UniProtKB - Q2NL67 (PARP6_HUMAN)
Protein
Protein mono-ADP-ribosyltransferase PARP6
Gene
PARP6
Organism
Homo sapiens (Human)
Status
Functioni
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.1 Publication
Catalytic activityi
- L-cysteinyl-[protein] + NAD+ = H+ + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]1 Publication
GO - Molecular functioni
- NAD+ ADP-ribosyltransferase activity Source: GO_Central
- protein ADP-ribosylase activity Source: UniProtKB
GO - Biological processi
- positive regulation of dendrite morphogenesis Source: Ensembl
- protein ADP-ribosylation Source: GO_Central
- protein auto-ADP-ribosylation Source: UniProtKB
- protein mono-ADP-ribosylation Source: UniProtKB
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Ligand | NAD |
Enzyme and pathway databases
BRENDAi | 2.4.2.30, 2681 |
PathwayCommonsi | Q2NL67 |
Reactomei | R-HSA-197264, Nicotinamide salvaging R-HSA-9683610, Maturation of nucleoprotein |
Names & Taxonomyi
Protein namesi | Recommended name: Protein mono-ADP-ribosyltransferase PARP6Curated (EC:2.4.2.-1 Publication)Alternative name(s): ADP-ribosyltransferase diphtheria toxin-like 17 Short name: ARTD17 Poly [ADP-ribose] polymerase 6 Short name: PARP-6 |
Gene namesi | Name:PARP6Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000137817.16 |
HGNCi | HGNC:26921, PARP6 |
neXtProti | NX_Q2NL67 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 56965 |
OpenTargetsi | ENSG00000137817 |
PharmGKBi | PA134900863 |
Miscellaneous databases
Pharosi | Q2NL67, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2380187 |
Polymorphism and mutation databases
BioMutai | PARP6 |
DMDMi | 116248567 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000252430 | 1 – 630 | Protein mono-ADP-ribosyltransferase PARP6Add BLAST | 630 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 237 | ADP-ribosylcysteine1 Publication | 1 | |
Modified residuei | 600 | ADP-ribosyl aspartic acid1 Publication | 1 |
Post-translational modificationi
Auto-mono-ADP-ribosylated.1 Publication
Keywords - PTMi
ADP-ribosylationProteomic databases
PaxDbi | Q2NL67 |
PeptideAtlasi | Q2NL67 |
PRIDEi | Q2NL67 |
ProteomicsDBi | 61417 [Q2NL67-1] 61418 [Q2NL67-2] 61419 [Q2NL67-3] |
PTM databases
iPTMneti | Q2NL67 |
PhosphoSitePlusi | Q2NL67 |
Expressioni
Gene expression databases
Bgeei | ENSG00000137817, Expressed in left lobe of thyroid gland and 239 other tissues |
ExpressionAtlasi | Q2NL67, baseline and differential |
Genevisiblei | Q2NL67, HS |
Organism-specific databases
HPAi | ENSG00000137817, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 121286, 11 interactors |
STRINGi | 9606.ENSP00000456348 |
Chemistry databases
BindingDBi | Q2NL67 |
Miscellaneous databases
RNActi | Q2NL67, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 394 – 620 | PARP catalyticPROSITE-ProRule annotationAdd BLAST | 227 |
Phylogenomic databases
eggNOGi | ENOG502QPRC, Eukaryota |
GeneTreei | ENSGT00950000183129 |
InParanoidi | Q2NL67 |
OMAi | LGLQLKX |
OrthoDBi | 268345at2759 |
PhylomeDBi | Q2NL67 |
TreeFami | TF323413 |
Family and domain databases
InterProi | View protein in InterPro IPR012317, Poly(ADP-ribose)pol_cat_dom |
Pfami | View protein in Pfam PF00644, PARP, 1 hit |
PROSITEi | View protein in PROSITE PS51059, PARP_CATALYTIC, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q2NL67-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDIKGQFWND DDSEGDNESE EFLYGVQGSC AADLYRHPQL DADIEAVKEI
60 70 80 90 100
YSENSVSIRE YGTIDDVDID LHINISFLDE EVSTAWKVLR TEPIVLRLRF
110 120 130 140 150
SLSQYLDGPE PSIEVFQPSN KEGFGLGLQL KKILGMFTSQ QWKHLSNDFL
160 170 180 190 200
KTQQEKRHSW FKASGTIKKF RAGLSIFSPI PKSPSFPIIQ DSMLKGKLGV
210 220 230 240 250
PELRVGRLMN RSISCTMKNP KVEVFGYPPS PQAGLLCPQH VGLPPPARTS
260 270 280 290 300
PLVSGHCKNI PTLEYGFLVQ IMKYAEQRIP TLNEYCVVCD EQHVFQNGSM
310 320 330 340 350
LKPAVCTREL CVFSFYTLGV MSGAAEEVAT GAEVVDLLVA MCRAALESPR
360 370 380 390 400
KSIIFEPYPS VVDPTDPKTL AFNPKKKNYE RLQKALDSVM SIREMTQGSY
410 420 430 440 450
LEIKKQMDKL DPLAHPLLQW IISSNRSHIV KLPLSRLKFM HTSHQFLLLS
460 470 480 490 500
SPPAKEARFR TAKKLYGSTF AFHGSHIENW HSILRNGLVN ASYTKLQLHG
510 520 530 540 550
AAYGKGIYLS PISSISFGYS GMGKGQHRMP SKDELVQRYN RMNTIPQTRS
560 570 580 590 600
IQSRFLQSRN LNCIALCEVI TSKDLQKHGN IWVCPVSDHV CTRFFFVYED
610 620 630
GQVGDANINT QDPKIQKEIM RVIGTQVYTN
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BQK2 | H3BQK2_HUMAN | Poly [ADP-ribose] polymerase | PARP6 | 564 | Annotation score: | ||
F5H3B4 | F5H3B4_HUMAN | Poly [ADP-ribose] polymerase | PARP6 | 553 | Annotation score: | ||
H3BQM7 | H3BQM7_HUMAN | Protein mono-ADP-ribosyltransferase... | PARP6 | 73 | Annotation score: | ||
H3BUQ6 | H3BUQ6_HUMAN | Protein mono-ADP-ribosyltransferase... | PARP6 | 124 | Annotation score: | ||
H3BRR4 | H3BRR4_HUMAN | Poly (ADP-ribose) polymerase family... | PARP6 hCG_40464 | 519 | Annotation score: | ||
H3BRZ3 | H3BRZ3_HUMAN | Protein mono-ADP-ribosyltransferase... | PARP6 | 451 | Annotation score: | ||
H3BTI3 | H3BTI3_HUMAN | Protein mono-ADP-ribosyltransferase... | PARP6 | 26 | Annotation score: | ||
H3BSK7 | H3BSK7_HUMAN | Protein mono-ADP-ribosyltransferase... | PARP6 | 80 | Annotation score: | ||
H3BMA3 | H3BMA3_HUMAN | Protein mono-ADP-ribosyltransferase... | PARP6 | 251 | Annotation score: | ||
H3BQ70 | H3BQ70_HUMAN | Protein mono-ADP-ribosyltransferase... | PARP6 | 17 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
The sequence BAB14969 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB59261 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 29 | S → N in BAB14092 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 264 | E → G in BAB13896 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 388 | S → N in BAB14969 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 436 | R → RQ in BAB14092 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 436 | R → RQ in CAB98250 (Ref. 4) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_020963 | 373 – 388 | NPKKK…KALDS → MVELDPRTTPHSDGPD in isoform 3. 1 PublicationAdd BLAST | 16 | |
Alternative sequenceiVSP_020964 | 389 – 630 | Missing in isoform 3. 1 PublicationAdd BLAST | 242 | |
Alternative sequenceiVSP_020965 | 498 – 518 | LHGAA…SISFG → EWEKDSTGCPPRMSWSRDTT G in isoform 2. 2 PublicationsAdd BLAST | 21 | |
Alternative sequenceiVSP_020966 | 519 – 630 | Missing in isoform 2. 2 PublicationsAdd BLAST | 112 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK021790 mRNA Translation: BAB13896.1 AK022547 mRNA Translation: BAB14092.1 AK024703 mRNA Translation: BAB14969.1 Different initiation. BC110902 mRNA Translation: AAI10903.1 AL122091 mRNA Translation: CAB59261.1 Different initiation. AL390093 mRNA Translation: CAB98250.1 |
CCDSi | CCDS10241.2 [Q2NL67-1] |
PIRi | T34522 |
RefSeqi | NP_001310451.1, NM_001323522.1 [Q2NL67-1] NP_001310461.1, NM_001323532.1 [Q2NL67-1] NP_064599.2, NM_020214.3 [Q2NL67-1] |
Genome annotation databases
Ensembli | ENST00000260376; ENSP00000260376; ENSG00000137817 [Q2NL67-2] ENST00000287196; ENSP00000287196; ENSG00000137817 [Q2NL67-1] ENST00000569795; ENSP00000456348; ENSG00000137817 [Q2NL67-1] |
GeneIDi | 56965 |
KEGGi | hsa:56965 |
UCSCi | uc002auc.4, human [Q2NL67-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK021790 mRNA Translation: BAB13896.1 AK022547 mRNA Translation: BAB14092.1 AK024703 mRNA Translation: BAB14969.1 Different initiation. BC110902 mRNA Translation: AAI10903.1 AL122091 mRNA Translation: CAB59261.1 Different initiation. AL390093 mRNA Translation: CAB98250.1 |
CCDSi | CCDS10241.2 [Q2NL67-1] |
PIRi | T34522 |
RefSeqi | NP_001310451.1, NM_001323522.1 [Q2NL67-1] NP_001310461.1, NM_001323532.1 [Q2NL67-1] NP_064599.2, NM_020214.3 [Q2NL67-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 121286, 11 interactors |
STRINGi | 9606.ENSP00000456348 |
Chemistry databases
BindingDBi | Q2NL67 |
ChEMBLi | CHEMBL2380187 |
PTM databases
iPTMneti | Q2NL67 |
PhosphoSitePlusi | Q2NL67 |
Polymorphism and mutation databases
BioMutai | PARP6 |
DMDMi | 116248567 |
Proteomic databases
PaxDbi | Q2NL67 |
PeptideAtlasi | Q2NL67 |
PRIDEi | Q2NL67 |
ProteomicsDBi | 61417 [Q2NL67-1] 61418 [Q2NL67-2] 61419 [Q2NL67-3] |
Protocols and materials databases
Antibodypediai | 14201, 162 antibodies |
DNASUi | 56965 |
Genome annotation databases
Ensembli | ENST00000260376; ENSP00000260376; ENSG00000137817 [Q2NL67-2] ENST00000287196; ENSP00000287196; ENSG00000137817 [Q2NL67-1] ENST00000569795; ENSP00000456348; ENSG00000137817 [Q2NL67-1] |
GeneIDi | 56965 |
KEGGi | hsa:56965 |
UCSCi | uc002auc.4, human [Q2NL67-1] |
Organism-specific databases
CTDi | 56965 |
DisGeNETi | 56965 |
EuPathDBi | HostDB:ENSG00000137817.16 |
GeneCardsi | PARP6 |
HGNCi | HGNC:26921, PARP6 |
HPAi | ENSG00000137817, Low tissue specificity |
neXtProti | NX_Q2NL67 |
OpenTargetsi | ENSG00000137817 |
PharmGKBi | PA134900863 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QPRC, Eukaryota |
GeneTreei | ENSGT00950000183129 |
InParanoidi | Q2NL67 |
OMAi | LGLQLKX |
OrthoDBi | 268345at2759 |
PhylomeDBi | Q2NL67 |
TreeFami | TF323413 |
Enzyme and pathway databases
BRENDAi | 2.4.2.30, 2681 |
PathwayCommonsi | Q2NL67 |
Reactomei | R-HSA-197264, Nicotinamide salvaging R-HSA-9683610, Maturation of nucleoprotein |
Miscellaneous databases
BioGRID-ORCSi | 56965, 12 hits in 839 CRISPR screens |
ChiTaRSi | PARP6, human |
GenomeRNAii | 56965 |
Pharosi | Q2NL67, Tchem |
PROi | PR:Q2NL67 |
RNActi | Q2NL67, protein |
Gene expression databases
Bgeei | ENSG00000137817, Expressed in left lobe of thyroid gland and 239 other tissues |
ExpressionAtlasi | Q2NL67, baseline and differential |
Genevisiblei | Q2NL67, HS |
Family and domain databases
InterProi | View protein in InterPro IPR012317, Poly(ADP-ribose)pol_cat_dom |
Pfami | View protein in Pfam PF00644, PARP, 1 hit |
PROSITEi | View protein in PROSITE PS51059, PARP_CATALYTIC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PARP6_HUMAN | |
Accessioni | Q2NL67Primary (citable) accession number: Q2NL67 Secondary accession number(s): Q9H7C5 Q9UFG4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 17, 2006 |
Last sequence update: | February 7, 2006 | |
Last modified: | December 2, 2020 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM