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Protein

Argininosuccinate lyase

Gene

argH

Organism
Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:Msp_0618
OrganismiMethanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)
Taxonomic identifieri339860 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanosphaera
Proteomesi
  • UP000001931 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002407911 – 465Argininosuccinate lyaseAdd BLAST465

Interactioni

Protein-protein interaction databases

STRINGi339860.Msp_0618

Structurei

3D structure databases

ProteinModelPortaliQ2NGN7
SMRiQ2NGN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01748 Archaea
COG0165 LUCA
HOGENOMiHOG000242744
KOiK01755
OMAiSIMPHKK
OrthoDBiPOG093Z09KV

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 2 hits
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit

Sequencei

Sequence statusi: Complete.

Q2NGN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLRAGRFDG QMTDDAAQFS SSIEFDKRIF KSDIKCNRAH TTMLIEEGII
60 70 80 90 100
PKESGKKILK ALDKLEKEGI GALNLDPSFE DIHMALEDYV TKEIGDEAGF
110 120 130 140 150
MHTAKSRNDQ VCTDIRLTLK EEIENTISNI KSFIKTIVEM AKENTHTLFI
160 170 180 190 200
AYTHLQHAQP TTFAHHLMAY ANELRRDCER LIDTYKRVDM NPLGSAALTT
210 220 230 240 250
TGFPINRERT TELLGFSKVM DNSIDGVSSR DFAAEAIFDY AMLSTTLGKI
260 270 280 290 300
SDEIVIWSSY EFRMVECSNQ YSSTSSIMPQ KKNPDIAELS RGKSTIAYGE
310 320 330 340 350
LMTVLSMIKG IPHSYNRDLQ EVTPHLWNAI DNTNDILRIV HGMLSTLTIN
360 370 380 390 400
KDRTEELAGA NFATATELAD VMVREKNLPF RTAHRIVGRV VSEAIDDNIT
410 420 430 440 450
THDIDNDYVN RVSVEVMGKP INLGEDLVKQ ALNPLRNVKS RTVIGGCAPE
460
AVNDAIEKME IFLNE
Length:465
Mass (Da):52,209
Last modified:February 7, 2006 - v1
Checksum:iA48E83EBDCB8B668
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000102 Genomic DNA Translation: ABC57016.1
RefSeqiWP_011406216.1, NC_007681.1

Genome annotation databases

EnsemblBacteriaiABC57016; ABC57016; Msp_0618
GeneIDi3855335
KEGGimst:Msp_0618

Similar proteinsi

Entry informationi

Entry nameiARLY_METST
AccessioniPrimary (citable) accession number: Q2NGN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: February 7, 2006
Last modified: February 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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