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Protein

Poly [ADP-ribose] polymerase 6

Gene

PARP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation

GO - Molecular functioni

  • NAD+ ADP-ribosyltransferase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
LigandNAD

Enzyme and pathway databases

BRENDAi2.4.2.30 2681
ReactomeiR-HSA-197264 Nicotinamide salvaging

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymerase 6 (EC:2.4.2.30)
Short name:
PARP-6
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 17
Short name:
ARTD17
Gene namesi
Name:PARP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000137817.16
HGNCiHGNC:26921 PARP6
neXtProtiNX_Q2NL67

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi56965
OpenTargetsiENSG00000137817
PharmGKBiPA134900863

Chemistry databases

ChEMBLiCHEMBL2380187

Polymorphism and mutation databases

BioMutaiPARP6
DMDMi116248567

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002524301 – 630Poly [ADP-ribose] polymerase 6Add BLAST630

Proteomic databases

PaxDbiQ2NL67
PRIDEiQ2NL67
ProteomicsDBi61417
61418 [Q2NL67-2]
61419 [Q2NL67-3]

PTM databases

iPTMnetiQ2NL67
PhosphoSitePlusiQ2NL67

Expressioni

Gene expression databases

BgeeiENSG00000137817 Expressed in 226 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_PARP6
ExpressionAtlasiQ2NL67 baseline and differential
GenevisibleiQ2NL67 HS

Organism-specific databases

HPAiHPA026991

Interactioni

Protein-protein interaction databases

BioGridi121286, 10 interactors
STRINGi9606.ENSP00000287196

Chemistry databases

BindingDBiQ2NL67

Structurei

3D structure databases

ProteinModelPortaliQ2NL67
SMRiQ2NL67
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini394 – 620PARP catalyticPROSITE-ProRule annotationAdd BLAST227

Phylogenomic databases

eggNOGiENOG410IE5T Eukaryota
ENOG410ZI9J LUCA
GeneTreeiENSGT00390000017707
HOGENOMiHOG000115451
HOVERGENiHBG057572
InParanoidiQ2NL67
KOiK15258
OMAiAGGHCKN
OrthoDBiEOG091G02PT
PhylomeDBiQ2NL67
TreeFamiTF323413

Family and domain databases

InterProiView protein in InterPro
IPR012317 Poly(ADP-ribose)pol_cat_dom
PfamiView protein in Pfam
PF00644 PARP, 1 hit
PROSITEiView protein in PROSITE
PS51059 PARP_CATALYTIC, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q2NL67-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDIKGQFWND DDSEGDNESE EFLYGVQGSC AADLYRHPQL DADIEAVKEI
60 70 80 90 100
YSENSVSIRE YGTIDDVDID LHINISFLDE EVSTAWKVLR TEPIVLRLRF
110 120 130 140 150
SLSQYLDGPE PSIEVFQPSN KEGFGLGLQL KKILGMFTSQ QWKHLSNDFL
160 170 180 190 200
KTQQEKRHSW FKASGTIKKF RAGLSIFSPI PKSPSFPIIQ DSMLKGKLGV
210 220 230 240 250
PELRVGRLMN RSISCTMKNP KVEVFGYPPS PQAGLLCPQH VGLPPPARTS
260 270 280 290 300
PLVSGHCKNI PTLEYGFLVQ IMKYAEQRIP TLNEYCVVCD EQHVFQNGSM
310 320 330 340 350
LKPAVCTREL CVFSFYTLGV MSGAAEEVAT GAEVVDLLVA MCRAALESPR
360 370 380 390 400
KSIIFEPYPS VVDPTDPKTL AFNPKKKNYE RLQKALDSVM SIREMTQGSY
410 420 430 440 450
LEIKKQMDKL DPLAHPLLQW IISSNRSHIV KLPLSRLKFM HTSHQFLLLS
460 470 480 490 500
SPPAKEARFR TAKKLYGSTF AFHGSHIENW HSILRNGLVN ASYTKLQLHG
510 520 530 540 550
AAYGKGIYLS PISSISFGYS GMGKGQHRMP SKDELVQRYN RMNTIPQTRS
560 570 580 590 600
IQSRFLQSRN LNCIALCEVI TSKDLQKHGN IWVCPVSDHV CTRFFFVYED
610 620 630
GQVGDANINT QDPKIQKEIM RVIGTQVYTN
Length:630
Mass (Da):71,115
Last modified:February 7, 2006 - v1
Checksum:i5762F55F59AA9873
GO
Isoform 2 (identifier: Q2NL67-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     498-518: LHGAAYGKGIYLSPISSISFG → EWEKDSTGCPPRMSWSRDTTG
     519-630: Missing.

Show »
Length:518
Mass (Da):58,483
Checksum:iADE86E3EC4A1EAF8
GO
Isoform 3 (identifier: Q2NL67-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     373-388: NPKKKNYERLQKALDS → MVELDPRTTPHSDGPD
     389-630: Missing.

Note: No experimental confirmation available.
Show »
Length:388
Mass (Da):43,328
Checksum:iEC93A6A029417B01
GO

Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BQK2H3BQK2_HUMAN
Poly [ADP-ribose] polymerase
PARP6
564Annotation score:
F5H3B4F5H3B4_HUMAN
Poly [ADP-ribose] polymerase
PARP6
553Annotation score:
H3BUQ6H3BUQ6_HUMAN
Poly [ADP-ribose] polymerase 6
PARP6
124Annotation score:
H3BQM7H3BQM7_HUMAN
Poly [ADP-ribose] polymerase 6
PARP6
73Annotation score:
H3BRR4H3BRR4_HUMAN
Poly (ADP-ribose) polymerase family...
PARP6 hCG_40464
519Annotation score:
H3BRZ3H3BRZ3_HUMAN
Poly [ADP-ribose] polymerase 6
PARP6
451Annotation score:
H3BTE2H3BTE2_HUMAN
Poly [ADP-ribose] polymerase 6
PARP6
76Annotation score:
H3BSK7H3BSK7_HUMAN
Poly [ADP-ribose] polymerase 6
PARP6
80Annotation score:
A0A087X1Y8A0A087X1Y8_HUMAN
Poly [ADP-ribose] polymerase 6
PARP6
440Annotation score:
H3BUY2H3BUY2_HUMAN
Poly [ADP-ribose] polymerase 6
PARP6
73Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence BAB14969 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB59261 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29S → N in BAB14092 (PubMed:14702039).Curated1
Sequence conflicti264E → G in BAB13896 (PubMed:14702039).Curated1
Sequence conflicti388S → N in BAB14969 (PubMed:14702039).Curated1
Sequence conflicti436R → RQ in BAB14092 (PubMed:14702039).Curated1
Sequence conflicti436R → RQ in CAB98250 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020963373 – 388NPKKK…KALDS → MVELDPRTTPHSDGPD in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_020964389 – 630Missing in isoform 3. 1 PublicationAdd BLAST242
Alternative sequenceiVSP_020965498 – 518LHGAA…SISFG → EWEKDSTGCPPRMSWSRDTT G in isoform 2. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_020966519 – 630Missing in isoform 2. 2 PublicationsAdd BLAST112

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021790 mRNA Translation: BAB13896.1
AK022547 mRNA Translation: BAB14092.1
AK024703 mRNA Translation: BAB14969.1 Different initiation.
BC110902 mRNA Translation: AAI10903.1
AL122091 mRNA Translation: CAB59261.1 Different initiation.
AL390093 mRNA Translation: CAB98250.1
CCDSiCCDS10241.2 [Q2NL67-1]
PIRiT34522
RefSeqiNP_001310451.1, NM_001323522.1 [Q2NL67-1]
NP_001310461.1, NM_001323532.1 [Q2NL67-1]
NP_064599.2, NM_020214.3 [Q2NL67-1]
UniGeneiHs.270244

Genome annotation databases

EnsembliENST00000260376; ENSP00000260376; ENSG00000137817 [Q2NL67-2]
ENST00000287196; ENSP00000287196; ENSG00000137817 [Q2NL67-1]
ENST00000569795; ENSP00000456348; ENSG00000137817 [Q2NL67-1]
GeneIDi56965
KEGGihsa:56965
UCSCiuc002auc.4 human [Q2NL67-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021790 mRNA Translation: BAB13896.1
AK022547 mRNA Translation: BAB14092.1
AK024703 mRNA Translation: BAB14969.1 Different initiation.
BC110902 mRNA Translation: AAI10903.1
AL122091 mRNA Translation: CAB59261.1 Different initiation.
AL390093 mRNA Translation: CAB98250.1
CCDSiCCDS10241.2 [Q2NL67-1]
PIRiT34522
RefSeqiNP_001310451.1, NM_001323522.1 [Q2NL67-1]
NP_001310461.1, NM_001323532.1 [Q2NL67-1]
NP_064599.2, NM_020214.3 [Q2NL67-1]
UniGeneiHs.270244

3D structure databases

ProteinModelPortaliQ2NL67
SMRiQ2NL67
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121286, 10 interactors
STRINGi9606.ENSP00000287196

Chemistry databases

BindingDBiQ2NL67
ChEMBLiCHEMBL2380187

PTM databases

iPTMnetiQ2NL67
PhosphoSitePlusiQ2NL67

Polymorphism and mutation databases

BioMutaiPARP6
DMDMi116248567

Proteomic databases

PaxDbiQ2NL67
PRIDEiQ2NL67
ProteomicsDBi61417
61418 [Q2NL67-2]
61419 [Q2NL67-3]

Protocols and materials databases

DNASUi56965
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260376; ENSP00000260376; ENSG00000137817 [Q2NL67-2]
ENST00000287196; ENSP00000287196; ENSG00000137817 [Q2NL67-1]
ENST00000569795; ENSP00000456348; ENSG00000137817 [Q2NL67-1]
GeneIDi56965
KEGGihsa:56965
UCSCiuc002auc.4 human [Q2NL67-1]

Organism-specific databases

CTDi56965
DisGeNETi56965
EuPathDBiHostDB:ENSG00000137817.16
GeneCardsiPARP6
HGNCiHGNC:26921 PARP6
HPAiHPA026991
neXtProtiNX_Q2NL67
OpenTargetsiENSG00000137817
PharmGKBiPA134900863
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE5T Eukaryota
ENOG410ZI9J LUCA
GeneTreeiENSGT00390000017707
HOGENOMiHOG000115451
HOVERGENiHBG057572
InParanoidiQ2NL67
KOiK15258
OMAiAGGHCKN
OrthoDBiEOG091G02PT
PhylomeDBiQ2NL67
TreeFamiTF323413

Enzyme and pathway databases

BRENDAi2.4.2.30 2681
ReactomeiR-HSA-197264 Nicotinamide salvaging

Miscellaneous databases

ChiTaRSiPARP6 human
GenomeRNAii56965
PROiPR:Q2NL67

Gene expression databases

BgeeiENSG00000137817 Expressed in 226 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_PARP6
ExpressionAtlasiQ2NL67 baseline and differential
GenevisibleiQ2NL67 HS

Family and domain databases

InterProiView protein in InterPro
IPR012317 Poly(ADP-ribose)pol_cat_dom
PfamiView protein in Pfam
PF00644 PARP, 1 hit
PROSITEiView protein in PROSITE
PS51059 PARP_CATALYTIC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPARP6_HUMAN
AccessioniPrimary (citable) accession number: Q2NL67
Secondary accession number(s): Q9H7C5
, Q9H9X6, Q9HAF3, Q9NPS6, Q9UFG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: February 7, 2006
Last modified: November 7, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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