UniProtKB - Q2NKI4 (Q2NKI4_MOUSE)
Protein
Protein kinase C
Gene
Prkcg
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
- EC:2.7.11.13ARBA annotation
- ATP + L-threonyl-[protein] = ADP + H+ + O-phospho-L-threonyl-[protein]UniRule annotationARBA annotationEC:2.7.11.13UniRule annotationARBA annotation
Cofactori
Ca2+ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 195 | Phosphatidylinositol 4,5-bisphosphateUniRule annotation | 1 | |
Binding sitei | 245 | Phosphatidylinositol 4,5-bisphosphateUniRule annotation | 1 | |
Binding sitei | 329 | ATPUniRule annotation | 1 | |
Active sitei | 429 | Proton acceptorUniRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- calcium-dependent protein kinase C activity Source: UniProtKB-EC
- protein serine kinase activity Source: RHEA
- protein threonine kinase activity Source: RHEA
- zinc ion binding Source: InterPro
GO - Biological processi
- intracellular signal transduction Source: InterPro
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseUniRule annotationARBA annotation, Transferase |
Ligand | ATP-bindingUniRule annotationARBA annotation, CalciumARBA annotation, Metal-binding, Nucleotide-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Protein kinase CUniRule annotationARBA annotation (EC:2.7.11.13UniRule annotationARBA annotation) |
Gene namesi | |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97597, Prkcg |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm ARBA annotation
Other locations
- Membrane ARBA annotation; Peripheral membrane protein ARBA annotation
Keywords - Cellular componenti
CytoplasmARBA annotationPTM / Processingi
Keywords - PTMi
PhosphoproteinARBA annotationProteomic databases
ProteomicsDBi | 333117 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000078816, Expressed in CA1 field of hippocampus and 126 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 85 | Phorbol-ester/DAG-typeInterPro annotationAdd BLAST | 51 | |
Domaini | 100 – 150 | Phorbol-ester/DAG-typeInterPro annotationAdd BLAST | 51 | |
Domaini | 170 – 260 | C2InterPro annotationAdd BLAST | 91 | |
Domaini | 250 – 563 | Protein kinaseInterPro annotationAdd BLAST | 314 | |
Domaini | 564 – 634 | AGC-kinase C-terminalInterPro annotationAdd BLAST | 71 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.UniRule annotationARBA annotation
Keywords - Domaini
Zinc-fingerARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000161219 |
HOGENOMi | CLU_000288_54_2_1 |
Family and domain databases
CDDi | cd00029, C1, 2 hits |
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR000008, C2_dom IPR035892, C2_domain_sf IPR020454, DAG/PE-bd IPR011009, Kinase-like_dom_sf IPR002219, PE/DAG-bd IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR014375, Protein_kinase_C_a/b/g IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00130, C1_1, 2 hits PF00168, C2, 1 hit PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
PIRSFi | PIRSF000550, PKC_alpha, 2 hits |
PRINTSi | PR00360, C2DOMAIN PR00008, DAGPEDOMAIN |
SMARTi | View protein in SMART SM00109, C1, 2 hits SM00239, C2, 1 hit SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS50004, C2, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS00479, ZF_DAG_PE_1, 2 hits PS50081, ZF_DAG_PE_2, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q2NKI4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGLGPGGGD SEGGPRPLFC RKGALRQKVV HEVKSHKFTA RFFKQPTFCS
60 70 80 90 100
HCTDFIWGIG KQGLQCQVCS FVVHRRCHEF VTFECPGAGK GPQTDDPRNK
110 120 130 140 150
HKFRLHSYSS PTFCDHCGSL LYGLVHQGMK CSCCEMNVHR RCVRSVPSLC
160 170 180 190 200
GVDHTERRGR LQLEIRAPTS DEIHITVGEA RNLIPMDPNG LSDPYVKLKL
210 220 230 240 250
IPDPRNLTKQ KTKTVKATLN PVWNETFVFN LKPGDVERRL SVEVWDWDRT
260 270 280 290 300
SRNDFMGAMS FGVSELLKAP VDGWYKLLNQ EEGEYYNVPV ADADNCSLLQ
310 320 330 340 350
KFEACNYPLE LYEVMLAERR GSDELYAIKI LKKDVIVQDD DVDCTLVEKR
360 370 380 390 400
VLALGGRGPG GRPHFLTQLH STFQTPDRLY FVMEYVTGGD LMYHIQQLGK
410 420 430 440 450
FKEPHAAFYA AEIAIGLFFL HNQGIIYRDL KLDNVMLDAE GHIKITDFGM
460 470 480 490 500
CKENVFPGST TRTFCGTPDY IAPEIIAYQP YGKSVDWWSF GVLLYEMLAG
510 520 530 540 550
QPPFDGEDEE ELFQAIMEQT VTYPKSLSRE AVAICKGFLT KHPGKRLGSG
560 570 580 590 600
PDGEPTIRAH GFFRWIDWER LERLEIAPPF RPRPCGRSGE NFDKFFTRAA
610 620 630 640
PALTPPDRLV LASIDQADFQ GFTYVNPDFV HPDARSPTSP VPVPVM
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP63318 | KPCG_MOUSE | Protein kinase C gamma type | Prkcg Pkcc, Pkcg, Prkcc | 697 | Annotation score: | ||
A0A0N4SWF4 | A0A0N4SWF4_MOUSE | Protein kinase C gamma type | Prkcg | 31 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC217111 Genomic DNA No translation available. CAAA01093154 Genomic DNA No translation available. BC111807 mRNA Translation: AAI11808.1 |
RefSeqi | NP_001278363.1, NM_001291434.1 |
Genome annotation databases
Ensembli | ENSMUST00000172109; ENSMUSP00000131351; ENSMUSG00000078816 |
GeneIDi | 18752 |
UCSCi | uc012ewe.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC217111 Genomic DNA No translation available. CAAA01093154 Genomic DNA No translation available. BC111807 mRNA Translation: AAI11808.1 |
RefSeqi | NP_001278363.1, NM_001291434.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
ProteomicsDBi | 333117 |
Protocols and materials databases
Antibodypediai | 32756, 641 antibodies |
DNASUi | 18752 |
Genome annotation databases
Ensembli | ENSMUST00000172109; ENSMUSP00000131351; ENSMUSG00000078816 |
GeneIDi | 18752 |
UCSCi | uc012ewe.2, mouse |
Organism-specific databases
CTDi | 5582 |
MGIi | MGI:97597, Prkcg |
Phylogenomic databases
GeneTreei | ENSGT00940000161219 |
HOGENOMi | CLU_000288_54_2_1 |
Miscellaneous databases
BioGRID-ORCSi | 18752, 0 hits in 52 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000078816, Expressed in CA1 field of hippocampus and 126 other tissues |
Family and domain databases
CDDi | cd00029, C1, 2 hits |
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR000008, C2_dom IPR035892, C2_domain_sf IPR020454, DAG/PE-bd IPR011009, Kinase-like_dom_sf IPR002219, PE/DAG-bd IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR014375, Protein_kinase_C_a/b/g IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00130, C1_1, 2 hits PF00168, C2, 1 hit PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
PIRSFi | PIRSF000550, PKC_alpha, 2 hits |
PRINTSi | PR00360, C2DOMAIN PR00008, DAGPEDOMAIN |
SMARTi | View protein in SMART SM00109, C1, 2 hits SM00239, C2, 1 hit SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS50004, C2, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS00479, ZF_DAG_PE_1, 2 hits PS50081, ZF_DAG_PE_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q2NKI4_MOUSE | |
Accessioni | Q2NKI4Primary (citable) accession number: Q2NKI4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 7, 2006 |
Last sequence update: | February 7, 2006 | |
Last modified: | April 7, 2021 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |