrogenase
Gene
pdxB
Organism
Sodalis glossinidius (strain morsitans)
Status
Functioni
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.UniRule annotation
Catalytic activityi
- 4-phospho-D-erythronate + NAD+ = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H+ + NADHUniRule annotationEC:1.1.1.290UniRule annotation
: pyridoxine 5'-phosphate biosynthesis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate.UniRule annotationProteins known to be involved in the 5 steps of the subpathway in this organism are:
- no protein annotated in this organism
- Erythronate-4-phosphate dehydrogenase (pdxB), Erythronate-4-phosphate dehydrogenase (pdxB)
- Phosphoserine aminotransferase (serC), Phosphoserine aminotransferase (serC)
- 4-hydroxythreonine-4-phosphate dehydrogenase (pdxA), 4-hydroxythreonine-4-phosphate dehydrogenase (pdxA)
- Pyridoxine 5'-phosphate synthase (pdxJ)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate, the pathway pyridoxine 5'-phosphate biosynthesis and in Cofactor biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 45 | SubstrateUniRule annotation | 1 | |
Binding sitei | 66 | SubstrateUniRule annotation | 1 | |
Binding sitei | 146 | NADUniRule annotation | 1 | |
Binding sitei | 175 | NAD; via carbonyl oxygenUniRule annotation | 1 | |
Active sitei | 208 | UniRule annotation | 1 | |
Binding sitei | 232 | NADUniRule annotation | 1 | |
Active sitei | 237 | UniRule annotation | 1 | |
Active sitei | 254 | Proton donorUniRule annotation | 1 | |
Binding sitei | 257 | NAD; via amide nitrogenUniRule annotation | 1 | |
Binding sitei | 258 | SubstrateUniRule annotation | 1 |
GO - Molecular functioni
- 4-phosphoerythronate dehydrogenase activity Source: UniProtKB-EC
- NAD binding Source: InterPro
- protein dimerization activity Source: InterPro
GO - Biological processi
- pyridoxine biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Pyridoxine biosynthesis |
Ligand | NAD |
Enzyme and pathway databases
BioCyci | SGLO343509:SGP1_RS14695-MONOMER |
UniPathwayi | UPA00244;UER00310 |
Names & Taxonomyi
Protein namesi | Recommended name: Erythronate-4-phosphate dehydrogenaseUniRule annotation (EC:1.1.1.290UniRule annotation) |
Gene namesi | Name:pdxBUniRule annotation Ordered Locus Names:SG1621 |
Organismi | Sodalis glossinidius (strain morsitans) |
Taxonomic identifieri | 343509 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Pectobacteriaceae › Sodalis › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000297477 | 1 – 377 | Erythronate-4-phosphate dehydrogenaseAdd BLAST | 377 |
Interactioni
Subunit structurei
Homodimer.
UniRule annotationGO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 343509.SG1621 |
Family & Domainsi
Sequence similaritiesi
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.UniRule annotation
Phylogenomic databases
eggNOGi | COG0111, Bacteria |
HOGENOMi | CLU_019796_4_0_6 |
OMAi | SAPGCNA |
OrthoDBi | 1638924at2 |
Family and domain databases
CDDi | cd12158, ErythrP_dh, 1 hit |
Gene3Di | 3.30.1370.170, 1 hit |
HAMAPi | MF_01825, PdxB, 1 hit |
InterProi | View protein in InterPro IPR006139, D-isomer_2_OHA_DH_cat_dom IPR029753, D-isomer_DH_CS IPR029752, D-isomer_DH_CS1 IPR006140, D-isomer_DH_NAD-bd IPR020921, Erythronate-4-P_DHase IPR024531, Erythronate-4-P_DHase_dimer IPR036291, NAD(P)-bd_dom_sf IPR038251, PdxB_dimer_sf |
PANTHERi | PTHR42938:SF3, PTHR42938:SF3, 1 hit |
Pfami | View protein in Pfam PF00389, 2-Hacid_dh, 1 hit PF02826, 2-Hacid_dh_C, 1 hit PF11890, DUF3410, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00065, D_2_HYDROXYACID_DH_1, 1 hit PS00671, D_2_HYDROXYACID_DH_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q2NSH9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKILVDENMP YAEALFGRLG DVQTVAGRAI PAPALALADA LMVRSVTRVD
60 70 80 90 100
GALLDGSRVK FVGTATAGTD HVDEDWLAQA GIGFSVAPGC NAIAVVEYVF
110 120 130 140 150
SALLWLAQRD GFALRDKTVG IVGVGNVGGR LQRRLNAFGV RTLLCDPPLA
160 170 180 190 200
EAGAPGDWQP LETLVAEADV LTFHTPLTLA GRHATWHQVD EALLAALPAG
210 220 230 240 250
RIIINACRGA VVDNAALLQA LEGGKPLSVV LDVWEPEPAL SLPLLARVDI
260 270 280 290 300
GTAHIAGYTL EGKARGTTQV FDAYSAYVGS DERASLAALL PPPAVERIRL
310 320 330 340 350
RGAIDEEALR LLSHLVYDVR RDDMQLRRVA GLPGEFDRLR KNYYQRREWS
360 370
SLCVETDNSI GADALRQLGF QARPFAG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP008232 Genomic DNA Translation: BAE74896.1 |
RefSeqi | WP_011411449.1, NZ_LN854557.1 |
Genome annotation databases
EnsemblBacteriai | BAE74896; BAE74896; SG1621 |
KEGGi | sgl:SG1621 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP008232 Genomic DNA Translation: BAE74896.1 |
RefSeqi | WP_011411449.1, NZ_LN854557.1 |
3D structure databases
SMRi | Q2NSH9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 343509.SG1621 |
Genome annotation databases
EnsemblBacteriai | BAE74896; BAE74896; SG1621 |
KEGGi | sgl:SG1621 |
Phylogenomic databases
eggNOGi | COG0111, Bacteria |
HOGENOMi | CLU_019796_4_0_6 |
OMAi | SAPGCNA |
OrthoDBi | 1638924at2 |
Enzyme and pathway databases
UniPathwayi | UPA00244;UER00310 |
BioCyci | SGLO343509:SGP1_RS14695-MONOMER |
Family and domain databases
CDDi | cd12158, ErythrP_dh, 1 hit |
Gene3Di | 3.30.1370.170, 1 hit |
HAMAPi | MF_01825, PdxB, 1 hit |
InterProi | View protein in InterPro IPR006139, D-isomer_2_OHA_DH_cat_dom IPR029753, D-isomer_DH_CS IPR029752, D-isomer_DH_CS1 IPR006140, D-isomer_DH_NAD-bd IPR020921, Erythronate-4-P_DHase IPR024531, Erythronate-4-P_DHase_dimer IPR036291, NAD(P)-bd_dom_sf IPR038251, PdxB_dimer_sf |
PANTHERi | PTHR42938:SF3, PTHR42938:SF3, 1 hit |
Pfami | View protein in Pfam PF00389, 2-Hacid_dh, 1 hit PF02826, 2-Hacid_dh_C, 1 hit PF11890, DUF3410, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00065, D_2_HYDROXYACID_DH_1, 1 hit PS00671, D_2_HYDROXYACID_DH_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PDXB_SODGM | |
Accessioni | Q2NSH9Primary (citable) accession number: Q2NSH9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 24, 2007 |
Last sequence update: | February 7, 2006 | |
Last modified: | December 2, 2020 | |
This is version 88 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families