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Protein

UPF0561 protein C2orf68

Gene

C2orf68

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0561 protein C2orf68
Gene namesi
Name:C2orf68
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000168887.10
HGNCiHGNC:34353 C2orf68
neXtProtiNX_Q2NKX9

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168887
PharmGKBiPA162379474

Polymorphism and mutation databases

BioMutaiC2orf68
DMDMi121941598

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003287851 – 166UPF0561 protein C2orf68Add BLAST166

Proteomic databases

PaxDbiQ2NKX9
PeptideAtlasiQ2NKX9
PRIDEiQ2NKX9
ProteomicsDBi61415
61416 [Q2NKX9-3]

PTM databases

iPTMnetiQ2NKX9
PhosphoSitePlusiQ2NKX9

Expressioni

Gene expression databases

BgeeiENSG00000168887
CleanExiHS_C2orf68
ExpressionAtlasiQ2NKX9 baseline and differential
GenevisibleiQ2NKX9 HS

Organism-specific databases

HPAiHPA051143

Interactioni

Protein-protein interaction databases

BioGridi132926, 12 interactors
IntActiQ2NKX9, 12 interactors
STRINGi9606.ENSP00000304410

Structurei

3D structure databases

ProteinModelPortaliQ2NKX9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi92 – 95Poly-Ser4

Sequence similaritiesi

Belongs to the UPF0561 family.Curated

Phylogenomic databases

eggNOGiENOG410IZ82 Eukaryota
ENOG4111P0A LUCA
GeneTreeiENSGT00390000001901
HOGENOMiHOG000111329
HOVERGENiHBG096819
InParanoidiQ2NKX9
OMAiPGLCCKP
OrthoDBiEOG091G15G9
PhylomeDBiQ2NKX9
TreeFamiTF328804

Family and domain databases

InterProiView protein in InterPro
IPR018888 UPF0561
PANTHERiPTHR34256 PTHR34256, 1 hit
PfamiView protein in Pfam
PF10573 UPF0561, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2NKX9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAGPHPRPG HCCKPGGRLD MNHGFVHHIR RNQIARDDYD KKVKQAAKEK
60 70 80 90 100
VRRRHTPAPT RPRKPDLQVY LPRHRDVSAH PRNPDYEESG ESSSSGGSEL
110 120 130 140 150
EPSGHQLFCL EYEADSGEVT SVIVYQGDDP GKVSEKVSAH TPLDPPMREA
160
LKLRIQEEIA KRQSQH
Length:166
Mass (Da):18,751
Last modified:February 7, 2006 - v1
Checksum:i5BE55D1865157951
GO
Isoform 2 (identifier: Q2NKX9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-127: DVSAHPRNPD...EVTSVIVYQG → GEAARPACLQ...PPQRSQISAE
     128-166: Missing.

Note: No experimental confirmation available.
Show »
Length:127
Mass (Da):14,481
Checksum:i37D911D0A03D52B0
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03279276 – 127DVSAH…IVYQG → GEAARPACLQPARSSCNALP FSIGKNHFLLLRFSSSRLFP EPPPQRSQISAE in isoform 2. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_032793128 – 166Missing in isoform 2. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK124808 mRNA Translation: BAC85956.1
AK300003 mRNA Translation: BAG61822.1
CH471053 Genomic DNA Translation: EAW99495.1
BC111483 mRNA Translation: AAI11484.1
CCDSiCCDS42704.1 [Q2NKX9-1]
RefSeqiNP_001013671.2, NM_001013649.3 [Q2NKX9-1]
UniGeneiHs.516159

Genome annotation databases

EnsembliENST00000306336; ENSP00000304410; ENSG00000168887 [Q2NKX9-1]
ENST00000409734; ENSP00000386301; ENSG00000168887 [Q2NKX9-3]
GeneIDi388969
KEGGihsa:388969
UCSCiuc002sqc.3 human [Q2NKX9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCB068_HUMAN
AccessioniPrimary (citable) accession number: Q2NKX9
Secondary accession number(s): B4DT10, Q4G0J7, Q6ZVA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: February 7, 2006
Last modified: July 18, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

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