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UniProtKB - Q2NEH1 (GATD_METST)

Entry version 79 (02 Dec 2020)
Sequence version 1 (07 Feb 2006)
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Protein

Glutamyl-tRNA(Gln) amidotransferase subunit D

Gene

gatD

Organism
Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei101UniRule annotation1
Active sitei177UniRule annotation1
Active sitei178UniRule annotation1
Active sitei254UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MSTA339860:G1G4W-1413-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutamyl-tRNA(Gln) amidotransferase subunit DUniRule annotation (EC:6.3.5.-UniRule annotation)
Short name:
Glu-ADT subunit DUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gatDUniRule annotation
Ordered Locus Names:Msp_1411
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMethanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri339860 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaea › Euryarchaeota › Methanomada group › Methanobacteria › Methanobacteriales › Methanobacteriaceae › Methanosphaera ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001931 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_10000254601 – 438Glutamyl-tRNA(Gln) amidotransferase subunit DAdd BLAST438

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of GatD and GatE.

UniRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		339860.Msp_1411

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q2NEH1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini91 – 421Asparaginase/glutaminasePROSITE-ProRule annotationAdd BLAST331

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the asparaginase 1 family. GatD subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		arCOG01924, Archaea

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_019134_2_1_2

Identification of Orthologs from Complete Genome Data

More...OMAi		VRKNHTS

Database of Orthologous Groups

More...OrthoDBi		61613at2157

Family and domain databases

Conserved Domains Database

More...CDDi		cd08962, GatD, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.30.520, 1 hit
3.40.50.1170, 1 hit
3.40.50.40, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00586, GatD, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006033, AsnA_fam
IPR036152, Asp/glu_Ase-like_sf
IPR006034, Asparaginase/glutaminase-like
IPR027475, Asparaginase/glutaminase_AS2
IPR040919, Asparaginase_C
IPR011878, GatD
IPR040918, GatD_N
IPR037222, GatD_N_sf
IPR027473, L-asparaginase_C
IPR027474, L-asparaginase_N
IPR037152, L-asparaginase_N_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00710, Asparaginase, 1 hit
PF17763, Asparaginase_C, 1 hit
PF18195, GatD_N, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF500175, Glu_ADT_D, 1 hit
PIRSF001220, L-ASNase_gatD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00139, ASNGLNASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00870, Asparaginase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF141300, SSF141300, 1 hit
SSF53774, SSF53774, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00519, asnASE_I, 1 hit
TIGR02153, gatD_arch, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00144, ASN_GLN_ASE_1, 1 hit
PS00917, ASN_GLN_ASE_2, 1 hit
PS51732, ASN_GLN_ASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q2NEH1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYEEYLKDF LEISNITVGD TVKVTKPHIE HEGMLLEKPD YSNENTIILK 
        60         70         80         90        100
LDSGYNIGID IKDAKIEKIS EGKKPQIELD PVDKKISDKK KNLSILSTGG 
       110        120        130        140        150
TVASVIDYKT GAVHPAFTAD DLLRATPELV DYANINAKAI FNILSENMTP 
       160        170        180        190        200
EYWKKTATTI YDEINNGADG IIIAHGTDTM HYTASALSFM IDSPVPIVLT 
       210        220        230        240        250
GAQRSSDRPS SDAFTNLMAS VNAAKSDIAE VTICMHGTED DSYCDLHRGT 
       260        270        280        290        300
RARKMHTSRR DTFTSINMNP LARIENNKVT INDTQVKYTK RNEKELSLNT 
       310        320        330        340        350
NLADKVALIK MYPGISPEII DIYVDKNYDG IVIEGTGLGH CSDDVITSIT 
       360        370        380        390        400
RATSEDIPVV MTSQCLFGRT NMNVYSSGRR LLQNNVIGVG DMLPETAYTK 
       410        420        430 
LLWAAGQTDN VSEIYEIMKT NLKGEMDTTL SQNYFIKN
Length:438
Mass (Da):48,554
Last modified:February 7, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7A3E1F16EC2866FE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CP000102 Genomic DNA Translation: ABC57782.1

NCBI Reference Sequences

More...RefSeqi		WP_011406981.1, NC_007681.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		ABC57782; ABC57782; Msp_1411

Database of genes from NCBI RefSeq genomes

More...GeneIDi		41325984

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mst:Msp_1411

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000102 Genomic DNA Translation: ABC57782.1
RefSeqiWP_011406981.1, NC_007681.1

3D structure databases

SMRiQ2NEH1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi339860.Msp_1411

Genome annotation databases

EnsemblBacteriaiABC57782; ABC57782; Msp_1411
GeneIDi41325984
KEGGimst:Msp_1411

Phylogenomic databases

eggNOGiarCOG01924, Archaea
HOGENOMiCLU_019134_2_1_2
OMAiVRKNHTS
OrthoDBi61613at2157

Enzyme and pathway databases

BioCyciMSTA339860:G1G4W-1413-MONOMER

Family and domain databases

CDDicd08962, GatD, 1 hit
Gene3Di2.30.30.520, 1 hit
3.40.50.1170, 1 hit
3.40.50.40, 1 hit
HAMAPiMF_00586, GatD, 1 hit
InterProiView protein in InterPro
IPR006033, AsnA_fam
IPR036152, Asp/glu_Ase-like_sf
IPR006034, Asparaginase/glutaminase-like
IPR027475, Asparaginase/glutaminase_AS2
IPR040919, Asparaginase_C
IPR011878, GatD
IPR040918, GatD_N
IPR037222, GatD_N_sf
IPR027473, L-asparaginase_C
IPR027474, L-asparaginase_N
IPR037152, L-asparaginase_N_sf
PfamiView protein in Pfam
PF00710, Asparaginase, 1 hit
PF17763, Asparaginase_C, 1 hit
PF18195, GatD_N, 1 hit
PIRSFiPIRSF500175, Glu_ADT_D, 1 hit
PIRSF001220, L-ASNase_gatD, 1 hit
PRINTSiPR00139, ASNGLNASE
SMARTiView protein in SMART
SM00870, Asparaginase, 1 hit
SUPFAMiSSF141300, SSF141300, 1 hit
SSF53774, SSF53774, 1 hit
TIGRFAMsiTIGR00519, asnASE_I, 1 hit
TIGR02153, gatD_arch, 1 hit
PROSITEiView protein in PROSITE
PS00144, ASN_GLN_ASE_1, 1 hit
PS00917, ASN_GLN_ASE_2, 1 hit
PS51732, ASN_GLN_ASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGATD_METST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2NEH1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: December 2, 2020
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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