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UniProtKB - Q2NL68 (PRSR3_HUMAN)

Entry version 106 (10 Feb 2021)
Sequence version 1 (07 Feb 2006)
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Protein

Proline and serine-rich protein 3

Gene

PROSER3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q2NL68

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q2NL68

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proline and serine-rich protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PROSER3
Synonyms:C19orf55
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25204, PROSER3

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q2NL68

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000167595.14

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		148137

Open Targets

More...OpenTargetsi		ENSG00000167595

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162378639

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q2NL68, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PROSER3

Domain mapping of disease mutations (DMDM)

More...DMDMi		121941602

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002994821 – 480Proline and serine-rich protein 3Add BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei408PhosphoserineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q2NL68

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q2NL68

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q2NL68

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q2NL68

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q2NL68

PeptideAtlas

More...PeptideAtlasi		Q2NL68

PRoteomics IDEntifications database

More...PRIDEi		Q2NL68

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		61420 [Q2NL68-1]
61421 [Q2NL68-2]
61422 [Q2NL68-3]
61423 [Q2NL68-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q2NL68

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q2NL68

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000167595, Expressed in right testis and 130 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q2NL68, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q2NL68, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000167595, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127121, 15 interactors

Protein interaction database and analysis system

More...IntActi		Q2NL68, 12 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000380116

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q2NL68, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili419 – 451Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi209 – 248Ser-richAdd BLAST40
Compositional biasi381 – 384Pro-rich4

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S6GS, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000001986

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_022718_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q2NL68

Identification of Orthologs from Complete Genome Data

More...OMAi		FSPHIFW

Database of Orthologous Groups

More...OrthoDBi		1610316at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q2NL68

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037646, PROSER3

The PANTHER Classification System

More...PANTHERi		PTHR22045, PTHR22045, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q2NL68-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDRSLPVFSI QDSPFGDAPL GRSHYWPSQS QTWCPKTLSP SRSQRSRLPQ 
        60         70         80         90        100
APKALATGPN SPELFEESWP SSSGTPSLPS TTEGQMWASP APTLIDSGDS 
       110        120        130        140        150
VVAKYINRFR QAQPTSREER QPAGPTPADF WWLQSDSPDP SSQSAAAGAN 
       160        170        180        190        200
KPEGRPHTAV PTAVNVTSAS HAVAPLQEIK QNLHTWNSSL LDLETLSLQS 
       210        220        230        240        250
RAARLLKRSK ASISSSSSLS PSDASTSSFP TSSDGLSPFS ETFIPDSSKG 
       260        270        280        290        300
LGPRAPASPA PAQAQTPTPA PAPASSQAPL RPEDDILYQW RQRRKLEQAQ 
       310        320        330        340        350
GSKGDRAWVP PLTPALRTLA ESLKAKALPP AAGSVIRKSE ATPSPGACLQ 
       360        370        380        390        400
PEVPLSPAEQ ATTVKASPPA FQVGSPEALA PPPPAADHAP SEALLAQAAL 
       410        420        430        440        450
LLQAAEDSDG SEFQDDPVLQ VLRAHRAELS RQKREADARL SFLLDQAEDL 
       460        470        480
GSWSPPAGSP PRSPRRLLRR EGDSLEARRL
Length:480
Mass (Da):51,075
Last modified:February 7, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i68BF6EA452455363
GO
Isoform 2 (identifier: Q2NL68-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     145-145: Missing.
     210-220: Missing.
     320-336: AESLKAKALPPAAGSVI → VSRGREEPGGSWRRGWV
     337-480: Missing.

Show »
Length:324
Mass (Da):35,010
Checksum:iF1AF183E66C9B4A6
GO
Isoform 3 (identifier: Q2NL68-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     145-145: Missing.
     182-194: NLHTWNSSLLDLE → VTSPFTPSLGCLN
     195-480: Missing.

Show »
Length:193
Mass (Da):20,721
Checksum:i0906FB3895B74972
GO
Isoform 4 (identifier: Q2NL68-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     182-194: NLHTWNSSLLDLE → VTSPFTPSLGCLN
     195-480: Missing.

Show »
Length:194
Mass (Da):20,792
Checksum:i183806E76277B354
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JFW7C9JFW7_HUMAN
Proline and serine-rich protein 3
PROSER3
255Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GXU6F5GXU6_HUMAN
Proline and serine-rich protein 3
PROSER3
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3L1S4R3L1_HUMAN
Proline and serine-rich protein 3
PROSER3
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZ53M0QZ53_HUMAN
Proline and serine-rich protein 3
PROSER3
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y8D9A0A2R8Y8D9_HUMAN
Proline and serine-rich protein 3
PROSER3
468Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W7U6F8W7U6_HUMAN
Proline and serine-rich protein 3
PROSER3
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QY86M0QY86_HUMAN
Proline and serine-rich protein 3
PROSER3
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFI8H0YFI8_HUMAN
Proline and serine-rich protein 3
PROSER3
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH17947 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q2NL68-2)
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti209P → S in BAB70878 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_056845302S → R. Corresponds to variant dbSNP:rs231219Ensembl.1
Natural variantiVAR_061631365K → N. Corresponds to variant dbSNP:rs231217Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027698145Missing in isoform 2 and isoform 3. 2 Publications1
Alternative sequenceiVSP_027699182 – 194NLHTW…LLDLE → VTSPFTPSLGCLN in isoform 3 and isoform 4. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_027700195 – 480Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST286
Alternative sequenceiVSP_027701210 – 220Missing in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_027702320 – 336AESLK…AGSVI → VSRGREEPGGSWRRGWV in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_027703337 – 480Missing in isoform 2. 1 PublicationAdd BLAST144

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK055219 mRNA Translation: BAB70878.1
AL833894 mRNA Translation: CAD38750.2
AC002398 Genomic DNA No translation available.
BC017947 mRNA Translation: AAH17947.1 Different initiation.
BC110893 mRNA Translation: AAI10894.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46056.2 [Q2NL68-1]

NCBI Reference Sequences

More...RefSeqi		NP_001034976.2, NM_001039887.2 [Q2NL68-1]
XP_011524838.1, XM_011526536.2 [Q2NL68-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000396908; ENSP00000380116; ENSG00000167595 [Q2NL68-1]
ENST00000536950; ENSP00000466822; ENSG00000167595 [Q2NL68-3]
ENST00000537459; ENSP00000439886; ENSG00000167595 [Q2NL68-4]
ENST00000620918; ENSP00000482508; ENSG00000167595 [Q2NL68-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		148137

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:148137

UCSC genome browser

More...UCSCi		uc002obo.2, human [Q2NL68-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055219 mRNA Translation: BAB70878.1
AL833894 mRNA Translation: CAD38750.2
AC002398 Genomic DNA No translation available.
BC017947 mRNA Translation: AAH17947.1 Different initiation.
BC110893 mRNA Translation: AAI10894.1
CCDSiCCDS46056.2 [Q2NL68-1]
RefSeqiNP_001034976.2, NM_001039887.2 [Q2NL68-1]
XP_011524838.1, XM_011526536.2 [Q2NL68-2]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi127121, 15 interactors
IntActiQ2NL68, 12 interactors
STRINGi9606.ENSP00000380116

PTM databases

iPTMnetiQ2NL68
PhosphoSitePlusiQ2NL68

Genetic variation databases

BioMutaiPROSER3
DMDMi121941602

Proteomic databases

EPDiQ2NL68
jPOSTiQ2NL68
MassIVEiQ2NL68
MaxQBiQ2NL68
PaxDbiQ2NL68
PeptideAtlasiQ2NL68
PRIDEiQ2NL68
ProteomicsDBi61420 [Q2NL68-1]
61421 [Q2NL68-2]
61422 [Q2NL68-3]
61423 [Q2NL68-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		44565, 41 antibodies

Genome annotation databases

EnsembliENST00000396908; ENSP00000380116; ENSG00000167595 [Q2NL68-1]
ENST00000536950; ENSP00000466822; ENSG00000167595 [Q2NL68-3]
ENST00000537459; ENSP00000439886; ENSG00000167595 [Q2NL68-4]
ENST00000620918; ENSP00000482508; ENSG00000167595 [Q2NL68-2]
GeneIDi148137
KEGGihsa:148137
UCSCiuc002obo.2, human [Q2NL68-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		148137
DisGeNETi148137

GeneCards: human genes, protein and diseases

More...GeneCardsi		PROSER3
HGNCiHGNC:25204, PROSER3
HPAiENSG00000167595, Low tissue specificity
neXtProtiNX_Q2NL68
OpenTargetsiENSG00000167595
PharmGKBiPA162378639
VEuPathDBiHostDB:ENSG00000167595.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S6GS, Eukaryota
GeneTreeiENSGT00390000001986
HOGENOMiCLU_022718_0_0_1
InParanoidiQ2NL68
OMAiFSPHIFW
OrthoDBi1610316at2759
PhylomeDBiQ2NL68

Enzyme and pathway databases

PathwayCommonsiQ2NL68
SignaLinkiQ2NL68

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		148137, 2 hits in 113 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		148137
PharosiQ2NL68, Tdark

Protein Ontology

More...PROi		PR:Q2NL68
RNActiQ2NL68, protein

Gene expression databases

BgeeiENSG00000167595, Expressed in right testis and 130 other tissues
ExpressionAtlasiQ2NL68, baseline and differential
GenevisibleiQ2NL68, HS

Family and domain databases

InterProiView protein in InterPro
IPR037646, PROSER3
PANTHERiPTHR22045, PTHR22045, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRSR3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2NL68
Secondary accession number(s): Q8NDI3, Q8WWC8, Q96NL4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 7, 2006
Last modified: February 10, 2021
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
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