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Entry version 122 (02 Dec 2020)
Sequence version 1 (07 Feb 2006)
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Protein

GTPase NRas

Gene

NRAS

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP) (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi10 – 18GTPBy similarity9
Nucleotide bindingi29 – 30GTPBy similarity2
Nucleotide bindingi57 – 61GTPSequence analysis5
Nucleotide bindingi116 – 119GTPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SSC-1169092, Activation of RAS in B cells
R-SSC-1250347, SHC1 events in ERBB4 signaling
R-SSC-1433557, Signaling by SCF-KIT
R-SSC-171007, p38MAPK events
R-SSC-179812, GRB2 events in EGFR signaling
R-SSC-180336, SHC1 events in EGFR signaling
R-SSC-186763, Downstream signal transduction
R-SSC-1963640, GRB2 events in ERBB2 signaling
R-SSC-210993, Tie2 Signaling
R-SSC-2179392, EGFR Transactivation by Gastrin
R-SSC-2424491, DAP12 signaling
R-SSC-2871796, FCERI mediated MAPK activation
R-SSC-375165, NCAM signaling for neurite out-growth
R-SSC-5218921, VEGFR2 mediated cell proliferation
R-SSC-5654688, SHC-mediated cascade:FGFR1
R-SSC-5654693, FRS-mediated FGFR1 signaling
R-SSC-5654699, SHC-mediated cascade:FGFR2
R-SSC-5654700, FRS-mediated FGFR2 signaling
R-SSC-5654704, SHC-mediated cascade:FGFR3
R-SSC-5654706, FRS-mediated FGFR3 signaling
R-SSC-5654712, FRS-mediated FGFR4 signaling
R-SSC-5654719, SHC-mediated cascade:FGFR4
R-SSC-5658442, Regulation of RAS by GAPs
R-SSC-5673000, RAF activation
R-SSC-5673001, RAF/MAP kinase cascade
R-SSC-5674135, MAP2K and MAPK activation
R-SSC-5675221, Negative regulation of MAPK pathway
R-SSC-6798695, Neutrophil degranulation
R-SSC-8849471, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-SSC-8851805, MET activates RAS signaling
R-SSC-9607240, FLT3 Signaling
R-SSC-9634635, Estrogen-stimulated signaling through PRKCZ
R-SSC-9648002, RAS processing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GTPase NRas (EC:3.6.5.2By similarity)
Alternative name(s):
Transforming protein N-Ras
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NRAS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000314985 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4
  • UP000008227 Componenti: Chromosome 4

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:98827, NRAS

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002611231 – 186GTPase NRasAdd BLAST186
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000261124187 – 189Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei89PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki170Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi181S-palmitoyl cysteineBy similarity1
Lipidationi186S-farnesyl cysteineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoylated by the ZDHHC9-GOLGA7 complex. Depalmitoylated by ABHD17A, ABHD17B and ABHD17C. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.By similarity
Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).By similarity
Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes.By similarity
Phosphorylation at Ser-89 by STK19 enhances NRAS-association with its downstream effectors.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Lipoprotein, Methylation, Palmitate, Phosphoprotein, Prenylation, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q2MJK3

PeptideAtlas

More...
PeptideAtlasi
Q2MJK3

PRoteomics IDEntifications database

More...
PRIDEi
Q2MJK3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSSSCG00000006753, Expressed in lung and 37 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q2MJK3, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (active GTP-bound form preferentially) with RGS14.

Interacts (active GTP-bound form) with RASSF7 (By similarity).

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9823.ENSSSCP00000007203

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q2MJK3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni166 – 185Hypervariable regionBy similarityAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi32 – 40Effector region9

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0395, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158947

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_041217_9_8_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q2MJK3

Identification of Orthologs from Complete Genome Data

More...
OMAi
RIPCKLM

Database of Orthologous Groups

More...
OrthoDBi
1259506at2759

TreeFam database of animal gene trees

More...
TreeFami
TF312796

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027417, P-loop_NTPase
IPR005225, Small_GTP-bd_dom
IPR001806, Small_GTPase
IPR020849, Small_GTPase_Ras-type

The PANTHER Classification System

More...
PANTHERi
PTHR24070, PTHR24070, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00071, Ras, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00231, small_GTP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51421, RAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q2MJK3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET
60 70 80 90 100
CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNSKSF ADINLYREQI
110 120 130 140 150
KRVKDSDDVP MVLVGNKCDL PTRTVDTKQA HELAKSYGIP FIETSAKTRQ
160 170 180
GVEDAFYTLV REIRQYRMKK LNSSDDGTQG CMGLPCVVM
Length:189
Mass (Da):21,229
Last modified:February 7, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6898D3F6815B1EC7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ325522 mRNA Translation: ABC55723.1

NCBI Reference Sequences

More...
RefSeqi
NP_001038002.1, NM_001044537.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSSCT00000038488; ENSSSCP00000046185; ENSSSCG00000032477
ENSSSCT00005016701; ENSSSCP00005009969; ENSSSCG00005010802
ENSSSCT00015088424; ENSSSCP00015036059; ENSSSCG00015065826
ENSSSCT00025020871; ENSSSCP00025008582; ENSSSCG00025015558
ENSSSCT00030071584; ENSSSCP00030032626; ENSSSCG00030051390
ENSSSCT00035052241; ENSSSCP00035021001; ENSSSCG00035039325
ENSSSCT00040026984; ENSSSCP00040011402; ENSSSCG00040019987
ENSSSCT00045016798; ENSSSCP00045011590; ENSSSCG00045009917
ENSSSCT00050054942; ENSSSCP00050023236; ENSSSCG00050040592
ENSSSCT00055024396; ENSSSCP00055019361; ENSSSCG00055012395
ENSSSCT00060096238; ENSSSCP00060041641; ENSSSCG00060070493
ENSSSCT00065040494; ENSSSCP00065017119; ENSSSCG00065029998
ENSSSCT00070009201; ENSSSCP00070007551; ENSSSCG00070004868

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100739349

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ssc:100739349

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ325522 mRNA Translation: ABC55723.1
RefSeqiNP_001038002.1, NM_001044537.1

3D structure databases

SMRiQ2MJK3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000007203

Proteomic databases

PaxDbiQ2MJK3
PeptideAtlasiQ2MJK3
PRIDEiQ2MJK3

Genome annotation databases

EnsembliENSSSCT00000038488; ENSSSCP00000046185; ENSSSCG00000032477
ENSSSCT00005016701; ENSSSCP00005009969; ENSSSCG00005010802
ENSSSCT00015088424; ENSSSCP00015036059; ENSSSCG00015065826
ENSSSCT00025020871; ENSSSCP00025008582; ENSSSCG00025015558
ENSSSCT00030071584; ENSSSCP00030032626; ENSSSCG00030051390
ENSSSCT00035052241; ENSSSCP00035021001; ENSSSCG00035039325
ENSSSCT00040026984; ENSSSCP00040011402; ENSSSCG00040019987
ENSSSCT00045016798; ENSSSCP00045011590; ENSSSCG00045009917
ENSSSCT00050054942; ENSSSCP00050023236; ENSSSCG00050040592
ENSSSCT00055024396; ENSSSCP00055019361; ENSSSCG00055012395
ENSSSCT00060096238; ENSSSCP00060041641; ENSSSCG00060070493
ENSSSCT00065040494; ENSSSCP00065017119; ENSSSCG00065029998
ENSSSCT00070009201; ENSSSCP00070007551; ENSSSCG00070004868
GeneIDi100739349
KEGGissc:100739349

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4893
VGNCiVGNC:98827, NRAS

Phylogenomic databases

eggNOGiKOG0395, Eukaryota
GeneTreeiENSGT00940000158947
HOGENOMiCLU_041217_9_8_1
InParanoidiQ2MJK3
OMAiRIPCKLM
OrthoDBi1259506at2759
TreeFamiTF312796

Enzyme and pathway databases

ReactomeiR-SSC-1169092, Activation of RAS in B cells
R-SSC-1250347, SHC1 events in ERBB4 signaling
R-SSC-1433557, Signaling by SCF-KIT
R-SSC-171007, p38MAPK events
R-SSC-179812, GRB2 events in EGFR signaling
R-SSC-180336, SHC1 events in EGFR signaling
R-SSC-186763, Downstream signal transduction
R-SSC-1963640, GRB2 events in ERBB2 signaling
R-SSC-210993, Tie2 Signaling
R-SSC-2179392, EGFR Transactivation by Gastrin
R-SSC-2424491, DAP12 signaling
R-SSC-2871796, FCERI mediated MAPK activation
R-SSC-375165, NCAM signaling for neurite out-growth
R-SSC-5218921, VEGFR2 mediated cell proliferation
R-SSC-5654688, SHC-mediated cascade:FGFR1
R-SSC-5654693, FRS-mediated FGFR1 signaling
R-SSC-5654699, SHC-mediated cascade:FGFR2
R-SSC-5654700, FRS-mediated FGFR2 signaling
R-SSC-5654704, SHC-mediated cascade:FGFR3
R-SSC-5654706, FRS-mediated FGFR3 signaling
R-SSC-5654712, FRS-mediated FGFR4 signaling
R-SSC-5654719, SHC-mediated cascade:FGFR4
R-SSC-5658442, Regulation of RAS by GAPs
R-SSC-5673000, RAF activation
R-SSC-5673001, RAF/MAP kinase cascade
R-SSC-5674135, MAP2K and MAPK activation
R-SSC-5675221, Negative regulation of MAPK pathway
R-SSC-6798695, Neutrophil degranulation
R-SSC-8849471, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-SSC-8851805, MET activates RAS signaling
R-SSC-9607240, FLT3 Signaling
R-SSC-9634635, Estrogen-stimulated signaling through PRKCZ
R-SSC-9648002, RAS processing

Gene expression databases

BgeeiENSSSCG00000006753, Expressed in lung and 37 other tissues
ExpressionAtlasiQ2MJK3, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR027417, P-loop_NTPase
IPR005225, Small_GTP-bd_dom
IPR001806, Small_GTPase
IPR020849, Small_GTPase_Ras-type
PANTHERiPTHR24070, PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071, Ras, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR00231, small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421, RAS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRASN_PIG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2MJK3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: February 7, 2006
Last modified: December 2, 2020
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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