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Protein

Kinesin-like protein KIF2A

Gene

KIF2A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi267 – 274ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Motor protein
Biological processCell cycle, Cell division, Differentiation, Mitosis, Neurogenesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF2A
Gene namesi
Name:KIF2A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002537141 – 660Kinesin-like protein KIF2AAdd BLAST660

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei48PhosphoserineBy similarity1
Modified residuei51PhosphothreonineBy similarity1
Modified residuei70PhosphothreonineBy similarity1
Modified residuei73PhosphoserineBy similarity1
Modified residuei75N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ2NL05

Interactioni

Subunit structurei

Interacts with AURKA, PSRC1 and PLK1.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ2NL05
SMRiQ2NL05
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini177 – 507Kinesin motorPROSITE-ProRule annotationAdd BLAST331

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 171GlobularSequence analysisAdd BLAST171

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili614 – 653Sequence analysisAdd BLAST40

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000231329
HOVERGENiHBG003875
InParanoidiQ2NL05
KOiK10393

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q2NL05-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVTSLNEDNE SVTVEWIENG DTKGKEIDLE SIFSLNPDLV PDEDIEPSPE
60 70 80 90 100
TPPPPTSSAK VNKIVKNRRT VASIKNEPPP RDNRVVGSAR ARPSQLPEQS
110 120 130 140 150
SSAQQNARRK SNCVKEVEKL QEKREKRRLQ QQELREKRAQ DVDATNPNYE
160 170 180 190 200
IMCMIRDFRG SLDYRPLTTA DPIDEHRICV CVRKRPLNKK ETQMKDLDVI
210 220 230 240 250
TIPSKDVVMV HEPKQKVDLT RYLENQTFRF DYAFDDSAPN EMVYRFTARP
260 270 280 290 300
LVETIFERGM ATCFAYGQTG SGKTHTMGGD FSGKNQDCSK GIYALAARDV
310 320 330 340 350
FLMLKKPNYK KLELQVNATF FEIYSGKVFD LLNRKTKLRV LEDGKQQVQV
360 370 380 390 400
VGLQEREVKC VEDVLKLIDI GNSCRTSGQT SANAHSSRSH AVFQIILRRK
410 420 430 440 450
GKLHGKFSLI DLAGNERGAD TSSADRQTRL EGAEINKSLL AHKECIRALG
460 470 480 490 500
RNKPHTPFRA SKLTQVLRDS FIGENSRTCM IATISPGMAS CENTLNTLRY
510 520 530 540 550
ANRVKELTVD PTAAGDVRPI MHHPPNQIDD LEAQWGVGSS PQRDDLKLLC
560 570 580 590 600
EQNEEEVSPQ LFTFHEAVSQ MVEMEEQVVE DHRAVFQESI RWLEDEKALL
610 620 630 640 650
EMTEEVDYDV DSYATQLEAI LEQKIDILTE LRDKVKSFRA ALQEEEQASK
660
QINPKRPRAL
Length:660
Mass (Da):74,994
Last modified:February 7, 2006 - v1
Checksum:i4D0143CDFF51361E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111267 mRNA Translation: AAI11268.1
RefSeqiNP_001070541.1, NM_001077073.1
UniGeneiBt.107239

Genome annotation databases

GeneIDi768014
KEGGibta:768014

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111267 mRNA Translation: AAI11268.1
RefSeqiNP_001070541.1, NM_001077073.1
UniGeneiBt.107239

3D structure databases

ProteinModelPortaliQ2NL05
SMRiQ2NL05
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ2NL05

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi768014
KEGGibta:768014

Organism-specific databases

CTDi3796

Phylogenomic databases

HOGENOMiHOG000231329
HOVERGENiHBG003875
InParanoidiQ2NL05
KOiK10393

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKIF2A_BOVIN
AccessioniPrimary (citable) accession number: Q2NL05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: February 7, 2006
Last modified: October 25, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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