UniProtKB - Q2NL68 (PRSR3_HUMAN)
Protein
Proline and serine-rich protein 3
Gene
PROSER3
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Proline and serine-rich protein 3 |
Gene namesi | Name:PROSER3 Synonyms:C19orf55 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25204, PROSER3 |
neXtProti | NX_Q2NL68 |
VEuPathDBi | HostDB:ENSG00000167595.14 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 148137 |
OpenTargetsi | ENSG00000167595 |
PharmGKBi | PA162378639 |
Miscellaneous databases
Pharosi | Q2NL68, Tdark |
Genetic variation databases
BioMutai | PROSER3 |
DMDMi | 121941602 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000299482 | 1 – 480 | Proline and serine-rich protein 3Add BLAST | 480 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 408 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q2NL68 |
jPOSTi | Q2NL68 |
MassIVEi | Q2NL68 |
MaxQBi | Q2NL68 |
PaxDbi | Q2NL68 |
PeptideAtlasi | Q2NL68 |
PRIDEi | Q2NL68 |
ProteomicsDBi | 61420 [Q2NL68-1] 61421 [Q2NL68-2] 61422 [Q2NL68-3] 61423 [Q2NL68-4] |
PTM databases
iPTMneti | Q2NL68 |
PhosphoSitePlusi | Q2NL68 |
Expressioni
Gene expression databases
Bgeei | ENSG00000167595, Expressed in right testis and 130 other tissues |
ExpressionAtlasi | Q2NL68, baseline and differential |
Genevisiblei | Q2NL68, HS |
Organism-specific databases
HPAi | ENSG00000167595, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ2NL68
Protein-protein interaction databases
BioGRIDi | 127121, 15 interactors |
IntActi | Q2NL68, 12 interactors |
STRINGi | 9606.ENSP00000380116 |
Miscellaneous databases
RNActi | Q2NL68, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 419 – 451 | Sequence analysisAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 209 – 248 | Ser-richAdd BLAST | 40 | |
Compositional biasi | 381 – 384 | Pro-rich | 4 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502S6GS, Eukaryota |
GeneTreei | ENSGT00390000001986 |
HOGENOMi | CLU_022718_0_0_1 |
InParanoidi | Q2NL68 |
OMAi | FSPHIFW |
OrthoDBi | 1610316at2759 |
PhylomeDBi | Q2NL68 |
Family and domain databases
InterProi | View protein in InterPro IPR037646, PROSER3 |
PANTHERi | PTHR22045, PTHR22045, 2 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q2NL68-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDRSLPVFSI QDSPFGDAPL GRSHYWPSQS QTWCPKTLSP SRSQRSRLPQ
60 70 80 90 100
APKALATGPN SPELFEESWP SSSGTPSLPS TTEGQMWASP APTLIDSGDS
110 120 130 140 150
VVAKYINRFR QAQPTSREER QPAGPTPADF WWLQSDSPDP SSQSAAAGAN
160 170 180 190 200
KPEGRPHTAV PTAVNVTSAS HAVAPLQEIK QNLHTWNSSL LDLETLSLQS
210 220 230 240 250
RAARLLKRSK ASISSSSSLS PSDASTSSFP TSSDGLSPFS ETFIPDSSKG
260 270 280 290 300
LGPRAPASPA PAQAQTPTPA PAPASSQAPL RPEDDILYQW RQRRKLEQAQ
310 320 330 340 350
GSKGDRAWVP PLTPALRTLA ESLKAKALPP AAGSVIRKSE ATPSPGACLQ
360 370 380 390 400
PEVPLSPAEQ ATTVKASPPA FQVGSPEALA PPPPAADHAP SEALLAQAAL
410 420 430 440 450
LLQAAEDSDG SEFQDDPVLQ VLRAHRAELS RQKREADARL SFLLDQAEDL
460 470 480
GSWSPPAGSP PRSPRRLLRR EGDSLEARRL
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JFW7 | C9JFW7_HUMAN | Proline and serine-rich protein 3 | PROSER3 | 255 | Annotation score: | ||
F5GXU6 | F5GXU6_HUMAN | Proline and serine-rich protein 3 | PROSER3 | 93 | Annotation score: | ||
S4R3L1 | S4R3L1_HUMAN | Proline and serine-rich protein 3 | PROSER3 | 90 | Annotation score: | ||
M0QZ53 | M0QZ53_HUMAN | Proline and serine-rich protein 3 | PROSER3 | 167 | Annotation score: | ||
A0A2R8Y8D9 | A0A2R8Y8D9_HUMAN | Proline and serine-rich protein 3 | PROSER3 | 468 | Annotation score: | ||
F8W7U6 | F8W7U6_HUMAN | Proline and serine-rich protein 3 | PROSER3 | 86 | Annotation score: | ||
M0QY86 | M0QY86_HUMAN | Proline and serine-rich protein 3 | PROSER3 | 94 | Annotation score: | ||
H0YFI8 | H0YFI8_HUMAN | Proline and serine-rich protein 3 | PROSER3 | 52 | Annotation score: |
Sequence cautioni
The sequence AAH17947 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 2 (identifier: Q2NL68-2) | |||||
Sequence conflicti | 209 | P → S in BAB70878 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_056845 | 302 | S → R. Corresponds to variant dbSNP:rs231219Ensembl. | 1 | |
Natural variantiVAR_061631 | 365 | K → N. Corresponds to variant dbSNP:rs231217Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027698 | 145 | Missing in isoform 2 and isoform 3. 2 Publications | 1 | |
Alternative sequenceiVSP_027699 | 182 – 194 | NLHTW…LLDLE → VTSPFTPSLGCLN in isoform 3 and isoform 4. 2 PublicationsAdd BLAST | 13 | |
Alternative sequenceiVSP_027700 | 195 – 480 | Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST | 286 | |
Alternative sequenceiVSP_027701 | 210 – 220 | Missing in isoform 2. 1 PublicationAdd BLAST | 11 | |
Alternative sequenceiVSP_027702 | 320 – 336 | AESLK…AGSVI → VSRGREEPGGSWRRGWV in isoform 2. 1 PublicationAdd BLAST | 17 | |
Alternative sequenceiVSP_027703 | 337 – 480 | Missing in isoform 2. 1 PublicationAdd BLAST | 144 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK055219 mRNA Translation: BAB70878.1 AL833894 mRNA Translation: CAD38750.2 AC002398 Genomic DNA No translation available. BC017947 mRNA Translation: AAH17947.1 Different initiation. BC110893 mRNA Translation: AAI10894.1 |
CCDSi | CCDS46056.2 [Q2NL68-1] |
RefSeqi | NP_001034976.2, NM_001039887.2 [Q2NL68-1] XP_011524838.1, XM_011526536.2 [Q2NL68-2] |
Genome annotation databases
Ensembli | ENST00000396908; ENSP00000380116; ENSG00000167595 [Q2NL68-1] ENST00000536950; ENSP00000466822; ENSG00000167595 [Q2NL68-3] ENST00000537459; ENSP00000439886; ENSG00000167595 [Q2NL68-4] ENST00000620918; ENSP00000482508; ENSG00000167595 [Q2NL68-2] |
GeneIDi | 148137 |
KEGGi | hsa:148137 |
UCSCi | uc002obo.2, human [Q2NL68-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK055219 mRNA Translation: BAB70878.1 AL833894 mRNA Translation: CAD38750.2 AC002398 Genomic DNA No translation available. BC017947 mRNA Translation: AAH17947.1 Different initiation. BC110893 mRNA Translation: AAI10894.1 |
CCDSi | CCDS46056.2 [Q2NL68-1] |
RefSeqi | NP_001034976.2, NM_001039887.2 [Q2NL68-1] XP_011524838.1, XM_011526536.2 [Q2NL68-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 127121, 15 interactors |
IntActi | Q2NL68, 12 interactors |
STRINGi | 9606.ENSP00000380116 |
PTM databases
iPTMneti | Q2NL68 |
PhosphoSitePlusi | Q2NL68 |
Genetic variation databases
BioMutai | PROSER3 |
DMDMi | 121941602 |
Proteomic databases
EPDi | Q2NL68 |
jPOSTi | Q2NL68 |
MassIVEi | Q2NL68 |
MaxQBi | Q2NL68 |
PaxDbi | Q2NL68 |
PeptideAtlasi | Q2NL68 |
PRIDEi | Q2NL68 |
ProteomicsDBi | 61420 [Q2NL68-1] 61421 [Q2NL68-2] 61422 [Q2NL68-3] 61423 [Q2NL68-4] |
Protocols and materials databases
Antibodypediai | 44565, 41 antibodies |
Genome annotation databases
Ensembli | ENST00000396908; ENSP00000380116; ENSG00000167595 [Q2NL68-1] ENST00000536950; ENSP00000466822; ENSG00000167595 [Q2NL68-3] ENST00000537459; ENSP00000439886; ENSG00000167595 [Q2NL68-4] ENST00000620918; ENSP00000482508; ENSG00000167595 [Q2NL68-2] |
GeneIDi | 148137 |
KEGGi | hsa:148137 |
UCSCi | uc002obo.2, human [Q2NL68-1] |
Organism-specific databases
CTDi | 148137 |
DisGeNETi | 148137 |
GeneCardsi | PROSER3 |
HGNCi | HGNC:25204, PROSER3 |
HPAi | ENSG00000167595, Low tissue specificity |
neXtProti | NX_Q2NL68 |
OpenTargetsi | ENSG00000167595 |
PharmGKBi | PA162378639 |
VEuPathDBi | HostDB:ENSG00000167595.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S6GS, Eukaryota |
GeneTreei | ENSGT00390000001986 |
HOGENOMi | CLU_022718_0_0_1 |
InParanoidi | Q2NL68 |
OMAi | FSPHIFW |
OrthoDBi | 1610316at2759 |
PhylomeDBi | Q2NL68 |
Enzyme and pathway databases
PathwayCommonsi | Q2NL68 |
SignaLinki | Q2NL68 |
Miscellaneous databases
BioGRID-ORCSi | 148137, 2 hits in 113 CRISPR screens |
GenomeRNAii | 148137 |
Pharosi | Q2NL68, Tdark |
PROi | PR:Q2NL68 |
RNActi | Q2NL68, protein |
Gene expression databases
Bgeei | ENSG00000167595, Expressed in right testis and 130 other tissues |
ExpressionAtlasi | Q2NL68, baseline and differential |
Genevisiblei | Q2NL68, HS |
Family and domain databases
InterProi | View protein in InterPro IPR037646, PROSER3 |
PANTHERi | PTHR22045, PTHR22045, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PRSR3_HUMAN | |
Accessioni | Q2NL68Primary (citable) accession number: Q2NL68 Secondary accession number(s): Q8NDI3, Q8WWC8, Q96NL4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | February 7, 2006 | |
Last modified: | February 10, 2021 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants