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Entry version 126 (08 May 2019)
Sequence version 1 (07 Feb 2006)
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Protein

Pre-rRNA-processing protein TSR1 homolog

Gene

TSR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required during maturation of the 40S ribosomal subunit in the nucleolus.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRibosome biogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pre-rRNA-processing protein TSR1 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TSR1
Synonyms:KIAA1401
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25542 TSR1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611214 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q2NL82

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000167721

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670691

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TSR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
121948971

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003112741 – 804Pre-rRNA-processing protein TSR1 homologAdd BLAST804

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q2NL82

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q2NL82

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q2NL82

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q2NL82

PeptideAtlas

More...
PeptideAtlasi
Q2NL82

PRoteomics IDEntifications database

More...
PRIDEi
Q2NL82

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61424

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q2NL82

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q2NL82

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q2NL82

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167721 Expressed in 246 organ(s), highest expression level in epithelium of mammary gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q2NL82 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q2NL82 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA024434
HPA053087

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120842, 139 interactors

Protein interaction database and analysis system

More...
IntActi
Q2NL82, 36 interactors

Molecular INTeraction database

More...
MINTi
Q2NL82

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000301364

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6G18electron microscopy3.60u1-804[»]
6G4Selectron microscopy4.00u1-804[»]
6G4Welectron microscopy4.50u1-804[»]
6G51electron microscopy4.10u1-804[»]
6G53electron microscopy4.50u1-804[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q2NL82

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini81 – 248Bms1-type GAdd BLAST168

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi415 – 487Glu-richAdd BLAST73

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1980 Eukaryota
COG5177 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153195

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000165026

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q2NL82

KEGG Orthology (KO)

More...
KOi
K14799

Identification of Orthologs from Complete Genome Data

More...
OMAi
CGYRRFV

Database of Orthologous Groups

More...
OrthoDBi
186926at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q2NL82

TreeFam database of animal gene trees

More...
TreeFami
TF105717

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012948 AARP2CN
IPR039761 Bms1/Tsr1
IPR007034 BMS1_TSR1_C
IPR030387 G_Bms1/Tsr1_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12858 PTHR12858, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08142 AARP2CN, 1 hit
PF04950 RIBIOP_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00785 AARP2CN, 1 hit
SM01362 DUF663, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51714 G_BMS1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q2NL82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAHRPGPLK QQNKAHKGGR HRGRGSAQRD GKGRLALKTL SKKVRKELSR
60 70 80 90 100
VDQRHRASQL RKQKKEAVLA EKRQLGGKDG PPHQVLVVPL HSRISLPEAM
110 120 130 140 150
QLLQDRDTGT VHLNELGNTQ NFMLLCPRLK HRWFFTSARP GDLHVVLDMA
160 170 180 190 200
KVADTILFLL DPLEGWDSTG DYCLSCLFAQ GLPTYTLAVQ GISGLPLKKQ
210 220 230 240 250
IDTRKKLSKA VEKRFPHDKL LLLDTQQEAG MLLRQLANQK QQHLAFRDRR
260 270 280 290 300
AYLFAHAVDF VPSEENNLVG TLKISGYVRG QTLNVNRLLH IVGYGDFQMK
310 320 330 340 350
QIDAPGDPFP LNPRGIKPQK DPDMAMEICA TDAVDDMEEG LKVLMKADPG
360 370 380 390 400
RQESLQAEVI PDPMEGEQTW PTEEELSEAK DFLKESSKVV KKVPKGTSSY
410 420 430 440 450
QAEWILDGGS QSGGEGDEYE YDDMEHEDFM EEESQDESSE EEEEYETMTI
460 470 480 490 500
GESVHDDLYD KKVDEEAEAK MLEKYKQERL EEMFPDEVDT PRDVAARIRF
510 520 530 540 550
QKYRGLKSFR TSPWDPKENL PQDYARIFQF QNFTNTRKSI FKEVEEKEVE
560 570 580 590 600
GAEVGWYVTL HVSEVPVSVV ECFRQGTPLI AFSLLPHEQK MSVLNMVVRR
610 620 630 640 650
DPGNTEPVKA KEELIFHCGF RRFRASPLFS QHTAADKHKL QRFLTADMAL
660 670 680 690 700
VATVYAPITF PPASVLLFKQ KSNGMHSLIA TGHLMSVDPD RMVIKRVVLS
710 720 730 740 750
GHPFKIFTKM AVVRYMFFNR EDVLWFKPVE LRTKWGRRGH IKEPLGTHGH
760 770 780 790 800
MKCSFDGKLK SQDTVLMNLY KRVFPKWTYD PYVPEPVPWL KSEISSTVPQ

GGME
Length:804
Mass (Da):91,810
Last modified:February 7, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEDDBE6AD04E7F3A7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L1Q5I3L1Q5_HUMAN
Pre-rRNA-processing protein TSR1 ho...
TSR1
368Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4E8I3L4E8_HUMAN
Pre-rRNA-processing protein TSR1 ho...
TSR1
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4T0I3L4T0_HUMAN
Pre-rRNA-processing protein TSR1 ho...
TSR1
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91667 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA92639 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti350G → C in BAA91667 (PubMed:14702039).Curated1
Sequence conflicti737R → W in BAA92639 (PubMed:10718198).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037211386S → G1 PublicationCorresponds to variant dbSNP:rs2281726Ensembl.1
Natural variantiVAR_037212719N → S. Corresponds to variant dbSNP:rs2273983Ensembl.1
Natural variantiVAR_037213727K → Q. Corresponds to variant dbSNP:rs35019711Ensembl.1
Natural variantiVAR_037214750H → Q. Corresponds to variant dbSNP:rs35343613Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB037822 mRNA Translation: BAA92639.1 Different initiation.
CH471108 Genomic DNA Translation: EAW90552.1
BC019090 mRNA Translation: AAH19090.2
BC110851 mRNA Translation: AAI10852.1
BC126110 mRNA Translation: AAI26111.1
AK001396 mRNA Translation: BAA91667.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32525.1

NCBI Reference Sequences

More...
RefSeqi
NP_060598.3, NM_018128.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000301364; ENSP00000301364; ENSG00000167721

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55720

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55720

UCSC genome browser

More...
UCSCi
uc002fuj.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037822 mRNA Translation: BAA92639.1 Different initiation.
CH471108 Genomic DNA Translation: EAW90552.1
BC019090 mRNA Translation: AAH19090.2
BC110851 mRNA Translation: AAI10852.1
BC126110 mRNA Translation: AAI26111.1
AK001396 mRNA Translation: BAA91667.1 Different initiation.
CCDSiCCDS32525.1
RefSeqiNP_060598.3, NM_018128.4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6G18electron microscopy3.60u1-804[»]
6G4Selectron microscopy4.00u1-804[»]
6G4Welectron microscopy4.50u1-804[»]
6G51electron microscopy4.10u1-804[»]
6G53electron microscopy4.50u1-804[»]
SMRiQ2NL82
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120842, 139 interactors
IntActiQ2NL82, 36 interactors
MINTiQ2NL82
STRINGi9606.ENSP00000301364

PTM databases

iPTMnetiQ2NL82
PhosphoSitePlusiQ2NL82

Polymorphism and mutation databases

BioMutaiTSR1
DMDMi121948971

Proteomic databases

EPDiQ2NL82
jPOSTiQ2NL82
MaxQBiQ2NL82
PaxDbiQ2NL82
PeptideAtlasiQ2NL82
PRIDEiQ2NL82
ProteomicsDBi61424

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55720
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301364; ENSP00000301364; ENSG00000167721
GeneIDi55720
KEGGihsa:55720
UCSCiuc002fuj.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55720

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TSR1
HGNCiHGNC:25542 TSR1
HPAiHPA024434
HPA053087
MIMi611214 gene
neXtProtiNX_Q2NL82
OpenTargetsiENSG00000167721
PharmGKBiPA142670691

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1980 Eukaryota
COG5177 LUCA
GeneTreeiENSGT00940000153195
HOGENOMiHOG000165026
InParanoidiQ2NL82
KOiK14799
OMAiCGYRRFV
OrthoDBi186926at2759
PhylomeDBiQ2NL82
TreeFamiTF105717

Enzyme and pathway databases

ReactomeiR-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55720
PMAP-CutDBiQ2NL82

Protein Ontology

More...
PROi
PR:Q2NL82

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000167721 Expressed in 246 organ(s), highest expression level in epithelium of mammary gland
ExpressionAtlasiQ2NL82 baseline and differential
GenevisibleiQ2NL82 HS

Family and domain databases

InterProiView protein in InterPro
IPR012948 AARP2CN
IPR039761 Bms1/Tsr1
IPR007034 BMS1_TSR1_C
IPR030387 G_Bms1/Tsr1_dom
PANTHERiPTHR12858 PTHR12858, 1 hit
PfamiView protein in Pfam
PF08142 AARP2CN, 1 hit
PF04950 RIBIOP_C, 1 hit
SMARTiView protein in SMART
SM00785 AARP2CN, 1 hit
SM01362 DUF663, 1 hit
PROSITEiView protein in PROSITE
PS51714 G_BMS1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTSR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2NL82
Secondary accession number(s): Q8WUY5, Q9NVT0, Q9P2E6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: February 7, 2006
Last modified: May 8, 2019
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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